... SULFOXIDE IN RHEUMATOID ARTHRITIS PATIENTS IN JAPAN Jun Matsumoto, Jun Matsumoto Of the Committee on Clinical Drug Trial ... Search for more papers by this author Jun Matsumoto, Jun Matsumoto Of the Committee on Clinical Drug Trial of ...
Tópico(s): Lymphoma Diagnosis and Treatment
1967 - Wiley | Annals of the New York Academy of Sciences
Hirotsugu Hashimoto, Masahiro Yanagiya, Yoshio Suzuki, Masashi Kusakabe, Genki Usui, Jun Matsumoto, Hajime Horiuchi,
... Tokyo, JapanSearch for more papers by this authorJun Matsumoto, Jun Matsumoto Department of General Thoracic Surgery, NTT Medical ... Tokyo, JapanSearch for more papers by this authorJun Matsumoto, Jun Matsumoto Department of General Thoracic Surgery, NTT Medical Center ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2017 - Wiley | Pathology International
Kazuko Matsumoto, Jun Matsunami, Kazuhiro Mizuno, Hiroyuki Uemura,
... σ-Bond Formation in the Reaction with AcetoneKazuko Matsumoto, Jun Matsunami, Kazuhiro Mizuno, and Hiroyuki UemuraView Author Information ...
Tópico(s): Magnetism in coordination complexes
1996 - American Chemical Society | Journal of the American Chemical Society
Jun Matsumoto, Jun Nakajima, Eriho Takeuchi, Takeshi Fukami, Kan Nawata, Shinichi Takamoto,
Middle mediastinal paragangliomas are very rare, slow-growing tumors, but almost all of them are very hypervascular tumors. Complete surgical resection is difficult to achieve because of their proximity to the heart, great vessels, and trachea. We report successful complete resection incorporating preoperative embolization and a clamshell bilateral thoracotomy. Dr Matsumoto
Tópico(s): Meningioma and schwannoma management
2006 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Takafumi Yamamoto, Kazuyuki Imakiire, Shinya Hashiguchi, Jun Matsumoto, Jun Kadono, Nobuo Hamada, Takako Yoshioka, Shinichi Kitajima,
An 84-year-old man was admitted to our hospital with a 1-month history of epigastralgia. Upper gastrointestinal endoscopy revealed gastric cancer and a gastric submucosal tumor (SMT) on the greater curvature of the gastric body. By endoscopic ultrasonography, SMT was demonstrated as a well-circumscribed, smooth-bordered and hypoechoic mass localized in the submucosal layer. Total gastrectomy was performed. The histology of the resected specimen revealed a gastric lipoma and an early gastric cancer ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2004 - The Japanese Society of Internal Medicine | Internal Medicine
Jun Matsumoto, Jun Hirokawa, Hajime Akimoto, Yoshizumi Kajii,
A simple and compact instrument for NO2 measurement by laser-induced fluorescence (LIF) technique with a pulsed solid state laser and a multi-pass excitation system was developed and optimized for several conditions. As a result of laboratory experiment, the limit of detection (LOD) reached 94 pptv for 60 s integration. It was thought that an LIF instrument with this LOD value would be capable of quantifying sub-ppbv NO2 in unpolluted marine atmosphere. As the second step, a field test of the instrument ...
Tópico(s): Water Quality Monitoring and Analysis
2001 - Elsevier BV | Atmospheric Environment
Takatoshi Soga, Takahide Ohishi, Tetsuo Matsui, Tetsu Saito, Mitsuyuki Matsumoto, Jun Takasaki, Shun‐ichiro Matsumoto, Masazumi Kamohara, Hideki Hiyama, S. Yoshida, Kazuhiro Momose, Yoshitaka Ueda, Hitoshi Matsushime, Masato Kobori, Kiyoshi Furuichi,
A lysophospholipid series, such as lysophosphatidic acid, lysophosphatidylserine, and lysophosphatidylcholine (LPC), is a bioactive lipid mediator with diverse physiological and pathological functions. LPC has been reported to induce insulin secretion from pancreatic beta-cells, however, the precise mechanism has remained elusive to date. Here we show that an orphan G-protein-coupled receptor GPR119 plays a pivotal role in this event. LPC potently enhances insulin secretion in response to high concentrations ...
Tópico(s): Receptor Mechanisms and Signaling
2004 - Elsevier BV | Biochemical and Biophysical Research Communications
Akiko Ariga, Jun-ichi Namekawa, Naoki Matsumoto, Jun‐ichiro Inoue, Kazuo Umezawa,
We previously designed and synthesized an NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), that showed anti-inflammatory activity in vivo . In the present study we looked into its mechanism of inhibition. DHMEQ inhibited tumor necrosis factor-α (TNF-α)- and 12- O -tetradecanoylphorbol-13-acetate-induced transcriptional activity of NF-κB in human T cell leukemia Jurkat cells. It also inhibited the TNF-α-induced DNA binding of nuclear NF-κB but not the phosphorylation and degradation of IκB. Moreover, ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2002 - Elsevier BV | Journal of Biological Chemistry
Emily Omori, Sho Morioka, Kunihiro Matsumoto, Jun Ninomiya‐Tsuji,
... Kishimoto K. Hiyama A. Inoue J. Cao Z. Matsumoto K. Nature. 1999; 398: 252-256Crossref PubMed Scopus (1020) Google Scholar), JNK1 (FL), p65 (F-6; Santa Cruz), caspase-3 (Cell Signaling), CREB (Santa Cruz), and phospho-c-Jun (Ser73; Cell Signaling). Monoclonal antibodies were c-FLIP ( ... keratinocytes. Thus, only the basal level of c-Jun is regulated by TAK1. TAK1 is activated by the number of stimuli including cytokines and stresses (13Ninomiya-Tsuji J. Kishimoto K. Hiyama A. Inoue J. Cao Z. Matsumoto K. Nature. 1999; 398: 252-256Crossref PubMed Scopus ( ...
Tópico(s): interferon and immune responses
2008 - Elsevier BV | Journal of Biological Chemistry
Feng-Lei Hong, Jun Ishikawa, Kazuhiko Sugiyama, Atsushi Onae, Hirokazu Matsumoto, Jun Ye, J. L. Hall,
A comparison of two independent absolute optical frequency measurements has been carried out between the National Metrology Institute of Japan/National Institute of Advanced Industrial Science and Technology (NMIJ/AIST), Tsukuba, Japan and the JILA (formerly the Joint Institute for Laboratory Astrophysics), Boulder, CO, using a portable iodine-stabilized Nd:YAG laser. The agreement between the two absolute measurements is better than the measurement uncertainty of 6.7/spl times/10/sup -13/ that can ...
Tópico(s): Solid State Laser Technologies
2003 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Instrumentation and Measurement
Sunao Iyoda, Shannon D. Manning, Kazuko Seto, Keiko Kimata, Junko Isobe, Yoshiki Etoh, Sachiko Ichihara, Yuji Migita, Kikuyo Ogata, Mikiko Honda, Tsutomu Kubota, Kimiko Kawano, Kazutoshi Matsumoto, Jun Kudaka, Norio Asai, Junko Yabata, Kiyoshi Tominaga, Jun Terajima, Tomoko Morita‐Ishihara, Hidemasa Izumiya, Yoshitoshi Ogura, Takehito Saitoh, Atsushi Iguchi, Hideki Kobayashi, Yukiko Hara‐Kudo, Makoto Ohnishi, Reiko Arai, Masao Kawase, Yukiko Asano, Nanami Asoshima, Kazuki Chiba, Ichiro Furukawa, Toshiro Kuroki, Madoka Hamada, Seiya Harada, Takashi Hatakeyama, Takashi Hirochi, Yumiko Sakamoto, Midori Hiroi, Takashi Kanda, Kazumi Horikawa, Kaori Iwabuchi, Mitsuhiro Kameyama, Hitomi Kasahara, Shinya Kawanishi, Koji Kikuchi, Hiroyuki Ueno, Tomoko Kitahashi, Yuka Kojima, Noriko Konishi, Hiromi Obata, Akemi Kai, Tomomi Kono, Takayuki Kurazono, Masakado Matsumoto, Yuko Matsumoto, Yuhki Nagai, Hideki Naitoh, Hiroshi Nakajima, Hiromi Nakamura, Kunihiko Nakane, Keiko Nishi, Etsuko Saitoh, Hiroaki Satoh, Mitsuteru Takamura, Yutaka Shiraki, Junichi Tanabe, Keiko Tanaka, Yuki Tokoi, Jun Yatsuyanagi,
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection causes severe diseases such as bloody diarrhea and hemolytic uremic syndrome (HUS). Although EHEC O157:H7 strains have exhibited high genetic variability, their abilities to cause human diseases have not been fully examined.Clade typing and stx subtyping of EHEC O157:H7 strains, which were isolated in Japan during 1999-2011 from 269 HUS patients and 387 asymptomatic carriers (ACs) and showed distinct pulsed-field gel electrophoresis patterns, ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2014 - Oxford University Press | Open Forum Infectious Diseases
Shoko Ohura-Kajitani, Takashi Shiroto, Shigeo Godo, Yosuke Ikumi, Akiyo Ito, Shuhei Tanaka, Kōichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Kiyotaka Hao, Yoku Kikuchi, Kotaro Nochioka, Yasuharu Matsumoto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa,
Objective: It remains to be elucidated whether and how endothelial functions are impaired in peripheral circulation of patients with coronary functional disorders, such as vasospastic angina (VSA) and microvascular angina (MVA). We simultaneously examined endothelial functions of peripheral conduit and resistance arteries in patients with coronary functional disorders, with a special reference to NO and endothelium-dependent hyperpolarization factors. Approach and Results: Based on the results of ...
Tópico(s): Advanced MRI Techniques and Applications
2020 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Taisuke Kajino, Hong Ren, Shun‐ichiro Iemura, Tohru Natsume, Bjarki Stefansson, David L. Brautigan, Kunihiro Matsumoto, Jun Ninomiya‐Tsuji,
... one is the MAPK cascades to activate c-Jun N-terminal kinase (JNK) and p38 MAPK, and the other is the IκB kinase pathway ultimately leading to NF-κB activation (2Ninomiya-Tsuji J. Kishimoto K. Hiyama A. Inoue J. Cao Z. Matsumoto K. Nature. 1999; 398: 252-256Crossref PubMed Scopus ( ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2006 - Elsevier BV | Journal of Biological Chemistry
Kenji Umeki, Issei Tokimatsu, Chie Yasuda, Atsuko Iwata, Daisuke Yoshioka, Hiroshi Ishii, Ryo Shirai, Kenji Kishi, Kazufumi Hiramatsu, Bunroku Matsumoto, Jun‐ichi Kadota,
ABSTRACT Background and objective: More than 100 000 Japanese die of pneumonia every year. The number of people residing in nursing homes is increasing with the ageing of the population. In 2005, the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) published important guidelines for the management of healthcare‐associated pneumonia (HCAP). In Japan, however, the optimum strategy for management of HCAP is still unclear. The purpose of this study was to clarify the clinical ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2011 - Wiley | Respirology
Yang Chen, Dan Hu, Rikio Yabe, Hiroaki Tateno, Sheng-Ying Qin, Naoki Matsumoto, Jun Hirabayashi, Kazuo Yamamoto,
Malectin was first discovered as a novel endoplasmic reticulum (ER)-resident lectin from Xenopus laevis that exhibits structural similarity to bacterial glycosylhydrolases. Like other intracellular lectins involved in glycoprotein quality control, malectin is highly conserved in animals. Here results from in vitro membrane-based binding assays and frontal affinity chromatography confirm that human malectin binds specifically to Glc(2)Man(9)GlcNAc(2) (G2M9) N-glycan, with a K(a) of 1.97 × 10(5) M(-1), ...
Tópico(s): Glycosylation and Glycoproteins Research
2011 - American Society for Cell Biology | Molecular Biology of the Cell
Keigo Ueno, Yasuhiko Matsumoto, Jun Uno, Kaname Sasamoto, Kazuhisa Sekimizu, Yuki Kinjo, Hiroji Chibana,
The intestinal resident Candida glabrata opportunistically infects humans. However few genetic factors for adaptation in the intestine are identified in this fungus. Here we describe the C. glabrata CYB2 gene encoding lactate dehydrogenase as an adaptation factor for survival in the intestine. CYB2 was identified as a virulence factor by a silkworm infection study. To determine the function of CYB2, we analysed in vitro phenotypes of the mutant Δcyb2. The Δcyb2 mutant grew well in glucose medium ...
Tópico(s): Probiotics and Fermented Foods
2011 - Public Library of Science | PLoS ONE
Masatoshi Hagiwara, Ken-ichi Maegawa, Mamoru Suzuki, Ryo Ushioda, Kazutaka Araki, Yushi Matsumoto, Jun Hoseki, Kazuhiro Nagata, Kenji Inaba,
ER-associated degradation (ERAD) is an ER quality-control process that eliminates terminally misfolded proteins. ERdj5 was recently discovered to be a key ER-resident PDI family member protein that accelerates ERAD by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. We here solved the crystal structure of full-length ERdj5, thereby revealing that ERdj5 contains the N-terminal J domain and six tandem thioredoxin domains that can be divided into the N- and C-terminal ...
Tópico(s): Heat shock proteins research
2011 - Elsevier BV | Molecular Cell
Yoshifumi Imazu, Shigehisa Yanagi, Kahori Miyoshi, Hironobu Tsubouchi, Shu‐ichi Yamashita, Nobuhiro Matsumoto, Jun-ichi Ashitani, Kenji Kangawa, Masamitsu Nakazato,
Acute lung injury is a critical illness syndrome consisting of acute respiratory failure with bilateral pulmonary infiltrates that is refractory to current therapies. Acute lung injury is characterized by injury of the alveolar capillary barrier, neutrophil accumulation, and induction of pro-inflammatory cytokines followed by devastating lung fibrosis. Ghrelin, an acylated peptide produced in the stomach, increases food intake and growth hormone secretion, suppresses inflammation, and promotes cell ...
Tópico(s): Neuroscience of respiration and sleep
2011 - Elsevier BV | European Journal of Pharmacology
Wei‐Chun HuangFu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto, Jun Ninomiya‐Tsuji,
Osmotic stress activates MAPKs, including JNK and p38, which play important roles in cellular stress responses. Transforming growth factor-beta-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and can activate JNK and p38. TAK1 can also activate IkappaB kinase (IKK) that leads to degradation of IkappaB and subsequent NF-kappaB activation. We found that TAK1 is essential for osmotic stress-induced activation of JNK but is not an exclusive mediator of p38 activation. Furthermore, ...
Tópico(s): Melanoma and MAPK Pathways
2006 - Elsevier BV | Journal of Biological Chemistry
Shun‐ichiro Matsumoto, Chihiro Yamazaki, Koh‐hei Masumoto, Mamoru Nagano, Masanori Naito, Takatoshi Soga, Hideki Hiyama, Mitsuyuki Matsumoto, Jun Takasaki, Masazumi Kamohara, Ayako Matsuo, Hiroyuki Ishii, Masato Kobori, Masao Katoh, Hitoshi Matsushime, Kiyoshi Furuichi, Yasufumi Shigeyoshi,
Prokineticins, multifunctional secreted proteins, activate two endogenous G protein-coupled receptors PKR1 and PKR2. From in situ analysis of the mouse brain, we discovered that PKR2 is predominantly expressed in the olfactory bulb (OB). To examine the role of PKR2 in the OB, we created PKR1- and PKR2-gene-disrupted mice ( Pkr1 −/− and Pkr2 −/− , respectively). Phenotypic analysis indicated that not Pkr1 −/− but Pkr2 −/− mice exhibited hypoplasia of the OB. This abnormality was observed in the early developmental stages ...
Tópico(s): Neuroendocrine regulation and behavior
2006 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Manabu Hoshi, Seiichi Matsumoto, Jun Manabe, Taisuke Tanizawa, Toshio Shigemitsu, Naohiro Izawa, Kengo Takeuchi, Noriyoshi Kawaguchi,
Tópico(s): Oral and Maxillofacial Pathology
2006 - Springer Science+Business Media | International Journal of Clinical Oncology
Mikako Inoue, Takahiro Suzuki, Yutaka Fujita, Mayumi Oda, Nobuhiro Matsumoto, Jun Iijima, Toshihiro Yamase,
Synergistic effect of polyoxometalates, K(6)[P(2)W(18)O(62)].14H(2)O (P(2)W(18)), K(4)[SiMo(12)O(40)].3H(2)O (SiMo(12)), K(7)[PTi(2)W(10)O(40)].6H(2)O (PTi(2)W(10)), and K(9)H(5)[alpha-Ge(2)Ti(6)W(18)O(77)].16H(2)O (Ge(2)Ti(6)W(18)), in combination with a beta-lactam oxacillin against methicillin-resistant and vancomycin-resistant Staphylococcus aureus (characterized by possessing the penicillin-binding protein 2' (PBP2') as a cell-wall synthesis enzyme) with a high initial inoculum of 1 x 10(8) cfu/ml ( ...
Tópico(s): Metal complexes synthesis and properties
2006 - Elsevier BV | Biomedicine & Pharmacotherapy
Hakan Akça, Masachika Tani, Tomoyuki Hishida, Shingo Matsumoto, Jun Yokota,
To clarify the pathogenic and biological significance of EGFR mutations in lung cancer, we compared the status of ERBB family receptors, their downstream signal transductions and biological phenotypes between lung cancer cell lines with mutant and wild type EGFR. We initially analyzed expression and phosphorylation of ERBB family receptors and their major downstream proteins, AKT, p44/42 MAPK and STAT3, in a series of lung cancer cell lines with or without EGFR mutation. The expression levels of ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2006 - Elsevier BV | Lung Cancer
Motohiro Morioka, Takayuki Kawano, Shigetoshi Yano, Yutaka Kai, Hiromasa Tsuiki, Yutaka Yoshinaga, Jun Matsumoto, Tatsumi Maeda, Jun-ichiro Hamada, Hideyuki Yamamoto, Kohji Fukunaga, Jun‐ichi Kuratsu,
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2006 - Elsevier BV | Biochemical and Biophysical Research Communications
Young-Lim Choi, K Tsukasaki, Michael C. O’Neill, Yohei Yamada, Yasuyuki Onimaru, Kunio Matsumoto, Jun Ohashi, Yumi Yamashita, Shogo Tsutsumi, Ruri Kaneda, Shuji Takada, Hiroyuki Aburatani, S Kamihira, Takashi Nakamura, Masao Tomonaga, Hiroyuki Mano,
Adult T-cell leukemia (ATL) is an intractable malignancy of CD4+ T cells that is etiologically associated with infection by human T-cell leukemia virus-type I. Most individuals in the chronic stage of ATL eventually undergo progression to a highly aggressive acute stage. To clarify the mechanism responsible for this stage progression, we isolated CD4+ cells from individuals in the chronic (n=19) or acute (n=22) stages of ATL and subjected them to profiling of gene expression with DNA microarrays containing > ...
Tópico(s): Animal Disease Management and Epidemiology
2006 - Springer Nature | Oncogene
Manabu Hoshi, Seiichi Matsumoto, Jun Manabe, Taisuke Tanizawa, Toshio Shigemitsu, Naohiro Izawa, Xuedong Shi, Noriyoshi Kawaguchi,
Tópico(s): Cardiac tumors and thrombi
2006 - Springer Science+Business Media | International Journal of Clinical Oncology
Kazuya Matsumoto, Jun‐ichi Okano, Takakazu Nagahara, Yoshikazu Murawaki,
Vitamin K2 (VK2) is an anti-proliferative agent toward a variety of cancer including hepatocellular carcinoma (HCC). Because the growth inhibitory effect of VK2 to HCC has not been established yet, we investigated it in HCC cells in vitro. VK2 inhibited growth of Hep3B, but not of HepG2, HLF, and Huh6. VK2 induced the cell cycle arrest at the G1 phase and involvement of apoptosis was suggested because the sub-G1 fraction appeared in flow cytometric analysis and nuclear condensation and fragmentation ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2006 - Spandidos Publishing | International Journal of Oncology
Yuichi Miura, Shoichi Yoshihara, Mitsuru Ohnishi, Katsuya Honda, Masaaki Matsumoto, Jun Kawai, Masamichi Ishikawa, Hiroto Kobayashi, Akira Ōnuki,
We investigated adiabatic changes in a near-critical fluid on acoustic time scales using an ultrasensitive interferometer. A sound emitted by very weak continuous heating caused a stepwise adiabatic change at its front with a density change of order ${10}^{\ensuremath{-}7}\phantom{\rule{0.3em}{0ex}}\mathrm{g}∕{\mathrm{cm}}^{3}$ and a temperature change of order ${10}^{\ensuremath{-}5}\phantom{\rule{0.3em}{0ex}}\mathrm{K}$. Very small heat inputs at a heater produced short acoustic pulses with width ...
Tópico(s): Mechanical and Optical Resonators
2006 - American Physical Society | Physical Review E
Noriyuki Uemura, Taisuke Kajino, Hideki Sanjo, Shintaro Sato, Shizuo Akira, Kunihiro Matsumoto, Jun Ninomiya‐Tsuji,
Epstein-Barr virus latent membrane protein 1 (LMP1) activates NF-κB and c-Jun N-terminal kinase (JNK), which is essential for LMP1 oncogenic activity. Genetic analysis has revealed that tumor necrosis factor receptor-associated factor 6 (TRAF6) is an indispensable intermediate of LMP1 signaling leading to activation of both NF-κB and JNK. However, the mechanism by which LMP1 engages TRAF6 for activation of NF-κB and JNK is not well understood. Here we demonstrate that TAK1 mitogen-activated protein ...
Tópico(s): NF-κB Signaling Pathways
2006 - Elsevier BV | Journal of Biological Chemistry
Akira Mukai, Toshio Fukai, Yuko Matsumoto, Jun Ishikawa, Yasutaka Hoshino, Katsukiyo Yazawa, Ken‐ichi Harada, Yuzuru Mikami,
Transvalencin Z was isolated from a culture broth of Nocardia transvalensis IFM 10065, a clinical isolate from a Japanese patient with actinomycotic mycetoma. The transvalencin Z structure was determined using NMR and mass spectrometric analyses. The structure is similar to a partial structure of siderophores such as mycobactins and nocobactins, but the compound has no cytotoxic activity. Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2006 - Springer Nature | The Journal of Antibiotics