Tae‐Min Kim, Chang Hyeok An, Je‐Keun Rhee, Seung‐Hyun Jung, Sung Hak Lee, In-Pyo Baek, Min Sung Kim, Sug Hyung Lee, Yeun‐Jun Chung,
... Hyeok An 3, * , Je-Keun Rhee 1, 2 , Seung-Hyun Jung 2, 4, 7 , Sung Hak Lee 5 , In- ...
Tópico(s): Colorectal Cancer Screening and Detection
2015 - Impact Journals LLC | Oncotarget
Shinn Young Kim, Seung‐Hyun Jung, Min Sung Kim, In-Pyo Baek, Sung Hak Lee, Tae‐Min Kim, Yeun‐Jun Chung, Sug Hyung Lee,
// Shinn Young Kim 1, 3, * , Seung-Hyun Jung 1, 3, * , Min Sung Kim 2 , In-Pyo Baek 1, 3 , Sung Hak Lee 4 , Tae-Min Kim 5 , Yeun-Jun ...
Tópico(s): Genetic factors in colorectal cancer
2015 - Impact Journals LLC | Oncotarget
Seung‐Hyun Jung, Youn Jin Choi, Min Sung Kim, In-Pyo Baek, Sung Hak Lee, Ahwon Lee, Soo Young Hur, Tae‐Min Kim, Sug Hyung Lee, Yeun‐Jun Chung,
// Seung-Hyun Jung 1, 3, * , Youn Jin Choi 2, * , Min Sung Kim 2 , In-Pyo Baek 1, 3 , Sung ...
Tópico(s): Molecular Biology Techniques and Applications
2015 - Impact Journals LLC | Oncotarget
Shinn Young Kim, Seung‐Hyun Jung, Min Sung Kim, Mi-Ryung Han, Hyeon‐Chun Park, Eun Sun Jung, Sung Hak Lee, Sug Hyung Lee, Yeun‐Jun Chung,
// Shinn Young Kim 1, 4, 5, 6 , Seung-Hyun Jung 1, 2 , Min Sung Kim 2, 3 , Mi-Ryung Han 1, 4 , Hyeon-Chun Park 1, 4 , Eun Sun Jung 7 , Sung Hak ...
Tópico(s): Cancer-related gene regulation
2017 - Impact Journals LLC | Oncotarget
Youn Jin Choi, Seung‐Hyun Jung, Min Sung Kim, In-Pyo Baek, Jae-Keun Rhee, Sung Hak Lee, Soo Young Hur, Tae‐Min Kim, Yeun‐Jun Chung, Sug Hyung Lee,
// Youn Jin Choi 1, * Seung-Hyun Jung 2, 3, * Min Sung Kim 1 , In-Pyo Baek 2, 3 , Jae-Keun Rhee 4 , Sung Hak Lee 5 , Soo ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2015 - Impact Journals LLC | Oncotarget
Sung Hak Lee, Seung‐Hyun Jung, Tae‐Min Kim, Je‐Keun Rhee, Hyeon‐Chun Park, Min Sung Kim, Sung Soo Kim, Chang Hyeok An, Sug Hyung Lee, Yeun‐Jun Chung,
// Sung Hak Lee 1, * , Seung Hyun Jung 4, 6, * , Tae-Min Kim 2 , Je-Keun Rhee 2 , Hyeon-Chun Park 3, 4 , Min Sung Kim 5, 6 , ...
Tópico(s): Colorectal Cancer Treatments and Studies
2016 - Impact Journals LLC | Oncotarget
Seung‐Hyun Jung, Min Sung Kim, Chan Kwon Jung, Hyun-Chun Park, So Youn Kim, Jieying Liu, Ja Seong Bae, Sung Hak Lee, Tae‐Min Kim, Sug Hyung Lee, Yeun‐Jun Chung,
// Seung-Hyun Jung 1, 3 , Min Sung Kim 2 , Chan Kwon Jung 4 , Hyun-Chun Park 1, 3 , So ...
Tópico(s): Genetic factors in colorectal cancer
2016 - Impact Journals LLC | Oncotarget
Minje Kim, Sae-Bom Kwon, Seung Hoon Ham, Eui-Suk Jeong, Yang‐Kyu Choi, Kang Duk Choi, Jin Tae Hong, Seung Hyun Jung, Do‐Young Yoon,
... Kyu Choi , Kang Duk Choi , Jin Tae Hong , Seung Hyun Jung and Do-Young Yoon . J. Microbiol. Biotechnol. 2015; ...
Tópico(s): Ferroptosis and cancer prognosis
2015 - Springer Science+Business Media | Journal of Microbiology and Biotechnology
Chan Kwon Jung, Seung‐Hyun Jung, Sora Jeon, Young Mun Jeong, Yourha Kim, Sohee Lee, Ja Seong Bae, Yeun‐Jun Chung,
Background: Although most differentiated thyroid carcinomas (DTCs) have indolent behavior, DTCs with distant metastasis have a poor prognosis. However, there are no validated markers that predict the risk of distant metastasis and the prognosis of DTC. We aimed to develop a genetic classifier for predicting the outcomes of DTC patients with distant metastases. Methods: Targeted deep sequencing of 157 cancer-related genes was performed for 61 DTCs with distant metastases. A candidate mutation was ...
Tópico(s): BRCA gene mutations in cancer
2020 - Mary Ann Liebert, Inc. | Thyroid
Chan Kwon Jung, Seung‐Hyun Jung, Seon‐Hee Yim, Ji‐Han Jung, Hyun Joo Choi, Won Kyung Kang, Sung‐Won Park, Seong‐Taek Oh, Jun-Gi Kim, Sug Hyung Lee, Yeun‐Jun Chung,
Accurate prediction of regional lymph node metastasis (LNM) in endoscopically resected T1-stage colorectal cancers (CRCs) can reduce unnecessary surgeries. To identify miRNA markers that can predict LNM in T1-stage CRCs, the study was conducted in two phases; (I) miRNA classifier construction by miRNA-array and quantitative reverse transcription PCR (qRT-PCR) using 36 T1-stage CRC samples; (II) miRNA classifier validation in an independent set of 20 T1-stage CRC samples. The expression of potential downstream ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - Impact Journals LLC | Oncotarget
Soon Nam Kim, Su Jung Bae, Han Bok Kwak, Yong Ki Min, Seung-Hyun Jung, Cheol‐Hee Kim, Seong Hwan Kim,
Tópico(s): Rheumatoid Arthritis Research and Therapies
2011 - Springer Science+Business Media | Amino Acids
Produção Nacional
Revisado por pares
Jung-Hwa Choi, Yun-Mi Jeong, Sujin Kim, Boyoung Lee, Krishan Ariyasiri, Hyun-Taek Kim, Seung‐Hyun Jung, Kyu-Seok Hwang, Tae‐Ik Choi, Chulo Park, Won‐Ki Huh, Michael Carl, Jill A. Rosenfeld, Salmo Raskin, Alan Ma, Jozef Gécz, Hyung‐Goo Kim, Jin‐Soo Kim, Ho‐Chul Shin, Doo-Sang Park, Robert Gerlai, Bradley B. Jamieson, Joon S. Kim, Karl J. Iremonger, Sang H. Lee, Hee‐Sup Shin, Cheol‐Hee Kim,
Significance Emotion-related responses, such as fear and anxiety, are important behavioral phenomena in most animal species, as well as in humans. However, the underlying mechanisms of fear and anxiety in animals and in humans are still largely unknown, and anxiety disorders continue to represent a large unmet medical need in the human clinic. Animal models may speed up discovery of these mechanisms and may also lead to betterment of human health. Herein, we report the identification of a chemokine- ...
Tópico(s): Aquaculture disease management and microbiota
2018 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Chang Ho Oh, Seung‐Hyun Jung, Su Youn Bang, Dai In Park,
[reaction: see text] Unusual palladium-catalyzed arylative fragmentations of acyclic 3-allen-1-ols were observed. Oxidative addition of Pd(0) to aryl halides would form the arylpalladium halides, which added to the central carbon of allenes via carbopalladation to form the pi-allylpalladium intermediates. The pi-allylpalladium intermediates would be reductively eliminated via carbon-carbon cleavage to give the arylated dienes and the alpha-hydroxyalkylpalladium intermediates, which were further ...
Tópico(s): Catalytic Alkyne Reactions
2002 - American Chemical Society | Organic Letters
Seung‐Hyun Jung, Suhyun Kim, Ah‐Young Chung, Hyun–Taek Kim, Juhoon So, Jae-Ho Ryu, Hae‐Chul Park, Cheol‐Hee Kim,
The insulation of axons in the vertebrate nervous system by myelin is essential for efficient axonal conduction. Myelination disruption and remyelination failure can cause human diseases, such as multiple sclerosis and hereditary myelin diseases. However, despite progress in understanding myelination regulation, many important questions remain unanswered. To investigate the mechanisms underlying myelination in vivo, we generated transgenic zebrafish expressing enhanced green fluorescent protein ( ...
Tópico(s): Axon Guidance and Neuronal Signaling
2009 - Wiley | Developmental Dynamics
Seon‐Hee Yim, Tae‐Min Kim, Hongjie Hu, J.-H. Kim, Beom‐Jun Kim, Ji‐Young Lee, Bok Ghee Han, Sung‐Heui Shin, Seung‐Hyun Jung, Yeun‐Jun Chung,
Recent discovery of the copy number variation (CNV) in normal individuals has widened our understanding of genomic variation. However, most of the reported CNVs have been identified in Caucasians, which may not be directly applicable to people of different ethnicities. To profile CNV in East-Asian population, we screened CNVs in 3578 healthy, unrelated Korean individuals, using the Affymetrix Genome-Wide Human SNP array 5.0. We identified 144,207 CNVs using a pooled data set of 100 randomly chosen ...
Tópico(s): Genomics and Rare Diseases
2009 - Oxford University Press | Human Molecular Genetics
Dae Kil Jang, Chau Ha Pham, Ik Soo Lee, Seung-Hyun Jung, Ji Hye Jeong, Han‐Seung Shin, Hee Min Yoo,
A potential natural melanogenesis inhibitor was discovered in the form of a sesquiterpene isolated from the flowers of Inula britannica, specifically 6-O-isobutyrylbritannilactone (IBL). We evaluated the antimelanogenesis effects of IBL on B16F10 melanocytes and zebrafish embryos. As a result, we found that 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production was reduced in a dose-dependent manner in B16F10 cells by IBL. We also analyzed B16F10 cells that were and were not treated with IBMX, ...
Tópico(s): Skin Protection and Aging
2020 - Multidisciplinary Digital Publishing Institute | Molecules
Juyoun Shin, Shin-Seok Kang, Hyeonseop Byeon, Sung-Min Cho, Seon-Yeong Kim, Yeun‐Jun Chung, Seung‐Hyun Jung,
The outbreaks of the highly pathogenic avian influenza (HPAI) in 2016-2017 and 2017-2018, caused by novel reassortant clade 2.3.4.4 H5N6 viruses, resulted in the loss of one billion birds in South Korea. Here, we characterized the H5N6 viruses isolated from wild birds in South Korea from December 2017 to August 2019 by next-generation sequencing. The results indicated that clade 2.3.4.4 H5N6 viruses isolated in 2017 and 2019 shared almost identical nucleotide sequences with the HPAI H5N6 viruses ...
Tópico(s): Viral Infections and Vectors
2020 - Nature Portfolio | Scientific Reports
Seung‐Hyun Jung, Youn Jin Choi, Min Sung Kim, Hyeon‐Chun Park, Mi-Ryung Han, Soo Young Hur, Ahwon Lee, Ok Ran Shin, Jeana Kim, Sung Hak Lee, Dongwan Hong, Sang Yong Song, Yeun‐Jun Chung, Sug Hyung Lee,
Abstract Little is known about genomic alterations of gestational choriocarcinoma (GC), unique cancer that originates in pregnant tissues, and the progression mechanisms from the nonmalignant complete hydatidiform mole (CHM) to GC. Whole-exome sequencing (20 GCs) and/or single-nucleotide polymorphism microarray (29 GCs) were performed. We analyzed copy-neutral loss-of-heterozygosity (CN-LOH) in 29 GCs that exhibited androgenetic CN-LOHs (20 monospermic, 8 dispermic) and no CN-LOH (one with NLRP7 mutation). ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Springer Nature | Experimental & Molecular Medicine
Seung‐Hyun Jung, Byung‐Hee Hwang, Sun Shin, Eunhye Park, Sin‐Hee Park, Chan Woo Kim, Eunmin Kim, Eun Ho Choo, Ik Jun Choi, Filip K. Świrski, Kiyuk Chang, Yeun‐Jun Chung,
Abstract Heart failure (HF) is a frequent consequence of myocardial infarction (MI). Identification of the precise, time-dependent composition of inflammatory cells may provide clues for the establishment of new biomarkers and therapeutic approaches targeting post-MI HF. Here, we investigate the spatiotemporal dynamics of MI-associated immune cells in a mouse model of MI using spatial transcriptomics and single-cell RNA-sequencing (scRNA-seq). We identify twelve major immune cell populations; their ...
Tópico(s): Cardiac Fibrosis and Remodeling
2022 - Nature Portfolio | Nature Communications
Sun Shin, Yong Hyun Park, Seung‐Hyun Jung, Sun‐Hee Jang, Mee Young Kim, Ji Youl Lee, Yeun‐Jun Chung,
Abstract Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize the overtreatment of indolent cases and help choosing appropriate treatment. The levels of circulating microRNAs (miRNAs) from body fluids can be used as noninvasive prognostic biomarkers. In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR-142-3p, miR-451, and miR-636. When evaluating ...
Tópico(s): MicroRNA in disease regulation
2021 - Nature Portfolio | npj Genomic Medicine
Yoon‐Seob Kim, Sun Shin, Seung‐Hyun Jung, Young Min Park, Gyeong Sin Park, Sug Hyung Lee, Yeun‐Jun Chung,
The mechanism underlying the progression of actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) in situ (SCCIS) to SCC remains unclear. To investigate this, we performed regional microdissection and targeted deep sequencing in SCC (n = 10) and paired adjacent sun-damaged epidermis (SE)/AK/SCCIS (n = 13) samples to detect mutations and copy number alterations. Most (11/13) SE/AK/SCCIS tissues harbored ≥1 driver alterations, indicating their precancerous nature. All pairs except one showed genome ...
Tópico(s): Plant Disease Resistance and Genetics
2021 - Elsevier BV | Journal of Investigative Dermatology
Ja Seong Bae, Seung‐Hyun Jung, Mitsuyoshi Hirokawa, Andrey Bychkov, Akira Miyauchi, Sohee Lee, Yeun‐Jun Chung, Chan Kwon Jung,
Tópico(s): Neuroendocrine Tumor Research Advances
2021 - Springer Science+Business Media | Endocrine Pathology
Tae‐Min Kim, S-A Ha, H K Kim, Jae Won Yoo, Suhyun Kim, Yim Sh, Seung‐Hyun Jung, D.-W. Kim, Y-J Chung, Jin‐Wou Kim,
The use of selective inhibitors targeting Bcr-Abl kinase is now established as a standard protocol in the treatment of chronic myelogenous leukemia; however, the acquisition of drug resistance is a major obstacle limiting the treatment efficacy. To elucidate the molecular mechanism of drug resistance, we established K562 cell line models resistant to nilotinib and imatinib. Microarray-based transcriptome profiling of resistant cells revealed that nilotinib- and imatinib-resistant cells showed the ...
Tópico(s): Quinazolinone synthesis and applications
2011 - Springer Nature | Blood Cancer Journal
Jae Hyuk Shin, Kee-Yong Ha, Seung‐Hyun Jung, Yeun‐Jun Chung,
Comparative genomic hybridization (CGH) microarrays.To identify genomic copy number variations (CNVs) in degenerative lumbar scoliosis (DLS) patients, and investigate the possibility of genetic predisposition in DLS.Genome scanning technology enables search for presence of CNVs. CGH microarray is a useful procedure in a genome-wide study.Among 45 consecutive patients who were diagnosed as DLS, 15 patients who manifested greatest Cobb's angle were selected for the array-CGH based CNV analysis. Control ...
Tópico(s): Congenital heart defects research
2011 - Lippincott Williams & Wilkins | Spine
Hae-Jin Hu, Eun‐Heui Jin, Seon-Hee Yim, So‐Young Yang, Seung‐Hyun Jung, Seung-Hun Shin, Wan‐Uk Kim, Seung Cheol Shim, Tai-Gyu Kim, Yeun‐Jun Chung,
Although the genetic component in the etiology of rheumatoid arthritis (RA) has been consistently suggested, many novel genetic loci remain to uncover. To identify RA risk loci, we performed a genome-wide association study (GWAS) with 100 RA cases and 600 controls using Affymetrix SNP array 5.0. The candidate risk locus (APOM gene) was re-sequenced to discover novel promoter and coding variants in a group of the subjects. Replication was performed with the independent case-control set comprising of ...
Tópico(s): Galectins and Cancer Biology
2011 - Springer Nature | Experimental & Molecular Medicine
Kai Wermker, Seung‐Hyun Jung, L. Hüppmeier, U. Joos, Johannes Kleinheinz,
Head and neck cancer patients are prone to nutritional problems, partly due to the location and size of the disease, due to significant comorbidity and also often therapeutic intervention. Excessive weight loss after surgery reduces further the patients' physical resistibility and increases the complication rate for adjuvant radiation and or chemotherapy. Possible effective interventions are dietary counseling, nutritional supplements or drug interventions. Aim of our research was to reveal reliable ...
Tópico(s): Nutrition and Health in Aging
2011 - Elsevier BV | Oral Oncology
Kyeong-Won Yoo, Eun-Hye Kim, Seung‐Hyun Jung, Myungchull Rhee, Bon‐Kyoung Koo, Ki‐Jun Yoon, Young–Yun Kong, Cheol‐Hee Kim,
Notch signaling has an evolutionarily conserved function for cell fate determination and stem cell maintenance. Previously, we identified a novel component of the Notch signaling pathway in zebrafish, mind bomb , which encodes an E3 ubiquitin ligase essential for Notch signal activation. Further studies showed that Mind bomb −/− mouse embryos exhibited pan‐Notch phenotypes in various tissues, suggesting that Mind bomb function is conserved in mammals. Therefore we sought to understand the various molecular ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2006 - Wiley | FEBS Letters
Seung-Hyun Jung, Hyung-Seok Kim, Jae-Ho Ryu, Jung-Woo Gwak, Young‐Ki Bae, Cheol‐Hee Kim, Sang‐Yeob Yeo,
Previous studies have shown that Notch signaling not only regulates the number of early differentiating neurons, but also maintains proliferating neural precursors in the neural tube. Although it is well known that Notch signaling is closely related to the differentiation of adult neural stem cells, none of transgenic zebrafish provides a tool to figure out the relationship between Notch signaling and the differentiation of neural precursors. The goal of this study was to characterize Her4-positive ...
Tópico(s): MicroRNA in disease regulation
2012 - Springer Science+Business Media | Molecules and Cells
Seung‐Hyun Jung, Ahwon Lee, Seon-Hee Yim, Hae-Jin Hu, Chungyoul Choe, Yeun‐Jun Chung,
The full extent of chromosomal alterations and their biological implications in early breast carcinogenesis has not been well examined. In this study, we aimed to identify chromosomal alterations associated with poor prognosis in early-stage breast cancers (EBC).A total of 145 EBCs (stage I and II) were examined in this study. We analyzed copy number alterations in a discovery set of 48 EBCs using oligoarray-comparative genomic hybridization. In addition, the recurrently altered regions (RARs) associated ...
Tópico(s): Cancer-related Molecular Pathways
2012 - BioMed Central | BMC Cancer
Ji‐Hyun Kim, Seung-Hyun Jung, Yeong‐In Yang, Ji‐Hye Ahn, Jin‐Gyeong Cho, Kyung‐Tae Lee, Nam‐In Baek, Jung‐Hye Choi,
Artemisia leaves have long been used for the treatment of gynecological disorders, including infertility and dysmenorrhea, which can be commonly caused by endometriosis. In the present study, we investigated the effect of Artemisia princeps extract (APE) on the cell growth and apoptosis of human endometriotic cells. MTT assays and FACS analysis using PI and Annexin staining were performed to study cell viability, cell cycle progression, and apoptosis. We also explored the mechanism of APE-induced ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2012 - Elsevier BV | Journal of Ethnopharmacology