Eugenia Boulygina, Svetlana Tsygankova, Fedor Sharko, Natalia Slobodova, N. M. Gruzdeva, Sergey Rastorguev, Andrej B. Belinsky, Heinrich Härke, Anna Kadieva, Sergey Demidenko, Tatiana Shvedchikova, Maria V. Dobrovolskaya, И.К. Решетова, Dmitry S. Korobov, Artem Nedoluzhko,
The Koban archaeological culture is a well-known Northern and Central Caucasus culture that has been widely distributed throughout ... beginning of the Iron Age. Named after the Koban cemetery (Republic of North Ossetia, Russia), it had highly developed agriculture and metallurgy. The Koban culture had been dramatically transformed under the influence ... related to the origin, development, and ancestry of Koban culture due to significantly different opinions on the ... sequencing, the mitochondrial and Y-chromosomal diversity of Koban culture individuals, whose remains were excavated at the ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2020 - Elsevier BV | Journal of Archaeological Science Reports
Ina Koban, Birte Holtfreter, Nils‐Olaf Hübner, Rutger Matthes, Rabea Sietmann, E. Kindel, Klaus‐Dieter Weltmann, Alexander Welk, Axel Krämer, Thomas Kocher,
... discs in vitro – proof of principle experiment Ina Koban, Ina Koban Department of Restorative Dentistry, Periodontology and Endodontology, Unit ... GermanySearch for more papers by this author Ina Koban, Ina Koban Department of Restorative Dentistry, Periodontology and Endodontology, Unit ... Arndt University GreifswaldWalther-Rathenau-Straße 49a17487 GreifswaldGermanyEmail: ina.koban@uni-greifswald.de Conflicts of interest and source ... Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Koban I, Holtfreter B, Hübner N-O, Matthes R, ...
Tópico(s): Endodontics and Root Canal Treatments
2011 - Wiley | Journal Of Clinical Periodontology
... system, and its solution. Study of the Japanese koban, or police box, reveals the ways in which ... 2-year period investigated the ways in which koban both ‘take place’, as built forms within public ...
Tópico(s): Law in Society and Culture
2021 - SAGE Publishing | Crime Media Culture An International Journal
Leonie Koban, Peter J. Gianaros, Hedy Kober, Tor D. Wager,
... the self, illness and treatment. In this Perspective, Koban, Gianaros, Kober and Wager describe neural systems that ...
Tópico(s): Mental Health and Psychiatry
2021 - Nature Portfolio | Nature reviews. Neuroscience
Dmitry S. Korobov, А. В. Борисов,
... fields, associated with material and settlements of the Koban culture, culminated in over-exploitation of the land ... They largely avoided the areas rendered infertile by Koban period overexploitation. The morphology and chronology of the ...
Tópico(s): Ancient Mediterranean Archaeology and History
2013 - Cambridge University Press | Antiquity
Kazuhiko Ninomiya, T. Nagatomo, K. Kubo, P. Strasser, N. Kawamura, K. Shimomura, Yasuhiro Miyake, Tsutomu Saito, Wataru Higemoto,
... muon facility. We performed muon irradiation for Tempo-koban (Japanese old coin) for test experiment of elemental ... gold atoms were identified. The contents of Tempo-koban (Au:56%) was determined by muonic X-ray ...
Tópico(s): Particle Detector Development and Performance
2010 - IOP Publishing | Journal of Physics Conference Series
D. W. Hatcher, SangGuan You, J.E. Dexter, Clayton G. Campbell, Marta S. Izydorczyk,
... cross-pollinating common buckwheat (Fagopyrum esculentum Moench) varieties, Koban and Koto, and two self-pollinating lines, BR01 ... exhibited comparable milling and soba noodle properties to Koban. Koto exhibited slightly higher white flour yield and ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2007 - Elsevier BV | Food Chemistry
Koban: Neighbourhood Policing in Contemporary Japan Frank Leishman Frank Leishman * Department of Natural and Social Sciences, University ...
Tópico(s): Crime Patterns and Interventions
2007 - Oxford University Press | Policing A Journal of Policy and Practice
Hans Günter Koban, E. Koberstein,
... under physiological conditions of pH and temperatureHans G. Koban and Edgar KobersteinCite this: J. Agric. Food Chem. ...
Tópico(s): Enzyme Catalysis and Immobilization
1984 - American Chemical Society | Journal of Agricultural and Food Chemistry
Leonie Koban, Sangil Lee, Daniela S. Schelski, Marie‐Christine Simon, Caryn Lerman, Bernd Weber, Joseph W. Kable, Hilke Plaßmann,
Individual differences in delay discounting—how much we discount future compared to immediate rewards—are associated with general life outcomes, psychopathology, and obesity. Here, we use machine learning on fMRI activity during an intertemporal choice task to develop a functional brain marker of these individual differences in human adults. Training and cross-validating the marker in one dataset (Study 1, N = 110 male adults) resulted in a significant prediction–outcome correlation ( r = 0.49), generalized ...
Tópico(s): Blood Pressure and Hypertension Studies
2023 - Society for Neuroscience | Journal of Neuroscience
Leonie Koban, Tor D. Wager, Hedy Kober,
Craving is a core feature of substance use disorders. It is a strong predictor of substance use and relapse and is linked to overeating, gambling, and other maladaptive behaviors. Craving is measured via self-report, which is limited by introspective access and sociocultural contexts. Neurobiological markers of craving are both needed and lacking, and it remains unclear whether craving for drugs and food involve similar mechanisms. Across three functional magnetic resonance imaging studies (n = 99), ...
Tópico(s): Neural and Behavioral Psychology Studies
2022 - Nature Portfolio | Nature Neuroscience
Lada Kohoutová, Lauren Y. Atlas, Christian Büchel, Jason T. Buhle, Stephan Geuter, Marieke Jepma, Leonie Koban, Anjali Krishnan, Dong Hee Lee, Sungwoo Lee, Mathieu Roy, Scott M. Schafer, Liane Schmidt, Tor D. Wager, Choong‐Wan Woo,
Characterizing cerebral contributions to individual variability in pain processing is crucial for personalized pain medicine, but has yet to be done. In the present study, we address this problem by identifying brain regions with high versus low interindividual variability in their relationship with pain. We trained idiographic pain-predictive models with 13 single-trial functional MRI datasets (n = 404, discovery set) and quantified voxel-level importance for individualized pain prediction. With 21 ...
Tópico(s): Musculoskeletal pain and rehabilitation
2022 - Nature Portfolio | Nature Neuroscience
Pedro Franco, Ritesh Jain, Elizabeth Rosenkrands-Lange, Claudia Hey, M. Koban,
Abstract Regulators and pharmaceutical companies across the world are intensifying efforts to get increasingly complex and innovative drugs to patients with high unmet medical need in the shortest possible time frame. This article reviews pathways to expedite drug development and approval available in member countries of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use and Australia. It is concluded that the increasing availability of expedited ...
Tópico(s): Pharmaceutical studies and practices
2022 - Springer Science+Business Media | Therapeutic Innovation & Regulatory Science
Zhouxiao Li, Konstantin Christoph Koban, Thilo L. Schenck, Riccardo E. Giunta, Qingfeng Li, Yangbai Sun,
Background: Thanks to the rapid development of computer-based systems and deep-learning-based algorithms, artificial intelligence (AI) has long been integrated into the healthcare field. AI is also particularly helpful in image recognition, surgical assistance and basic research. Due to the unique nature of dermatology, AI-aided dermatological diagnosis based on image recognition has become a modern focus and future trend. Key scientific concepts of review: The use of 3D imaging systems allows clinicians ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2022 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Carmen Ranftler, Dietmar Nagl, Andreas Sparer, Andreas Röhrich, Michael Freissmuth, Ali El‐Kasaby, S. Nasrollahi Shirazi, Florian Koban, Cornelius Tschegg, Stéphane Nizet,
Clostridioides difficile (C . difficile) infection is a major public health problem worldwide. The current treatment of C . difficile -associated diarrhea relies on the use of antibacterial agents. However, recurrences are frequent. The main virulence factors of C . difficile are two secreted cytotoxic proteins toxin A and toxin B. Alternative research exploring toxin binding by resins found a reduced rate of recurrence by administration of tolevamer. Hence, binding of exotoxins may be useful in preventing ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2021 - Public Library of Science | PLoS ONE
Anja Stević, Kevin Koban, Alice Binder, Jörg Matthes,
Due to ‘stay-at-home’ measures, individuals increasingly relied on smartphones for social connection and for obtaining information about the COVID-19 pandemic. In a two-wave panel survey ( N Time2 = 416), we investigated associations between different types of smartphone use (i.e., communicative and non-communicative), friendship satisfaction, and anxiety during the first lockdown in Austria. Our findings revealed that communicative smartphone use increased friendship satisfaction over time, validating ...
Tópico(s): Digital Marketing and Social Media
2021 - SAGE Publishing | Mobile Media & Communication
Hilke Plaßmann, Daniela S. Schelski, Marie‐Christine Simon, Leonie Koban,
Everyday dietary decisions have important short-term and long-term consequences for health and well-being. How do we decide what to eat, and what physiological and neurobiological systems are involved in those decisions? Here, we integrate findings from thus-far separate literatures: (a) the cognitive neuroscience of dietary decision-making, and (b) growing evidence of gut-brain interactions and especially influences of the gut microbiome on diet and health outcomes. We review findings that suggest ...
Tópico(s): Diet and metabolism studies
2021 - Wiley | Wiley Interdisciplinary Reviews Cognitive Science
Kevin Koban, Ariadne Neureiter, Anja Stević, Jörg Matthes,
Considering that insufficient sleep has long been regarded as a significant public health challenge, the COVID-19 pandemic and its co-evolving infodemic have further aggravated many people's sleep health. People's engagement with pandemic-related news, particularly given that many people are now permanently online via smartphones, has been identified as a critical factor for sleep health, such that public health authorities have recommended limited news exposure. This two-wave panel survey, conducted ...
Tópico(s): Psychological and Temporal Perspectives Research
2021 - Elsevier BV | Computers in Human Behavior
Xiaochun Han, Yoni K. Ashar, Philip A. Kragel, Bogdan Petre, Victoria Schelkun, Lauren Y. Atlas, Luke J. Chang, Marieke Jepma, Leonie Koban, Elizabeth A. Reynolds Losin, Mathieu Roy, Choong‐Wan Woo, Tor D. Wager,
Identifying biomarkers that predict mental states with large effect sizes and high test-retest reliability is a growing priority for fMRI research. We examined a well-established multivariate brain measure that tracks pain induced by nociceptive input, the Neurologic Pain Signature (NPS). In N = 295 participants across eight studies, NPS responses showed a very large effect size in predicting within-person single-trial pain reports (d = 1.45) and medium effect size in predicting individual differences ...
Tópico(s): Musculoskeletal pain and rehabilitation
2021 - Elsevier BV | NeuroImage
Jörg Matthes, Kevin Koban, Ariadne Neureiter, Anja Stević,
Given that governmental prevention measures restricted most face-to-face communications, online self-disclosure via smartphones emerged as an alternative coping strategy that aimed at reducing the impact of the COVID-19 pandemic on people's psychological health. Prepandemic research demonstrated that online self-disclosure benefits people's psychological health by establishing meaningful relationships, obtaining social support, and achieving self-acceptance, particularly in times of crisis. However, ...
Tópico(s): Psychological and Temporal Perspectives Research
2021 - JMIR Publications | Journal of Medical Internet Research
Lanlan Zhang, Elizabeth A. Reynolds Losin, Yoni K. Ashar, Leonie Koban, Tor D. Wager,
Abstract Caregiving and other interpersonal interactions often require accurate perception of others' pain from nonverbal cues, but perceivers may be subject to systematic biases based on gender, race, and other contextual factors. Such biases could contribute to systematic under-recognition and undertreatment of pain. In 2 experiments, we studied the impact of perceived patient sex on lay perceivers' pain estimates and treatment recommendations. In Experiment 1 (N = 50), perceivers viewed facial video clips ...
Tópico(s): Healthcare professionals’ stress and burnout
2021 - Elsevier BV | Journal of Pain
Kevin Koban, Jonathan Biehl, Julian Bornemeier, Peter Ohler,
Based on the general assumption that even problematic behaviours are associated with an inherently health-promoting motivation to cope with unpleasant or unsatisfying life situations, the compensatory model of media use focuses on how psychosocial vulnerabilities moderate links between media behaviours and adverse outcomes. The present paper means to further develop this approach by exploring the moderating role of state- and trait-level factors (state: perceived stress; trait: social interaction ...
Tópico(s): Child Development and Digital Technology
2021 - Taylor & Francis | Behaviour and Information Technology
Hongbo Yu, Leonie Koban, Luke J. Chang, Ullrich Wagner, Anjali Krishnan, Patrik Vuilleumier, Xiaolin Zhou, Tor D. Wager,
Feeling guilty when we have wronged another is a crucial aspect of prosociality, but its neurobiological bases are elusive. Although multivariate patterns of brain activity show promise for developing brain measures linked to specific emotions, it is less clear whether brain activity can be trained to detect more complex social emotional states such as guilt. Here, we identified a distributed guilt-related brain signature (GRBS) across two independent neuroimaging datasets that used interpersonal ...
Tópico(s): Neural and Behavioral Psychology Studies
2020 - Oxford University Press | Cerebral Cortex
Konstantin Christoph Koban, Lucas Etzel, Zhouxiao Li, Montserrat Pazos, Stephan Schönecker, Claus Belka, Riccardo E. Giunta, Thilo L. Schenck, Stefanie Corradini,
Abstract Background Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we are still missing effective tools, which can objectively and reproducibly assess and document adverse events in breast cancer radiotherapy within the framework of clinical studies. The aim of the present study was to apply structured-light technology as a non-invasive and objective ...
Tópico(s): Breast Lesions and Carcinomas
2020 - BioMed Central | Radiation Oncology
Sascha Grobe, Christoffel P. S. Badenhorst, Thomas Bayer, Emil Hamnevik, Shuke Wu, Christoph W. Grathwol, Andreas Link, Sven Koban, Henrike Brundiek, Beatrice Großjohann, Uwe T. Bornscheuer,
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo- and regioselective 7β-hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydroxylate testosterone at the 7β-position but LCA is exclusively hydroxylated at the 6β-position, forming murideoxycholic acid (MDCA). Structural and 3DM analysis, and molecular docking were used to identify amino acid residues F84, S240, and V291 as specificity- ...
Tópico(s): Hormonal Regulation and Hypertension
2020 - Wiley | Angewandte Chemie International Edition
Stephan Geuter, Elizabeth A. Reynolds Losin, Mathieu Roy, Lauren Y. Atlas, Liane Schmidt, Anjali Krishnan, Leonie Koban, Tor D. Wager, Martin A Lindquist,
The brain transforms nociceptive input into a complex pain experience comprised of sensory, affective, motivational, and cognitive components. However, it is still unclear how pain arises from nociceptive input and which brain networks coordinate to generate pain experiences. We introduce a new high-dimensional mediation analysis technique to estimate distributed, network-level patterns that formally mediate the relationship between stimulus intensity and pain. We applied the model to a large-scale ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2020 - Oxford University Press | Cerebral Cortex
Linus Früh, Helge Kampen, Marcel B. Koban, Nadja Pernat, Günter A. Schaub, Doreen Werner,
Abstract Background Aedes japonicus japonicus , first detected in Europe in 2000 and considered established in Germany 10 years later, is of medical importance due to its opportunistic biting behaviour and its potential to transmit pathogenic viruses. Its seasonal phenology, temperature and land use preference related to oviposition in newly colonised regions remain unclear, especially in the context of co-occurring native mosquito species. Methods Focussing on regions in Germany known to be infested ...
Tópico(s): Viral Infections and Vectors
2020 - BioMed Central | Parasites & Vectors
Jane Moseley, Spiros Vamvakas, Michael Berntgen, Alison Cave, Xavier Kurz, Peter Arlett, Virginia Acha, Simon Bennett, Catherine Cohet, Solange Corriol‐Rohou, Emma Du Four, Christelle Lamoril, Anja Langeneckert, M. Koban, Muriel Pasté, Susan Sandler, Karin Van Baelen, Agnese Cangini, Sonia García, Mercè Obach, Emmanuel Gimenez Garcia, Leonor Varela‐Lema, Hanna‐Mari Jauhonen, Piia Rannanheimo, Deborah Morrison, Marc Van de Casteele, Anna Strömgren, Anders Viberg, Amr Makady, C Guilhaume,
The understanding of the benefit risk profile, and relative effectiveness of a new medicinal product, are initially established in a circumscribed patient population through clinical trials. There may be uncertainties associated with the new medicinal product that cannot be, or do not need to be resolved before launch. Postlicensing or postlaunch evidence generation (PLEG) is a term for evidence generated after the licensure or launch of a medicinal product to address these remaining uncertainties. ...
Tópico(s): Intellectual Property and Patents
2020 - Wiley | British Journal of Clinical Pharmacology
Marina López‐Solà, Stephan Geuter, Leonie Koban, James A. Coan, Tor D. Wager,
Abstract Supportive touch has remarkable benefits in childbirth and during painful medical procedures. But does social touch influence pain neurophysiology, ie, the brain processes linked to nociception and primary pain experience? What other brain processes beyond primary pain systems mediate their analgesic effects? In this study, women (N = 30) experienced thermal pain while holding their romantic partner's hand or an inert device. Social touch reduced pain and attenuated functional magnetic resonance ...
Tópico(s): Pain Management and Placebo Effect
2019 - Lippincott Williams & Wilkins | Pain
Ali El‐Kasaby, Ameya Kasture, Florian Koban, Matej Hoťka, Hafiz Muhammad Mazhar Asjad, Helmut Kubista, Michael Freissmuth, Sonja Sučić,
Diseases arising from misfolding of SLC6 transporters have been reported over recent years, e.g. folding-deficient mutants of the dopamine transporter and of the glycine transporter-2 cause infantile/juvenile Parkinsonism dystonia and hyperekplexia, respectively. Mutations in the coding sequence of the human creatine transporter-1 (hCRT-1/SLC6A8) gene result in a creatine transporter deficiency syndrome, which varies in its clinical manifestation from epilepsy, mental retardation, autism, development ...
Tópico(s): Ion channel regulation and function
2019 - Elsevier BV | Neuropharmacology