Ahmed El-Kordi, Anne Kästner, Sabrina Grube, Matthias Klugmann, Martin Begemann, Swetlana Sperling, Kurt Hammerschmidt, Christian Hammer, Beata Stepniak, Julia Patzig, Patricia de Monasterio‐Schrader, Nicola Strenzke, G. Flügge, Hauke Werner, Robert Pawlak, KA Nave, Hannelore Ehrenreich,
Claustrophobia, the well-known fear of being trapped in narrow/closed spaces, is often considered a conditioned response to traumatic experience. Surprisingly, we found that mutations affecting a single gene, encoding a stress-regulated neuronal protein, can cause claustrophobia. Gpm6a-deficient mice develop normally and lack obvious behavioral abnormalities. However, when mildly stressed by single-housing, these mice develop a striking claustrophobia-like phenotype, which is not inducible in wild- ...
Tópico(s): Neuroendocrine regulation and behavior
2013 - Springer Nature | Translational Psychiatry
Julia Johnke, Maayan Baron, Marina de Leeuw, Ariel Kushmaro, Édouard Jurkevitch, Hauke Harms, Antonis Chatzinotas,
Complex ecosystems harbor multiple predator and prey species whose direct and indirect interactions are understudied. In particular, the combined effects of predator diversity and resource preference on prey removal are not known. To better understand the effect of interspecies interactions combinations of micro-predators – i.e. protists (generalists), predatory bacteria (semi-specialists), and phages (specialists) – and bacterial prey were tracked over a 72-hour period in miniature membrane bioreactors. ...
Tópico(s): Genomics and Phylogenetic Studies
2017 - Frontiers Media | Frontiers in Ecology and Evolution
Hauke Jöns, Friedrich Lüth, Svea Mahlstedt, Julia Goldhammer, Sönke Hartz, Hans-Joachim Kühn,
Only in the last 20 years have German research institutes and heritage agencies turned their attention to the investigation of the settlements that were inundated by rapid sea-level rise during the Holocene. Over 142 sites have been recorded so far, the majority on the Baltic coastline, and mostly of Late Mesolithic and Early Neolithic date. Underwater excavations on the Baltic coast of sites such as Timmendorf-Nordmole, Neustadt and Strande demonstrate the presence of large and well-preserved assemblages ...
Tópico(s): Maritime and Coastal Archaeology
2020 - Springer International Publishing | Coastal research library
Olaf Jahn, Stefan Tenzer, Nicole Bartsch, Julia Patzig, Hauke Werner,
Myelin, the multilayered membrane that enwraps and insulates neuronal axons for fast signal propagation, is a plasma membrane specialization of oligodendrocytes and Schwann cells in the central and peripheral nervous system, respectively. Here we provide our lab protocols for the purification of myelin from mouse brains and for gel-based and gel-free proteomic applications, as well as a brief discussion with respect to our current knowledge of the myelin cytoskeleton.
Tópico(s): Ubiquitin and proteasome pathways
2012 - Humana Press | Neuromethods
Patricia de Monasterio‐Schrader, Olaf Jahn, Stefan Tenzer, Sven P. Wichert, Julia Patzig, Hauke Werner,
Tópico(s): RNA regulation and disease
2012 - Springer Nature | Cellular and Molecular Life Sciences
Julia Koopmeiners, Christina Diederich, Jennifer Solarczek, Hauke Voß, Janine Mayer, Wulf Blankenfeldt, Anett Schallmey,
Halohydrin dehalogenases (HHDHs) are of biotechnological interest due to their promiscuous epoxide ring-opening activity with a set of negatively charged nucleophiles, enabling the formation of C–C, C–N, or C–O bonds. The recent discovery of HHDH-specific sequence motifs aided the identification of a large number of halohydrin dehalogenases from public sequence databases, enlarging the biocatalytic toolbox substantially. During the characterization of 17 representatives of these phylogenetically ...
Tópico(s): Enzyme Structure and Function
2017 - American Chemical Society | ACS Catalysis
Julia Patzig, Michelle S. Dworschak, Ann‐Kristin Martens, Hauke Werner,
Abstract The capacity of cytoskeletal septins to mediate diverse cellular processes is related to their ability to assemble as distinct heterooligomers and higher order structures. However, in many cell types the functional relevance of septins is not well understood. This minireview provides a brief overview of our current knowledge about septins in the non-neuronal cells of the vertebrate nervous system, collectively termed ‘glial cells’, i.e., astrocytes, microglia, oligodendrocytes, and Schwann ...
Tópico(s): Nerve injury and regeneration
2013 - De Gruyter | Biological Chemistry
Annelie Steinbach, Stefanie Schulz, Julia Giebler, Stephan Schulz, Geertje J. Pronk, Ingrid Kögel‐Knabner, Hauke Harms, Lukas Y. Wick, Michael Schloter,
Abstract Clay minerals, charcoal and metal oxides are essential parts of the soil matrix and strongly influence the formation of biogeochemical interfaces in soil. We investigated the role of these parental materials for the development of functional microbial guilds using the example of alkane-degrading bacteria harbouring the alkane monooxygenase gene (alkB) in artificial mixtures composed of different minerals and charcoal, sterile manure and a microbial inoculum extracted from an agricultural ...
Tópico(s): Clay minerals and soil interactions
2014 - Springer Nature | The ISME Journal
Patricia de Monasterio‐Schrader, Julia Patzig, Wiebke Möbius, Benoit Barrette, Tadzio L. Wagner, Kathrin Kusch, Julia M. Edgar, Peter Brophy, Hauke Werner,
Deficiency of the major constituent of central nervous system (CNS) myelin, proteolipid protein (PLP), causes axonal pathology in spastic paraplegia type‐2 patients and in Plp1 null ‐mice but is compatible with almost normal myelination. These observations led us to speculate that PLP's role in myelination may be partly compensated for by other tetraspan proteins. Here, we demonstrate that the abundance of the structurally related tetraspanin‐2 (TSPAN2) is highly increased in CNS myelin of Plp1 null ‐ ...
Tópico(s): RNA Research and Splicing
2013 - Wiley | Glia
... element methods for nonlinear evolutionary convection–diffusion equationsJavier de Frutos and Julia Novo1 Aug 2008 | Computer Methods in Applied Mechanics and Engineering, Vol. 197, No. 45-48Variational multiscale a-posteriori error estimation for multi-dimensional transport problemsGuillermo Hauke, Daniel Fuster and Mohamed H. Doweidar1 Jun 2008 | ...
Tópico(s): Reservoir Engineering and Simulation Methods
1994 - World Scientific | Mathematical Models and Methods in Applied Sciences
Johann Jungclaus, Stephan Lorenz, Hauke Schmidt, Victor Brovkin, Nils Brüggemann, Fatemeh Chegini, Traute Crüger, P. De‐Vrese, Veronika Gayler, M. A. Giorgetta, Oliver Gutjahr, Helmuth Haak, Stefan Hagemann, Moritz Hanke, Tatiana Ilyina, Peter Korn, Jürgen Kröger, Leonidas Linardakis, Carolin Mehlmann, Uwe Mikolajewicz, Wolfgang A. Müller, Julia E. M. S. Nabel, Dirk Notz, Holger Pohlmann, Dian Putrasahan, Thomas Raddatz, Lennart Ramme, René Redler, Christian H. Reick, Thomas Riddick, Teffy Sam, Rainer Schneck, Reiner Schnur, Martin Schupfner, Jin‐Song von Storch, Fabian Wachsmann, Karl‐Hermann Wieners, Florian Ziemen, Björn Stevens, Jochem Marotzke, Martin Claußen,
Abstract This work documents the ICON‐Earth System Model (ICON‐ESM V1.0), the first coupled model based on the ICON (ICOsahedral Non‐hydrostatic) framework with its unstructured, icosahedral grid concept. The ICON‐A atmosphere uses a nonhydrostatic dynamical core and the ocean model ICON‐O builds on the same ICON infrastructure, but applies the Boussinesq and hydrostatic approximation and includes a sea‐ice model. The ICON‐Land module provides a new framework for the modeling of land processes and ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2022 - Wiley | Journal of Advances in Modeling Earth Systems
Julia Patzig, Olaf Jahn, Stefan Tenzer, Sven P. Wichert, Patricia de Monasterio‐Schrader, Susanne Rosfa, Jörg Kuharev, Kuo Yan, Ingo Bormuth, Juliane Bremer, Adriano Aguzzi, Foteini Orfaniotou, Dörte Hesse, Markus H. Schwab, Wiebke Möbius, Klaus‐Armin Nave, Hauke Werner,
Peripheral nerve myelin facilitates rapid impulse conduction and normal motor and sensory functions. Many aspects of myelin biogenesis, glia–axonal interactions, and nerve homeostasis are poorly understood at the molecular level. We therefore hypothesized that only a fraction of all relevant myelin proteins has been identified so far. Combining gel-based and gel-free proteomic approaches, we identified 545 proteins in purified mouse sciatic nerve myelin, including 36 previously known myelin constituents. ...
Tópico(s): Signaling Pathways in Disease
2011 - Society for Neuroscience | Journal of Neuroscience
Thorsten Mauritsen, Jürgen Bader, Tobias Becker, Jörg Behrens, Matthias Bittner, Renate Brokopf, Victor Brovkin, Martin Claußen, Traute Crueger, Monika Esch, Irina Fast, Stephanie Fiedler, Dagmar Fläschner, Veronika Gayler, M. A. Giorgetta, Daniel S. Goll, Helmuth Haak, Stefan Hagemann, Christopher Hedemann, Cathy Hohenegger, Tatiana Ilyina, Thomas M. Jahns, Diego Jiménez-De-La-Cuesta Otero, Johann Jungclaus, Thomas Kleinen, Silvia Kloster, Daniela Kracher, Stefan Kinne, Deike Kleberg, Gitta Lasslop, Luis Kornblueh, Jochem Marotzke, Daniela Matei, Katharina Meraner, Uwe Mikolajewicz, Kameswarrao Modali, Benjamin Möbis, Wolfgang A. Müller, Julia E. M. S. Nabel, Christine Nam, Dirk Notz, Sylvia S. Nyawira, Hanna Paulsen, Karsten Peters, Robert Pincus, Holger Pohlmann, Julia Pongratz, Max Popp, Thomas Raddatz, Sebastian Rast, René Redler, Christian H. Reick, Tim Rohrschneider, Vera Schemann, Hauke Schmidt, Reiner Schnur, Uwe Schulzweida, Katharina Six, Lukas Stein, Irene Stemmler, Björn Stevens, Jin‐Song von Storch, Fangxing Tian, Aiko Voigt, Philipp de Vrese, Karl‐Hermann Wieners, Stiig Wilkenskjeld, Alexander J. Winkler, E. Roeckner,
A new release of the Max Planck Institute for Meteorology Earth System Model version 1.2 (MPI-ESM1.2) is presented. The development focused on correcting errors in and improving the physical processes representation, as well as improving the computational performance, versatility, and overall user friendliness. In addition to new radiation and aerosol parameterizations of the atmosphere, several relatively large, but partly compensating, coding errors in the model's cloud, convection, and turbulence ...
Tópico(s): Meteorological Phenomena and Simulations
2019 - Wiley | Journal of Advances in Modeling Earth Systems
David A. Rothery, Matteo Massironi, Giulia Alemanno, Océane Barraud, S. Besse, Nicolas Bott, R. Brunetto, E. J. Bunce, P. K. Byrne, F. Capaccioni, M. T. Capria, Cristian Carli, Bernard Charlier, Thomas Cornet, G. Cremonese, Mario D’Amore, M. C. De Sanctis, A. Doressoundiram, Luigi Ferranti, G. Filacchione, Valentina Galluzzi, L. Giacomini, M. Grandé, L. Guzzetta, J. Helbert, Daniel Heyner, H. Hiesinger, Hauke Hußmann, R. H. Hyodo, T. Kohout, Alexander Kozyrev, M. L. Litvak, Alice Lucchetti, A. Malakhov, Christopher C. Malliband, Paolo Mancinelli, Julia Martikainen, A. Martindale, Alessandro Maturilli, A. Milillo, И. Г. Митрофанов, Maxim Mokrousov, A. Morlok, K. Muinonen, Olivier Namur, Alan Owens, L. R. Nittler, Joana S. Oliveira, P. Palumbo, M. Pajola, David L. Pegg, Antti Penttilä, R. Politi, F. Quarati, Cristina Re, А. Б. Санин, R. Schulz, Claudia Stangarone, Aleksandra N. Stojic, Vladislav Tretiyakov, Timo Väisänen, Indhu Varatharajan, I. Weber, Jack Wright, P. Wurz, F. Zambon,
Abstract BepiColombo has a larger and in many ways more capable suite of instruments relevant for determination of the topographic, physical, chemical and mineralogical properties of Mercury’s surface than the suite carried by NASA’s MESSENGER spacecraft. Moreover, BepiColombo’s data rate is substantially higher. This equips it to confirm, elaborate upon, and go beyond many of MESSENGER’s remarkable achievements. Furthermore, the geometry of BepiColombo’s orbital science campaign, beginning in 2026, ...
Tópico(s): Geology and Paleoclimatology Research
2020 - Springer Science+Business Media | Space Science Reviews
Christian Kellner, Sebastian Lutz, Hans‐Heinrich Oberg, Daniela Wesch, Anna Otte, Katarina Julia Diemer, Hauke Wilcken, Dirk Bauerschlag, Claus‐Christian Glüer, Christian Wichmann, Dieter Kabelitz, Jeanette H.W. Leusen, Katja Klausz, Andreas Humpe, Martin Gramatzki, Matthias Peipp,
Natural killer group 2 member D (NKG2D) plays an important role in the regulation of natural killer (NK) cell cytotoxicity in cancer immune surveillance. With the aim of redirecting NK cell cytotoxicity against tumors, the NKG2D ligand UL-16 binding protein 2 (ULBP2) was fused to a single-chain fragment variable (scFv) targeting the human epidermal growth factor receptor 2 (HER2). The resulting bispecific immunoligand ULBP2:HER2-scFv triggered NK cell-mediated killing of HER2-positive breast cancer cells ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2021 - De Gruyter | Biological Chemistry
Fokje L. Schaafsma, Carmen David, Doreen Kohlbach, Julia Ehrlich, Giulia Castellani, Benjamin Lange, Martina Vortkamp, A. Meijboom, Anna Fortuna-Wünsch, Antonia Immerz, Hannelore Cantzler, Apasiri Klasmeier, Nadezhda Zakharova, Katrin Schmidt, Anton Van de Putte, J.A. van Franeker, Hauke Flores,
Allometric relationships between body properties of animals are useful for a wide variety of purposes, such as estimation of biomass, growth, population structure, bioenergetic modelling and carbon flux studies. This study summarizes allometric relationships of zooplankton and nekton species that play major roles in polar marine food webs. Measurements were performed on 639 individuals of 15 species sampled during three expeditions in the Southern Ocean (winter and summer) and 2374 individuals of ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2022 - Springer Science+Business Media | Polar Biology
Faiza Kalfalah, Sabine Seggewiß, Regina Walter, Julia Tigges, María Moreno‐Villanueva, Alexander Bürkle, Sebastian Ohse, Hauke Busch, Melanie Boerries, Barbara Hildebrandt, Brigitte Royer‐Pokora, Fritz Boege,
Aging | doi:10.18632/aging.100723. Faiza Kalfalah, Sabine Seggewiß, Regina Walter, Julia Tigges, María Moreno-Villanueva, Alexander Bürkle, Sebastian Ohse, Hauke Busch, Melanie Boerries, Barbara Hildebrandt, Brigitte Royer-Pokora, Fritz Boege
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2015 - Impact Journals LLC | Aging
Joey P. A. J. Verdijk, Laurens A. van de Mortel, Freek ten Doesschate, Julia C. M. Pottkämper, Sven Stuiver, Willem B. Bruin, Chris Abbott, Miklós Árgyelán, Olga Therese Ousdal, Hauke Bartsch, Katherine L. Narr, Indira Tendolkar, Vince D. Calhoun, Joshua Lukemire, Ying Guo, Leif Oltedal, Guido van Wingen, Jeroen A. van Waarde,
Electroconvulsive therapy (ECT) is effective for major depressive episodes. Understanding of underlying mechanisms has been increased by examining changes of brain connectivity but studies often do not correct for test-retest variability in healthy controls (HC). In this study, we investigated changes in resting-state networks after ECT in a multicenter study.
Tópico(s): Electroconvulsive Therapy Studies
2023 - Elsevier BV | Brain stimulation
Manuel A. R. Ferreira, Eric R. Gamazon, Fares Al‐Ejeh, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Aðalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Jacopo Azzollini, Judith Balmañà, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Katarzyna Białkowska, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Åke Borg, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Trinidad Caldés, Maria A. Caligo, Daniele Campa, Ian Campbell, Federico Canzian, Jonathan Carter, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Hans Christiansen, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Julian Adlard, Munaza Ahmed, Julian Barwell, Angela Brady, Carole Brewer, Jackie Cook, Rosemarie Davidson, Alan C. Donaldson, Jacqueline Eason, Ros Eeles, D. Gareth Evans, Helen Gregory, Helen Hanson, Alex Henderson, Shirley Hodgson, Louise Izatt, Michael J. Kennedy, Fiona Lalloo, Clare M. Miller, Patrick J. Morrison, Kai‐Ren Ong, Jo Perkins, Mary Porteous, Mark T. Rogers, Lucy Side, Katie Snape, Lisa Walker, Patricia A. Harrington, Norbert Arnold, Bernd Auber, Nadja Bogdanova-Markov, Julika Borde, Almuth Caliebe, Nina Ditsch, Bernd Dworniczak, Stefanie Engert, Ulrike Faust, Andrea Gehrig, Eric Hahnen, Jan Hauke, Julia Hentschel, Wei He, Ellen Honisch, Walter Just, Karin Kast, Mirjam Larsen, Johannes Lemke, Huu Phuc Nguyen, Dieter Niederacher, Claus‐Eric Ott, Konrad Platzer, Esther Pohl‐Rescigno, Juliane Ramser, Kerstin Rhiem, Doris Steinemann, Christian Sutter, Raymonda Varon-Mateeva, Shan Wang‐Gohrke, Bernhard H. F. Weber, Fabienne Prieur, Pascal Pujol, Charlotte Sagne, Nicolas Sévenet, Hagay Sobol, Johanna Sokolowska, Dominique Stoppa-Lyonnet, Laurence Venat-Bouvet, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Miguel de la Hoya, Joe Dennis, Peter Devilee, Orland Dı́ez, Thilo Dörk, Alison M. Dunning, Miriam Dwek, Diana Eccles, Bent Ejlertsen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Eitan Friedman, Debra Frost, Marike Gabrielson, Manuela Gago-Domínguez, Patricia A. Ganz, Susan M. Gapstur, Judy E. Garber, Montserrat García‐Closas, José Á. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Wei He, Jane Heyworth, Manuel R. Teixeira, Antoinette Hollestelle, Robert N. Hoover, John L. Hopper, Peter J. Hulick, Keith Humphreys, Evgeny N. Imyanitov, Rosemary Balleine, Robert Baxter, Stephen Braye, Jane Carpenter, Jane E. Dahlstrom, John Forbes, Shin-Ru Lee, Deborah J. Marsh, Adrienne Morey, Nirmala Pathmanathan, Peter Simpson, Allan D. Spigelman, Nicholas Wilcken, Desmond Yip, Bernadette A. M. Heemskerk‐Gerritsen, Matti A. Rookus, Caroline Seynaeve, Frederieke H. van der Baan, Annemieke H. van der Hout, Lizet E. van der Kolk, Rob B. van der Luijt, Carolien H. M. van Deurzen, Helena C. van Doorn, Klaartje van Engelen, Liselotte van Hest, Theo A.M. van Os, Senno Verhoef, Maartje J. Vogel, Juul Wijnen, Alexander Miron, Miroslav Kapuscinski, Anita Bane, Eric A. Ross, Saundra S. Buys, Thomas Conner, Claudine Isaacs, Milena Jakimovska, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Rachel C. Jankowitz, Esther M. John, Nichola Johnson, Joseph Vijai, Beth Y. Karlan, Э. К. Хуснутдинова, Johanna I. Kiiski, Yon‐Dschun Ko, Michael E. Jones, Irene Konstantopoulou, Vessela N. Kristensen, Yael Laitman, Diether Lambrechts, Conxi Lázaro, Goska Leslie, Jenny Lester, Fabienne Lesueur, Sara Lindström, Jirong Long, Jennifer T. Loud, Jan Lubiński, Enes Makalic, Graham J. Mann, Mehdi Manoochehri, Sara Margolin, Tabea Maurer, Dimitrios Mavroudis, Lesley McGuffog, Alfons Meindl, Usha Menon, Kyriaki Michailidou, Austin Miller, Marco Montagna, Fernando Moreno, Lidia Moserle, Anna Marie Mulligan, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Ines Nevelsteen, Finn C. Nielsen, Liene Ņikitina-Zaķe, Robert L. Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Håkan Olsson, Ana Osório, J. Papp, Tjoung-Won Park-Simon, Michael T. Parsons, Inge Søkilde Pedersen, Ana Peixoto, Paolo Peterlongo, Paul D.P. Pharoah, Dijana Plaseska-Karanfilska, Bruce Poppe, Nadège Presneau, Paolo Radice, Johanna Rantala, Gad Rennert, Harvey A. Risch, Emmanouil Saloustros, Kristin Sanden, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Priyanka Sharma, Xiao-Ou Shu, Jacques Simard, Christian F. Singer, Penny Soucy, Melissa C. Southey, John J. Spinelli, Amanda B. Spurdle, Jennifer Stone, Anthony J. Swerdlow, William Tapper, Jack A. Taylor, Manuel R. Teixeira, Mary Beth Terry, Àlex Teulé, Mads Thomassen, Kathrin Thöne, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Thérèse Truong, Nadine Tung, Celine M. Vachon, Christi J. van Asperen, Ans M.W. van den Ouweland, Elizabeth J. van Rensburg, Ana Vega,
Abstract Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several ...
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Friedrich Miescher, Felix Hoppe‐Seyler, Bernhard Brüne, Johannes Büchner, Munich Ludwig, Münster Sies, Düsseldorf Turk, Ljubljana Wittinghofer, J Bergeron, Montreal Bogyo, Stanford Cadenas, Angeles Los, Florence Chiti, Dikic, C Main, Cambridge Dobson, Groningen Driessen, Ghent Gevaert, Bremen Hammann, Martinsried Hartl, Düsseldorf Häussinger, St Hiscott, Y Lucie, L.-O Igarashi, Jena Klotz, Munich Magdolen, Francisco San, Kyoto Narumiya, M. Naumann, Vancouver Overall, Uppsala Pejler, Freiburg Pfanner, Melbourne Pike, Krakow Potempa, Bonn Sandhoff, Zürich Schaffner, Heidelberg Sinning, Munich Sommerhoff, Richmond Spiegel, C Blattner, Karlsruhe Einsle, Freiburg Giehl, Giessen Hell, Heidelberg Helm, Mainz Herrmann, Kaiserslautern Heumann, Bochum Horstkorte, Halle Saale, Carola Hunte, Freiburg Knauer, Peter Rehling, Göttingen Schneider, Mainz Schuchardt, Hannover Seidel, Düsseldorf Sterner, Regensburg Villmann, Torsten Krüger, Responsible For, Advertisements Panagiota, Compuscript Typesetting, Shannon Ltd, Franz Printing, Julia Patzig, Hauke Werner,
Cytoskeletal septin proteins assemble as distinct heterooligomers and higher order-filaments as a prerequisite to mediate various cellular processes.This Highlight Issue of Biological Chemistry presents original data and overview articles on current topics in the biochemistry and cell biology of septins, as well as related physiological and pathophysiological aspects.In their article on pp.143-149 in this issue, Patzig and colleagues review what is known about septins in the non-neuronal cells of ...
2013 - De Gruyter | Biological Chemistry
F Corvinus, Rizky Widyaningsih, Julia I. Staubitz, C. Herold, KF Rahman, Hauke Lang, Peter Grimminger,
Einleitung: Die antirefluxchirurgischen Therapieoptionen wurden seit 2014 durch die Möglichkeit einer elektrischen Stimulation des gastroösophagealen Übergangs – EndoStim® II – erweitert. Das Verfahren steht für ein selektiertes Patientengut mit einem gastroösophagealen Reflux (GERD) und einer kleinen, maximal 3 cm messenden, Hiatushernie zur Verfügung. Ein integraler Bestandteil der präoperativen Diagnostik vor einer antirefluxchirurgischen Therapie ist die Hochauflösende Impedanzmanometrie (HRIM). Dabei ...
Tópico(s): Gastroesophageal reflux and treatments
2016 - Thieme Medical Publishers (Germany) | Zeitschrift für Gastroenterologie
Christopher Hakkaart, John F. Pearson, Louise Marquart, Joe Dennis, George A. R. Wiggins, Daniel R. Barnes, Bridget A. Robinson, Peter D. Mace, Kristiina Aittomäki, Irene L. Andrulis, Banu K. Arun, Jacopo Azzollini, Judith Balmañà, Rósa B. Barkardóttir, Sami Belhadj, Lieke P.V. Berger, Marinus J. Blok, Susanne E. Boonen, Julika Borde, Angela R. Bradbury, Joan Brunet, Saundra S. Buys, Maria A. Caligo, Ian Campbell, Wendy K. Chung, Kathleen Claes, Marie‐Agnès Collonge‐Rame, Jackie Cook, Casey Cosgrove, Fergus J. Couch, Mary B. Daly, Sita Dandiker, Rosemarie Davidson, Miguel de la Hoya, Robin De Putter, Capucine Delnatte, Mallika Dhawan, Orland Dı́ez, Yuan Chun Ding, Susan M. Domchek, Alan Donaldson, Jacqueline Eason, Douglas F. Easton, Hans Ehrencrona, Christoph Engel, D. Gareth Evans, Ulrike Faust, Lídia Feliubadaló, Florentia Fostira, Eitan Friedman, Megan N. Frone, Debra Frost, Judy E. Garber, Simon A. Gayther, Andrea Gehrig, Paul Gesta, Andrew K. Godwin, David E. Goldgar, Mark H. Greene, Eric Hahnen, Christopher R. Hake, Ute Hamann, Thomas van Overeem Hansen, Jan Hauke, Julia Hentschel, Wei He, Ellen Honisch, Peter J. Hulick, Evgeny N. Imyanitov, Klaartje van Engelen, Marijke R. Wevers, Claudine Isaacs, Louise Izatt, À. Izquierdo, Anna Jakubowska, Paul A. James, Ramūnas Janavičius, Esther M. John, Joseph Vijai, Beth Y. Karlan, Zoe Kemp, Judy Kirk, Irene Konstantopoulou, Marco J. Koudijs, Ava Kwong, Yael Laitman, Fiona Lalloo, Christine Lasset, Charlotte Kvist Lautrup, Conxi Lázaro, Clémentine Legrand, Goska Leslie, Fabienne Lesueur, L. Phuong, Siranoush Manoukian, Véronique Mari, John W.M. Martens, Lesley McGuffog, Noura Mebirouk, Alfons Meindl, Austin Miller, Marco Montagna, Lidia Moserle, Emmanuelle Mouret‐Fourme, Hannah Musgrave, Sophie Nambot, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow, Tú Nguyen‐Dumont, Liene Ņikitina-Zaķe, Kenneth Offit, Edith Oláh, Olufunmilayo I. Olopade, Ana Osório, Claus‐Eric Ott, Sue K. Park, Michael T. Parsons, Inge Søkilde Pedersen, Ana Peixoto, Pedro Pérez‐Segura, Paolo Peterlongo, Tímea Pócza, Paolo Radice, Juliane Ramser, Johanna Rantala, Gustavo C. Rodriguez, Karina Rønlund, Efraim H. Rosenberg, Maria Rossing, Rita K. Schmutzler, Payal D. Shah, Saba Sharif, Priyanka Sharma, Lucy Side, Jacques Simard, Christian F. Singer, Katie Snape, Doris Steinemann, Dominique Stoppa‐Lyonnet, Christian Sutter, Yen Y. Tan, Manuel R. Teixeira, Soo‐Hwang Teo, Mads Thomassen, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Alison Trainer, Vishakha Tripathi, Nadine Tung, Klaartje van Engelen, Elizabeth J. van Rensburg, Ana Vega, Alessandra Viel, Lisa Walker, Jeffrey N. Weitzel, Marike R. Wevers, Georgia Chenevix‐Trench, Amanda B. Spurdle, Antonis C. Antoniou, Logan C. Walker,
Abstract The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 BRCA2 pathogenic variant carriers. We used these results to prioritise a candidate breast cancer risk-modifier gene for laboratory analysis and biological validation. Notably, the HR for deletions in BRCA1 suggested an elevated breast cancer ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Nature Portfolio | Communications Biology
Produção Nacional
Revisado por pares
Timothy R. Rebbeck, Tara M. Friebel, Eitan Friedman, Ute Hamann, Dezheng Huo, Ava Kwong, Edith Oláh, Olufunmilayo I Olopade, Ángela R. Solano, Soo‐Hwang Teo, Mads Thomassen, Jeffrey N. Weitzel, TL Chan, Fergus J. Couch, David E. Goldgar, Torben A. Kruse, Edenir Inêz Palmero, Sue K. Park, Diana Torres, Elizabeth J. van Rensburg, Lesley McGuffog, Michael T. Parsons, Goska Leslie, Cora M. Aalfs, Julio Abugattas, Julian Adlard, Simona Agata, Kristiina Aittomäki, Lesley Andrews, Irene L. Andrulis, Aðalgeir Arason, Norbert Arnold, Banu Arun, Ella Asseryanis, Leo Auerbach, Jacopo Azzollini, Judith Balmañà, Monica Barile, Rósa B. Barkardóttir, Daniel Barrowdale, Javier Benı́tez, Andreas Berger, Raanan Berger, Amie Blanco, Kathleen R. Blazer, Marinus J. Blok, Valérie Bonadona, Bernardo Bonanni, Angela R. Bradbury, Carole Brewer, Bruno Buecher, Saundra S. Buys, Trinidad Caldés, Almuth Caliebe, Maria A. Caligo, Ian Campbell, Sandrine M. Caputo, Jocelyne Chiquette, Wendy K. Chung, Kathleen Claes, J. Margriet Collée, Jackie Cook, Rosemarie Davidson, Miguel de la Hoya, Kim De Leeneer, Antoine De Pauw, Capucine Delnatte, Orland Dı́ez, Yuan Chun Ding, Nina Ditsch, Susan M. Domchek, Cecilia M. Dorfling, Carolina Velázquez, Bernd Dworniczak, Jacqueline Eason, Douglas F. Easton, Rosalind A. Eeles, Hans Ehrencrona, Bent Ejlertsen, Christoph Engel, Stefanie Engert, D. Gareth Evans, Laurence Faivre, Lídia Feliubadaló, Sandra Fert Ferrer, Lenka Foretová, Jeffrey M. Fowler, Debra Frost, Henrique C.R. Galvão, Patricia A. Ganz, Judy E. Garber, Marion Gauthier‐Villars, Andrea Gehrig, Anne–Marie Gerdes, Paul Gesta, Giuseppe Giannini, Sophie Giraud, Gord Glendon, Andrew K. Godwin, Mark H. Greene, Jacek Gronwald, Angelica M. Gutierrez‐Barrera, Eric Hahnen, Jan Hauke, Alex Henderson, Julia Hentschel, Frans B. L. Hogervorst, Ellen Honisch, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, À. Izquierdo, Anna Jakubowska, Paul A. James, Ramūnas Janavičius, Uffe Birk Jensen, Esther M. John, Joseph Vijai, Katarzyna Kaczmarek, Beth Y. Karlan, Karin Kast, kConFab Investigators, Sung-Won Kim, Irene Konstantopoulou, Jacob Korach, Yael Laitman, Adriana Lasa, Christine Lasset, Conxi Lázaro, Annette Lee, Min Hyuk Lee, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Noralane M. Lindor, Michel Longy, Jennifer T. Loud, Karen H. Lu, Jan Lubiński, Eva Macháčková, Siranoush Manoukian, Véronique Mari, Cristina Martínez-Bouzas, Zoltán Mátrai, Noura Mebirouk, Hanne Meijers‐Heijboer, Alfons Meindl, Arjen R. Mensenkamp, Ugnius Mickys, Austin Miller, Marco Montagna, Kirsten B. Moysich, Anna Marie Mulligan, Jacob Musinsky, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow, Huu Phuc Nguyen, Dieter Niederacher, Henriette Roed Nielsen, Finn C. Nielsen, Robert L. Nussbaum, Kenneth Offit, Anna Öfverholm, Kai‐Ren Ong, Ana Osório, Laura Papi, J. Papp, Barbara Pasini, Inge Søkilde Pedersen, Ana Peixoto, Nina Peruga, Paolo Peterlongo, Esther Pohl, Nisha Pradhan, Karolina Prajzendanc, Fabienne Prieur, Pascal Pujol, Paolo Radice, Susan J. Ramus, Johanna Rantala, Muhammad Usman Rashid, Kerstin Rhiem, Mark E. Robson, Gustavo C. Rodriguez, Mark T. Rogers, Vilius Rudaitis, Ane Yde Schmidt, Rita K. Schmutzler, Leigha Senter, Payal D. Shah, Priyanka Sharma, Lucy Side, Jacques Simard, Christian F. Singer, Anne‐Bine Skytte, Thomas P. Slavin, Katie Snape, Hagay Sobol, Melissa C. Southey, Linda Steele, Doris Steinemann, Grzegorz Sukiennicki, Christian Sutter, Csilla I. Szabo, Yen Y. Tan, Manuel R. Teixeira, Mary Beth Terry, Àlex Teulé, Abigail Thomas, Darcy L. Thull, Marc Tischkowitz, Silvia Tognazzo, Amanda Ewart Toland, Sabine Topka, Alison H. Trainer, Nadine Tung, Christi J. van Asperen, Annemieke H. van der Hout, Lizet E. van der Kolk, Rob B. van der Luijt, Mattias Van Heetvelde, Liliana Varesco, Raymonda Varon‐Mateeva, Ana Vega, Cynthia Villarreal‐Garza, Anna von Wachenfeldt, Lisa Walker, Shan Wang‐Gohrke, Barbara Wappenschmidt, Bernhard H. F. Weber, Drakoulis Yannoukakos, Sook-Yee Yoon, Cristina Zanzottera, Jamal Zidan, Kristin K. Zorn, Christina G. Selkirk, Peter J. Hulick, Georgia Chenevix‐Trench, Amanda B. Spurdle, Antonis C. Antoniou, Katherine L. Nathanson,
The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on White in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutations ascertained from 69 centers in 49 countries on six continents. This study comprehensively describes the characteristics of the 1,650 unique BRCA1 and 1, ...
Tópico(s): DNA Repair Mechanisms
2018 - Wiley | Human Mutation
Florian Heitz, Konstantin Weber‐Lassalle, Corinna Ernst, Kathrin Möllenhoff, Nikolaus de Gregorio, Jan Hauke, D Dietrich, Julika Borde, Christian Jackisch, TW Park-Simon, LC Hanker, E Pohl-Rescigno, Katharina Prieske, Stefan Kommoss, F Marmé, Julia C. Stingl, S Rita, P Harter, Eric Hahnen,
Objective To identify acquired blood-specific mutations in clonal hematopoiesis (CH) genes that influence the risk of secondary, therapy-associated myeloid neoplasia.
Tópico(s): Chronic Myeloid Leukemia Treatments
2022 - Thieme Medical Publishers (Germany) | Geburtshilfe und Frauenheilkunde
Friederike Fröb, Sebastian Sonntag, Julia Pongratz, Hauke Schmidt, Tatiana Ilyina,
Abstract To monitor the success of carbon dioxide removal (CDR) or solar radiation management (SRM) that offset anthropogenic climate change, the forced response to any external forcing is required to be detectable against internal variability. Thus far, only the detectability of SRM has been examined using both a stationary and nonstationary detection and attribution method. Here, the spatiotemporal detectability of the forced response to artificial ocean alkalinization (AOA) and stratospheric aerosol ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2020 - American Geophysical Union | Earth s Future
Hauke Flores, Carmen David, Julia Ehrlich, Kristin Hardge, Doreen Kohlbach, Benjamin Lange, Barbara Niehoff, Eva‐Maria Nöthig, Ilka Peeken, Katja Metfies,
In the Arctic Ocean, sea-ice decline will significantly change the structure of biological communities. At the same time, changing nutrient dynamics can have similarly strong and potentially interacting effects. To investigate the response of the taxonomic and trophic structure of planktonic and ice-associated communities to varying sea-ice properties and nutrient concentrations, we analysed four different communities sampled in the Eurasian Basin in summer 2012: (1) protists and (2) metazoans from ...
Tópico(s): Isotope Analysis in Ecology
2019 - Springer Science+Business Media | Polar Biology
Christoph W. Korn, Gabriela Rosenblau, Julia M. Rodriguez Buritica, Hauke R. Heekeren,
A considerable literature on attribution theory has shown that healthy individuals exhibit a positivity bias when inferring the causes of evaluative feedback on their performance. They tend to attribute positive feedback internally (e.g., to their own abilities) but negative feedback externally (e.g., to environmental factors). However, all empirical demonstrations of this bias suffer from at least one of the three following drawbacks: First, participants directly judge explicit causes for their performance. ...
Tópico(s): Social and Intergroup Psychology
2016 - Public Library of Science | PLoS ONE
Sebastian Sonntag, Miriam Ferrer González, Tatiana Ilyina, Daniela Kracher, Julia E. M. S. Nabel, Ulrike Niemeier, Julia Pongratz, Christian H. Reick, Hauke Schmidt,
Abstract To contribute to a quantitative comparison of climate engineering (CE) methods, we assess atmosphere‐, ocean‐, and land‐based CE measures with respect to Earth system effects consistently within one comprehensive model. We use the Max Planck Institute Earth System Model (MPI‐ESM) with prognostic carbon cycle to compare solar radiation management (SRM) by stratospheric sulfur injection and two carbon dioxide removal methods: afforestation and ocean alkalinization. The CE model experiments are ...
Tópico(s): Climate Change, Adaptation, Migration
2018 - American Geophysical Union | Earth s Future
Johann Jungclaus, Édouard Bard, Mélanie Baroni, Pascale Braconnot, Jian Cao, Louise Chini, Tatiana Egorova, Michael N. Evans, J. Fidel González‐Rouco, Hugues Goosse, G. C. Hurtt, Fortunat Joos, Jed O. Kaplan, Myriam Khodri, Kees Klein Goldewijk, N. A. Krivova, Allegra N. LeGrande, Stephan Lorenz, Jürg Luterbacher, Wenmin Man, Amanda C. Maycock, Malte Meinshausen, Anders Moberg, Raimund Muscheler, Christoph Nehrbass‐Ahles, Bette L. Otto‐Bliesner, Steven J. Phipps, Julia Pongratz, Eugene Rozanov, Gavin A. Schmidt, Hauke Schmidt, W. Schmütz, Andrew Schurer, A. I. Shapiro, Michael Sigl, Jason E. Smerdon, S. K. Solanki, Claudia Timmreck, Matthew Toohey, Ilya Usoskin, Sebastian Wagner, Chi-Ju Wu, K. L. Yeo, Davide Zanchettin, Qiong Zhang, Eduardo Zorita,
Abstract. The pre-industrial millennium is among the periods selected by the Paleoclimate Model Intercomparison Project (PMIP) for experiments contributing to the sixth phase of the Coupled Model Intercomparison Project (CMIP6) and the fourth phase of the PMIP (PMIP4). The past1000 transient simulations serve to investigate the response to (mainly) natural forcing under background conditions not too different from today, and to discriminate between forced and internally generated variability on interannual ...
Tópico(s): Meteorological Phenomena and Simulations
2017 - Copernicus Publications | Geoscientific model development
Evangelos Tagkalos, Pieter C. van der Sluis, Eren Uzun, Felix Berlth, Julia I. Staubitz, Ines Gockel, Richard van Hillegersberg, Hauke Lang, Peter Grimminger,
For patients undergoing an Ivor Lewis esophagectomy with a circular stapled anastomosis, the optimal diameter of the used circular stapler to restore continuity is unknown. The aim of this study was to compare the 25 mm stapled versus the 28 mm stapled esophagogastric anastomosis after Ivor Lewis esophagectomy, focusing on anastomotic insufficiency and postoperative anastomotic strictures. Between February 2008 and June 2019, 349 consecutive patients underwent Ivor Lewis esophagectomy with gastric ...
Tópico(s): Esophageal and GI Pathology
2021 - Springer Science+Business Media | Journal of Gastrointestinal Surgery