Sheldon Decombe, François Loll, Laura Caccianini, Kévin Affannoukoué, Ignacio Izeddin, Julien Mozziconacci, Christophe Escudé, Judith Lopes,
Abstract Background Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of histone H3 on lysine 9 (H3K9me3). Although well studied using artificial chromosomes and global perturbations, the contribution of this epigenetic mark to chromatin structure and genome stability remains poorly known in a more natural context. Results Using transcriptional ...
Tópico(s): Genomic variations and chromosomal abnormalities
2021 - BioMed Central | Epigenetics & Chromatin
Jean Ollion, Julien Cochennec, François Loll, Christophe Escudé, Thomas Boudier,
The cell nucleus is a highly organized cellular organelle that contains the genome. An important step to understand the relationships between genome positioning and genome functions is to extract quantitative data from three-dimensional (3D) fluorescence imaging. However, such approaches are limited by the requirement for processing and analyzing large sets of images. Here we present a practical approach using TANGO (Tools for Analysis of Nuclear Genome Organization), an image analysis tool dedicated ...
Tópico(s): RNA Research and Splicing
2014 - Springer Science+Business Media | Methods in molecular biology
Jean Ollion, Julien Cochennec, François Loll, Christophe Escudé, Thomas Boudier,
The cell nucleus is a highly organized cellular organelle that contains the genetic material. The study of nuclear architecture has become an important field of cellular biology. Extracting quantitative data from 3D fluorescence imaging helps understand the functions of different nuclear compartments. However, such approaches are limited by the requirement for processing and analyzing large sets of images.Here, we describe Tools for Analysis of Nuclear Genome Organization (TANGO), an image analysis ...
Tópico(s): RNA Research and Splicing
2013 - Oxford University Press | Bioinformatics
Jean Ollion, François Loll, Julien Cochennec, Thomas Boudier, Christophe Escudé,
The cell nucleus is a highly organized structure and plays an important role in gene regulation. Understanding the mechanisms that sustain this organization is therefore essential for understanding genome function. Centromeric regions (CRs) of chromosomes have been known for years to adopt specific nuclear positioning patterns, but the significance of this observation is not yet completely understood. Here, using a combination of fluorescence in situ hybridization and immunochemistry on fixed human ...
Tópico(s): Chromosomal and Genetic Variations
2015 - American Society for Cell Biology | Molecular Biology of the Cell
Thomas Haschka, Loı̈c Ponger, Christophe Escudé, Julien Mozziconacci,
Abstract Summary Genomic sequences are widely used to infer the evolutionary history of a given group of individuals. Many methods have been developed for sequence clustering and tree building. In the early days of genome sequencing, these were often limited to hundreds of sequences but due to the surge of high throughput sequencing, it is now common to have millions of sampled sequences at hand. We introduce MNHN-Tree-Tools, a high performance set of algorithms that builds multi-scale, nested clusters ...
Tópico(s): Environmental DNA in Biodiversity Studies
2021 - Oxford University Press | Bioinformatics
Hélion du Mas des Bourboux, Jean-Marc Le Goff, Michael Blomqvist, Nicolás G. Busca, Julien Guy, J. Rich, Christophe Yèche, Julian Bautista, E. Burtin, Kyle Dawson, Daniel J. Eisenstein, Andreu Font-Ribera, D. Kirkby, Jordi Miralda‐Escudé, P. Noterdaeme, N. Palanque‐Delabrouille, Isabelle Pâris, Patrick Petitjean, Ignasi Pérez-Ràfols, Matthew M. Pieri, Nicholas P. Ross, David J. Schlegel, Donald P. Schneider, Anže Slosar, David H. Weinberg, Pauline Zarrouk,
We present a measurement of baryon acoustic oscillations (BAO) in the cross-correlation of quasars with the Ly$\alpha$-forest flux-transmission at a mean redshift $z=2.40$. The measurement uses the complete SDSS-III data sample: 168,889 forests and 234,367 quasars from the SDSS Data Release DR12. In addition to the statistical improvement on our previous study using DR11, we have implemented numerous improvements at the analysis level allowing a more accurate measurement of this cross-correlation. ...
Tópico(s): Astrophysics and Cosmic Phenomena
2017 - EDP Sciences | Astronomy and Astrophysics
Carole Fournier, Marion Mercey-Ressejac, Valentin Dérangère, Amal Al Kadi, David Rageot, C. Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice Navarro, Evelyne Jouvin‐Marche, Patrice N. Marche,
Tópico(s): Cancer Immunotherapy and Biomarkers
2025 - Elsevier BV | EBioMedicine
Produção Nacional
É. Aubourg, S. Bailey, Julian Bautista, Florian Beutler, Vaishali Bhardwaj, Dmitry Bizyaev, Michael R. Blanton, Michael Blomqvist, A. Bolton, Jo Bovy, H. Brewington, J. Brinkmann, Joel R. Brownstein, A. Burden, Nicolás G. Busca, W. Carithers, Chia-Hsun Chuang, Johan Comparat, Rupert A. C. Croft, Antonio J. Cuesta, Kyle Dawson, Timothée Delubac, Daniel J. Eisenstein, Andreu Font-Ribera, Jian Ge, J.M. Le Goff, Satya Gontcho A Gontcho, J. Richard Gott, James E. Gunn, Hong Guo, Julien Guy, J.–Ch. Hamilton, Shirley Ho, Klaus Honscheid, Cullan Howlett, D. Kirkby, Francisco-Shu Kitaura, Jean‐Paul Kneib, Khee‐Gan Lee, Dan Long, Robert H. Lupton, M. Vargas-Magaña, Viktor Malanushenko, Elena Malanushenko, Marc Manera, Claudia Maraston, Daniel Margala, Cameron K. McBride, Jordi Miralda‐Escudé, Adam D. Myers, Robert C. Nichol, P. Noterdaeme, Sebastián E. Nuza, Matthew D. Olmstead, Daniel Oravetz, Isabelle Pâris, Nikhil Padmanabhan, N. Palanque‐Delabrouille, Kaike Pan, Marcos Pellejero-Ibáñez, Will J. Percival, Patrick Petitjean, Matthew M. Pieri, Francisco Prada, Beth Reid, J. Rich, Natalie A. Roe, Ashley J. Ross, Nicholas P. Ross, Graziano Rossi, J. A. Rubiño-Martín, Ariel G. Sánchez, Lado Samushia, R. Génova-Santos, Claudia G. Scóccola, David J. Schlegel, Donald P. Schneider, Hee‐Jong Seo, Erin Sheldon, Audrey Simmons, Ramin Skibba, Anže Slosar, Michael A. Strauss, D. Thomas, Jeremy L. Tinker, Rita Tojeiro, J. Alberto Vázquez, Matteo Viel, David A. Wake, Benjamin A. Weaver, David H. Weinberg, W. M. Wood‐Vasey, Christophe Yèche, Idit Zehavi, Gong‐Bo Zhao,
We derive constraints on cosmological parameters and tests of dark energy models from the combination of baryon acoustic oscillation (BAO) measurements with cosmic microwave background (CMB) and Type Ia supernova (SN) data. We take advantage of high-precision BAO measurements from galaxy clustering and the Ly-alpha forest (LyaF) in the BOSS survey of SDSS-III. BAO data alone yield a high confidence detection of dark energy, and in combination with the CMB angular acoustic scale they further imply a ...
Tópico(s): Black Holes and Theoretical Physics
2015 - American Physical Society | Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D, Particles, fields, gravitation, and cosmology
Niels Kristian, Aagaard Christer, F Aas Cristiana Abazia, Nadir Abbas, Fariba Abbassi, Gian Luca, Abbati Jane, Abbott Amr, Abdelaal Manal, Abdelmalek Abo, Zed Abdelrhman, Ahmed Abdel‐Wahab, Mostafa Abdo, Ayman Kabbani, Abdul-Rahman Kanon, Abe Abecia, Nada Abedin, Stephan W. Aberle, Hanna Aberra Itziar, Abete Natali, Abeywickrama Samarakoon, George Abouda, Marwan Abouljoud, M. Abraham, George M. Abraham, Arun Abraham, Juan G. Abraldeṣ, Joanna Abramczyk, Ifat Abramovich, Rinat Abramovitch, Luis Abreu, Carvalho Fadi, Abu Baker, Muhammad Radzi, Abu Hassan, Samira Abu, Jhaisha Saif, Mahmud Abu, Mouch Naim, Abu-Freha Yehia, Abugabal Jeries, Abu-Hanna Mohamed, Abu-Nada Abdelrahman, Aburaia Ameer, Abutaleb Akaki, A N M Antônio, Accetta Laia, Aceituno María, Achalandabaso Weber, A. Longhi Silvia, Acosta-López Antonio, Acquaviva Gupse, Adali René, Adam Svetlana, Adamcova Selcanova, Ekaterine Adamia, Rafael Alejandre, Soo Aleman, Vanessa Alemanni, Daniel Alemu, Yusef Alenezi, Carlo Alessandria, Maria Grazia, Alessio Loredana, Alessio Sophie, Alex Leigh, Alexander Adibekian, Alexander Ian, Alexander Fuchs, Alexandra Gonçalo, Alexandrino Theodoros, Alexandra Alexopoulou, Ana Alfaro, Clara Alfaro‐Cervelló, Cervello Lludovico, Alfarone Bazga, Ali Hassan Ali, Fatima Al Ali, Angela Alibrandi, Eleonora Alimenti, Anna Benard, Aliwa Tom, Alix Saad, Alkaabi Alkhatib, Maia Alkhazashvili, Hüseyin Alkım, Dalia Allam, Marc Allard, Sophie Allen, Kathryn Allen, R. Aller, Rocío Aller de la Fuente, Francesca Alletto, Michael Allison, Chakib Alloui, Caroline Allsop, Lena Allweiss, Hussam Almasri, Bruna Almeida, Alessandro Almeida, Marion Almes, Carolina Almohalla, Carmen Alonso, Martin Saleh, Alqahtani Laurent, Alric Laith, Al-Rubaiy Rami, Al-Sayegh Deema, Alsoub Khalid, Alswat Enkhjargal, Altangerel Altenburg, Johannes Altenmüller, Adriana Alter, Heidi Altmann, Joseph Varuna, Aluvihare Aoife, Alvain Alvarado-Tapias, Mário Reis, Álvares-Da-Silva Laura Alvarez, Marı́a de Luján Alvarez, Ismael Álvarez‐Álvarez, Carmen Álvarez‐Navascués, Lionel Arrivé, Vicente Arroyo, Mehmet Arslan, Aysenur Arslan, Anita Reha, A. Carrión Tomás, Artaza Varasa, Elvis Arteaga, Gavin E. Arteel, Benedetta Artegiani, Andreea Adelina Artenie, Callum Arthurs, Renate Artmann, Florent Artru, Thierry Artzner, Manimozhiyan Arumugam, Rishi Aryal, Mahmoud Aryan, Erikc Jesús, Arzola-Renteria Hamid, Asadzadeh Aghdaei, Aliya Asghar, Candice Ashmore-Harris Sumar, Askar Gro, Askgaard Mujahid, Aslam Aslan, Ana Aslanikashvili, Jessica Aspas, Lars Asphaug, Richard Aspinall, Alexander I. Aspinall, Silvia Aspite, Keren Asraf, Sumeet K. Asrani, Suraphon Assawasuwannakit, Éric Assenat, Edmond Atallah, Ali Atay, Emmanouil Athanasiadis, Varinder Athwal, Francisco Javier Corcuera Atienza, Francisco Javier, Atienza Martín, Mo Atif, Cecilia Atik, Stephen D. Atkinson, Masanori Atsukawa, M.R. Attanasio, Nabeel Attarwala, Payance Audrey, Nicole Auer, Jérémy Augustin, Salvador Augustín, Igor Aurrekoetxea, Andrew D. Austin, G. Auzinger, José Manuel, Avendaño-Reyes Francisco, Averhoff Avian, Roberta Avigni, Matías A. Ávila, Gerson Avila, Emma Avitabile, Fábio Vinícius Marley Santos Lima, Awad El-Karim, Jonathan H. Axelrod, Ibrahim Ayada, María Ayala-Valverde, Margaret F. Bassendine, Christine Bassis, Dustin Gorka, Bastarrika Alemañ, Nina Bastati, Ramón Bataller, Suvd Batbaatar, Enkhtuul Batbold, Andrew Bathgate, Ayşe Batırel, Rui Batista, Clara Batista, Uyanga Bat-Osor, Salvatore Battaglia, A. Battisti, Purevjargal Bat-Ulzii, Martine Baudin, Ulrike Bauer, Jens Bauer, Anja Baumann, Cédric Baumann, Thomas F. Baumert, Joseph Baur, Alina Bauschen, Pierre Bauvin, Aditi Bawa, Nurcan Baykam, David Bayne, Fabio Becce, Chiara Becchetti, Lars P. Bechmann, Morten Beck Trelle, Britta Becker, Hans Becker, Racquel Henning, Beck-Nielsen Cheikh, Mohemed Bed, Nathalie Bédard, Erin Bedford, Pierre Bédossa, Lewis Beer, Lucian Beer, Niko Beerenwinkel, Neelu Begum, Jaideep Behari, Cynthia Behling, Christian Behrends, Patrick Behrendt, Lawrence J. Beilin, Hicran Bektasi, Nes Belasri, Assia Belblidia, Élaine Bell, John I. Bell, Sally Bell, Dawn Agne S Bellanger, Jonathan Bellet, Luca Saverio, Belli Ernest, Belmonte Luciano, B. C. Pinheiro Pereira, Chantal Bémeur, Ziv Ben, Ari Yasmina, Ben Merabet, Amel Ben, Saad Gil, Ben Yaacov, Marie-Therese Biotrel, Thomas D. Bird, Kohnke-Ertel Birgit, Rasmine Birn-Rydder, Otilia Bisbal, Alberto Biscontin, Maria Bishara, Jennifer Bissram, Sagnik Biswas, Debasis Biswas, Sagnik Biswas, Subhrajit Biswas, Baboucarr Bittaye, Paulo Fernando Souto Bittencourt, Sandra Bivegete, Maider Bizkarguenaga, Debora Bizzaro, Frederik Adam Bjerre, Niklas K. Björkström, Ronny Bjørnestad, Einar S. Björnsson, Blagoy Blagoev, Alasdair Blain, Lorraine Blaise, Marino Blanes, Antje Blank, Valentin Blank, Rainer Blasczkyk, Annabel Blasi, Delia Blaya, Minerva Blazquez Barba, Evan M. Bloch, Julia Blomdahl, Netta Rose, Blondheim Shraga, Stephen Bloom, Pamela Bloomer, Karine Blouin,
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