Véronique Giroux, Julien Stephan, Priya Chatterji, Ben Rhoades, E. Paul Wileyto, Andres J. Klein–Szanto, Christopher J. Lengner, Kathryn E. Hamilton, Anil K. Rustgi,
Two principal stem cell pools orchestrate the rapid cell turnover in the intestinal epithelium. Rapidly cycling Lgr5+ stem cells are intercalated between the Paneth cells at the crypt base (CBCs) and injury-resistant reserve stem cells reside above the crypt base. The intermediate filament Keratin 15 (Krt15) marks either stem cells or long-lived progenitor cells that contribute to tissue repair in the hair follicle or the esophageal epithelium. Herein, we demonstrate that Krt15 labels long-lived and ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2018 - Elsevier BV | Stem Cell Reports
Emmanuel Défossez, Julien Bourquin, Stephan H. von Reuß, Sergio Rasmann, Gaétan Glauser,
Abstract In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of metabolites in biological systems. The rapid progress in analytical equipment, coupled to the rise of powerful data processing tools, now provides unprecedented opportunities to deepen our understanding of the relationships between biochemical processes and physiological or phenotypic conditions in living organisms. However, to obtain unbiased data coverage of hundreds or thousands of metabolites ...
Tópico(s): Advanced Proteomics Techniques and Applications
2021 - Wiley | Mass Spectrometry Reviews
Niccolò Buetti, Mohamed Abbas, Didier Pittet, Marlieke E.A. de Kraker, Daniel A. Toledo-Teixeira, Marie‐Noëlle Chraïti, Valérie Sauvan, Julien Sauser, Stephan Harbarth, Walter Zingg,
Peripheral intravenous catheters (PVCs) are the most frequently used indwelling devices in hospitals worldwide. Peripheral intravenous catheter bloodstream infections (PVC-BSIs) are rare, but severe and preventable, adverse events.To investigate the incidence of PVC-BSIs after changing the policy of routine PVC replacement every 96 hours to clinically indicated replacement.This institution-wide, observational cohort study evaluated all patients hospitalized at a large university-affiliated hospital ...
Tópico(s): Patient Safety and Medication Errors
2021 - American Medical Association | JAMA Internal Medicine
Yun Meng, Kai Zou, Nan Hu, Xiaojian Lan, Liang Xu, Julien Zichi, Stephan Steinhauer, Val Zwiller, Xiaolong Hu,
Superconducting nanowire (nanostrip) single-photon detectors (SNSPDs) have shown unprecedented detection efficiency and timing properties, but simultaneously achieving polarization-insensitive high detection efficiency, low dark-count rate (DCR), fast speed, and low timing jitter remains a challenge. Here we report on our design, fabrication, and characterization of a cascaded superconducting avalanche photodetector composed of 40 nm wide NbTiN nanowires patterned into fractal curves. At the base temperature ...
Tópico(s): Photonic and Optical Devices
2019 - Optica Publishing Group | Optics Letters
Ashiq Hussain, Atefeh Pooryasin, Mo Zhang, Laura F. Loschek, Marco La Fortezza, Anja Friedrich, Catherine-Marie Blais, Habibe K. Üçpunar, Vicente A. Yépez, Martin Lehmann, Nicolas Gompel, Julien Gagneur, Stephan J. Sigrist, Ilona C Grunwald Kadow,
Loss of the sense of smell is among the first signs of natural aging and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Cellular and molecular mechanisms promoting this smell loss are not understood. Here, we show that Drosophila melanogaster also loses olfaction before vision with age. Within the olfactory circuit, cholinergic projection neurons show a reduced odor response accompanied by a defect in axonal integrity and reduction in synaptic marker proteins. Using behavioral functional ...
Tópico(s): Olfactory and Sensory Function Studies
2018 - eLife Sciences Publications Ltd | eLife
Ingrid Blanchard, Julien Siebert, Stephan Borensztajn, James Badro,
The long term thermal and dynamic evolution of Earth's core depends on its energy budget, and models have shown that radioactive decay due to K and U disintegration can contribute significantly to core dynamics and thermal evolution if substantial amounts of heat-producing elements are dissolved in the core during differentiation.Here we performed laser-heated diamond anvil cell experiments and measured K and U solubility in molten iron alloy at core formation conditions.Pyrolitic and basaltic silicate ...
Tópico(s): Geological Studies and Exploration
2017 - | Geochemical Perspectives Letters
Lise Boussemart, Isabelle Girault, Hélène Malka-Mahieu, Christine Mateus, Émilie Routier, Margot Rubington, Nyam Kamsu-Kom, M. Thomas, Gorana Tomasic, Sandrine Agoussi, Marie Breckler, Mélanie Laporte, Ludovic Lacroix, Alexander M.M. Eggermont, Andréa Cavalcanti, Florent Grange, Julien Adam, Stéphan Vagner, Caroline Robert,
BRAF inhibitors (BRAFi) elicit therapeutic responses in metastatic melanoma, but alarmingly, also induce the formation of secondary benign and malignant skin tumors. Here, we report the emergence and molecular characterization of 73 skin and extracutaneous tumors in 31 patients who underwent BRAFi therapy. The majority of patients presented with classic epidermal tumors such as verrucous papillomas, keratoacanthomas, and squamous cell carcinomas (SCC). However, 15 patients exhibited new or rapidly ...
Tópico(s): HER2/EGFR in Cancer Research
2016 - American Association for Cancer Research | Cancer Research
Simon Courgeon, Julien Bourget, Stéphan Jorry,
During the Pliocene–Quaternary, the Bonaparte Basin is characterized by a very wide (>600 km [>370 mi]) carbonate platform and 200-km-wide (125-mi-wide) Malita intrashelf basin (ISB). Using three-dimensional and two-dimensional seismic data combined with exploration well data, this study characterizes the stratigraphic evolution of the Malita ISB during the last 3.5 m.y. Two third-order transgressive sequences can be distinguished. A late Pliocene transgression occurred over an irregular topography resulting ...
Tópico(s): Seismic Imaging and Inversion Techniques
2016 - American Association of Petroleum Geologists | AAPG Bulletin
Maria Wächtler, Julien Guthmuller, Stephan Kupfer, Margherita Maiuri, Daniele Brida, Jürgen Popp, Sven Rau, Giulio Cerullo, Benjamin Dietzek,
The hydrogen-evolving photocatalyst [(tbbpy)2 Ru(tpphz)Pd(Cl)2 ](2+) (tbbpy=4,4'-di-tert-butyl-2,2'-bipyridine, tpphz=tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) shows excitation-wavelength-dependent catalytic activity, which has been correlated to the localization of the initial excitation within the coordination sphere. In this contribution the excitation-wavelength dependence of the early excited-state relaxation and the occurrence of vibrational coherences are investigated by sub-20 ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2015 - Wiley | Chemistry - A European Journal
Julien Vidal, Stephan Lany, Jason Francis, Robert S. Kokenyesi, Janet Tate,
Emergence of a terawatt scalable photovoltaic (PV) thin film technology is currently impeded by the limited supply of relatively rare elements like In or Te, which has spurred active research in recent years on earth-abundant PV materials. Instead of searching for alternative PV materials, we approach the problem here by structural modification through alloying of a known PV material, namely, tin sulfide. Although SnS is a strong visible light absorber that is naturally p-doped, its indirect band ...
Tópico(s): Copper-based nanomaterials and applications
2014 - American Institute of Physics | Journal of Applied Physics
Jan Funke, Julien Martel, Stephan Gerhard, Bjoern Andres, Dan Cireşan, Alessandro Giusti, Luca Maria Gambardella, Jürgen Schmidhuber, Hanspeter Pfister, Albert Cardona, Matthew Cook,
The automatic reconstruction of neurons from stacks of electron microscopy sections is an important computer vision problem in neuroscience. Recent advances are based on a two step approach: First, a set of possible 2D neuron candidates is generated for each section independently based on membrane predictions of a local classifier. Second, the candidates of all sections of the stack are fed to a neuron tracker that selects and connects them in 3D to yield a reconstruction. The accuracy of the result ...
Tópico(s): Electron and X-Ray Spectroscopy Techniques
2014 - Springer Science+Business Media | Lecture notes in computer science
Julien Genovino, Stephan Lütz, Dalibor Sameš, B. Barry Touré,
The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we compared biotransformations to classical and new chemical C–H oxidation methods using oxcarbazepine, naproxen, and an early compound hit (phthalazine 1). These studies illustrated the low preparative efficacy of biotransformations and the inability of chemical ...
Tópico(s): Oxidative Organic Chemistry Reactions
2013 - American Chemical Society | Journal of the American Chemical Society
Julien Vidal, Stephan Lany, Mayeul d’Avezac, Alex Zunger, Andriy Zakutayev, Jason Francis, Janet Tate,
SnS is a potential earth-abundant photovoltaic (PV) material. Employing both theory and experiment to assess the PV relevant properties of SnS, we clarify on whether SnS has an indirect or direct band gap and what is the minority carrier effective mass as a function of the film orientation. SnS has a 1.07 eV indirect band gap with an effective absorption onset located 0.4 eV higher. The effective mass of minority carrier ranges from 0.5 m0 perpendicular to the van der Waals layers to 0.2 m0 into ...
Tópico(s): Semiconductor materials and interfaces
2012 - American Institute of Physics | Applied Physics Letters
Kristina Pitzschel, Julien Bachmann, Stephan Martens, Josep M. Montero-Moreno, Judith Kimling, Guido Meier, Juan Escrig, Kornelius Nielsch, Detlef Görlitz,
Anodic alumina membranes with modulated pore diameters serve as template for the preparation of magnetic nanowires. Filling the pores with Ni by electrodeposition delivers wires replicating the variation in modulation in pore diameter from 80 to 160 nm. Such structures are of interest for the observation and control of magnetic domain wall motion. Single-object characterization utilizing the magneto-optical Kerr effect magnetometry evidences a strong correlation between geometric parameters and ...
Tópico(s): Nanowire Synthesis and Applications
2011 - American Institute of Physics | Journal of Applied Physics
Olivier David, Julien Bastin, Stéphan Chabardès, Lorella Minotti, Philippe Kahane,
Patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes allow to obtain data of exceptional value for studying brain dynamics in correlation with pathophysiological and cognitive processes. Direct electrical stimulation (DES) of cortical regions and axonal tracts in those patients elicits a number of very specific perceptual or behavioral responses, but also abnormal responses due to specific configurations of epileptic networks. Here, we review how anatomo- ...
Tópico(s): Neural dynamics and brain function
2010 - Frontiers Media | Frontiers in Systems Neuroscience
Julien Savatier, Stéphan Jalaguier, Matthew Ferguson, Vincent Cavaillès, Catherine A. Royer,
Quantitative characterization of protein interactions in live cells remains one of the most important challenges in modern biology. In the present work we have used two-photon, two-color, fluorescence cross-correlation spectroscopy (FCCS) in transiently transfected COS-7 cells to measure the concentrations and interactions of estrogen receptor (ER) subtypes alpha and beta with one of their transcriptional coactivator proteins, TIF2, as well as heterodimerization between the two ER subtypes. Using ...
Tópico(s): Receptor Mechanisms and Signaling
2009 - American Chemical Society | Biochemistry
Julien Colombelli, Stephan W. Grill, Ernst H. K. Stelzer,
A laser nanodissection system for in vivo and in situ biological tissues is presented. A pulsed laser beam operating at a wavelength of 355 nm enables diffraction limited dissection, providing an optimal tool for intracellular nanosurgery. Coupled into a conventional inverted microscope and scanned across a field of up to 100×100 μm2, this optical nanoscalpel performs in vivo photoablation and plasma-induced ablation inside organisms ranging from intracellular organelles to embryos. The system allows ...
Tópico(s): Diamond and Carbon-based Materials Research
2004 - American Institute of Physics | Review of Scientific Instruments
Julien Favand, Stephan Haas, Karlo Penc, Frédéric Mila, Elbio Dagotto,
Using the Ogata-Shiba wave function, the spectral functions of the one-dimensional infinite U Hubbard model are calculated for various concentrations. It is shown that the ``shadow band'' feature due to 2k_F fluctuations becomes more intense close to half-filling. Comparing these results with exact diagonalization data obtained on finite clusters for the finite U Hubbard model and for the t-J model, it is also shown that this feature remains well-defined for physically reasonable values of the parameters ( ...
Tópico(s): Surface and Thin Film Phenomena
1997 - American Physical Society | Physical review. B, Condensed matter
Vincenzo Vento, Sébastien Multon, Ramzi Ramadan, Philippe Deleuze, Dominique Fabre, Julien Guihaire, Stéphan Haulon,
Standard surgical repair of acute type A aortic dissection is associated with high mortality rates, especially in high-risk patients. In an attempt to improve survival in frail patients, we evaluated the outcomes after ascending aorta wrapping in a high-risk patient cohort.This single-center retrospective cohort study included all consecutive patients treated using ascending aorta wrapping for an acute type A aortic dissection from 2008 to 2019. The primary end points included 30-day mortality, ...
Tópico(s): Cardiac Valve Diseases and Treatments
2020 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Frank Stüber, Stéphan Julien, F. Recasens,
The shrinking core model has been used in some cases to describe kinetics of extraction of seeds with a supercritical fluid as solvent, despite the fact that seed geometry may be quite irregular and internal walls may strongly affect diffusion and the liquid-fluid-solid equilibria. Consequently, the values of model parameters (effective diffusivity, particle-fluid mass-transfer coefficient) hardly, if ever, prove meaningful or have a limited value. In the present work, the extraction of benzene, ...
Tópico(s): Diffusion Coefficients in Liquids
1997 - Elsevier BV | Chemical Engineering Science
Matthieu P. Boisgontier, Boris Cheval, Peter van Ruitenbeek, Oron Levin, Olivier Renaud, Julien Chanal, Stephan P. Swinnen,
Functional and structural imaging studies have demonstrated the involvement of the brain in balance control. Nevertheless, how decisive grey matter density and white matter microstructural organisation are in predicting balance stability, and especially when linked to the effects of ageing, remains unclear. Standing balance was tested on a platform moving at different frequencies and amplitudes in 30 young and 30 older adults, with eyes open and with eyes closed. Centre of pressure variance was ...
Tópico(s): Cerebral Palsy and Movement Disorders
2016 - Elsevier BV | Gait & Posture
Thierry Adoukonou, Mendinatou Agbétou, Roland Bangbotché, Oyéné Kossi, Pervenche Fotso Mefo, Julien Magné, Dismand Stéphan Houinato, Pierre‐Marie Preux, Philippe Lacroix,
The burden of stroke is high in Africa, but few data are available on the long-term outcome of strokes in this area.We aimed to study the long-term outcome of stroke survivors in Parakou from 2012 to 2018.It was a cohort study and included 247 stroke patients admitted to the University Hospital of Parakou from January 1, 2012 to April 30, 2018. Each patient was followed up for at least 1 year. The modified RANKIN scale was used to evaluate patients. Verbal autopsy was used to ascertain the cause ...
Tópico(s): Healthcare Systems and Practices
2020 - Elsevier BV | Journal of Stroke and Cerebrovascular Diseases
Ronan Guillossou, Julien Le Roux, Stéphan Brosillon, Romain Mailler, Emmanuelle Vulliet, Catherine Morlay, F. Nauleau, Vincent Rocher, Johnny Gaspéri,
Advanced processes for the removal of organic micropollutants (OMPs) from wastewater effluents include adsorption onto activated carbon, ozonation, or a combination of both processes. The removal of 28 OMPs present in a real wastewater effluent was studied by ozonation coupled to activated carbon adsorption and compared to a sole adsorption. The influence of the specific ozone dose (0.09-1.29 gO3/gDOC) and the influence of the powdered activated carbon (PAC) dose (2, 5 and 10 mg/L) were first studied ...
Tópico(s): Water Treatment and Disinfection
2019 - Elsevier BV | Chemosphere
S. Schulte Althoff, Marianne Grüneberg, Janine Reunert, Julien H. Park, Stephan Rust, Chris Mühlhausen, Yoshinao Wada, René Santer, Thorsten Marquardt,
Congenital disorders of glycosylation form a rapidly growing group of inherited metabolic diseases. As glycosylation affects proteins all over the organism, a mutation in a single gene leads to a multisystemic disorder. We describe a patient with TMEM165-CDG with facial dysmorphism, nephrotic syndrome, cardiac defects, enlarged cerebral ventricles, feeding problems, and neurological involvement. Having confirmed the diagnosis via prenatal diagnostics, we were able to observe the glycosylation right ...
Tópico(s): RNA modifications and cancer
2015 - Wiley | JIMD Reports
Cédric Gervaise, Bazile Kinda, Julien Bonnel, Y. Stéphan, Simon Vallez,
An inversion scheme is proposed, relying upon the inversion of the noise of a moving ship measured on a single distant hydrophone. The spectrogram of the measurements exhibits striations which depend on waveguide parameters. The periodic behavior of striations versus range are used to estimate the differences of radial wavenumber between couples of propagative modes at a given frequency. These wavenumber differences are stacked for several frequencies to form the relative dispersion curves. Such ...
Tópico(s): Geophysical Methods and Applications
2012 - Acoustical Society of America | The Journal of the Acoustical Society of America
... author Author Information Donna Esposito1,2,3,5, Julien P. Fey1,4,5, Stephan Eberhard5, Amanda J. Hicks1 and David B. Stern ...
Tópico(s): Microbial Natural Products and Biosynthesis
2003 - Springer Nature | The EMBO Journal
Marianna Adamo, Giulio Russo, Matteo Pagnesi, Edoardo Pancaldi, Hannes Alessandrini, Martin Andreas, Luigi P. Badano, Daniel Braun, Kim A. Connelly, Paolo Denti, Rodrigo Estévez‐Loureiro, Neil Fam, Mara Gavazzoni, Rebecca T. Hahn, Claudia Harr, Jöerg Hausleiter, Dominique Himbert, Daniel Kalbacher, Edwin Ho, Azeem Latib, Edith Lubos, Sebastian Ludwig, Laura Lupi, Philipp Lurz, Vanessa Moñivas, Georg Nickenig, Daniela Pedicino, Giovanni Pedrazzini, Alberto Pozzoli, Denise Pires Marafon, Roberta Pastorino, Fabien Praz, J Rodés-Cabau, Christian Besler, Anne Rebecca Schöber, Joachim Schöfer, Andrea Scotti, Kerstin Piayda, Horst Sievert, Gilbert H.L. Tang, Alessandro Sticchi, David Messika‐Zeitoun, Hölger Thiele, Florian Schlotter, Ralph Stephan von Bardeleben, John G. Webb, Julien Dreyfus, Stephan Windecker, Martin B. Leon, Francesco Maisano, Marco Metra, Maurizio Taramasso,
Data on the prognostic role of the TRI-SCORE in patients undergoing transcatheter tricuspid valve intervention (TTVI) are limited. The aim of this study was to evaluate the performance of the TRI-SCORE in predicting outcomes of patients undergoing TTVI. TriValve (Transcatheter Tricuspid Valve Therapies) is a large multicenter multinational registry including patients undergoing TTVI. The TRI-SCORE is a risk model recently proposed to predict in-hospital mortality after tricuspid valve surgery. The ...
Tópico(s): Cardiovascular Function and Risk Factors
2024 - Elsevier BV | КАРДИОЛОГИЯ УЗБЕКИСТАНА
Daniel Costabel, Afshin Nabiyan, Avinash Chettri, Franz Jacobi, Magdalena Heiland, Julien Guthmuller, Stephan Kupfer, Maria Wächtler, Benjamin Dietzek‐Ivanšić, Carsten Streb, Felix H. Schacher, Kalina Peneva,
We report on a photocatalytic setup that utilizes the organic photosensitizer (PS) diiodo-BODIPY and the non-precious-metal-based hydrogen evolution reaction (HER) catalyst (NH4)2[Mo3S13] together with a polyampholytic unimolecular matrix poly(dehydroalanine)-graft-poly(ethylene glycol) (PDha-g-PEG) in aqueous media. The system shows exceptionally high performance with turnover numbers (TON > 7300) and turnover frequencies (TOF > 450 h-1) that are typical for noble-metal-containing systems. Excited-state ...
Tópico(s): Advanced Photocatalysis Techniques
2023 - American Chemical Society | ACS Applied Materials & Interfaces
Silvio D. Brugger, Lukas J. Troxler, Susanne Rüfenacht, Pascal M. Frey, Brigitte Morand, Rudolf Geyer, Kathrin Mühlemann, Stefan Höck, Wolfgang Thormann, Julien Furrer, Stephan Christen, Markus Hilty,
Serotype 19A strains have emerged as a cause of invasive pneumococcal disease after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), and serotype 19A has now been included in the recent 13-valent vaccine (PCV13). Genetic analysis has revealed at least three different capsular serotype 19A subtypes, and nutritional environment-dependent variation of the 19A capsule structure has been reported. Pneumococcal vaccine effectiveness and serotyping accuracy might be impaired by structural ...
Tópico(s): Respiratory viral infections research
2016 - American Society for Microbiology | Infection and Immunity
Veerle Sterken, Andrew J. Westphal, N. Altobelli, E. Grün, Jon K. Hillier, Frank Postberg, R. Srama, Carlton Allen, D. R. Anderson, Asna Ansari, S. Bajt, R. Bastien, Nabil Bassim, Hans A. Bechtel, J. Borg, Frank E. Brenker, J. C. Bridges, Donald E. Brownlee, M. J. Burchell, Manfred Burghammer, A. L. Butterworth, Hitesh Changela, Peter Cloetens, Andrew M. Davis, Ryan Doll, Christine Floss, G. J. Flynn, D. Frank, Z. Gainsforth, P. R. Heck, P. Höppe, Bruce S. Hudson, J. Huth, Brit Hvide, Anton Kearsley, A. J. King, Barry Lai, J. Leitner, Laurence Lemelle, Hugues Leroux, Ariel Leonard, Robert Lettieri, William Marchant, L. R. Nittler, R. C. Ogliore, Wei Ja Ong, Mark C. Price, Scott A. Sandford, J. A. Sans, Sylvia Schmitz, Tom Schoonjans, Geert Silversmit, Alexandre Simionovici, Vicente Armando Solé, T. Stephan, Julien Stodolna, R. M. Stroud, S. R. Sutton, M. Trieloff, Peter Tsou, A. Tsuchiyama, Tolek Tyliszczak, Bart Vekemans, László Vincze, Joshua Von Korff, Naomi Wordsworth, Daniel Zevin, M. E. Zolensky,
Abstract On the basis of an interstellar dust model compatible with Ulysses and Galileo observations, we calculate and predict the trajectories of interstellar dust ( ISD ) in the solar system and the distribution of the impact speeds, directions, and flux of ISD particles on the Stardust Interstellar Dust Collector during the two collection periods of the mission. We find that the expected impact velocities are generally low (<10 km s −1 ) for particles with the ratio of the solar radiation pressure force ...
Tópico(s): Stellar, planetary, and galactic studies
2014 - Wiley | Meteoritics and Planetary Science