Yoshinari Hattori, Yoshifumi Ubara, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenichi Oohashi, Kenmei Takaichi,
A 58-year-old Japanese woman on hemodialysis (HD) was admitted for intractable rheumatoid arthritis. Even after HD was started due to end-stage renal failure in 2004, her arthropathy worsened. A soluble tumor necrosis factor receptor inhibitor (etanercept at 25 mg twice weekly), tacrolimus (2 mg daily), and prednisolone (10 mg daily) had been administered since 2005, but high disease activity had persisted. She was admitted to our hospital in July 2007. C-reactive protein (CRP) was 6.8 mg/dL, and the ...
Tópico(s): Gout, Hyperuricemia, Uric Acid
2012 - Taylor & Francis | Amyloid
Nobuhiro Ayuzawa, Yoshifumi Ubara, Keiichi Sumida, Masayuki Yamanouchi, Eiko Hasegawa, Eriko Hiramatsu, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Masateru Kawabata, Kenichi Ohashi, Kennmei Takaichi,
A 68-year-old Japanese woman with asthma of recent onset and a long history of membranous glomerulonephropathy (MN) was admitted because of multifocal pulmonary infiltrates, marked eosinophilia, mild renal dysfunction, a rash on her feet, and right median nerve paralysis. Although MPO- and PR3-ANCA were negative, skin biopsy demonstrated leukocytoclastic vasculitis and Churg-Strauss Syndrome (CSS) was diagnosed. She also had salivary gland swelling and a high serum IgG4 level. Renal biopsy revealed ...
Tópico(s): Urticaria and Related Conditions
2012 - The Japanese Society of Internal Medicine | Internal Medicine
Koki Mise, Yoshifumi Ubara, Masanori Matsumoto, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenichi Ohashi, Koichi Kokame, Toshiyuki Miyata, Yoshihiro Fujimura, Kenmei Takaichi,
Thrombotic thrombocytopenic purpura (TTP) is frequently associated with renal abnormalities, but there have been few reports about renal abnormalities in patients with hereditary TTP. In particular, little is known about the long-term prognosis of patients with childhood-onset congenital TTP. We report a Japanese patient with congenital TTP (Upshaw–Schulman syndrome) who was followed for 19 years after initiation of hemodialysis when he was 22 years old. At the age of 6 years, the first episode of ...
Tópico(s): Platelet Disorders and Treatments
2013 - BioMed Central | BMC Nephrology
Kanae Nonaka, Yoshifumi Ubara, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Yoko Kuroda, Kenichi Oohashi,
Objective The prognosis of patients with hypertensive emergencies has recently improved dramatically owing to the development of effective antihypertensive therapy. We examined the histological and clinical features of patients with hypertensive emergency-related nephropathy. Methods Twelve patients (11 men and one woman) were diagnosed as having hypertensive emergencies with acute renal failure according to the Joint National Committee-7 classification of blood pressure for adults and underwent ...
Tópico(s): Blood Pressure and Hypertension Studies
2013 - The Japanese Society of Internal Medicine | Internal Medicine
Rikako Hiramatsu, Yoshifumi Ubara, Naoki Sawa, Eiko Hasegawa, Masahiro Kawada, Aya Imafuku, Keiichi Sumida, Koki Mise, Masayuki Yamanouchi, Toshiharu Ueno, Akinari Sekine, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Atsushi Wake, Shuichi Taniguchi,
Allogeneic hematopoietic stem cell transplantation (HSCT)–related membranous glomerulonephritis (MGN) is poorly understood. A total of 830 patients who underwent HSCT at Toranomon Hospital from 2000 to 2012 were evaluated retrospectively, including 621 patients receiving umbilical cord blood transplantation (UCBT) and 208 patients receiving unrelated bone marrow transplantation. MGN was diagnosed in 5 patients after UCBT (versus none after bone marrow transplantation) and occurred concomitantly with ...
Tópico(s): Platelet Disorders and Treatments
2015 - Elsevier BV | Human Pathology
Satoshi Hamanoue, Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Koki Mise, Noriko Hayami, Naoki Sawa, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Masahide Yazaki, Shu‐ichi Ikeda, Yoshifumi Ubara,
Familial Mediterranean fever (FMF) is a well-known cause of secondary AA amyloidosis. Colchicine is generally considered to be the most effective treatment for FMF and FMF-associated amyloidosis, but the management of patients who are refractory to colchicine remains controversial. We encountered a 51-year-old Japanese man with suspected FMF, who had periodic fever with abdominal pain, polyarthritis, and nephropathy (serum creatinine of 1.9 mg/dL and 24-h protein excretion of 3.8 g). FMF was diagnosed ...
Tópico(s): interferon and immune responses
2015 - Oxford University Press | Modern Rheumatology
Hiroki Mizuno, Naoki Sawa, Shun Watanabe, Daisuke Ikuma, Akinari Sekine, Masahiro Kawada, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Michio Nagata, Yutaka Yamaguchi, Yoshifumi Ubara,
Thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome is a severe subtype of idiopathic multicentric Castleman's disease, characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, and organomegaly. Renal complication of this disease can be life-threatening and sometimes requires hemodialysis, but it has not been elucidated in detail.Case-series was designed to evaluate the renal histology of patients with TAFRO syndrome treated at our hospital. ...
Tópico(s): Viral-associated cancers and disorders
2020 - Elsevier BV | Kidney International Reports
Masayuki Yamanouchi, Kengo Furuichi, Miho Shimizu, Tadashi Toyama, Yuta Yamamura, Megumi Oshima, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Yuki Oba, Shusaku Matsuoka, Daisuke Ikuma, Hiroki Mizuno, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Yukio Yuzawa, Hiroshi Kitamura, Yoshiki Suzuki, Hiroshi Satō, Noriko Uesugi, Yoshihiko Ueda, Shinichi Nishi, Hitoshi Yokoyama, Tomoya Nishino, Ken‐ichi Samejima, Kentaro Kohagura, Yugo Shibagaki, Hirofumi Makino, Seiichi Matsuo, Yoshifumi Ubara, Takashi Wada,
Prognosticating disease progression in patients with diabetic kidney disease (DKD) is challenging, especially in the early stages of kidney disease. Anemia can occur in the early stages of kidney disease in diabetes. We therefore postulated that serum hemoglobin (Hb) concentration, as a reflection of incipient renal tubulointerstitial impairment, can be used as a marker to predict DKD progression.Drawing on nationally representative data of patients with biopsy-proven DKD, 246 patients who had an ...
Tópico(s): Hemoglobinopathies and Related Disorders
2021 - Oxford University Press | Nephrology Dialysis Transplantation
Shun Watanabe, Naoki Sawa, Hiroki Mizuno, Masayuki Yamanouchi, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yutaka Yamaguchi, Yoshifumi Ubara,
Abstract We encountered 3 cases of acute kidney injury that occurred after treatment with a SGLT2 inhibitor. In case 1, serum creatinine increased from 1.65 to 3.0 mg/dL, in case 2, serum creatinine increased from 1.03 to 1.21 mg/dL, and in case 3, serum creatinine increased from 0.8 to 1.1 mg/dL. Renal biopsy showed isometric vacuolization on tubules, that was completely negative for Periodic acid-Schiff (PAS) stain in case 1, and was partially negative for PAS stain in case 2 and 3, consistent ...
Tópico(s): Diabetes Management and Research
2021 - Springer Science+Business Media | CEN Case Reports
Masato Sawamura, Naoki Sawa, Masayuki Yamanouchi, Daisuke Ikuma, Akinari Sekine, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, Noriko Hayami, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yutaka Yamaguchi, Yoshifumi Ubara,
Abstract Background and purpose We examined whether advances in treatment strategies from older disease-modifying antirheumatic drugs (DMARDs) to new biologic agents and methotrexate improved renal complications and outcome in patients with rheumatoid arthritis (RA). Methods We reviewed records of 156 patients with RA who underwent kidney biopsy at our institute between January 1990 and December 2019. All patients were assigned to one of three periods: period 1, 1990–1999 ( n = 48); period 2, 2000–2009( ...
Tópico(s): Vasculitis and related conditions
2021 - Springer Science+Business Media | Clinical and Experimental Nephrology
Masaki Hatano, Izuru Kitajima, Seizo Yamamoto, Masaki Nakamura, K. Isawa, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Yoshifumi Ubara,
Patients on hemodialysis develop carpal tunnel syndrome (CTS) due to an accumulation of dialysis-related β2 microglobulin (β2m) amyloid (DRA). In Japan, dialysis technology has progressed remarkably in the past 40 years and has increased the time until patients require surgery for CTS. However, unclear is whether the time from the start of hemodialysis to the first surgery for CTS is associated with β2m clearance by the different hemodialysis techniques. Therefore, we retrospectively evaluated β2m ...
Tópico(s): Tendon Structure and Treatment
2021 - Springer Science+Business Media | Clinical and Experimental Nephrology
Yoshiki Tsuchiya, Yoshifumi Ubara, Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Yuji Marui, Naoki Sawa, Fumi Takemoto, Kenmei Takaichi,
Tópico(s): Drug-Induced Ocular Toxicity
2011 - Springer Science+Business Media | Clinical and Experimental Nephrology
Akinari Sekine, Eiko Hasegawa, Rikako Hiramatsu, Koki Mise, Keiichi Sumida, Toshiharu Ueno, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara,
Renovascular lesions of lupus nephritis (LN) were classified into five categories by D'Agati in Heptinstall's Pathology of the Kidney, with thrombotic microangiopathy (TMA) and clinical thrombotic thrombocytopenic purpura (TTP) being combined. We encountered 2 cases with histological LN (class III and lass V), and they presented with clinical features of TTP, such as acute renal failure, microangiopathic hemolytic anemia, thrombocytopenia, fever, and central neurologic symptoms. Immunosuppressive therapy ...
Tópico(s): Vasculitis and related conditions
2015 - Karger Publishers | Case Reports in Nephrology and Dialysis
Takafumi Toyohara, Noriko Hayami, Yoshifumi Ubara,
... volume is limited by nephromegaly. We acknowledge Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki ...
Tópico(s): Renal and Vascular Pathologies
2011 - Elsevier BV | American Journal of Kidney Diseases
Yoshifumi Ubara, Tetsuo Tagami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Syohei Nakanishi, Hideyuki Katori, Takaaki Yamagata, Fumi Takemoto, Shigeko Hara, Kumi Aita, Shigeo Hara, Yoshihisa Mikami, Kenmei Takaichi,
We report a patient with renal tubulointerstitial fibrosis and symptomatic osteomalacia associated with Fanconi syndrome. A 55-year-old woman was hospitalized because of an inability to walk. Beginning approximately 2 years previously, she had experienced gradually worsening pain in the hips, shoulders, and trunk, culminating in a bedridden state. Serum urea nitrogen was 38 mg/dl; creatinine, 2.6 mg/dl; uric acid. 3.6 mg/dl; phosphate, 2.3 mg/dl; and alkaline phosphatase, 2111 IU/l. Urinary β2 microglobulin ...
Tópico(s): Parathyroid Disorders and Treatments
2005 - Oxford University Press | Modern Rheumatology
Yoshiki Tsuchiya, Yoshifumi Ubara, Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Yuji Marui, Naoki Sawa, Fumi Takemoto, Kenmei Takaichi,
Tópico(s): Pediatric Urology and Nephrology Studies
2010 - Springer Science+Business Media | Clinical and Experimental Nephrology
Yoshiki Tsuchiya, Yoshibumi Ubara, Ryo Hiramatsu, Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Eiju Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Yuhji Marui, Naoki Sawa, Shigeo Hara, K. Takaichi, Kenichi Oohashi,
We trace the 34-year history of a member of the first Japanese family in which lecithin-cholesterol acyltransferase (LCAT) deficiency was diagnosed. Marriage between cousins with low LCAT activity was responsible for familial LCAT deficiency (FLD). In 1976, a 27-year-old Japanese man was noted to have FLD based on proteinuria, hematuria, grayish corneal opacity and low LCAT activity (9.83%). Genetic analysis showed insertion of G-G-C coding glycine at codon 141. Total cholesterol (C) was low at 108 ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2011 - Dustri-Verlag | Clinical Nephrology
Rikako Hiramatsu, Yoshifumi Ubara, Noriko Hayami, Masayuki Yamanouchi, Eiko Hasegawa, Keiichi Sumida, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Norio Amizuka, Kenmei Takaichi,
A 55-year-old woman who had been on hemodialysis for 5years was admitted for evaluation of a hard mass in the right hip region. Her serum calcium (Ca)-phosphate (P) product was elevated. Radiographs showed periarticular calcified masses in the soft tissues around both hips and shoulders, which were characteristic of uremic tumoral calcinosis (UTC). Biopsy specimens were obtained from both right hip mass and the right iliac crest. Histological examination of hip mass revealed bone-like tissue with marrow, ...
Tópico(s): Medical Imaging and Pathology Studies
2012 - Elsevier BV | Bone
Jun-ichi Inenaga, Toshiharu Ueno, Masahiro Kawada, Aya Imafuku, Koki Mise, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Toshikazu Okaneya, Yoshifumi Ubara,
A 52-year-old Japanese woman was admitted to our hospital with the renal pelvic mass lesion detected on a health screening examination. The surgical specimen contained a mass exhibiting the histological features of immunoglobulin (Ig)G4-related disease, including lymphoplasmacytic infiltration and sclerosis with numerous IgG4-producing plasma cells. Postoperatively, an elevation of the serum IgG4 level was confirmed at 403 mg/dL; however, there was no evidence of tubulointerstitial nephritis or glomerulopathy, ...
Tópico(s): Neuroendocrine Tumor Research Advances
2015 - The Japanese Society of Internal Medicine | Internal Medicine
Daisuke Takada, Keiichi Sumida, Akinari Sekine, Ryo Hazue, Masayuki Yamanouchi, Tatsuya Suwabe, Noriko Hayami, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Yoshifumi Ubara,
Various renal manifestations are known to develop in patients with liver disease, including chronic hepatitis and cirrhosis. We evaluated renal disease in two 47-year-old Japanese men with liver cirrhosis and chronic alcoholism for 34 years and 27 years, respectively. Renal biopsy demonstrated massive wire loop-like deposits in the subendothelial space of the glomerular basement membrane and in the mesangium. However, immunofluorescence was only positive for IgA and C3, and electron microscopy did ...
Tópico(s): Celiac Disease Research and Management
2017 - BioMed Central | BMC Nephrology
Maki Urushihara, Hiroshi Satō, Akira Shimizu, Hitoshi Sugiyama, Hitoshi Yokoyama, Hiroshi Hataya, Kentaro Matsuoka, Takayuki Okamoto, Daisuke Ogino, Kenichiro Miura, Riku Hamada, Satoshi Hibino, Yuko Shima, Tomohiko Yamamura, Koichi Kitamoto, Masayuki Ishihara, Takao Konomoto, Motoshi Hattori, Naoyuki Hasebe, Naoki Nakagawa, Sekiya Shibazaki, T Miyamoto, Masanori Ito, Saori Nishio, Daigo Nakazawa, Takayuki Okamoto, Yasuyuki Sato, Akira Suzuki, Norihito Moniwa, Marenao Tanaka, Yuichiro Fukasawa, Hideki Takizawa, Jun Soma, Izaya Nakaya, Junichiro James Kazama, K. Tanaka, Mizuko Tanaka, Toshinobu Sato, Satoru Sanada, H Hashimoto, Mariko Miyazaki, Tasuku Nagasawa, Takayuki Okamoto, Tsuneo Konta, Kazunobu Ichikawa, Daisuke Ogino, Hiroshi Kitamura, Toshiyuki Imasawa, Chieko Matsumura, Naotake Akutsu, Koichi Kamura, T. Takeda, Toshihiko Ishimitsu, Keiju Hiromura, Yoriaki Kaneko, Hidekazu Ikeuchi, Toru Sakairi, Daisuke Nagata, Osamu Saitô, Tetsu Akimoto, Akito Maeshima, Takashi Yokoo, Nobuo Tsuboi, Kentaro Koike, Yudo Tanno, Shinya Yokote, Yoichi Miyazaki, Hiroyuki Ueda, Masahiro Okabe, Mai Tanaka, Masato Ikeda, Akihiro Shimizu, Yusuke Suzuki, Tomohito Goda, Masao Kihara, Miyuki Takagi, Masahiro Ishikawa, Shinya Kaname, Miho Karube, Kazuhito Fukuoka, Takahisa Kawakami, Itaru Ebihara, Chihiro Sato, Yukinao Sakai, Akio Hirama, Akiko Mii, Yoshinobu Fuke, Masanori Abe, Hirokazu Okada, Tsutomu Inoue, Takatsugu Iwashita, Yuta Kogure, Koichi Kanozawa, Hajime Hasegawa, Masamitsu Ubukata, Takanori Shibata, Yoshihiko Inoue, Tomo Suzuki, Daisuke Ichikawa, Sayuri Shirai, Yugo Shibagaki, Takehiko Wada, Masafumi Fukagawa, Yoshihide Fujigaki, Shigeo Horie, Satoru Muto, Masaki Kobayashi, Kouichi Hirayama, Homare Shimohata, Riku Hamada, Hiroshi Hataya, Motoshi Hattori, Kenichiro Miura, Kiyonobu Ishizuka, Naoto Kaneko, Kosaku Nitta, Keiko Uchida, Takahito Moriyama, Yoshifumi Ubara, Tatsuya Suwabe, Junichi Hoshino, Noriko Hayami, Masaomi Nangaku, Tetsuhiro Tanaka, Yoshifumi Hamasaki, Kenjiro Honda, Yutaka Harita, Shoichiro Kanda, Yuko Kajiho, Kunihiro Yamagata, Joichi Usui, Tetsuya Kawamura, Kouichi Tamura, Hiromichi Wakui, Tomohiko Kanaoka, Ryu Kobayashi, Nobuhito Hirawa, Sanae Saka, Akira Fujiwara, Ichiei Narita, Shunsuke Goto, Yumi Itoh, Naofumi Imai, Yuji Kamijo, Koji Hashimoto, Akinori Yamaguchi, Kosuke Sonoda, Kazuya Takahashi, Fumihiko Furuya, Kiyoki Kitagawa, Hitoshi Yokoyama, Keiji Fujimoto, Norifumi Hayashi, Daisuke Koya, Munehiro Kitada, Yuka Kuroshima, Takashi Wada, Kengo Furuichi, Miho Shimizu, Norihiko Sakai, Yasuhiro Katou, Tomohiko Yamamura, Yoshitaka Koshino, Chikako Takaeda, Haruyoshi Yoshida, Takayasu Horiguchi, Yasuyuki Shinozaki, Masahiko Kawabata, Satoshi Ota, Yoh-ichi Ishida, Masayuki Iwano, Naoki Takahashi, Kenji Kasuno, Daisuke Mikami, Hidenori Yamazaki, Naoya Fujita, Satoshi Hibino, Kazuki Tanaka, Yasuhiko Ito, Takuhito Nagai, Takayuki Katsuno, Hironobu Nobata, Shogo Kimura, Yuka Soga, Masanori Sakakima, Yukio Yuzawa, Naotake Tsuboi, Hiroki Hayashi, Kazuo Takahashi, Hideo Yasuda, Naro Ohashi, Taichi Sato, Asami Takeda, Yasuhiro Otsuka, Minamo Ono, Tatsuya Tomonari, Michio Fukuda, Masashi Mizuno, Taisei Suzuki, Satoru Kominato, Hirotake Kasuga, Shoichi Maruyama, Yoshinari Yasuda, Tomoki Kosugi, Takuji Ishimoto, Noriko Mori, Satoshi Tanaka, Tomohiro Murata, Mika Fujimoto, Kan Katayama, Yokkaichi Hazu, Yasuhide Mizutani, Hitoshi Kodera, Masato Miyake, Kazumasa Oka, Nobuyuki Kajiwara, Tatsuo Tsukamoto, Tomomi Endo, Eri Muso, Shinichi Nishi, Shunsuke Goto, Kazumoto Iijima, Kandai Nozu, Tomohiko Yamamura, Yoko Adachi, Takaaki Nishihara, Michitsugu Kamezaki, Koichi Seta, Kensei Yahata, Keiichi Tamagaki, Tetsuro Kusaba, Yayoi Shiotsu, Motoko Yanagita, Hideki Yokoi, Kaoru Sakai, Akira Ishii, Kazuhiko Tsuruya, Ken‐ichi Samejima, Fumiki Yoshihara, Katsuhito Mori, Akihiro Tsuda, Shinya Nakatani, Yoshio Konishi, Takashi Morikawa, Chizuko Kitabayashi, Rika Fujimaru, Terumasa Hayashi, Tatsuya Shoji, Katsusuke Yamamoto, Akira Ashida, Akira Sugawara, Masao Koshikawa, Yoshihisa Ogawa, Tomoko Kawanishi, Atsushi Yamauchi, Katsuyuki Nagatoya, Daisuke Mori, Ryota Haga, Yoshitaka Isaka, Ryohei Yamamoto, Tomoko Namba‐Hamano, Toshiki Nishio, Shin‐ichi Araki, Shigeichi Shoji, Kenjiro Yamakawa, Senji Okuno, Megumu Fukunaga, Yuko Shima, Taketsugu Hama, Takashi Shigematsu, Masaki Ohya, Naoki Kashihara, Kenichiro Asano, Motoko Kanzaki, Kosuke Fukuoka, Takao Masaki, Shigehiro Doi, Ayumu Nakashima, Toshiki Doi, Kan Yamazaki, Nobuyoshi Sugiyama, Yuichiro Inaba, Kouji Ozeki, Makoto Hiramatsu, Keisuke Maruyama, Noriya Momoki, Hiroshi Morinaga, Ayu Akiyama, Natsumi Uchiyama, Mariko Nishiwaki, Tsuyoshi Imai, Takafumi Ito, Masahiro Egawa, Shohei Fukunaga, Shinichi Okada, Koichi Kitamoto,
Springer Science+Business Media
Yoshiki Tsuchiya, Yoshifumi Ubara, Makoto Anzai, Rikako Hiramatsu, Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Yuji Marui, Naoki Sawa, Shigeko Hara, Kenmei Takaichi, Kenichi Oohashi,
Idiopathic basal ganglia calcification (IBGC) is a syndrome in which bilateral cerebral calcification occurs despite the absence of abnormal calcium metabolism. A 17-year-old Japanese female was admitted for investigation of intermittent proteinuria from the age of 12 years. On admission, her blood pressure was 126/60 mmHg and her serum creatinine was 0.8 mg/dL. Although computed tomography revealed bilateral striopallidodentate calcinosis, her level of intelligence and neurological findings were ...
Tópico(s): Neurological disorders and treatments
2011 - The Japanese Society of Internal Medicine | Internal Medicine
Natsuki Shima, Keiichi Sumida, Masahiro Kawada, Akinari Sekine, Masayuki Yamanouchi, Rikako Hiramatsu, Noriko Hayami, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara,
A 42-year-old woman with systemic lupus erythematosus (SLE) was admitted to our hospital for evaluation of severe thrombocytopenia. She was treated with steroids, intravenous cyclophosphamide, intravenous immunoglobulin, and plasma exchange, but her thrombocytopenia did not improve. Renal biopsy showed class IV-S(C) + V lupus nephritis, according to the classification of the International Society of Nephrology/Renal Pathology Society. The PA-IgG and serum thrombopoietin (TPO) levels were elevated. Her ...
Tópico(s): Blood disorders and treatments
2018 - Hindawi Publishing Corporation | Case Reports in Rheumatology
Yôichi Ôshima, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Akinari Sekine, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Takeshi Fujii, Kenmei Takaichi, Yoshifumi Ubara,
Recent reports suggest helper T-cell abnormalities in minimal-change nephrotic syndrome (MCNS), which often complicate allergic disorders that show a similar helper T-cell profile with Th2/Th17 predominance. However, the effect of anti-allergy therapy on MCNS remains unknown. This retrospective study included 51 patients with biopsy-proven MCNS recruited between November 2012 and October 2015, with follow-up through November 2017. We analyzed relapse and temporal daily corticosteroid dose with and ...
Tópico(s): Urticaria and Related Conditions
2020 - Nature Portfolio | Scientific Reports
Osamu Yamazaki, Yoshifumi Ubara, Tatsuya Suwabe, Shohei Nakanishi, Junichi Hoshino, Naoki Sawa, Noriko Hayami, Masayuki Yamanouchi, Fumi Takemoto, Kenmei Takaichi, Kazuhiro Masuoka, Kenichi Oohashi,
Tópico(s): Polyomavirus and related diseases
2009 - Springer Science+Business Media | Clinical and Experimental Nephrology
Hiroki Mizuno, Akinari Sekine, Masahiko Oguro, Yôichi Ôshima, Masahiro Kawada, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Rikako Hiramatsu, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa, Takashi Fujii, Kenmei Takaichi, Kenichi Ohashi, Yoshifumi Ubara,
An 84-year-old Japanese man was admitted due to anasarca, thrombocytopenia, systemic inflammation, and progressive renal insufficiency, resistance to diuretics, glucocorticoid therapy, and plasma exchange. Renal biopsy showed diffuse endocapillary proliferation and mesangiolysis without any immune deposits. Tocilizumab suppressed systemic inflammation, resulting in improvement of anasarca and renal dysfunction, but thrombocytopenia persisted and platelet-associated IgG antibody was elevated. Although ...
Tópico(s): Viral-associated cancers and disorders
2018 - Elsevier BV | Human Pathology
Yusuke Ito, Akinari Sekine, Daisuke Takada, Junko Yabuuchi, Yuta Kogure, Toshiharu Ueno, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Hiroaki Kikuchi, Shintaro Mandai, Motoko Chiga, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Yoshifumi Ubara,
A 37-year-old Japanese man with a serum creatinine level of 2.5 mg/dL and hepatomegaly was admitted to our hospital for investigation of renal failure. Magnetic resonance imaging (MRI) showed hepatomegaly with small cystic lesions that had high signal intensity on T2-weighted images. There was no splenomegaly, and the kidneys were nearly normal in size with a few small cystic lesions. Renal biopsy revealed that interstitial fibrosis and tubular atrophy affected 60% of the cortex. There was cystic ...
Tópico(s): Pediatric Urology and Nephrology Studies
2017 - Dustri-Verlag | Clinical Nephrology
Natsuki Shima, Noriko Hayami, Hiroki Mizuno, Masahiro Kawada, Akinari Sekine, Keiichi Sumida, Rikako Hiramatsu, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Seiji Minota, Yoshifumi Ubara,
A 32-year-old Japanese woman was admitted to our hospital for evaluation of microscopic hematuria with a positive family history. Percutaneous renal biopsy was performed under real-time ultrasound guidance using a 16-gauge automated needle and three specimens were obtained. She had no risk factors for hemorrhage. However, macroscopic hematuria developed from 5 days after biopsy and persisted for 4 days. Her Hb decreased markedly from 15.0 to 8.1 g/dL. Enhanced computed tomography revealed urinary ...
Tópico(s): Renal and Vascular Pathologies
2019 - Springer Science+Business Media | CEN Case Reports
Natsuki Shima, Naoki Sawa, Masayuki Yamanouchi, Hiroki Mizuno, Masahiro Kawada, Akinari Sekine, Rikako Hiramatsu, Noriko Hayami, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara,
Abstract A renal histology of an 81-year-old man with a 30-year history of diabetes mellitus (DM), as well as diabetic retinopathy and neuropathy, was examined. The patient’s blood pressure was controlled within the normal range (less than 140/75 mmHg) using antihypertensive agents including angiotensin receptor blocker. Edematous management was achieved by a strict salt diet (less than 6 g/per day). However, this patient’s glycemic control was poor with HbA1c 8–10%. Serum creatinine was 0.87 mg/dL ...
Tópico(s): Diabetes Treatment and Management
2020 - Springer Science+Business Media | CEN Case Reports
Makoto Fukuda, Hiroki Mizuno, Rikako Hiramatsu, Akinari Sekine, Masahiro Kawada, Eiko Hasegawa, Masayuki Yamanouchi, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Motoaki Miyazono, Yoshifumi Ubara,
A 60-year-old Japanese woman with polymyositis (PM) developed hemolytic anemia (hemoglobin of 7.3 g/dL), thrombocytopenia (platelet of 9.1×104/µL), and acute kidney injury (Cre of 4.7 mg/dL) at 14 days after starting steroid therapy. Renal biopsy revealed glomerular endothelial swelling with fibrin thrombi and fragmented erythrocytes in the capillary lumens. Hemolytic uremic syndrome (HUS) with thrombotic microangiopathy (TMA) was diagnosed. Hemodialysis and plasma exchange/plasma transfusion were initiated, ...
Tópico(s): Genetic Syndromes and Imprinting
2021 - Dustri-Verlag | Clinical Nephrology