Þorgerður Sigurðardóttir, Þóra Steingrímsdóttir, Árni Árnason, Kari Bø,
Tópico(s): Anorectal Disease Treatments and Outcomes
2011 - Springer Science+Business Media | International Urogynecology Journal
Þorgerður Sigurðardóttir, Þóra Steingrímsdóttir, Árni Árnason, Kari Bø,
To investigate test-retest intra-rater reliability of measurements of pelvic floor muscle (PFM) strength using Myomed 932 (Enraf-Nonius, Delft, the Netherlands).Test-retest intra-rater reliability test with a 2-7 day interval.Physiotherapy outpatient clinic in association with the Department of Physiotherapy, University of Iceland.Twenty healthy female volunteers in Reykjavik metropolitan area, Iceland, with a mean age of 43.8 (SD 9.8) years, mean body mass index (BMI) 26.2 (SD 5.3), and mean parity ...
Tópico(s): Anorectal Disease Treatments and Outcomes
2009 - Informa | Acta Obstetricia Et Gynecologica Scandinavica
Kári Árnason, Kristín Briem, Árni Árnason,
BACKGROUND: Studies show a high cumulative prevalence of musculoskeletal disorders among musicians. Increased emphasis is needed on studying the effectiveness of education and prevention courses in music schools. OBJECTIVES: To investigate the effects on music students of an education and prevention course on body awareness and their attitude toward health and prevention. METHODS: 23 music students participated in this prospective descriptive comparative study, with 13 students taking the course ...
Tópico(s): Sports injuries and prevention
2018 - | Medical Problems of Performing Artists
Kári Arnason, Árni Árnason, Kristín Briem,
Most research studies investigating the prevalence of musculoskeletal disorders affecting musicians and music students have focused on classical music, while less is known about their prevalence in other music genres. The purpose of this study was to document cumulative and point prevalence of playing-related musculoskeletal disorders (PRMD) among music students in Iceland and, specifically, to identify differences between those studying classical vs rhythmic music. We hypothesized that students ...
Tópico(s): Musculoskeletal pain and rehabilitation
2014 - | Medical Problems of Performing Artists
David M. White, Teiji Takeda, Leslie J. DeGroot, Kári Stéfansson, Barry G.W. Arnason,
We isolated and characterized the human β-Trace protein (βTP) gene promoter. βTP, also known as prostaglandin D2 synthase, is a lipocalin secreted from the choroid plexus and meninges into cerebrospinal fluid. Basal transcription of the βTP gene is directed from a core promoter found within the first 325 bases of the 5′-flanking sequence. The βTP gene promoter is responsive to thyroid hormone (3,3′,5-triiodothyronine, T3) and efficiently repressed by unliganded human thyroid hormone receptor β (TRβ). ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
1997 - Elsevier BV | Journal of Biological Chemistry
M. Kelly Nicholas, Andrew G. Chenelle, Margaret M. Brown, Kāri Stefánsson, B. G. W. Arnason,
This chapter examines the prevention of neural allograft rejection in a mouse following an in vivo depletion of L3T4 + but not LYT-2 + T-lymphocytes. In the experiment described in the chapter, a mouse model for fetal neural transplantation as a means of determining the degree of immunological privilege afforded neural tissue following transplantation to the central nervous system (CNS). Although L3T4 + T-cells consistently outnumbered LYT-2 + T-cells in isolates from neural allograft, the relative numbers ...
Tópico(s): Reproductive System and Pregnancy
1990 - Elsevier BV | Progress in brain research
M. Kelly Nicholas, Jack P. Antel, Kāri Stefánsson, B. G. W. Arnason,
In order to examine questions concerning immunologic privilege of the central nervous system, we placed neocortical transplants into cerebral ventricles of mice. We compared the fates of transplants between fully H-2 compatible (isografts) and H-2 incompatible (allografts) animals. Histologic evaluation comparing animals from iso- and allograft groups revealed significant differences in the number of inflammatory cells and in the degree of necrosis within the grafts. Response to allografted tissue ...
Tópico(s): RNA Interference and Gene Delivery
1987 - American Association of Immunologists | The Journal of Immunology
Laufey T. Ámundadóttir, Sverrir Thorvaldsson, Daníel F. Guðbjartsson, Patrick Sulem, Kristleifur Kristjánsson, Sigurður Árnason, Jeffrey R. Gulcher, Jóhannes Björnsson, Augustine Kong, Unnur Þorsteinsdóttir, Kári Stéfansson,
Background The contribution of low-penetrant susceptibility variants to cancer is not clear. With the aim of searching for genetic factors that contribute to cancer at one or more sites in the body, we have analyzed familial aggregation of cancer in extended families based on all cancer cases diagnosed in Iceland over almost half a century. Methods and Findings We have estimated risk ratios (RRs) of cancer for first- and up to fifth-degree relatives both within and between all types of cancers diagnosed ...
Tópico(s): DNA Repair Mechanisms
2004 - Public Library of Science | PLoS Medicine
Hákon Hákonarson, Unnur Steina Björnsdóttir, Eva Halapi, Snæbjörn Pálsson, Elva Adalsteinsdottir, Davíð Gíslason, Gudmundur Finnbogason, Þórarinn Gíslason, Kristleifur Kristjánsson, T. J. Arnason, Illugi Birkisson, Michael L. Frigge, Augustine Kong, Jeffrey R. Gulcher, Kāri Stefánsson,
Asthma is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Numerous loci and candidate genes have been reported to show linkage and association to asthma and atopy. Although some studies reporting these observations are compelling, no gene has been mapped that confers a sufficiently high risk of asthma to meet the stringent criteria for genomewide significance. Using 175 extended Icelandic ...
Tópico(s): Digestive system and related health
2002 - Elsevier BV | The American Journal of Human Genetics
Hákon Hákonarson, Unnur Steina Björnsdóttir, Eva Halapi, Jonathan P. Bradfield, Florian Zink, Magali Mouy, Hildur Helgadóttir, Asta Solilja Gudmundsdottir, Hjalti Andrason, Asdis E. Adalsteinsdottir, Kristleifur Kristjánsson, Illugi Birkisson, T. J. Arnason, Margrét B. Andrésdóttir, Davíð Gíslason, Þórarinn Gíslason, Jeffrey R. Gulcher, Kāri Stefánsson,
Gene expression profiles were examined in freshly isolated peripheral blood mononuclear cells (PBMC) from two independent cohorts (training and test sets) of glucocorticoid (GC)-sensitive ( n = 64) and GC-resistant ( n = 42) asthma patients in search of genes that accurately predict responders and nonresponders to inhaled corticosteroids. A total of 11,812 genes were examined with high-density oligonucleotide microarrays in both resting PBMC (106 patients) and cells treated in vitro with IL-1β and TNF-α combined ( ...
Tópico(s): Ion channel regulation and function
2005 - National Academy of Sciences | Proceedings of the National Academy of Sciences
VikenL. Babikian, Kári Stéfansson, MichaelE. Dieperink, BarryG.W. Arnason, LindaS. Marton, BarryE. Levy,
Tópico(s): Acute Myeloid Leukemia Research
1985 - Elsevier BV | The Lancet
M. Kelly Nicholas, Kāri Stefánsson, Jack P. Antel, B. G. W. Arnason,
Histologic and immunocytochemical analyses of fetal neocortical tissue transplanted to the lateral ventricle of inbred adult mice indicate that this tissue survives transplantation well if the donor and host are isogeneic. The major histocompatibility complex (MHC) of the mouse is known as the H-2 locus. H-2-incompatible neural transplants (allografts), unlike their H-2-identical counterpart (isografts), are characterized by the presence of T cells comprising both major T-cell subsets and macrophages, ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
1987 - Wiley | Journal of Neuroscience Research
M. Kelly Nicholas, Oren Sagher, J. P. Hartley, Kāri Stefánsson, Barry G.W. Arnason,
This chapter describes the phenotypic analysis of T cells isolated from the brains of mice with iso- and allogeneic intraventricular neural transplants. The chapter indicates the preponderance of MHC class II restricted T lymphocytes in most neural allografts when mice differ completely at the MHC and at mH loci. Depletion of class II-restricted T cells in host mice permits the survival of fully histoincompatible orthotopic skin grafts, while depletion of class I-restricted cells does not. Although, ...
Tópico(s): Nerve injury and regeneration
1988 - Elsevier BV | Progress in brain research
Illugi Birkisson, Eva Halapi, Unnur Steina Björnsdóttir, Dana L. Shkolny, Elva Adalsteinsdottir, T. J. Arnason, Davíð Gíslason, Þórarinn Gíslason, Jeffrey R. Gulcher, Kāri Stefánsson, Hákon Hákonarson,
Recent evidence suggests that deficiency in the Th1 cytokine pathway may underlie the susceptibility to allergic asthma. This study examined whether (1) single-nucleotide polymorphisms exist in the promoter region of the two interleukin (IL)-12 subunit genes in patients with asthma; (2) messenger RNA and protein expressions of signal transducers and activators of transcription, IL-12, IFN-γ, and their receptors are altered in asthma; and (3) linkage to genes in the Th1 pathway is present in families ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2004 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
S. Q. Liu, Ian M. Scott, Yvan Pelletier, Kari Kramp, Tony Durst, S. R. Sims, John T. Arnason,
Dillapiol, the main constituent in dill Anethum sowa Roxb. ex Fleming (Apiaceae) oil and wild pepper, Piper aduncum L. (Piperaceae), is an effective cytochrome P450 inhibitor similar to piperonylbutoxide (PBO). Laboratory and field trials with pyrethrum Chrysanthemum cinerariifolium (Trevir.) vis. extracts combined with dillapiol (1:5 and 1:16 ratio) were effective against both insecticide-susceptible and -resistant Colorado potato beetle Leptinotarsa decemlineata (Say). In the laboratory, pyrethrum efficacy ...
Tópico(s): Insect and Pesticide Research
2014 - Oxford University Press | Journal of Economic Entomology
Sara Szuchet, Kári Stéfansson, Robert L. Wollmann, Glyn Dawson, Barry G.W. Arnason,
Tópico(s): Immune cells in cancer
1980 - Elsevier BV | Brain Research
Kāri Stefánsson, Robert L. Wollmann, Blake W. Moore, B. G. W. Arnason,
Tópico(s): Osteoarthritis Treatment and Mechanisms
1982 - Nature Portfolio | Nature
Kári Arnason, Atli Ágústsson, Hilde Fredriksen, Elis Thor Rafnsson, Kristín Briem,
Background Little is known about the influence of kinetic chain strength and power on shoulder problems in handball players or the impact of participation-related shoulder load (PSL) during a season. Suboptimal activity of the kinetic chain during throwing might make the shoulder more vulnerable. Purpose The purpose of this study was to assess 1) the association between pre-season measurements and shoulder problems among handball players and 2) whether pre-season strength and power influence the ...
Tópico(s): Musculoskeletal pain and rehabilitation
2024 - | International Journal of Sports Physical Therapy
Hákon Hákonarson, Unnur Steina Björnsdóttir, Elínborg Ostermann, T. J. Arnason, Asdis E. Adalsteinsdottir, Eva Halapi, Dana L. Shkolny, Kristleifur Kristjánsson, Sigurbjörg Anna Guðnadóttir, Michael L. Frigge, Davíð Gíslason, Þórarinn Gíslason, Augustine Kong, Jeffrey R. Gulcher, Kāri Stefánsson,
Numerous asthma and atopy loci have been reported in studies demonstrating associations of the asthma-related phenotypes atopy, elevated IgE levels, and bronchial hyperresponsiveness with alleles of microsatellite markers and single-nucleotide polymorphisms (SNPs) within specific cytokine/chemokine and IgE-regulating genes. Although the studies reporting these observations are compelling, most of them lack statistical power. We assessed the nature, pattern, and frequency of SNPs in 24 candidate genes ...
Tópico(s): Dermatology and Skin Diseases
2001 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Virginie Treyvaud Amiguet, Kari Kramp, Jinqin Mao, Calum McRae, Andrew Goulah, Linda E. Kimpe, Jules M. Blais, John T. Arnason,
This study investigated the potential of Northern shrimp (Pandelus borealis Kreyer) by-products as a source of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). The by-products (heads, shell and tail) of processing accounted for approximately 50–60% of the catch. Supercritical CO2 extraction (SFE) of the by-products at 35 MPa and 40 °C generated a deep red oil, rich in ω-3 PUFAs, specifically 7.8 ± 0.06% eicosapentaenoic acid (EPA) and 8.0 ± 0.07 % docosahexaenoic acid (DHA).
Tópico(s): Aquaculture Nutrition and Growth
2011 - Elsevier BV | Food Chemistry
Kāri Stefánsson, Linda S. Marton, Jack P. Antel, Robert L. Wollmann, Raymond P. Roos, Gregorio Chejfec, B. G. W. Arnason,
Tópico(s): Peripheral Neuropathies and Disorders
1983 - Springer Science+Business Media | Acta Neuropathologica
Martha Mullally, Christian Cayer, Kari Kramp, Marco Otárola Rojas, Pablo Sanchez Vindas, Mario Garcia, Luis Poveda Álvarez, Tony Durst, Zul Merali, Vance L. Trudeau, John T. Arnason,
The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test the hypothesis that extracts and the active principle act at the pharmacologically important GABAA-benzodiazepine (GABAA-BZD) receptor. Leaf extracts prepared by ethyl acetate extraction or supercritical extraction, previously determined to have 5.54 mg/g and 6.78 mg/g of the active principle, betulinic acid, respectively, reduced behavioural parameters associated with anxiety in a rat model. When animals ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2014 - NRC Research Press | Canadian Journal of Physiology and Pharmacology
Martha Mullally, Kari Kramp, Chris Cayer, Ammar Saleem, Fida Ahmed, Calum McRae, John P. Baker, Andrew Goulah, Marco Otorola, Pablo Sanchez, Mario Garcia, Luis Poveda, Zul Merali, Tony Durst, Vance L. Trudeau, John T. Arnason,
The purpose of this work was to develop an extraction technique to yield a betulinic acid-(BA) enriched extract of the traditional anti-anxiety plant Souroubea sympetala Gilg (Marcgraviaceae). Five extraction techniques were compared: supercritical carbon dioxide extraction (SCE), conventional solvent extraction with ethyl acetate (EtOAc), accelerated solvent extraction (ASE), ultrasonic assisted extraction (UAE) and soxhlet extraction (Sox). The EtOAc and SCE extraction methods resulted in BA-enriched ...
Tópico(s): Phytochemicals and Antioxidant Activities
2010 - Wiley | Phytotherapy Research
Kári Stéfansson, Jack P. Antei, Joël Oger, James Burns, AvertanoB. C. Noronha, Raymond P. Roos, Barry G.W. Arnason, Gunnar Guðmundsson,
Abstract Selected Properties of Peripheral blood lymphocytes (PBLs) from five ambulatory affected individuals of a kindred with autosomal dominant cerebrovascular amyloidosis were studied. The percentage of PBLs bearing surface membrane immunoglobulin (SmIg + cells) was increased in the patient group (30 ± 3% versus 20 ± 2%; p < 0.05). The Percentage of PBLs forming early and total E‐rosettes was comparable in patient and control groups. Mitogenic response to concanavalin A (Con A) was suggestively reduced ...
Tópico(s): Renal Diseases and Glomerulopathies
1980 - Wiley | Annals of Neurology
... Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Arnason, J. & D.G. Malone. 1995. Role of mast ...
Tópico(s): Click Chemistry and Applications
1999 - Wiley | Annals of the New York Academy of Sciences
Agnar Helgason, Kāri Stefánsson,
... allegation. Rather, they cite a recent article by Arnason (Arnason, 2003Arnason E Genetic heterogeneity of Icelanders.Ann Hum ... 59 (erratum 59:747): 185-203PubMed Google Scholar). Arnason (Arnason, 2003Arnason E Genetic heterogeneity of Icelanders.Ann Hum ... recorded in HVRBASE. After correcting the erroneous sequences, Arnason recalculates genetic diversity statistics presented in table 1 ... population size is materially affected by the errors” (Arnason Arnason, 2003Arnason E Genetic heterogeneity of Icelanders.Ann ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2003 - Elsevier BV | The American Journal of Human Genetics
Miriam C. Souroujon, Sara Fuchs,
... A. Burres, F. W. Fitch & B. G. W. Arnason. 1980. Nature (London) 286: 738–739. 20 Pachner, ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1986 - Wiley | Annals of the New York Academy of Sciences
Agnar Helgason, George Nicholson, Kāri Stefánsson, Peter Donnelly,
... genetic drift, and not admixture (as proposed by Arnason, 2003) is the most likely cause of the ...
Tópico(s): Genetic diversity and population structure
2003 - Wiley | Annals of Human Genetics
Kāri Stefánsson, Linda S. Marton, B. G. W. Arnason,
Acta Neurologica ScandinavicaVolume 69, Issue S98 p. 359-360 HUMORAL IMMUNE RESPONSE TO MAJOR MYELIN PROTEINS IN EXPERIMENTAL ALLERGIC NEURITIS , Department of Neurology, University of Turku, Turku, FinlandSearch for more papers by this author, Department of Neurology, University of Turku, Turku, FinlandSearch for more papers by this authorK. Stefansson, K. Stefansson Department of Neurology, University of Chicago, Chicago, IL 60637, U.S.ASearch for more papers by this authorL. S. Marton, L. S. Marton ...
Tópico(s): Vestibular and auditory disorders
2009 - Wiley | Acta Neurologica Scandinavica
Martha Mullally, Kari Kramp, Ammar Saleem, Marco Otorola Rojas, Pablo Sanchez Vindas, Mario Garcia, Luis Poveda Álvarez, Tony Durst, Vance L. Trudeau, John T. Arnason,
A rapid, two-solvent, HPLC-APCI-MS method was developed to identify and quantify four pentacyclic triterpenes (betulinic acid, ursolic acid, α-amyrin and β-amyrin) in extracts of the neotropical medicinal plant Souroubea sympetala. Analysis of plant organs, wood, bark, leaves, immature fruit and flowers, indicated that the phytochemical distribution and quantity of triterpenes varies across the plant, with betulinic acid and ursolic acid the major constituents in the bark, wood, fruit and flowers ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2008 - SAGE Publishing | Natural Product Communications