Kim Bolland, John Whitehead, Erik Cobo, Julio J Secades,
The International Citicoline Trial in acUte Stroke is a sequential phase III study of the use of the drug citicoline in the treatment of acute ischaemic stroke, which was initiated in 2006 in 56 treatment centres. The primary objective of the trial is to demonstrate improved recovery of patients randomized to citicoline relative to those randomized to placebo after 12 weeks of follow-up. The primary analysis will take the form of a global test combining the dichotomized results of assessments on ...
Tópico(s): Stroke Rehabilitation and Recovery
2008 - Wiley | Pharmaceutical Statistics
Katika Nawapun, Mary Patrice Eastwood, Daysi Diaz-Cobos, Julio Jiménez, Michaël Aertsen, O. Gómez, Filip Claus, E. Gratacós, Jan Deprest,
We aimed to assess in vivo changes in lung and liver volumes in fetuses with isolated congenital diaphragmatic hernia, either expectantly managed or treated in utero.This is a secondary analysis of prospectively collected data at two fetal therapy centers. We used archived magnetic resonance images of fetuses taken ≥7 days apart, creating paired observations in 20 expectantly managed cases, 41 with a second magnetic resonance prior to balloon reversal and 64 after balloon removal. We measured observed ...
Tópico(s): Tracheal and airway disorders
2015 - Wiley | Prenatal Diagnosis
Antoni Dávalos, José Álvarez‐Sabín, José Castillo, Exuperio Díez‐Tejedor, José M. Ferro, Eduardo Martínez‐Vila, Joaquı́n Serena, Tomás Segura, Vítor Tedim Cruz, Jaime Masjuán, Erik Cobo, Julio J Secades,
Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger trial.We undertook a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke admitted at university hospitals in Germany, Portugal, and Spain. Using a centralised minimisation process, patients were randomly assigned in a 1:1 ratio to ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2012 - Elsevier BV | The Lancet
A.M. Cobo, Julio Martínez Martínez, Loreto Martorell, Montserrat Baiget, Keith Johnson,
The genetic defect underlying myotonic dystrophy (DM) has been identified as the expansion of an unstable trinucleotide repeat sequence, and this discovery has led to new approaches to diagnosis and genetic counselling in families with the disorder. We report the genetic analysis of a consanguineous DM family in which two asymptomatic sisters had been shown to be homozygous for the ‘at risk’ haplotype. PCR analysis of the region spanning the trinucleotide expansion demonstrated that both sisters possessed ...
Tópico(s): Genetic Neurodegenerative Diseases
1993 - Oxford University Press | Human Molecular Genetics
Michael Cobo, Julio R. Ortiz, Steven G. Safran,
Tópico(s): Ocular Disorders and Treatments
1992 - Elsevier BV | American Journal of Ophthalmology
Erik Cobo, Julio J Secades, Francesc Miras, José Antonio González, Jeffrey L. Saver, Cristina Corchero, Roser Rius, Antoni Dávalos,
There is a lack of agreement regarding measuring the effects of stroke treatment in clinical trials, which often relies on the dichotomized value of 1 outcome scale. Alternative analyses consist mainly of 2 strategies: use all the information from an ordinal scale and combine information from several outcome scales in a single estimate.We reanalyzed 3 outcome scales that assessed patient recovery (modified Rankin Scale, National Institutes of Health Stroke Scale, and Barthel Index). With data collected ...
Tópico(s): Stroke Rehabilitation and Recovery
2009 - Lippincott Williams & Wilkins | Stroke
Fernando Llovet, Victoria de Rojas, Emanuela Interlandi, Clara Martín, Rosario Cobo-Soriano, Julio Ortega‐Usobiaga, Julio Baviera,
To investigate the incidence, culture results, risk factors, and visual outcomes of infectious keratitis after LASIK, and examine treatment strategies.Retrospective study.We included 107 613 patients who underwent LASIK at Clínica Baviera (Instituto Oftalmológico Europeo, Spain) from September 2002 to May 2008.The medical records of post-LASIK patients (204 586 eyes) were reviewed to identify cases of infectious keratitis. Incidence, risk factors, clinical course, days to diagnosis, medical and surgical ...
Tópico(s): Corneal Surgery and Treatments
2009 - Elsevier BV | Ophthalmology
Rafael de la Espriella, Enrique Santas, Isabel Zegrí Reiriz, José Luis Górriz, Marta Cobo Marcos, Julio Núñez,
La retención renal de sodio y agua, con la consiguiente expansión y redistribución del volumen de líquido extracelular, constituye una de las principales características fisiopatológicas de la insuficiencia cardiaca. No obstante, la detección, monitorización y manejo de la congestión continúa representando un verdadero desafío para el clínico. En el presente documento se revisa la literatura histórica y contemporánea acerca de los métodos disponibles para evaluar la congestión desde una perspectiva ...
Tópico(s): Cardiac pacing and defibrillation studies
2021 - Elsevier BV | Nefrología
Victoria de Rojas, Fernando Llovet, M Ontañón Martínez, Rosario Cobo-Soriano, Julio Ortega‐Usobiaga, Jaime Beltrán, Julio Baviera,
PURPOSE: To evaluate the incidence, culture results, risk factors, treatment strategies, and visual outcomes of infectious keratitis after surface ablation. SETTING: Multicenter study in Spain. DESIGN: Case series. METHODS: The medical records of patients who had surface ablation between January 2003 and December 2009 were reviewed to identify cases of infectious keratitis. The incidence, risk factors, clinical course, days to diagnosis, medical and surgical treatment, and visual outcome were recorded. ...
Tópico(s): Corneal Surgery and Treatments
2011 - Lippincott Williams & Wilkins | Journal of Cataract & Refractive Surgery
Guillermo Burillo–Putze, Pere Munné, Antonio Due as, M.A. Pinillos, Jose Manuel Naveiro, Julio Cobo, Javier Alonso,
Objective No studies have been published on global acute intoxication in Spanish emergency departments. We therefore designed a multicentre study to identify the epidemiology and management of intoxicated patients in Spain. Methods We prospectively recorded cases from 14 emergency departments during 14 randomized days between February and April 2000. We included all age groups and all kinds of acute intoxication patients (including alcohol), except food-related cases, inert foreign bodies and deaths ...
Tópico(s): Healthcare Decision-Making and Restraints
2003 - Lippincott Williams & Wilkins | European Journal of Emergency Medicine
Nistal, Julio Cobo Mora, Paniagua,
Bilateral testicular biopsies and clinical histories from 34 adult men with maturational arrest of spermatogonia were examined. According to the morphology of Sertoli cell nuclei, five testicular types of spermatogonial maturational arrest were established. In type I lesion, Sertoli cells resembled the immature Sertoli cells of infant testes. These cells had a round, regularly outlined, dark nucleus with a small nucleolus. The seminiferous tubules showed no apparent lumen and a poorly developed ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
1998 - Wiley | Andrology
H.L. Wyatt, Ming K. Heng, Samuel Meerbaum, J. D. Hestenes, Julio Cobo, Robert M. Davidson, E Corday,
Cross-sectional echocardiography was used to quantify left ventricular mass noninvasively in 21 dogs. Short- and long-axis cross-sectional images of the left ventricle were reproducibly traced at endocardial and epicardial borders during stop-motion video-tape replay. We used area, length and diameter measurements to calculate left ventricular mass by seven mathematic models, including the standard formulas used with M-mode echocardiography and cineangiography. Calculated mass was compared with ...
Tópico(s): Cardiovascular Disease and Adiposity
1979 - Lippincott Williams & Wilkins | Circulation
Rosario Cobo-Soriano, Julio Ortega‐Usobiaga, Beatriz Rodríguez-Gutiérrez, Víctor Tejerina, Fernando Llovet, Bruno Casco, Julio Baviera,
To evaluate the visual and refractive outcomes of trifocal intraocular lens (IOL) implantation in eyes previously treated with myopic and hyperopic corneal refractive laser surgery.Clinica Baviera-AIER-Eye group, Spain.Retrospective comparative case series.The series was divided into 2 groups according to the type of corneal laser refraction (myopic and hyperopic). The main visual and refractive outcome measures included corrected distance visual acuity (CDVA) and uncorrected distance and near visual ...
Tópico(s): Corneal surgery and disorders
2021 - Lippincott Williams & Wilkins | Journal of Cataract & Refractive Surgery
Carlos Cobos, Alexander Paz, Julio Luna, Cristian Erazo, Martha Mendoza,
The calibration of traffic-flow simulation models continues to be a significant problem without a generalized, comprehensive, and low-cost solution. Existing calibration approaches either have not explicitly addressed the multi-objective characteristics of the problem or determining their hyperparameters requires significant effort. In addition, statistical evaluation of alternative solution algorithms is not performed to ensure dominance and stability. This study proposes an adaptation and advanced ...
Tópico(s): Simulation Techniques and Applications
2020 - Institute of Electrical and Electronics Engineers | IEEE Access
Carlos Cobos, Cristian Erazo, Julio Luna, Martha Mendoza, Carlos Alberto Gaviria-López, Cristian Arteaga, Alexander Paz,
Tópico(s): Vehicle emissions and performance
2016 - Springer Science+Business Media | Lecture notes in computer science
Lorena Sanz, Silvia Murillo‐Cuesta, Pedro Cobo, Rafael Cediel-Algovia, Julio Contreras, Teresa Rivera, Isabel Varela‐Nieto, Carlos Avendaño,
Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound stimuli, enriched in frequencies up to 20 kHz ("violet" noises) to examine their impact on hearing thresholds and cochlear cytoarchitecture after short exposure. In addition, we developed a ...
Tópico(s): Noise Effects and Management
2015 - Frontiers Media | Frontiers in Aging Neuroscience
Rosario Cobo-Soriano, Jaime Beltrán, Julio Baviera,
Objectives To determine the anatomic and functional outcomes of photorefractive surgery in patients with underlying systemic diseases that are traditionally listed as relative or absolute contraindications. Design Observational retrospective case–control study. Participants The case groups were composed of 275 eyes of 141 consecutive patients who underwent a LASIK procedure with any of the following underlying conditions: autoimmune connective-tissue disorders (n = 62), psoriasis (n = 91), intestinal ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2006 - Elsevier BV | Ophthalmology
Produção Nacional
Revisado por pares
Marguerite Lovgren, Lillia Dell'Acqua, Rosario Palacio, Gabriela Echániz‐Aviles, Araceli Soto‐Noguerón, Elizabeth Castañeda, Clara Inés Agudelo, Ingrid Heitmann, Maria Cristina de Cunto Brandileone, Rosemeire Cobo Zanella, Alicia Rossi, Julio Pace, James Talbot,
ABSTRACT An international, multicenter study compared trimethoprim-sulfamethoxazole MICs for 743 Streptococcus pneumoniae isolates (107 to 244 isolates per country) by E test, using Mueller-Hinton agar supplemented with 5% defibrinated horse blood or 5% defibrinated sheep blood, with MICs determined by the National Committee for Clinical Laboratory Standards broth microdilution reference method. Agreement within 1 log 2 dilution and minor error rates were 69.3 and 15.5%, respectively, on sheep blood- ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1999 - American Society for Microbiology | Journal of Clinical Microbiology
Julio Ortega‐Usobiaga, Rosario Cobo-Soriano, Fernando Llovet, Francisco Ramos, Jaime Beltrán, Julio Baviera-Sabater,
ABSTRACT PURPOSE: To evaluate factors that influence retreatment results after primary hyperopic LASIK. METHODS: Restrospective study of 86 eyes of 61 patients that underwent LASIK to correct primary hyperopic spherical equivalent refraction and a second hyperopic retreatment due to undercorrection. All procedures were performed with the Technolas Keracor 217C excimer laser, lifting the preexisting flap for the retreatment. Preoperatively, under cycloplegia, mean spherical equivalent refraction ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2007 - Slack Incorporated (United States) | Journal of Refractive Surgery
Rafael de la Espriella, Enrique Santas, Isabel Zegrí Reiriz, José Luis Górriz, Marta Cobo Marcos, Julio Núñez,
Renal sodium and water retention with resulting extracellular volume expansion and redistribution are hallmark features of heart failure syndromes. However, congestion assessment, monitoring, and treatment represent a real challenge in daily clinical practice. This document reviewed historical and contemporary evidence of available methods for determining volume status and discuss pharmacological aspects and pathophysiological principles that underlie diuretic use. La retención renal de sodio y ...
Tópico(s): Potassium and Related Disorders
2022 - Elsevier BV | Nefrología (English Edition)
Victoria de Rojas, Rosa Rodríguez-Conde, Rosario Cobo-Soriano, Jaime Beltrán, Fernando Llovet, Julio Baviera,
PURPOSE: To report the outcomes of laser in situ keratomileusis (LASIK) in patients with a history of ocular herpes simplex virus (HSV) or herpes zoster ophthalmicus (HZO). SETTING: Clínica Baviera, Instituto Oftalmológico Europeo, Madrid, Spain. METHODS: In this retrospective case series, the records of eyes with a history of ocular herpes that had LASIK from 2003 through 2005 were reviewed. The main outcome measure was postoperative recurrence of ocular herpes. RESULTS: Forty-nine eyes (48 patients) ...
Tópico(s): Ocular Surface and Contact Lens
2007 - Lippincott Williams & Wilkins | Journal of Cataract & Refractive Surgery
Domingo A. Pascual‐Figal, J. L. Zamorano, Mar Domingo, Herminio Morillas, Julio Núñez, Marta Cobo Marcos, Alejandro Riquelme‐Pérez, Albert Teis, Enrique Santas, César Caro Martínez, José Manuel García Pinilla, José F. Rodríguez‐Palomares, David Dobarro, Maria Alejandra Restrepo‐Córdoba, José Ramón González‐Juanatey, Antoni Bayés‐Genís,
ABSTRACT Aims Dapagliflozin improves the prognosis of patients with heart failure (HF), regardless of left ventricular ejection fraction (LVEF). However, its effect on cardiac remodelling parameters, specifically left atrial (LA) remodelling, is not well established. Methods and results The DAPA‐MODA trial (NCT04707352) is a multicentre, single‐arm, open‐label, prospective and interventional study that aimed to evaluate the effect of dapagliflozin on cardiac remodelling parameters over 6 months. Patients ...
Tópico(s): Heart Failure Treatment and Management
2023 - Elsevier BV | European Journal of Heart Failure
Francisco Javier Torrijo Echarri, Julio Garzón-Roca, Julio Company, Guillermo Cobos,
An important issue in any rock engineering project is the adequate prediction of tool consumption. Excavation tools are subjected to wear, and repair/replacement of those tools is usually an important expense on any excavation budget. The key factor that affects wear of excavation tools is rock abrasivity. In mining and civil engineering, rock abrasivity is typically measured by the Cerchar abrasivity index (CAI), which is obtained in laboratory from a Cerchar abrasivity test. This paper studied ...
Tópico(s): Drilling and Well Engineering
2018 - Springer Science+Business Media | Bulletin of Engineering Geology and the Environment
Enriqueta Felip, Margarita Majem, Bernard Doger, Timothy Clay, Enric Carcereny, Igor Bondarenko, Julio A. Peguero, Manuel Cobo, Martin Förster, Grygorii Ursol, Gema García Ledo, Laia Vilà, Matthew Krebs, Wade T. Iams, Christian Mueller, Frédéric Triebel,
9003 Background: Eftilagimod alpha (E) is a soluble LAG-3 protein binding to a subset of MHC class II molecules to mediate antigen presenting cell (APC)/CD8 T-cell activation. Stimulation of the APCs and subsequent T cell recruitment with E may lead to stronger anti-tumor responses than observed with pembrolizumab (P) alone. We hereby report results of the extended first-line non-small cell lung carcinoma (NSCLC) cohort of the TACTI-002 (“Two ACTive Immunotherapies”) phase II trial. Methods: Pts with ...
Tópico(s): Ferroptosis and cancer prognosis
2022 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Francisco Javier Torrijo Echarri, Julio Garzón-Roca, Guillermo Cobos, Miguel Ángel Eguibar,
This paper presents the implementation of a learning methodology following a student-centred approach. The methodology is based on the use of project based and cooperative learning and mainly consists of commissioning students to prepare a presentation on a topic of their subject. Students work in groups, and later must deliver a real lecture to their colleagues. The proposed methodology was applied across 7 years and its implementation was monitored via day-to-day observations, annual surveys, ...
Tópico(s): Biomedical and Engineering Education
2021 - Multidisciplinary Digital Publishing Institute | Education Sciences
Elsa Rojas, Víctor Herrera, María Consuelo Miranda, Diana P. Rojas, Adriana Miranda Gómez, Christian Pallares, Sara M. Cobos, Lissethe Pardo, Margarita Gélvez, Andrés Páez, Julio César Mantilla, Anilza Bonelo, Édgar Parra, Luis Villar,
According to the World Health Organization, 98% of fatal dengue cases can be prevented; however, endemic countries such as Colombia have recorded higher case fatality rates during recent epidemics. We aimed to identify the predictors of mortality that allow risk stratification and timely intervention in patients with dengue. We conducted a hospital-based, case-control (1:2) study in two endemic areas of Colombia (2009-2015). Fatal cases were defined as having either 1) positive serological test (IgM ...
Tópico(s): Viral Infections and Vectors
2019 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Produção Nacional
Revisado por pares
Luz Fernández, Andréa Cardoso Ventura, José Célio Silveira Andrade, Julio Lumbreras, José Ramón Cobo-Benita,
Purpose The clean development mechanism (CDM) project is a cost-effective instrument to reduce greenhouse gas (GHG) emissions and to transfer technology and capital from industrialized to developing countries. HRM practices are important sustainable development co-benefits of CDM projects and Brazil is the third largest CDM project developer in the world. The purpose of this paper is to analyze the HRM practices declared by Brazilian CDM projects and how these practices have been, in fact, implemented ...
Tópico(s): Sustainable Building Design and Assessment
2017 - Emerald Publishing Limited | International Journal of Operations & Production Management
Reynaldo Cobos Méndez, Julio de Oliveira Filho, Douwe Dresscher, Jan F. Broenink,
Composability and modularity in relation to physics are useful properties in the development of cyber-physical systems that interact with their environment. The bond-graph modeling language offers these properties. When systems structures conform to the bond-graph notation, all interfaces are defined as physical “power ports” which are guaranteed to exchange power. Having a single type of interface is a key feature when aiming for modular, composable systems. Furthermore, the facility to monitor ...
Tópico(s): Model-Driven Software Engineering Techniques
2020 - Springer Science+Business Media | Lecture notes in computer science
Carlos I. Ponte‐Negretti, Jesus E Isea-Perez, Alberto J. Lorenzatti, Patricio López‐Jaramillo, Fernando Stuardo Wyss-Q, Xavier Pintó, Fernando Laņas, Josefina Medina, Livia T Machado-H, Mónica Acevedo, Paola Varleta, Alfonso Bryce, Carlos Carrera, Carlos Ernesto Peñaherrera, José Ramón Gómez-M, Alfredo Lozada, Alonso Merchan-V, Daniel Piskorz, Enrique Morales, María Paniagua, Félix Medina-Palomin, Raul Alejandro Villar-M, Leonardo Cobos, Enrique Gómez-Alvares, Rodrigo Alonso, Juan Colán‐Hernández, Julio A. Chirinos, Jofre Lara, Vladimir Ullauri, Ildefonso Arocha,
This is an executive summary made by a group of experts named Latin American Academy for the study of Lipids (ALALIP). In the current clinical guidelines, atherogenic dyslipidemia (AD) is a poorly recognized entity. Due to the frequent lipid alterations associated with AD in Latin America (LA), we organized a group of experts named (ALALIP) to generate a document in order to analyze their prevalence and to offer practical recommendations. Methodology: using the Delphi methodology, we conducted a comprehensive ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2017 - Elsevier BV | International Journal of Cardiology
Eduardo Redondo‐Cerezo, Antonio Sánchez-Robaina, J.G. Martínez Cara, Manuel Ojeda-Hinojosa, Ana Matas-Cobos, Antonio Damián Sánchez-Capilla, Mercedes López de Hierro Ruíz, Julio Pleguezuelo-Díaz, Javier de Teresa,
Only a few reports have addressed non-anesthesiologist-administered propofol for endoscopic ultrasonography (EUS), but none specifically in high-risk patients. Our aim was to study the application of a propofol sedation protocol for EUS in average-risk and high-risk patients.This was a prospective observational study including 446 patients referred for EUS. We analyzed the induction time, procedure duration, recovery times, and patients' comfort and safety. Sedation was administered by a trained ...
Tópico(s): Nausea and vomiting management
2012 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology