Stéphane Terry, Cécile Dalban, Nathalie Rioux‐Leclercq, Julien Adam, Maxime Meylan, Stéphanie Buart, Antoine Bougoüin, Alexandra Lespagnol, Frédéric Dugay, Irelka Colina Moreno, Guillaume Lacroix, James B. Lorens, Gro Gausdal, Wolf H. Fridman, Fathia Mami‐Chouaib, Nathalie Chaput, Benoit Beuselinck, Sylvie Chabaud, Janice Barros-Monteiro, Yann Vano, Bernard Escudier, Catherine Sautès‐Fridman, Laurence Albigès, Salem Chouaı̈b,
A minority of patients currently respond to single-agent immune-checkpoint blockade (ICB), and strategies to increase response rates are urgently needed. AXL is a receptor tyrosine kinase commonly associated with drug resistance and poor prognosis in many cancer types, including in clear-cell renal cell carcinoma (ccRCC). Recent experimental cues in breast, pancreatic, and lung cancer models have linked AXL with immune suppression and resistance to antitumor immunity. However, its role in intrinsic ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2021 - American Association for Cancer Research | Clinical Cancer Research
Moníque Capron, Laurent Béghin, Céline C. Leclercq, Julien Labreuche, Arnaud Dendooven, Annie Standaert–Vitse, Marie Delbeke, Adeline Porcherie, Maria Nachury, Arnaud Boruchowicz, Jean‐Louis Dupas, Mathurin Fuméry, Thierry Paupard, Sylviane Catteau, Dominique Deplanque, Jean–Fréderic Colombel, Pierre Desreumaux,
Despite the development of novel therapies, inflammatory bowel diseases remain an innovative treatment challenge. Helminth therapy is a new promising approach, and a key issue is the identification of helminth-derived anti-inflammatory mediators. P28 glutathione-S-transferase (P28GST), a protein derived from schistosomes, a trematode parasitic helminth, was shown to reduce intestinal inflammation in experimental colitis by down-regulating the Th1/Th17 response. In this multicenter, open-label, pilot ...
Tópico(s): Pancreatitis Pathology and Treatment
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
S. Leclercq, Julien Thézé, Mohamed Amine Chebbi, Isabelle Giraud, Bouziane Moumen, Lise Ernenwein, Pierre Grève, Clément Gilbert, Richard Cordaux,
Sex determination is a fundamental developmental pathway governing male and female differentiation, with profound implications for morphology, reproductive strategies, and behavior. In animals, sex differences between males and females are generally determined by genetic factors carried by sex chromosomes. Sex chromosomes are remarkably variable in origin and can differ even between closely related species, indicating that transitions occur frequently and independently in different groups of organisms. ...
Tópico(s): Plant Virus Research Studies
2016 - National Academy of Sciences | Proceedings of the National Academy of Sciences
John-Eric Dufour, S. Leclercq, Julien Schneider, Stéphane Roux, François Hild,
The aim of the present study is to measure complex shapes of tested objects by using a priori information given by their CAD model via stereocorrelation. To follow a 3D object during its deformation and to determine 3D surface displacement fields, a first measurement of the object shape is necessary. It is achieved by updating the CAD reference via a global approach to stereocorrelation. Once the 3D shape has been determined, the next step is to measure 3D displacement fields during loading. The ...
Tópico(s): Optical measurement and interference techniques
2016 - Elsevier BV | Optics and Lasers in Engineering
M.-C. Brianso, Mathilde Leclercq, Julien Jacques,
Tópico(s): Cancer Treatment and Pharmacology
1979 - International Union of Crystallography | Acta Crystallographica Section B
Maryline Blin, Julien Fumey, Camille Lejeune, Maxime Policarpo, Julien Leclercq, Stéphane Père, Jorge Torres‐Paz, Constance Pierre, Boudjema Imarazene, Sylvie Rétaux,
Animals in many phyla are adapted to and thrive in the constant darkness of subterranean environments. To do so, cave animals have presumably evolved mechano- and chemosensory compensations to the loss of vision, as is the case for the blind characiform cavefish, Astyanax mexicanus. Here, we systematically assessed the olfactory capacities of cavefish and surface fish of this species in the lab as well as in the wild, in five different caves in northeastern Mexico, using an olfactory setup specially ...
Tópico(s): Marine Biology and Ecology Research
2020 - Multidisciplinary Digital Publishing Institute | Diversity
Tiago Mendonça, Cécile Bienboire‐Frosini, Fanny Menuge, Julien Leclercq, Céline Lafont‐Lecuelle, Sana Arroub, Patrick Pageat,
Equine-assisted therapies (EATs) have been widely used in the treatment of patients with mental or physical conditions. However, studies on the influence of equine-assisted therapy (EAT) on equine welfare are very recent, and the need for further research is often highlighted. The aim of this study was to investigate whether EAT creates negative or positive emotions in horses, and the influence of patients' expectations (one group of patients had physical and psychological expectations and one group ...
Tópico(s): Animal Behavior and Welfare Studies
2019 - Multidisciplinary Digital Publishing Institute | Animals
Tiago Mendonça, Cécile Bienboire‐Frosini, Izabela Kowalczyk, Julien Leclercq, Sana Arroub, Patrick Pageat,
The learning and cognitive challenges that horses may face differ according to the activities in which they are involved. The aim of this investigation was to study the influence of equine activities on the behavioral responses and autonomic nervous system (ANS) activity of adult horses. Forty-one horses were divided into four groups: dressage (9), jumping (10), eventing (13) and equine-assisted activity/therapy (9). A test was created to compare the horses’ behavioral and physiological responses to ...
Tópico(s): Meat and Animal Product Quality
2019 - Multidisciplinary Digital Publishing Institute | Animals
Sarah O’Connor, Karine Greffard, Mickaël Leclercq, Pierre Julien, S. John Weisnagel, Claudia Gagnon, Arnaud Droit, Jean‐François Bilodeau, Iwona Rudkowska,
Scope Metabolomics is increasingly used to identify biomarkers of diet or chronic diseases, such as type 2 diabetes. Yet, metabolite signatures following dairy intake in hyperinsulinemic subjects have not been identified. The objective is to evaluate the effects of a high dairy diet (HD) for 6 weeks (4 servings or more per day), compared with an adequate dairy diet (AD) (2 servings or less per day), on serum metabolite profiles in hyperinsulinemic adults. Methods and results In this crossover trial, ...
Tópico(s): Fatty Acid Research and Health
2019 - Wiley | Molecular Nutrition & Food Research
Jorge Torres‐Paz, Julien Leclercq, Sylvie Rétaux,
Sequential developmental events, starting from the moment of fertilization, are crucial for the acquisition of animal body plan. Subtle modifications in such early events are likely to have major impacts in later morphogenesis, bringing along morphological diversification. Here, comparing the blind cave and the surface morphotypes of Astyanax mexicanus fish, we found heterochronies during gastrulation that produce organizer and axial mesoderm tissues with different properties (including differences ...
Tópico(s): Ichthyology and Marine Biology
2019 - eLife Sciences Publications Ltd | eLife
Míriam Marcet‐Rius, Patrick Pageat, Cécile Bienboire‐Frosini, Eva Teruel, Philippe Monneret, Julien Leclercq, Céline Lafont‐Lecuelle, Alessandro Cozzi,
A better understanding of animal emotions is an important goal in disciplines ranging from neuroscience to animal welfare science, but few reliable tools exist for measuring these emotions. Play behaviour is generally recognized as a trigger of positive emotions in mammals, and previous studies have suggested that tail movement (a behaviour often seen during play) may indicate positive emotions in pigs, while ear movements may indicate negative emotions, or a decrease in positive emotions. This study ...
Tópico(s): Meat and Animal Product Quality
2018 - Elsevier BV | Applied Animal Behaviour Science
Míriam Marcet‐Rius, Alessandro Cozzi, Cécile Bienboire‐Frosini, Eva Teruel, Camille Chabaud, Philippe Monneret, Julien Leclercq, Céline Lafont‐Lecuelle, Patrick Pageat,
Numerous studies have shown that providing straw to pigs can reduce undesirable behaviours such as aggression, tail biting and stereotypy. The measurement of various neuromodulators can be helpful in assessing the development of positive behaviours and overall animal welfare. The oxytocin release is frequently linked to positive emotions and positive welfare. It has been suggested that oxytocin modulates the serotoninergic system. This study aims to investigate the potential effect of straw provision ...
Tópico(s): Animal Behavior and Welfare Studies
2018 - Elsevier BV | animal
Míriam Marcet‐Rius, Alessandro Cozzi, Cécile Bienboire‐Frosini, Eva Teruel, Camille Chabaud, Philippe Monneret, Julien Leclercq, Céline Lafont‐Lecuelle, Patrick Pageat,
Positive welfare is more than the absence of negative experiences. Nevertheless, there are few feasible animal-based measures for positive welfare. This study aimed to investigate whether object and social play behaviours in pigs, which is believed to trigger positive emotions, is linked to peripheral oxytocin and/or serotonin changes over time. Moreover, the study examines the relationship between tail movement, play behaviour, and peripheral levels of oxytocin and serotonin in animals that have ...
Tópico(s): Neuroendocrine regulation and behavior
2018 - Elsevier BV | Applied Animal Behaviour Science
Mohsine Driowya, Julien Leclercq, Valérie Verones, Amélie Barczyk, Marie Lecoeur, Nicolas Renault, Nathalie Flouquet, Alina Ghinet, Pascal Berthelot, Nicolas Lebègue,
A series of 1-phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5-ones designed as conformationally restricted CA-4 analogues, were tested for their tubulin polymerization and growth inhibitory activities. The 3-hydroxy-4-methoxy derivatives 11d and 12d are potent inhibitors of tubulin assembly but only the N-methylated amid counterpart 12d possesses potent anticancer activity in a large panel of cancer cell lines. Upon treatment with compound 12d, remarkable cell shape changes as cell migration and tube ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2016 - Elsevier BV | European Journal of Medicinal Chemistry
Zacharie Segaoula, Julien Leclercq, Valérie Verones, Nathalie Flouquet, Marie Lecoeur, Lionel Ach, Nicolas Renault, Amélie Barczyk, Patricia Melnyk, Pascal Berthelot, Xavier Thuru, Nicolas Lebègue,
Benzopyridothiadiazepine (2a) and benzopyridooxathiazepine (2b) were modified to produce tricyclic quinazolinone 15-18 or benzothiadiazine 26-27 derivatives. These compounds were evaluated in cytotoxicity and tubulin inhibition assays and led to potent inhibitors of tubulin polymerization. N-[2(4-Methoxyphenyl)ethyl]-1,2-dihydro-pyrimidino[2,1-b]quinazolin-6-one (16a) exhibited the best in vitro cytotoxic activity (GI50 10-66.9 nM) against the NCI 60 human tumor cell line and significant potency against ...
Tópico(s): Enzyme function and inhibition
2016 - American Chemical Society | Journal of Medicinal Chemistry
... cz/zoy024Piotr Bursztyka, Céline Lafont-Lecuelle, Eva Teruel, Julien Leclercq, Antoine Brin Behavioural response of xerophilous land snail ...
Tópico(s): Marine and fisheries research
1992 - University of Chicago Press | The American Naturalist
Julien Leclercq, Bernard Swynghedauw, P. Bouveret, C. Faucomprez, V. Piguet,
70 human hearts were studied less than 36 hours after death. The apex, and in some cases other parts of the myocardium were homogenized, DNA, hydroxyproline content, myofibrillar Ca2+ and Mg2+ ATPase were measured. In normal hearts the DNA and collagen content were 372 +/- 9 mg and 36 +/- 7 mg. Ca2+ and Mg2+ ATPase of the myofibrils prepared from these hearts have shown the same specific activity (35 +/- 5 and 34 +/- 6 nmol/min./mg) as those from fresh biopsies taken during open-chest surgery. The heart weight correlates ...
Tópico(s): Muscle Physiology and Disorders
1976 - Wiley | European Journal of Clinical Investigation
Laurent Legendre, J. Rode, Isabelle Germon, Marie Pavie, Carla Quiviger, Maxime Policarpo, Julien Leclercq, Stéphane Père, Julien Fumey, Carole Hyacinthe, Claudia Patricia Ornelas‐García, Luis Espinasa, Sylvie Rétaux, Didier Casañe,
The sizes of Astyanax mexicanus blind cavefish populations of North-East Mexico are demographic parameters of great importance for investigating a variety of ecological, evolutionary, and conservation issues. However, few estimates have been obtained. For these mobile animals living in an environment difficult to explore as a whole, methods based on capture-mark-recapture are appropriate, but their feasibility and interpretation of results depend on several assumptions that must be carefully examined. ...
Tópico(s): Marine Ecology and Invasive Species
2023 - Science Press | 动物学研究
Mathilde Leclercq, André Collet, Julien Jacques,
La stabilité racémiques vrais est définie par la variation d'énergie libre ΔGφ de la “réaction” D-solide + L-solide → DL-solide. ΔGφ, variant de 0 à − 2 kcal mol−1 environ, est approximativement proportionnelle à la différence des températures de fusion du racémique et des antipodes, TRf − TAf. Dans la plupart des cas étudiés, la formation des racémiques vrais est exothermique. L'étude de la variation de ΔGφ avec la température permet d'expliquer l'apparition de transitions cristallines entre racémique vrai ...
Tópico(s): Orbital Angular Momentum in Optics
1976 - Elsevier BV | Tetrahedron
S. Leclercq, Martin Lavigne, Julien Girard, Philippe Chiron, Pascal‐André Vendittoli,
The performance of second-generation metal-on-metal bearings has led to the reintroduction of hip resurfacing. The goal of this multicentre study was to evaluate the short-term radiological and clinical outcomes with the Durom hip resurfacing system. The Durom hip-resurfacing system will have similar results to other hip resurfacing systems and traditional hip arthroplasty implants. In the four participating centers, 580 patients (406 men, 174 women) and 644 hips were included. The average patient ...
Tópico(s): Hip disorders and treatments
2013 - Elsevier BV | Orthopaedics & Traumatology Surgery & Research
Julien Leclercq, Jorge Torres‐Paz, Maxime Policarpo, François Agnès, Sylvie Rétaux,
ABSTRACT Developmental evolution and diversification of morphology can arise through changes in the regulation of gene expression or protein-coding sequence. To unravel mechanisms underlying early developmental evolution in cavefish of the species Astyanax mexicanus, we compared transcriptomes of surface-dwelling and blind cave-adapted morphs at the end of gastrulation. Twenty percent of the transcriptome was differentially expressed. Allelic expression ratios in cave X surface hybrids showed that ...
Tópico(s): Marine Biology and Ecology Research
2024 - The Company of Biologists | Development
Leila Khorraminezhad, Mickaël Leclercq, Sarah O’Connor, Pierre Julien, S. John Weisnagel, Claudia Gagnon, Arnaud Droit, Iwona Rudkowska,
Tópico(s): Nutritional Studies and Diet
2020 - Springer Science+Business Media | European Journal of Nutrition
Cuifang Duan, Xavier Argout, Virginie Gébelin, Marilyne Summo, Jean-François Dufayard, Julie Leclercq, Kuswanhadi, Piyanuch Piyatrakul, Julien Pirrello, Maryannick Rio, Antony Champion, Pascal Montoro,
Abstract Background Rubber tree ( Hevea brasiliensis ) laticifers are the source of natural rubber. Rubber production depends on endogenous and exogenous ethylene (ethephon). AP2/ERF transcription factors, and especially Ethylene-Response Factors, play a crucial role in plant development and response to biotic and abiotic stresses. This study set out to sequence transcript expressed in various tissues using next-generation sequencing and to identify AP2/ERF superfamily in the rubber tree. Results The ...
Tópico(s): Plant Gene Expression Analysis
2013 - BioMed Central | BMC Genomics
B. Fantin, Roland Leclercq, Yann Merlé, L Saint-Julien, C Veyrat, J Duval, C Carbon,
In order to determine the microbiological and pharmacokinetic parameters that best predicted the in vivo antistaphylococcal activity of the streptogramin RP 59500 (quinupristin-dalfopristin), we evaluated the activity in rabbit aortic endocarditis of three regimens of quinupristin-dalfopristin against five strains of Staphylococcus aureus with various streptogramin B-type antibiotic resistance phenotypes and susceptible to streptogramin A-type antibiotics. Quinupristin-dalfopristin was as active ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
1995 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Nicolas Debry, Talel Trimech, Thomas Gandet, Flavien Vincent, Ilir Hysi, Cédric Delhaye, Guillaume Cayla, Mohamad Koussa, Françis Juthier, Florence Leclercq, Max Pécheux, Saïd Ghostine, Julien Labreuche, Thomas Modine, Éric Van Belle,
No randomised study comparing the outcomes of transcarotid (TC) and transaxillary (TAx) TAVR has been conducted to date. The purpose of this study was to understand which approach should be the preferred alternative by comparing their outcomes using a propensity-matched comparison in a French multicentre registry.From 2010 to 2018, a French multicentre prospective registry included 502 patients, with 374 undergoing TC-TAVR and 128 TAx-TAVR for symptomatic aortic stenosis. Patients treated through ...
Tópico(s): Cardiac Arrhythmias and Treatments
2020 - European Association of Percutaneous Cardiovascular Interventions | EuroIntervention
Frédéric Sacher, Laurent Fauchier, Serge Bovéda, Christian de Chillou, Pascal Defaye, Jean‐Claude Deharo, Estelle Gandjbakhch, Vincent Probst, Ariel Cohen, Christophe Leclercq, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Thibaud Lacour, Christophe Saint Etienne, Bertrand Pierre, Nicolas Clémenty, Pierre Deharo, Dominique Babuty, Christophe Gaborit, Gregory Y.H. Lip,
Background and Purpose- Atrial fibrillation (AF) is known to increase risk of ischemic stroke (IS), but the risk of IS in isolated sinus node disease (SND) is unclear. We compared the incidence of IS in patients with SND, patients with AF, and in a control population with other cardiac diseases (disease of the circulatory system using the International Classification of Diseases, Tenth Revision). Methods- This French longitudinal cohort study was based on the national database covering hospital care ...
Tópico(s): Acute Ischemic Stroke Management
2020 - Lippincott Williams & Wilkins | Stroke
Giulia Berzero, Guillaume Taïeb, Romain Marignier, Nadia Younan, Julien Savatovsky, Delphine Leclercq, Dimitri Psimaras,
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Tópico(s): CNS Lymphoma Diagnosis and Treatment
2018 - Wiley | European Journal of Neurology
Julien Thézé, S. Leclercq, Bouziane Moumen, Richard Cordaux, Clément Gilbert,
Recent studies in paleovirology have uncovered myriads of endogenous viral elements (EVEs) integrated in the genome of their eukaryotic hosts. These fragments result from endogenization, that is, integration of the viral genome into the host germline genome followed by vertical inheritance. So far, most studies have used a virus-centered approach, whereby endogenous copies of a particular group of viruses were searched in all available sequenced genomes. Here, we follow a host-centered approach whereby ...
Tópico(s): Viral Infections and Vectors
2014 - Oxford University Press | Genome Biology and Evolution
Julien Pirrello, Julie Leclercq, Florence Dessailly, Maryannick Rio, Piyanuch Piyatrakul, Kuswanhadi Kuswanhadi, Chaorong Tang, Pascal Montoro,
Latex harvesting in Hevea brasiliensis amounts to strong abiotic stress that can cause a halt in production in the most susceptible clones. Although the role of jasmonic acid has been suggested in laticifer differentiation, its role in latex production and in the response to harvesting stress has received very little attention. Only a few key genes acting in the COI-JAZ-MYC module have been isolated and studied at transcriptional level. Use of a reference transcriptome obtained on rubber clone PB ...
Tópico(s): Insect and Pesticide Research
2014 - BioMed Central | BMC Plant Biology
Julien Raft, Maximilien Leclercq, Dan Longrois, Claude Meistelman,
Recently, three case reports have suggested the possible efficacy of sugammadex in anaphylactic shock refractory to conventional treatment induced by rocuronium. We report a new case of severe anaphylactic reaction to rocuronium treated with sugammadex. After 18 minutes of conventional treatment because of persistent cardiocirculatory failure and bronchospasm, a bolus of 2000 mg (18 mg/kg) of sugammadex was injected. This was associated with rapid correction of arterial hypotension and bronchoconstriction. ...
Tópico(s): Drug-Induced Adverse Reactions
2011 - Elsevier BV | Annales Françaises d Anesthésie et de Réanimation