Jonathan P. Piccini, Valeria Caso, Stuart J. Connolly, Keith A.A. Fox, Jonas Oldgren, W. Schuyler Jones, Diana A. Gorog, Václav Durdil, Thomas Viethen, Christoph Neumann, Hardi Mundl, Manesh R. Patel, Johann Auer, Martin Hubauer, Sead Pandzic, Eva Preishuber, Carina Primus-Grabscheit, Dietmar Reitgruber, Florian Schmalzer, Christopher Adlbrecht, Andreas Schober, Johannes Hajos, Christoph Keil, Alexandra Schratter, Matthias Frick, Magdalena Benda, Maximilian Mächler, Beatrix Mutschlechner, Christoph H. Saely, Lukas Sprenger, Michael Lichtenauer, Miriam Eber, Uta C. Hoppe, Tobias Kolbitsch, Peter Jirak, Moritz Mirna, Robert Schönbauer, Jutta Bergler‐Klein, Christian Hengstenberg, Stefan Stojković, Douglas S. Scherr, M Manninger-Wünscher, Ursula Rohrer, Markus Stühlinger, Wilfried Schgoer, Jana M. Schwarzl, Helmut Pürerfellner, Michael Derndorfer, Christian Ebner, Veronika Eder, Γεώργιος Κόλλιας, Thomas Sturmberger, Stefan Sieghartsleitner, Johan Vijgen, Peter Koopman, Karl Dujardin, Wim Anné, Michel de Ceuninck, René Tavernier, Mattias Duytschaever, Sébastien Knecht, Luc Missault, Yves Vandekerckhove, Tom Rossenbacker, Bavo Ector, Filip Charlier, Philippe Debruyne, Willem Dewilde, Luc Janssens, John Roosen, Bart Vankelecom, Hein Heidbüchel, Michiel Delesie, G. M. M. Vervoort, Hans Rombouts, Thomas Vanassche, Matthias M. Engelen, Peter Verhamme, Rik Willems, Christian Constance, Nicolas Pranno, Jafna L. Cox, Iqbal Bata, Laurent Macle, Martín Aguilar, J. Tourigny, Marc Dubuc, Katia Dyrda, Peter G. Guerra, Paul Khairy, Blandine Mondésert, Léna Rivard, Denis Roy, Rafik Tadros, Mario Talajic, Bernard Thibault, Isabelle Nault, L. Blier, Jean Champagne, Franck Molin, Gilles O’Hara, François Philippon, Benoît Plourde, J. Sarrazin, Christian E. W. Steinberg, Zdeněk Coufal, David Balazsik, M Mikulica, Jakub Zápeca, Ondřej Čermák, Tomas Drasnar, Matej Falc, Josef Hornof, Blazej Racz, Danica Weissova, Hana Línková, Eva Pašková, Róbert Petr, Andrea Širáková, Jiří Kettner, Ales Benak, Martin Holek, Ivo Podpera, Monika Podperova, V. Vančura, Tomas Jandik, Jiři Šmı́d, Vratislav Dedek, J. Banik, Václav Durdil, Tomáš Hnát, Nicolas Lellouche, Ségolène Rouffiac, Guillaume Taldir, Valentin Bridonneau, Philippe Couffon, M. Daudin, Cécile Hamon, Jonathan Lacaze, A Quentin, Christophe Thébault, Emmanuel Boiffard, Olivier Billon, Fabien Miette, Hervé Pouliquen, Guillaume Turlotte, Hervé Gorka, Franck Albert, Sandrine Bayle, R. Bensaid, Madalina Dasoveanu, Thibaud Demichili, Téodora Dutoiu, Cliff Khalil, Caterina Loghin, Grégoire Range, Laurent Roussel, Pierre Socié, Christophe Thuaire, Fabrice Extramiana, Vincent Algalarrondo, Haten Boughanmi, Noreddine El Mansour, Usman Mohammad, Romain Sellier, Meyer Elbaz, Clémence Laperche, Philippe Maury, Róbert Gábor Kiss, Tünde Borsányi, Zoltán Gingl, Balaza Polgar, Béla Benczúr, A. Bodor, Tamas Hepp, Éva Maláti, László Nagy, Norbert Erdei, Jozsef Kapus, Katalin Kapus, Brigitta Tóth, Andras Matoltsy, Tunde Kiss, Béla Merkely, Szilvia Herczeg, Orsolya Kiss, Zoltán Salló, Kálmán Tóth, Tamás Habon, Miklós Rábai, Kinga Tótsimon, Z Zilahi, G. Bencze, János Sánta, Dániel Aradi, Barbara Kelemen, Leonardo Bolognese, Martina Nesti, Pasquale Notarstefano, Simona D’Orazio, Franco Cosmi, Cecilia Becattini, Giancarlo Agnelli, Belinda Broccatelli, Maria Giulia Mosconi, Maurizio Paciaroni, Chiara Urbini, Vito Maurizio Parato, Camilla Notaristefani, Michele Scarano, Pietro Ameri, G. Ghigliotti, Giulia Guglielmi, Roberta Lotti, Andrea Merlo, María Lorenza Muiesan, Andrea Abondio, Caterina Berasi, Elena Mattiuzzo, Claudio Mutti, Massimo Salvetti, Pasquale Pignatelli, Danilo Menichelli, Daniele Pastori, Eiji Tamiya, Takahiro Μatsumoto, Tomosato Takabe, Shoichi Yamamoto, Haruyo Yamashita, Shinichi Higashiue, Onichi Furuya, Norihiko Hiramatsu, Kensuke Kasuga, Saburo Kojima, Masatoshi Komooka, Satoshi Kuroyanagi, Makoto Matsuura, Tetsushi Takemoto, Shuji Yamamoto, Katusmi Saito, Takuro Abe, Issei Ishida, Yuji Iwanami, Shohei Kataoka, Tetsu Moriyama, Akira Murohashi, Akihito Sasaki, Yuichiro Nakamura, Tetsuya Ueno, Akira Shimane, Tomoyo Hamana, Hirotoshi Ichibori, Tomohiro Inoue, Mitsuaki Itoh, Seigo Iwane, Hiroya Kawai, Tatsuya Kokawa, Akiko Masumoto, Koki Matsuo, Taishi Miyata, Shinsuke Nakano, Shogo Oishi, Tetsuari Onishi, Takahiro Sawada, Takayuki Saito, Mitsuhiko Shoda, Nobuyuki Takahashi, Tomofumi Takaya, Yasuyo Taniguchi, Shota Tsukamoto, Yasue Tsukishiro, Yoshiro Tsukiyama, Hiroshi Tsunamoto, Kenzo Uzu, Hiroyuki Yamamoto, Tetsuya Yamamoto, Kiminobu Yokoi, Chiaki Yoshida, Nobuhiro Watanabe, Tetsuo Betsuyaku, Kumiko Adachi, Kouichi Awane, Daisuke Goto, Mamoru Sakakibara, Masashi Watanabe, Hideki Ueno, Yoshitaka Hiroe, Koshi Matsuo, K. Ayata, Ko Fukuda, Yoshiki Hata, Katsushi Hashimoto, Hiroaki Matsumi, Akira Nikaido, Shuichi Okamoto, Iveta Sime,
Direct-acting oral anticoagulant use for stroke prevention in atrial fibrillation is limited by bleeding concerns. Asundexian, a novel, oral small molecule activated coagulation factor XIa (FXIa) inhibitor, might reduce thrombosis with minimal effect on haemostasis. We aimed to determine the optimal dose of asundexian and to compare the incidence of bleeding with that of apixaban in patients with atrial fibrillation.In this randomised, double-blind, phase 2 dose-finding study, we compared asundexian ...
Elsevier BV
Masaaki Miyata, Koki Matsushita, Ryunosuke Shindo, Yutaro Shimokawa, Yoshimasa Sugiura, Michiaki Yamashita,
Selenoneine is a novel organic selenium compound markedly found in the blood, muscles, and other tissues of fish. This study aimed to determine whether selenoneine attenuates hepatocellular injury and hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD). Mice lacking farnesoid X receptor (FXR) were used as a model for fatty liver disease, because they exhibited hepatomegaly, hepatic steatosis, and hepatic inflammation. Fxr-null mice were fed a 0.3 mg Se/kg selenoneine-containing ...
Tópico(s): Trace Elements in Health
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Seiji Naganuma, Hiroshi Itoh, Shuichiro Uchiyama, Hiroyuki Tanaka, Koki Nagaike, Shiro Miyata, Shunro Uchinokura, Yoshitsugu Nuki, Yutaka Akiyama, Kazuo Chijiiwa, Hiroaki Kataoka,
We previously reported a novel small gene, designated hepatocyte growth factor activator inhibitor type 2 (HAI-2) related small peptide (H2RSP), in the process of the search for splicing variant forms of HAI-2 by 3′-rapid amplification of cDNA ends method [Biochem. Biophys. Res. Commun. 288 (2001) 390]. Human H2RSP gene consisted of four exons spanning approximately 1 kbp and was located in 11 kbp downstream of HAI-2 gene. In this study, we cloned and characterized the mouse counterpart of H2RSP gene, ...
Tópico(s): Peptidase Inhibition and Analysis
2003 - Elsevier BV | Biochemical and Biophysical Research Communications
Shuhei Nomura, Akifumi Eguchi, Daisuke Yoneoka, Takayuki Kawashima, Yuta Tanoue, Michio Murakami, Haruka Sakamoto, Keiko Maruyama‐Sakurai, Stuart Gilmour, Shoi Shi, Hiroyuki Kunishima, Satoshi Kaneko, Megumi Adachi, Koki Shimada, Yoshiko Yamamoto, Hiroaki Miyata,
Identifying and understanding reasons for being unsure or unwilling regarding intention to be vaccinated against coronavirus disease (COVID-19) may help to inform future public health messages aimed at increasing vaccination coverage. We analyzed a broad array of individual's psychological dispositions with regard to decision-making about COVID-19 vaccination in Japan.A nationally representative cross-sectional web survey was conducted with 30053 Japanese adults aged 20 years or older at the end ...
Tópico(s): Misinformation and Its Impacts
2021 - Elsevier BV | The Lancet Regional Health - Western Pacific
Daisuke Yoneoka, Akifumi Eguchi, Shuhei Nomura, Takayuki Kawashima, Yuta Tanoue, Michio Murakami, Haruka Sakamoto, Keiko Maruyama‐Sakurai, Stuart Gilmour, Shoi Shi, Hiroyuki Kunishima, Satoshi Kaneko, Megumi Adachi, Koki Shimada, Yoshiko Yamamoto, Hiroaki Miyata,
Optimizing media campaigns for those who were unsure or unwilling to take coronavirus disease (COVID-19) vaccines is required urgently to effectively present public health messages aimed at increasing vaccination coverage. We propose a novel framework for selecting tailor-made media channels and their combinations for this task.An online survey was conducted in Japan during February to March, 2021, with 30,053 participants. In addition to their sociodemographic characteristics, it asked the attitude ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2021 - Elsevier BV | The Lancet Regional Health - Western Pacific
Koki Tabata, Kanji Miyata, Norihiro Yuasa, Eiji Takeuchi, Yasutomo Goto, Yoichiro Kobayashi,
症例は77歳，女性．1997年，他院で左腎癌にて左腎臓摘出術を施行され，2005年，CTで左下腹部腫瘤を指摘された．2007年1月，腫瘤の精査・加療のため当科を受診した．CTでは小腸に接する直径5cmの球形の腫瘤を認めた．FDG-PETにて腫瘤はSUV=4.5と高集積を示したが，中心には集積を認めずリング状を呈した．小腸GISTを最も疑い小腸部分切除を行った．腫瘤は小腸間膜に主座を有し，硬く，割面では厚い被膜をもち中心は壊死状であった．病理組織学的に腫瘤内に線維性異物を認め，それに対する反応性の組織球，異物巨細胞の集簇から成る異物肉芽腫と診断された．腹腔内異物肉芽腫の術前診断には病歴，超音波，CT所見に加えてFDG-PETにおける集積形態，リング状集積に注意すべきである．
Tópico(s): Foreign Body Medical Cases
2009 - Japan Surgical Association | Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
Susumu Hara, Koki Nakagami, Kikuko Miyata, Mitsuo Tsuchiya, Eiichirou Tsujii,
Recently, extensive studies have focused on realizing novel mobility technologies, with special consideration for the aging society.The primary aim of these studies is to establish autonomous driving technology (ADT).Mainly, the objects of ADT are four-wheel motor vehicles, and new technologies are investigated from various viewpoints such as vehicle development and infrastructure improvements.However, ADT for motorcycles has received scant attention.In Japan, the motorcycle mortality rate is approximately ...
Tópico(s): Autonomous Vehicle Technology and Safety
2020 - Japan Society Mechanical Engineers | Journal of Advanced Mechanical Design Systems and Manufacturing
Hiroyuki Tanaka, Koki Nagaike, Naoki Takeda, Hiroshi Itoh, Kazuyo Kohama, Tsuyoshi Fukushima, Shiro Miyata, Shuichiro Uchiyama, Shunro Uchinokura, Takeshi Shimomura, Keiji Miyazawa, Naomi Kitamura, Gen Yamada, Hiroaki Kataoka,
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-associated Kunitz-type serine proteinase inhibitor that was initially identified as a potent inhibitor of hepatocyte growth factor activator. HAI-1 is also a cognate inhibitor of matriptase, a membrane-associated serine proteinase. HAI-1 is expressed predominantly in epithelial cells in the human body. Its mRNA is also abundant in human placenta, with HAI-1 specifically expressed by villous cytotrophoblasts. In order to address ...
Tópico(s): Liver physiology and pathology
2005 - Taylor & Francis | Molecular and Cellular Biology
Hikaru Tanaka, Haruko Masumiya, Toshiyuki Sekine, Junya Kase, Toru Kawanishi, Takao Hayakawa, Setsuya Miyata, Yoichi Sato, Ryu Nakamura, Koki Shigenobu,
Two-dimensional and line-scan analyses of the early phase Ca2+ transients in rat cardiomyocytes were performed with a rapid-scanning laser confocal microscope and fluo-3 to elucidate the mechanism of activation of Ca2+ release from the sarcoplasmic reticulum in atrial myocytes which lack a well developed T-tubular network. On electrical stimulation of ventricular myocytes, Ca2+ concentration began to rise earliest at the Z-line level and became uniform throughout the cytoplasm within about 10 msec. ...
Tópico(s): Ion channel regulation and function
2001 - Elsevier BV | Life Sciences
Kazutaka Mukai, Hajime Ohmura, Yuji Takahashi, Yusaku Ebisuda, Koki Yoneda, Hirofumi Miyata,
The purpose of this study was to determine whether acute high-intensity interval exercise or sprint interval exercise induces greater physiological and skeletal muscle responses compared to moderate-intensity continuous exercise in horses.In a randomized crossover design, eight trained Thoroughbred horses performed three treadmill exercise protocols consisting of moderate-intensity continuous exercise (6 min at 70% VO2max; MICT), high-intensity interval exercise (6 × 30 s at 100% VO2max; HIIT), and ...
Tópico(s): Exercise and Physiological Responses
2023 - Frontiers Media | Frontiers in Veterinary Science
Takeshi Yamada, Hideki Endo, Hiroshi Hasegawa, Yoshihiro Kakeji, Hiroyuki Yamamoto, Hiroaki Miyata, Koki Otsuka, Akihisa Matsuda, Hiroshi Yoshida, Yuko Kitagawa,
Abstract Background Anemia has negative effects on long‐term outcomes of rectal cancer patients; however, its status as a risk factor for severe complications is disputed. Perioperative risks may differ based on the severity of pre‐surgical anemia; nonetheless, no previous study has investigated these differences. This study identified risks of severe postoperative complications in rectal cancer patients based on severity of their pre‐surgical anemia. Materials and Methods This study enrolled patients ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2024 - Wiley | Annals of Gastroenterological Surgery
Keigo Kimura, Yoshitsugu Inoue, Seishi Asari, Atsuko Sunada, Yuichi Ohashi, Yoshikazu Shimomura, Chie Sotozono, Koji Hatano, Masahiko Fukuda, Hiroshi Eguchi, Kaoru Araki‐Sasaki, Takashi Suzuki, Saichi Hoshi, Toru Tobe, Takashi Yaguchi, Koichi Makimura, Yoshitsugu Tagawa, Hidetaka Shunji MasaharaYokokura, Megumi Uematsu, Hiroyuki Namba, Daisuke Todokoro, Tetsuro Oshika, Yuichi Kaji, Hiroto Obata, Shiro Amano, Takashi Miyai, Masahiko Usui, Hiroshi Gotô, Shigeto Kumakura, Etsuko Takamura, Kazumi Shinozaki, Masakazu Yamada, Chika Shigeyasu, Noriko Inada, Mitsuru Sawa, Manabu Mochizuki, Kei Morohoshi, Tairo Kimura, Hisashi Nakagawa, Norio Usui, Koji Hatano, Saichi Hoshi, Kazuko Kitagawa, Kiyofumi Mochizuki, Shigeru Kinoshita, Chie Sotozono, Naoyuki Maeda, Takeshi Soma, Hisataka Fujimoto, Yoshikazu Shimomura, Masahiko Fukuda, Yoshitsugu Inoue, Dai Miyazaki, Tai-ichiro Chikama, Koh-Hei Sonoda, Naoyuki Morishige, Hiroshi Eguchi, Tatsuro Miyamoto, Hiroshi Shiota, Yuichi Ohashi, Toshihiko Uno, Atsushi Shiraishi, Takashi Suzuki, Shigeki Okamoto, Tamaki Sumi, Eiichi Uchio, M. Ozawa, Kaoru Araki‐Sasaki, Naoki Kumagai, Koki Matsumoto, Yu Monden, Masafumi Uematsu, Kazunori Miyata, Ryohei Nejima, Seishi Asari, Atsuko Sunada, Keigo Kimura, Takashi Yaguchi, Koichi Makimura,
To determine the effects of a combination of two antifungal drugs against causative fungi of fungal keratitis in Japan.Multicenter prospective observational study.Eighteen isolates of yeast-like fungi and 22 isolates of filamentous fungi collected by the Multicenter Prospective Observational Study of Fungal Keratitis in Japan were studied. Specially manufactured minimum inhibitory concentration (MIC) measurement plates were used to test the effectiveness of 10 combinations of two antifungal drugs ...
Tópico(s): Fungal Infections and Studies
2022 - Springer Science+Business Media | Japanese Journal of Ophthalmology
Hiroshi Itoh, Seiji Naganuma, Naoki Takeda, Shiro Miyata, Shunro Uchinokura, Tsuyoshi Fukushima, Shuichiro Uchiyama, Hiroyuki Tanaka, Koki Nagaike, Takeshi Shimomura, Keiji Miyazawa, Gen Yamada, Naomi Kitamura, Masashi Koono, Hiroaki Kataoka,
Hepatocyte growth factor activator (HGFA) is a serum proteinase that specifically converts an inactive single-chain form of hepatocyte growth factor (HGF) into an active 2-chain form. HGFA is produced in its precursor form and then activated in injured tissues. To address the precise role of HGFA and to investigate the mechanisms of HGF activation in injured tissues, we generated mice deficient in HGFA.HGFA-deficient mice were generated using targeted gene disruption. The regenerating process of intestinal ...
Tópico(s): Pancreatic function and diabetes
2004 - Elsevier BV | Gastroenterology
Yuki Higashimoto, Masaru Ihira, Yu Miyazaki, Ayumi Kuboshiki, Sayaka Yoshinaga, Hiroyuki Hiramatsu, Ryota Suzuki, Masafumi Miyata, Hiroki Miura, Satoshi Komoto, Jun Yukitake, Koki Taniguchi, Yoshiki Kawamura, Tetsushi Yoshikawa,
RotaTeq (RV5) is a widely used live attenuated pentavalent rotavirus (RV) vaccine. Although fecal shedding of RV vaccine strains persists for long time periods, it is unclear how each vaccine strain replicates in intestinal tissue and is excreted in stool. To examine this issue, we established RV5 genotype-specific real-time reverse transcription-PCR (RT-PCR) assays. Five real-time RT-PCR assays were designed for the VP7 gene in genotypes G1, G2, G3, G4, and G6. All assays exhibited excellent linearity, ...
Tópico(s): Animal Virus Infections Studies
2018 - American Society for Microbiology | Journal of Clinical Microbiology
Koki Shimada, Hiroyuki Yamamoto, Eiji Nakatani, Hiraku Kumamaru, Shiori Nishimura, Nao Ichihara, Norimichi Hirahara, Kiyoshi Mori, Masato Kotani, Yoshiki Miyachi, Hiroaki Miyata,
Objective The incidence of type 1 diabetes mellitus (T1DM) and hypothyroidism as immune-related adverse events (irAEs) after programmed cell death-1 inhibitor (PD-1i) administration has not yet been sufficiently evaluated in a real clinical setting. To assess the incidence of T1DM and hypothyroidism among PD-1is and to identify the risk factors associated with hypothyroidism using a large claims database. Methods This cohort study used the Shizuoka Kokuho database in Japan from 2012 to 2018, including ...
Tópico(s): COVID-19 and healthcare impacts
2020 - Elsevier BV | Endocrine Practice
Hiroyuki Hiramatsu, Ryota Suzuki, Arisa Nagatani, Hiroko Boda, Masafumi Miyata, Fumihiko Hattori, Hiroki Miura, Ken Sugata, Shigeki Yamada, Satoshi Komoto, Koki Taniguchi, Masaru Ihira, Naoko Nishimura, Takao Ozaki, Tetsushi Yoshikawa,
This study was conducted to assess the transmissibility of rotavirus vaccine strains after rotavirus vaccination in a neonatal intensive care unit (NICU).Pentavalent (RV5) or monovalent (RV1) rotavirus vaccine was administered to infants admitted to the NICU. Nineteen vaccinated infants and 49 unvaccinated infants whose beds were located in close proximity to the vaccinated infants were enrolled in this study. Dissemination and fecal shedding of vaccine viruses within the NICU were examined using real- ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2017 - Oxford University Press | The Journal of Infectious Diseases
Shuhei Nomura, Haruka Sakamoto, Santosh Kumar Rauniyar, Koki Shimada, Hiroyuki Yamamoto, Shun Kohsaka, Nao Ichihara, Hiraku Kumamaru, Hiroaki Miyata,
Abstract Background Hemoglobin A1c (HbA1c) levels are routinely measured during health check-ups and are used as an indicator of glycemic control in Japan. However, only a few studies have followed up individuals to assess the risk of diabetes development and worsening based on HbA1c screening results. This study evaluated the relationship between HbA1c screening results and the risk of diabetes development and worsening. Methods Data were collected from the Shizuoka Kokuho Database, a Japanese administrative ...
Tópico(s): Diabetes Management and Education
2021 - BioMed Central | BMC Public Health
Sora Tarumoto, Koki Hatagaki, Rina Miyata, Tomoyuki Kajiwara, Takashi Ninomiya,
Tópico(s): Topic Modeling
2024 - | Journal of Natural Language Processing
Masunori Matsuzaki, Kazuhiro Yamamoto, Masafumi Yano, Koki Nakamura, Yuko Miyata, Kenkichi Sugiura, Emi Nakata, Hiroyuki Tsutsui,
BackgroundChronic heart failure (CHF) is an increasingly common cardiovascular disease despite recent advances in its diagnosis and management.Methods and resultsA multicenter, open-label study was designed to assess the efficacy and safety of 60-week treatment with candesartan in Japanese patients with mild to moderate CHF. Primary efficacy endpoints were changes from baseline in plasma brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), end-diastolic dimension, and New York ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2013 - Elsevier BV | Journal of Cardiology
Yusuke Kawashima, Tomoyuki Hamachi, Akio Yamauchi, Koki Nishimura, Yuma Nakashima, Saiya Fujiwara, Nobuo Kimizuka, Tomohiro Ryu, Tetsu Tamura, Masaki Saigo, Ken Onda, Shunsuke Sato, Yasuhiro Kobori, Kenichiro Tateishi, Т. Уесака, Go Watanabe, Kiyoshi Miyata, Nobuhiro Yanai,
Singlet fission (SF), converting a singlet excited state into a spin-correlated triplet-pair state, is an effective way to generate a spin quintet state in organic materials. Although its application to photovoltaics as an exciton multiplier has been extensively studied, the use of its unique spin degree of freedom has been largely unexplored. Here, we demonstrate that the spin polarization of the quintet multiexcitons generated by SF improves the sensitivity of magnetic resonance of water molecules ...
Tópico(s): Solid-state spectroscopy and crystallography
2023 - Nature Portfolio | Nature Communications
Koki Mise, Yoshifumi Ubara, Masanori Matsumoto, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenichi Ohashi, Koichi Kokame, Toshiyuki Miyata, Yoshihiro Fujimura, Kenmei Takaichi,
Thrombotic thrombocytopenic purpura (TTP) is frequently associated with renal abnormalities, but there have been few reports about renal abnormalities in patients with hereditary TTP. In particular, little is known about the long-term prognosis of patients with childhood-onset congenital TTP. We report a Japanese patient with congenital TTP (Upshaw–Schulman syndrome) who was followed for 19 years after initiation of hemodialysis when he was 22 years old. At the age of 6 years, the first episode of ...
Tópico(s): Platelet Disorders and Treatments
2013 - BioMed Central | BMC Nephrology
Koki Nakanishi, Chie Tanaka, Mitsuro Kanda, Kazushi Miyata, Kazuhiro Furukawa, Osamu Maeda, Dai Shimizu, Shizuki Sugita, Naomi Kakushima, Satoshi Furune, Hiroki Kawashima, Yuichi Ando, Tomoki Ebata, Yasuhiro Kodera,
This retrospective study examined early the predictive factors for successful conversion surgery (CS) with R0 resection in patients with metastatic gastric cancer (MGC) who underwent systemic chemotherapy. This study included 204 patients diagnosed with metastatic gastric adenocarcinoma, who received chemotherapy between 2009 and 2019. Of these patients, 31 (15%) underwent CS with R0 resection. The incidence of CS with R0 resection was not affected by the volume of metastatic lesions or the presence ...
Tópico(s): Metastasis and carcinoma case studies
2023 - Multidisciplinary Digital Publishing Institute | Cancers
Gil Yeroslavsky, Kyohei Okubo, Masakazu Umezawa, Karina Nigoghossian, Doan Thi Kim Dung, Keiji Miyata, Koki Nomura, Masao Kamimura, Kohei Soga,
The field of self-reporting materials is gaining increased attention recently. These materials can convey the forces applied to them without the need to integrate external devices. The ability to report strain exerted onto polymers is especially important, as it might give indication of high levels of force that may damage the material. These materials could also be applied to in-dwelling medical devices such as artificial tendons and heart valves. In this work, we designed a self-reporting system ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2020 - The Society of Photopolymer Science and Technology (SPST) | Journal of Photopolymer Science and Technology
Tomoko Kobayashi, Shintaro Iwama, Ayana Yamagami, Tetsushi Izuchi, Koji Suzuki, Koki Otake, Yoshinori Yasuda, Masahiko Ando, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Tetsunari Hase, Naoki Nishio, S. Mori, Tomoya Shimokata, Tomoyasu Sano, Kaoru Niimi, Nobuhisa Yoshikawa, Shusuke Akamatsu, Yukio Ando, Masashi Akiyama, Michihiko Sone, Makoto Ishii, Hiroshi Arima,
Abstract Background Anti-programmed cell death-1 (ligand-1) antibody [PD-(L)1-Ab] can cause destructive thyroiditis and/or hypothyroidism. In addition, tyrosine kinase inhibitors (TKIs) frequently induce hypothyroidism. The aim of this prospective study is to examine the incidence and clinical characteristics of thyroid dysfunction induced by combination therapy of a PD-(L)1-Ab and TKI [PD-(L)1-Ab/TKI]. Methods A total of 757 patients treated with PD-(L)1-Ab or PD-(L)1-Ab/TKI were evaluated for anti- ...
Tópico(s): Neuroendocrine Tumor Research Advances
2024 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Takahiro Miyoshi, Hideki Endo, Hiroyuki Yamamoto, Koki Shimada, Hiraku Kumamaru, Nao Ichihara, Yoshiki Miyachi, Hiroaki Miyata,
Abstract Background The risk of choking increases with aging, and the number of cases of choking-induced cardiac arrest is increasing. However, few studies have examined the prognosis of choking-induced cardiac arrest. The aim of this study was to reveal the rates of survival and dependence on devices in the long term after choking-induced cardiac arrest. Methods We analyzed data from the Shizuoka Kokuho Database, which consists of claims data of approximately 2.2 million people, from April 2012 ...
Tópico(s): Intensive Care Unit Cognitive Disorders
2022 - BioMed Central | BMC Emergency Medicine
Koki Mitani, Takeshi Miyata, Wataru Shiraishi, Yu Abekura, Yuji Agawa, Tomoya Ogawa, Takao Morita, Wataru Yoshizaki, Ryuji Hamamoto, Takashi Nagahori, Yusuke Nakazawa, Yukiko Inamori, Taketo Hatano,
Tópico(s): Neurosurgical Procedures and Complications
2025 - Elsevier BV | Brain Hemorrhages
Koki Hayashi, Ryohei Miyata, Masanori OODAIRA, Masato Tomita, Michio Sato, Nobutoshi Ando,
症例は80歳，女性．肛門縁から15cmの全周性2型腫瘍に対し高位前方切除術を施行した．術後第1病日より仙骨前面ドレーンから多量の乳縻様排液を認めリンパ漏と診断，禁食・利尿剤投与などで改善傾向となり第23病日に退院となった．術後1カ月頃よりリンパ漏が増悪し，オクトレオチドや利尿剤を投与するも改善に乏しく適宜腹水穿刺を施行した．術後112病日に診断的治療として両側鼠径リンパ節穿刺からリピオドールによるリンパ管造影を施行，腹部大動脈分岐部直上左側の外側大動脈リンパ節周囲から造影剤漏出を認め瘻孔部位と考えられた．術後151日目のCTで著明な腹水減少が得られ，現在，術後3年で無再発生存中である．保存的治療に反応しない消化管術後難治性リンパ漏に対しては外科的治療が推奨されているが，奏効率は高くない．リピオドールによる治療的リンパ管造影は，消化管術後難治性リンパ漏に対して有用な治療手段となり得る．
Tópico(s): Vascular Malformations and Hemangiomas
2018 - Japan Surgical Association | Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
Koki Tabata, Kanji Miyata, Norihiro Yuasa, Eiji Takeuchi, Yasutomo Goto, Hideo Miyake, Hidemasa Nagai, Yoichiro Kobayashi, Masafumi Ito,
症例は74歳の男性で，2002年に十二指腸乳頭部腫瘍に対し開腹十二指腸乳頭部腫瘍切除が施行され，病理組織学的に高度異型腺腫であり，切除断端陰性と診断された．2008年，黄疸を主訴に当院を受診した．内視鏡検査で十二指腸乳頭部に不整な腫瘤を認め，生検で中分化型腺癌と診断された．下部消化管内視鏡検査にて，S状結腸にひだ集中と辺縁隆起を伴う不整な潰瘍性病変を認め，生検所見を考慮して転移性腫瘍と診断した．十二指腸乳頭部癌，同時性S状結腸転移と診断し膵頭十二指腸切除術・S状結腸切除術を施行した．病理組織学的検査所見は中分化型腺癌，Panc1b，Du2，N2（#13b，#14d，#17d），EM0，M1（S状結腸），Stage IVbであった．S状結腸転移は血行性あるいはリンパ行性転移と考えられた．大腸に孤立性転移を認める十二指腸乳頭部癌は極めてまれで，内視鏡所見，生検所見から術前診断しえたので報告する．
Tópico(s): Genetic factors in colorectal cancer
2013 - The Japan Society of Mechanical Engineers | The Japanese Journal of Gastroenterological Surgery
Koki Tabata, Kanji Miyata, Norihiro Yuasa, Eiji Takeuchi, Yasutomo Goto, Hideo Miyake, Hidemasa Nagai, Yoichiro Kobayashi, Dai Kajiura, Masafumi Ito,
背景:Ki-67標識率（％）（以下MIB-1）は細胞増殖率の代表的な指標で，肺癌・乳癌・などでは多くの研究がされてきたが，食道癌では臨床病理学的因子・予後との関連には一定の結論がない．目的:食道扁平上皮癌の原発巣におけるMIB-1と臨床病理学的因子との関連を検討し，予後の指標になるかを明らかにする．方法:対象は2006年から2008年までに根治切除を施行した術前未治療の食道扁平上皮癌25例．切除標本原発巣のMIB-1を測定し，臨床病理学的因子，予後，術前FDG-PETにおける原発巣のmaxSUVとの関連を検討した．結果:MIB-1は平均42.3％（13.0～73.2％）で，リンパ節転移（P=0.002），病期（p=0.007）と有意な関連を認めた．MIB-1は40％をカットオフ値すると無再発生存率に有意差を認めた（p=0.035）．またMIB-1はmaxSUVと相関のある傾向を認めた（p=0.051）．結論:MIB-1はリンパ系進展や病期と関連し，予後の指標となる．MaxSUVは予後予測因子となる可能性がある．
Tópico(s): Gastric Cancer Management and Outcomes
2011 - Japan Surgical Association | Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
David E. Kandzari, Raymond R. Townsend, Kazuomi Kario, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Stuart J. Pocock, Konstantinos Tsioufis, D. Konstantinidis, James W. Choi, Cara East, Lucas Lauder, Debbie L. Cohen, Taisei Kobayashi, Axel Schmid, David P. Lee, Adrian Ma, Joachim Weil, Tolga Agdirlioglu, Markus P. Schlaich, Sharad Shetty, Chandan Devireddy, Janice P. Lea, Jiro Aoki, Andrew S.P. Sharp, Richard Anderson, Martin Fahy, Vanessa DeBruin, Sandeep Brar, Michael Böhm, Yale Wang, Desmond Jay, Brent McLaurin, Carl Lomboy, Suhail Allaqaband, Fuad Jan, Bharat Gummadi, Marc R. Litt, Fidel Garcia, Jasvindar Singh, Angela L. Brown, James W. Choi, Ashley Paul, Andrew S.P. Sharp, James Coulson, Aravinda Nanjundappa, Ganpat G. Thakker, James Campbell, Benjamin Honton, Bruno Farah, Manesh R. Patel, Antonio Gutiérrez, Crystal C. Tyson, Laura P. Svetkey, Marat Fudim, Neha J. Pagidipati, Schuyler Jones, Sreekanth Vemulapalli, Chandan Devireddy, Ambar Kulshreshtha, Bryan Wells, Janice P. Lea, Bryan Batson, Robert B. Wilkins, Faisal Sharif, Abdullahi Mohamed Khair, Abhishek Wilson Pallippattu, Aishah Alhmoudi, Brian Gaffney, Christian Cawley, Colin Gorry, Hanan Hamed, Jennifer Carron, John Birrane, Liesbeth Rosseel, Mattia Lunardi, Michael J. Cronin, Myles McKittrick, Naeif Almagal, Noman Khalid, Qussai Shehahd, Shirjeel Shahzad, Simone Fezzi, Stanislav Tyulkin, Xavier Armario, Sanjit S. Jolly, Gordon Yip, Jon-David Schwalm, Michael Tsang, Shamir R. Mehta, Philipp Lurz, Christian Binner, Danilo Obradović, Florian Fahr, Ines Richter, Johannes Rotta detto Loria, Karl Fengler, Karl‐Philipp Rommel, Mateo Marin‐Cuartas, Matthias Lerche, Philipp Hartung, Phillip Münch, Robert Höllriegel, Silke John, Satoru Otsuji, Hirofumi Kusumoto, Hiroto Tamaru, Kasumi Ishibuchi, Katsuyuki Hasegawa, Ken Sugimoto, Mikio Kakishita, Rui Ishii, Shin Takiuchi, Shingo Yasuda, Sho Nakabayashi, Wataru Yamamoto, Yorihiko Higashino, Yuji Shimatani, Yusuke Taniguchi, Konstantinos Tsioufis, Alexandros Kasiakogias, D. Konstantinidis, E. Andrikou, Κωνσταντίνος Κωνσταντίνου, Kyriakos Dimitriadis, Theodoros Kalos, Debbie L. Cohen, Garvey Rene, Jordana B. Cohen, Maria Bonanni, Matthew G. Denker, Rasi Wickramisinghe, Robert Wilensky, Tai Kobayashi, Venkatesh Y. Anjan, Yonghong Huan, Walter Herbert Haught, Joshua Krasnow, Alejandro Arias Väsquez, C. Gessler, Christopher Roth, David Drenning, Enrique M. Velasquez, George Soliman, James E. Murphy, Kaushik K. Jain, Michael Butler, Mihir Kanitkar, Phillip Laney, Ross J. Hunter, Shi-Chi Cheng, Thomas C. Wright, Walter Herbert Haught, Neil Chapman, Ahran Arnold, Alexandra N. Nowbar, Azara Janmohamed, Ben Corden, Christopher Cook, Christopher Rajkumar, Daniel Keene, David Thompson, Henry Seligman, James P. Howard, Justin E. Davies, Mark Sweeney, Matthew Shun‐Shin, Michael Foley, Nicholas M. Quaife, Rasha Al‐Lamee, Savvas Hadjiphilippou, Sayan Sen, Yousif Ahmad, Kazuomi Kario, Hayato Shimizu, Hirotaka Waki, Keisuke Narita, Masahisa Shimpo, Satoshi Hoshide, Takahiro Komori, Yukako Ogoyama, Yukiyo Ogata, Yusuke Oba, Mohanned Bisharat, Anton Lishmanov, Mohanned Bisharat, Travis Jeffords, Magdi Ghali, Beth Chia, Rachel Onsrud, Randolph Rough, Jiro Aoki, Daijiro Tomii, Fumiko Mori, Hosei Kikushima, Kai Ninomiya, Kazuyuki Yahagi, Kengo Tanabe, Kôsuke Nakamura, Kota Komiyama, Masaaki Nakase, Masahiko Asami, Naoto Setoguchi, Tetsu Tanaka, Yu Horiuchi, Yusuke Watanabe, Dmitriy N. Feldman, Geoffrey Bergman, Ines Sherifi, Luke Kim, Nivee Amin, Robert M. Minutello, S. Chiu Wong, Stephen McCullough, Richard D’Souza, Andrew S.P. Sharp, Hibba Kurdi, Richard D’Souza, Sarah Statton, Tony Watkinson, Barry Bertolet, Amit Gupta, Benjamin Blossom, Chris Bell, D.C. Hill, Francisco Sierra, James G. Johnson, John Estess, Joseph P. Adams, Katie McDuffie, Lee Ferguson, Nelson Little, Richard Dane Ballard, Roger A. Williams, Wanda Ikeda, William J. Calhoun, William L. Carroll, Avneet Singh, Benjamin J. Hirsh, Perwaiz Meraj, Rajiv Jauhar, Harsh Golwala, Jose Rueda, Kellie Graham, Ramsey Al-Hakim, Robert Rope, David E. Kandzari, Dariush Bahrami, Denise Reedus, Shukri David, Iram Rehman, Khalid Zakaria, Nishit Choksi, Samer Kazziha, Sarwan Kumar, Souheil Saba, Susan Steigerwalt, Yassir Sirajeldin, Omar Hyder, Herbert D. Aronow, Andrea Connors, Douglas Shemin, Clare Bent, Terry Levy, Vivek Kodoth, Markus P. Schlaich, Márcio Galindo Kiuchi, Revathy Carnagarin, Sharad Shetty, Sabino R. Torre, Howard Levitt, Lin Chen, Sarah Fan, Sergio Waxman, Wendy Porr, George Mangos, Brendan Smyth, Cathie Lane, Mark Sader, Kirit Patel, Anjani Rao, Brett Milford, Guneet Ahluwalia, Jaqueline Sennott, Justin Field, Nihar Jena, Stacy Loree, John Graham, Abdul Al‐Hesayen, Akshay Bagai, Junya Shite, Amane Kozuki, Atsushi Suzuki, Eri Masuko, Fumitaka Soga, Hiroyuki Asada,
Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications.
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