Magnus Bygren, Richard Weigel, Sir Richard Branson, Alfonso Martinez Cearra, Espen Ronneberg, Raj Persaud,
... amused New fiction No entry Immigration Katharine Graham Valdivieso Economist Conferences Courses Courses Tenders Appointments Appointments Appointments ...
2001 - Gale Group | The Economist
Juan Pablo Valdivieso, Juan de Dios Rivera,
Tópico(s): Plant Parasitism and Resistance
2013 - Springer Science+Business Media | Fire Technology
Diana V. Burbano, Juan Carlos Valdivieso, Juan Carlos Izurieta, Thomas C. Meredith, Diego Quiroga,
Tourism growth in biodiversity conservation areas presents both challenges and opportunities for sustainability. The COVID-19 pandemic brought both into focus in the Galapagos. This study engages with tourism service providers and regulators in Puerto Ayora, Santa Cruz Island, to explore how ‘sustainability’ has been integrated into evolving links between tourism and conservation since the implementation of the Ecotourism Model a decade ago. Findings suggest that to achieve sustainability, priorities ...
Tópico(s): Cruise Tourism Development and Management
2022 - Elsevier BV | Annals of Tourism Research Empirical Insights
R Robles, Joan Figueras, Víctor Sánchez Turrión, Carlos Margarit, Andrés Moyá, Evaristo Varó, Javier Calleja, Andrés Valdivieso, Juan Carlos García Valdecasas, Pedro Benito López, Manuel Arias, Emilio Vicente, Carmelo Loinaz, Julio Santoyo Santoyo, Manuel Gómez Fleitas, Ángel Bernardos, Laura Lladó, Pablo Ramı́rez, F.S Bueno, Eduardo Jaurrieta, Pascual Parrilla,
To assess the real utility of orthotopic liver transplantation (OLT) in patients with cholangiocarcinoma, we need series with large numbers of cases and long follow-ups. The aim of this paper is to review the Spanish experience in OLT for hilar and peripheral cholangiocarcinoma and to try to identify the prognostic factors that could influence survival.Palliative treatment of nondisseminated irresectable cholangiocarcinoma carries a zero 5-year survival rate. The role of OLT in these patients is ...
Tópico(s): Transplantation: Methods and Outcomes
2004 - Lippincott Williams & Wilkins | Annals of Surgery
Shaoxian Song, Alejandro López–Valdivieso, Juan Luis Reyes-Bahena, Hugo Israel Bermejo-Perez, O. Trass,
The hydrophobic flocculation of galena fines induced by potassium amyl xanthate (PAX) in aqueous suspensions has been studied using laser diffraction, electrophoretic light scattering, contact angle, and microflotation measurements. The measurements were performed on <2 µm, 2-5 µm, 5-10 µm, and <30 µm size galena by varying several parameters, including PAX concentration, pH, original particle size, kerosene concentration, and suspension stirring. The experimental results have demonstrated that the ...
Tópico(s): Coagulation and Flocculation Studies
2000 - Elsevier BV | Journal of Colloid and Interface Science
Shaoxian Song, Alejandro López–Valdivieso, Juan Luis Reyes-Bahena, Hugo Israel Bermejo-Perez,
Abstract The hydrophobic flocculation of sphalerite fines in aqueous suspensions induced by ethyl and amyl xanthates has been investigated using laser diffraction, electrophoretic light scattering and contact angle measurements. The investigation includes studying the effects of various parameters, namely hydrocarbon chain length of xanthate ions, xanthate concentration, pH, original particle size and stirring strength, and approaching the mechanisms of the hydrophobic flocculation. The experimental ...
Tópico(s): Characterization and Applications of Magnetic Nanoparticles
2001 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects
Shaoxian Song, Alejandro López–Valdivieso, Juan Luis Reyes-Bahena, C. Lara-Valenzuela,
The flotation of galena and sphalerite fines in the form of flocs, which is termed floc flotation, has been studied in the present work. The flocs formed through hydrophobic flocculation induced by potassium amyl xanthate (PAX) and kinetic energy input. The studies were performed on single minerals of −20 μm size by using micro-flotation and floc size measurements. Several parameters, including pH, PAX concentration, kerosene addition and stirring strength, have been investigated for their effects ...
Tópico(s): Tailings Management and Properties
2001 - Elsevier BV | Minerals Engineering
Carlos Daniel Pinacho-Pinacho, Miguel Calixto‐Rojas, Adriana García‐Vásquez, Ismael Guzmán‐Valdivieso, Juan José Barrios-Gutiérrez, Miguel Rubio,
Tópico(s): Aquaculture disease management and microbiota
2021 - Springer Science+Business Media | Parasitology Research
Jorge Baruch Pineda-Farías, Paulino Barragán‐Iglesias, Alann Valdivieso-Sánchez, Juan Rodrı́guez-Silverio, Francisco Javier Flores‐Murrieta, Vinicio Granados‐Soto, Héctor Isaac Rocha‐González,
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2017 - Elsevier BV | Pharmacological Reports
Ángel Leonardo Valdivieso Caraguay, Juan Pablo Vásconez, Lorena Isabel Barona López, Marco E. Benalcázar,
In recent years, hand gesture recognition (HGR) technologies that use electromyography (EMG) signals have been of considerable interest in developing human-machine interfaces. Most state-of-the-art HGR approaches are based mainly on supervised machine learning (ML). However, the use of reinforcement learning (RL) techniques to classify EMGs is still a new and open research topic. Methods based on RL have some advantages such as promising classification performance and online learning from the user's ...
Tópico(s): Gaze Tracking and Assistive Technology
2023 - Multidisciplinary Digital Publishing Institute | Sensors
R. Charco, M. Caralt, Laura Lladó, Andrés Valdivieso, Juan Fabregat, A. Matarranz, I González-Pinto, Fernando Pardo, Emilio Fábrega, Itxarone Bilbao,
Tópico(s): Liver Disease and Transplantation
2011 - Elsevier BV | Transplantation Proceedings
Francisco Javier Pérez‐Benito, Carlos Sáez, J. Alberto Conejero, Salvador Tortajada, Bernardo Valdivieso, Juan M. García‐Gómez,
Objective To evaluate the effects of Process-Reengineering interventions on the Electronic Health Records (EHR) of a hospital over 7 years. Materials and methods Temporal Variability Assessment (TVA) based on probabilistic data quality assessment was applied to the historic monthly-batched admission data of Hospital La Fe Valencia, Spain from 2010 to 2016. Routine healthcare data with a complete EHR was expanded by processed variables such as the Charlson Comorbidity Index. Results Four Process-Reengineering ...
Tópico(s): Data Quality and Management
2019 - Public Library of Science | PLoS ONE
olvida en diversas ocasiones el rigor profesional, al no respetar lo investigado y lo escrito por quienes lo antecedieron, ya que 10 presenta como hallazgo5, investigaciones e interpretaciones propias.Pondré algunos ejemplos que prueben 10 antes dicho . .Para ello seguiré el índice.del libro que, por cierto, casi reproduce la estructura de El Mundo 01meca de 1. Bernal, publicado once años antes.Nueve son los capítulos que 10 componen: 1.El descubrimiento de los olmecas; II.El corazón del mundo almeca; ...
Tópico(s): Architecture and Art History Studies
1986 - National Autonomous University of Mexico | Anales del Instituto de Investigaciones Estéticas
Enrique Sánchez-Valdivieso, Juan Jesús Cruz, Raquel Salazar-Lugo, M. Abad, Alberto Gómez-Alonso, Adrián Blanco‐Gómez, Rogelio González‐Sarmiento,
British Journal of Cancer (2002) 86, 1362–1363. DOI: 10.1038/sj/bjc/6600245 www.bjcancer.com © 2002 Cancer Research UK
Tópico(s): HER2/EGFR in Cancer Research
2002 - Springer Nature | British Journal of Cancer
Vicent Blanes-Selva, Vicente Ruiz‐García, Salvador Tortajada, José-Miguel Benedí, Bernardo Valdivieso, Juan M. García‐Gómez,
Background: Palliative care is referred to a set of programs for patients that suffer life-limiting illnesses. These programs aim to guarantee a minimum level of quality of life (QoL) for the last stage of life. They are currently based on clinical evaluation of risk of one-year mortality. Objectives: The main objective of this work is to develop and validate machine-learning based models to predict the exitus of a patient within the next year using data gathered at hospital admission. Methods: Five ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2021 - SAGE Publishing | Health Informatics Journal
Juan A. Valdivieso, Miguel Ángel Carbonero, Luis Jorge Martín Antón,
Se establece una propuesta conceptual del estilo de enseñanza del profesorado de EP constituida por un conjunto de dimensiones holísticas e integradoras, de naturaleza introyectiva y proyectiva, que sirven de base para la elaborar la "Escala de Evaluación de la Competencia Autopercibida del Docente de Educación Primaria (ECAD-EP)", escala que puede ser empleada como un instrumento de evaluación con propiedades psicométricas válidas y fiables, idónea para poder cuantificar el perfil competencial del ...
Tópico(s): Higher Education Teaching and Evaluation
2012 - Elsevier BV | Revista de Psicodidáctica
Anibal Gustavo Yllesca Ramos, J. Cervera, Andrés Valdivieso, Daniel Pérez, Juan Vasallo, José M. Cuyás,
The main objective is to evaluate the complications and problems encountered in a population with inner ear congenital malformation undergoing cochlear implantation.The present study includes 33 patients with congenital inner ear malformation, from a total population of 346 cochlear implant patients, implanted from February 1993 to March 2004. Radiological evaluation and neurological exams were performed to all these patients in order to evaluate all the preoperative conditions.The most common cochlear ...
Tópico(s): Ear Surgery and Otitis Media
2005 - Elsevier BV | Acta Otorrinolaringológica Española
Juan Carlos Valdivieso, Paul F.J. Eagles, Joan Carles Gil,
Despite the increasing number of protected areas around the world and their importance in the conservation of species and ecosystems, protected areas management capacity remains difficult to evaluate. A standard is needed to help policy makers compare the goals with the results obtained. This empirical research builds a tool to analyze the management efficiency and predicts the new touristic outcomes in case of a policy change. Using as example the state parks agencies in the USA, this paper develops ...
Tópico(s): Conservation, Biodiversity, and Resource Management
2014 - Taylor & Francis | Journal of Environmental Planning and Management
Miguel Ángel Carbonero, Luis Jorge Martín Antón, Eugenio Monsalvo, Juan A. Valdivieso,
This study focuses on the analysis of the differences observed between students with different levels of academic performance in their social attitudes and personal responsibility towards study, according to various theories and models. Participants were 235 students from the third cycle of Primary Education (10-12 years old). They completed two attitude rating scales: (a) <em>Assessment Scale of Social Responsibility Attitudes of Primary School Pupils </em>(EARSA-P, Monsalvo, 2012b), consisting ...
Tópico(s): Educational Innovations and Technology
2015 - Servicio de Publicaciones | Anales de Psicología
Produção Nacional
Revisado por pares
Andrés Reyes-Harker, Carlos Fernando Ruiz-Valdivieso, Andrés Mora, Juan Carlos Ramírez-Arias, Guillermo Rodríguez, Felipe de la Parra, Víctor Caballero, Maurício Parra, Néstor Moreno, Brian K. Horton, Joel E. Saylor, Alejandro Silva, V. Valencia, Daniel F. Stöckli, Vladimir Blanco,
New biostratigraphic zonations, core descriptions, sandstone petrography, facies analysis, and seismic information are compared with published detrital and bedrock geo- and thermochronology to build a Cenozoic paleogeographic reconstruction of the Andean retroarc region of Colombia, encompassing the ancestral Central Cordillera, Middle Magdalena Valley, Eastern Cordillera, and Llanos basin. We identify uplifted sediment source areas, provenance domains, depositional environments, and thickness changes ...
Tópico(s): Reservoir Engineering and Simulation Methods
2015 - American Association of Petroleum Geologists | AAPG Bulletin
Mercedes Santos, Sofía Serrano-Dúcar, Juan González‐Valdivieso, Reinaldo Vallejo, Alessandra Girotti, Purificación Cuadrado, Francisco Javier Arias,
Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a higher degree of complexity and accuracy. Moreover, their sequences, which are derived from structural protein-based modules, can easily be modified to include bioactive motifs that improve their functions and material-host interactions, ...
Tópico(s): Silk-based biomaterials and applications
2018 - Bentham Science Publishers | Current Medicinal Chemistry
Antonio Martínez-Millana, María Argente, Bernardo Valdivieso, Vicente Traver, Juan Francisco Merino-Torres,
Electronic health records and computational modelling have paved the way for the development of Type 2 Diabetes risk scores to identify subjects at high risk. Unfortunately, few risk scores have been externally validated, and their performance can be compromised when routine clinical data is used. The aim of this study was to assess the performance of well-established risk scores for Type 2 Diabetes using routinely collected clinical data and to quantify their impact on the decision making process ...
Tópico(s): Machine Learning in Healthcare
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Juan González‐Valdivieso, Alessandra Girotti, Raquel Muñoz, José Carlos Rodríguez‐Cabello, Francisco Javier Arias,
This work investigates the physicochemical properties and in vitro accuracy of a genetically engineered drug-delivery system based on elastin-like block recombinamers. The DNA recombinant techniques allowed us to create this smart complex polymer containing bioactive sequences for internalization, lysosome activation under acidic pH, and blockage of cellular growth by a small peptide inhibitor. The recombinant polymer reversibly self-assembled when the temperature was increased above 15 °C into nanoparticles ...
Tópico(s): Supramolecular Self-Assembly in Materials
2019 - American Chemical Society | Biomacromolecules
Reinaldo Vallejo, Juan González‐Valdivieso, Mercedes Santos, Soraya Rodríguez‐Rojo, Francisco Javier Arias,
This study presents a new groundbreaking methodology for integrating innovative concepts to develop novel drug-delivery strategies. This methodology combines genetically engineered elastin-like recombinamers (ELRs) with supercritical fluid (SCF) techniques to encapsulate a poorly water-soluble drug in a one-step process. The chemotherapeutic agent docetaxel (DTX) is encapsulated with a block copolymer ELR containing the RGD peptide, a specific target sequence for cancer cells, using the supercritical ...
Tópico(s): Nanoparticle-Based Drug Delivery
2020 - Elsevier BV | Journal of Industrial and Engineering Chemistry
Yanping Yang, Huan Yang, Yago Alcaina, Janusz Puc, Alyssa Birt, Yogindra Vedvyas, Michael Gallagher, Srinija Alla, Maria Cristina Riascos, Jaclyn E. McCloskey, Karrie Du, Juan González‐Valdivieso, Irene M. Min, Elisa de Stanchina, Matt Britz, Eric von Hofe, Moonsoo M. Jin,
Abstract The limited number of targetable tumor-specific antigens and the immunosuppressive nature of the microenvironment within solid malignancies represent major barriers to the success of chimeric antigen receptor (CAR)-T cell therapies. Here, using epithelial cell adhesion molecule (EpCAM) as a model antigen, we used alanine scanning of the complementarity-determining region to fine-tune CAR affinity. This allowed us to identify CARs that could spare primary epithelial cells while still effectively ...
Tópico(s): Advancements in Semiconductor Devices and Circuit Design
2023 - Nature Portfolio | Nature Communications
Tania B. López-Méndez, Miguel Sánchez‐Álvarez, Flavia Trionfetti, José Luís Pedraz, Marco Tripodi, Marco Cordani, Raffaele Strippoli, Juan González‐Valdivieso,
Abstract In recent years, progress in nanotechnology provided new tools to treat cancer more effectively. Advances in biomaterials tailored for drug delivery have the potential to overcome the limited selectivity and side effects frequently associated with traditional therapeutic agents. While autophagy is pivotal in determining cell fate and adaptation to different challenges, and despite the fact that it is frequently dysregulated in cancer, antitumor therapeutic strategies leveraging on or targeting ...
Tópico(s): Adenosine and Purinergic Signaling
2023 - BioMed Central | Cell & Bioscience
Dirk Roos, Karin van Leeuwen, Amy P. Hsu, Debra Long Priel, Amber Begtrup, Rhonda Brandon, Marie José Stasia, Faris G. Bakri, Nezihe Köker, Mustafa Yavuz Köker, Manisha Madkaika, Martin de Boer, María Bravo García‐Morato, Juan Luis Valdivieso Shephard, Joachim Roesler, Hirokazu Kanegane, Toshinao Kawai, Gigliola Di Matteo, Mohammad Shahrooei, Jacinta Bustamante, Amit Rawat, Pandiarajan Vignesh, Esmaeil Mortaz, Abbas Fayezi, Deniz Çağdaş, İlhan Tezcan, Maleewan Kitcharoensakkul, Mary C. Dinauer, Isabelle Meyts, Baruch Wolach, Antônio Condino‐Neto, Christa S. Zerbe, Steven M. Holland, Harry L. Malech, John I. Gallin, Douglas B. Kuhns,
Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. CGD patients suffer from severe bacterial and fungal infections. The disease is caused by a lack of superoxide production by the leukocyte enzyme NADPH oxidase. Superoxide and subsequently formed other reactive oxygen species (ROS) are instrumental in killing phagocytosed micro-organisms in neutrophils, eosinophils, monocytes and macrophages. The leukocyte NADPH oxidase is composed of five ...
Tópico(s): Calcium signaling and nucleotide metabolism
2021 - Elsevier BV | Blood Cells Molecules and Diseases
Juan González‐Valdivieso, Alessandra Girotti, J. Schneider, Francisco Javier Arias,
Cancer has reached pandemic dimensions in the whole world. Although current medicine offers multiple treatment options against cancer, novel therapeutic strategies are needed due to the low specificity of chemotherapeutic drugs, undesired side effects and the presence of different incurable types of cancer. Among these new strategies, nanomedicine arises as an encouraging approach towards personalized medicine with high potential for present and future cancer patients. Therefore, nanomedicine aims ...
Tópico(s): Nanoplatforms for cancer theranostics
2021 - Elsevier BV | International Journal of Pharmaceutics
Produção Nacional
Revisado por pares
Dirk Roos, Karin van Leeuwen, Amy P. Hsu, Debra Long Priel, Amber Begtrup, Rhonda Brandon, Amit Rawat, Pandiarajan Vignesh, Manisha Madkaikar, Marie José Stasia, Faris G. Bakri, Martin de Boer, Joachim Roesler, Nezihe Köker, Mustafa Yavuz Köker, Marianne Antonius Jakobsen, Jacinta Bustamante, María Bravo García‐Morato, Juan Luis Valdivieso Shephard, Deniz Çağdaş, İlhan Tezcan, Roya Sherkat, Esmaeil Mortaz, Abbas Fayezi, Mohammad Shahrooei, Baruch Wolach, Lizbeth Blancas‐Galicia, Hirokazu Kanegane, Toshinao Kawai, Antônio Condino‐Neto, Mauno Vihinen, Christa S. Zerbe, Steven M. Holland, Harry L. Malech, John I. Gallin, Douglas B. Kuhns,
Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. CGD patients suffer from severe, recurrent bacterial and fungal infections. The disease is caused by mutations in the genes encoding the components of the leukocyte NADPH oxidase. This enzyme produces superoxide, which is subsequently metabolized to hydrogen peroxide and other reactive oxygen species (ROS). These products are essential for intracellular killing of pathogens by phagocytic leukocytes ( ...
Tópico(s): Inflammasome and immune disorders
2021 - Elsevier BV | Blood Cells Molecules and Diseases
Cristina Roure Nuez, M. González-Navarro, Juan González Valdivieso, Mireia Fuster Barrera, Antoni Broto Sumalla, Jordi Sarlé Rubí, Xavier García Eroles,
Evaluation of the effectiveness of a perioperative medication reconciliation program in patients scheduled for elective surgery on perioperative medication management protocol adherence.Ambispective cross-cohort study: prospective cohort (Group A), and retrospective control cohort (Group B) without intervention. Forty eight hours before admission a pharmacist generates a proposal on medication active prior to admission to be maintained/discontinued during the perioperative period according to the ...
Tópico(s): Hemodynamic Monitoring and Therapy
2012 - Elsevier BV | Medicina Clínica