... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Meng-Huee Lee, Magdalini Rapti, Gillian Murphy,
... MMP-2, their association rates with MMP-2 (k on) being over 10 -8m-1 s-1. The ... the total inhibitor concentration. Association Rate Constant Measurement (k on )—k on measurements were performed by adding N-TIMP mutants ( ... constant of equilibrium between enzyme and TIMP complex. k on values were calculated by linear regression of k on TIMP concentrations. Strategy for TIMP-1 Mutagenesis—Although ... The binding constant (K iapp) and association rate (k on) are shown in Table I. Clearly, N-TIMP- ... to N-TIMP-3 and N-TIMP-4 (k on N-TIMP-2, 10 × 10-5m-1 s- ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2003 - Elsevier BV | Journal of Biological Chemistry
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Ronald A. Li, Kwokyin Hui, Robert J. French, Kazuki Sato, Charles A. Henrikson, Gordon F. Tomaselli, Eduardo Marbán,
... Single-channel recordings identified the association rate constant, k on, as the primary determinant of the changes in affinity (k on increased 40- and 333-fold for μ-CTX ... Single-channel recordings identified the association rate constant, k on, as the primary determinant of the changes in affinity (k on increased 40- and 333-fold for μ-CTX ... 400 ms for blocked events. The kinetic parameters, k on and k off, were determined from mean unblocked ... t u〉 and 〈t b〉, respectively, as follows: k on = 1/(〈t u〉[toxin]), and k off = 1/ ...
Tópico(s): Neuroscience and Neuropharmacology Research
2003 - Elsevier BV | Journal of Biological Chemistry
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Ronald A. Li, Irene L. Ennis, Patricio Vélez, Gordon F. Tomaselli, Eduardo Marbán,
... k off) rates with little changes in association (k on) rates. We conclude that the acidic residues at ... k off) rates with little changes in association (k on) rates. We conclude that the acidic residues at ... τoff. The pseudo first order association rate constant (k on) and the first order dissociation rate constant (k ... τoff and, hence, the rate constants (i.e. k on and k off) for toxin binding and unbinding. ... the same mutations had relatively minor effects on k on (2- to 5-fold decrease,p > 0.05) ... channels, which displayed a 10-fold decrease in k on (p < 0.05). The kinetic equilibrium constants (K ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2000 - Elsevier BV | Journal of Biological Chemistry
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Akeo Shinkai, Mikito Ito, Hideharu Anazawa, Sachiko Yamaguchi, Kenya Shitara, Masabumi Shibuya,
... To determine the association and dissociation rate constants (k on and k off, respectively), the sensorgrams were analyzed ... the response at the start of the dissociation. k on was calculated using the model A + B = AB ... data to the equationR = R eq(1 − exp(−k on C +k off(t −t 0))), where C ... state response level. The final k off and k on values were calculated from the means of these ... ratio of these final kinetic constants (k off/k on). Protein concentrations were determined by the method of ... 5N-, and 4N-KDR proteins, the decreases in k on were of the same order of magnitude; however, ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1998 - Elsevier BV | Journal of Biological Chemistry
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Evgueni L. Saenko, Dorothea Scandella, Alexey V. Yakhyaev, Nicholas J. Greco,
... 3, Figure 4, Figure 5, the values of k on were determined from individual association kinetics data using ... koff)tCkon+koff(Eq. 3) The values of k on and R max were derived from nonlinear regression ... dissociation constants (K d) were calculated ask off/k on.Figure 3Determination of the kinetic parameters for C2 ... In Figs. 6 and 7, the values of k on and K d were determined from multiple association ... ks=konC+koff(Eq. 4) The value of k on was determined from the linear fit of k ... The k offvalue was calculated as K d ×k on using the values of K dand k on ...
Tópico(s): Platelet Disorders and Treatments
1998 - Elsevier BV | Journal of Biological Chemistry
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Anna Arbuzova, Jiyao Wang, Diana Murray, Jaison Jacob, David S. Cafiso, Stuart McLaughlin,
... a diffusion-limited association rate constant. For example,k on = 1011m−1 s−1 for the peptide binding ... 100-nm diameter phospholipid vesicles. As expected theoretically,k on is independent of factors that affect the molar ... a diffusion-limited association rate constant. For example,k on = 1011m−1 s−1 for the peptide binding ... 100-nm diameter phospholipid vesicles. As expected theoretically,k on is independent of factors that affect the molar ... step with a second-order association rate constant (k on) and a first-order dissociation rate constant (k ...
Tópico(s): Protein Structure and Dynamics
1997 - Elsevier BV | Journal of Biological Chemistry
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Yan Zhang, Joseph M. Scandura, William E. Van Nostrand, Peter N. Walsh,
... inhibitor of FXIa, with an association rate constant (k on) of 2.1 ± 0.2 × 106m−1 s− ... FXIa, I represents the inhibitor PN-2, and k on andk off are the forward and the reverse ... complexes represent dissociation progress curves. The rate constants (k on andk off) were obtained by nonlinear, least squares ... b−γ2(EI)0+b+γEquation 6 where k on and k offare the forward and reverse rate ... and the kinetic rate constants ascertained. The forward (k on) and reverse (k off) rate constants were obtained ... the result of an increased forward rate constant (k on increased from 3.2 to 43 × 106m−1 ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
1997 - Elsevier BV | Journal of Biological Chemistry
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Morris Benveniste, Mark L. Mayer,
... of agonist was used to estimate microscopic association ( k on ) and dissociation ( k off ) rate constants for antagonist ... series of 11 ω‐phosphono, α‐amino acids k on and k off varied 26 and 107 fold ... d ‐2‐amino‐7‐phosphonoheptanoic acid ( d ‐AP7): k on 1.4 × 10 7 m −1 s −1 ; ... association and dissociation rate constants were much slower: k on 1.1 × 10 6 m −1 s −1 ; ... yl)‐propyl‐1‐phosphonic acid (CPP) estimates for k on were similar, but for the l ‐isomer k ... 1.6 to 1.8 fold decrease in k on with little change in k off . In contrast, ...
Tópico(s): Chemical Reaction Mechanisms
1991 - Wiley | British Journal of Pharmacology
... of the British convoy which left Portsmouth, U.K. on July 29th, 1780 escorted by the warships Ramillies ...
1780 - Gale Group | SASII
Anna Maria Caccuri, Giovanni Antonini, Philip G. Board, Jack U. Flanagan, Michael W. Parker, Roberto Paolesse, Paola Turella, Giorgio Federici, Mario Lo Bello, Giorgio Ricci,
... mechanism occurs via a simple bimolecular reaction with k on andk off values at least hundred times lower (k on = (2.7 ± 0.8) × 104m−1s−1, k ... mechanism occurs via a simple bimolecular reaction with k on andk off values at least hundred times lower (k on = (2.7 ± 0.8) × 104m−1s−1, k ... GSHκoff ScHEME I Linear regression analysis gives a k on = (2.7 ± 0.8) × 104m−1 s−1and ... 37 °C (Fig. 3 A and TableI). As k on is far from the value expected for a ... dissociation constant for the pre-complex (k off/k on) is 1.4 mm. The microscopic rate constants ...
Tópico(s): Reproductive Health and Contraception
2001 - Elsevier BV | Journal of Biological Chemistry
Chapman Jones, Osborne I. Yellott, J. McIntosh, Anthony Green, E. Valenta, J. Craig Annan,
... Developer Is Supported This Week by "A. F. K.", On This Subjects, "Helios" in the Bradford Observer Says, ...
1899 - Gale Group | NCCO Photography
Frédéric Ducongé, Carmelo Di Primo, Jean‐Jacques Toulmé,
... the molar concentration of the injected RNA molecule,k on the association rate constant, andk off the dissociation ... 3 mm (Fig. 6 C). The rate constants, k on and k off, deduced from these sensorgrams are ... constants cannot be reasonably determined. At 10 mm, k on andk off are equal to 38 × 104m−1 ... these kinetic measurements, K d, equal tok off/k on, which confirms that the TAR-aptamer complex is ... K d(BIAcore)was calculated as k off/k on andK d(EMSA) was derived from electrophoretic mobility shift assays (Ducongé & Toulmé, 1999).k on, k off, andK d are the averages and ...
Tópico(s): RNA Research and Splicing
2000 - Elsevier BV | Journal of Biological Chemistry
FROM OUR MUSIC CRITIC, FROM A CORRESPONDENT, FROM OUR SPECIAL CORRESPONDENT, FROM OUR CORRESPONDENT, FROM OUR SALE ROOM CORRESPONDENT, From Our Own Correspondent, From Our Agricultural Correspondent, FROM OUR LABOUR CORRESPONDENT, From Our United Nations Correspondent, FROM OUR DIPLOMATIC CORRESPONDENT, FROM OUR OWN CORRESPONDENT, FROM OUR ATHENS CORRESPONDENT, From Our Rome Correspondent, FROM OUR MOTORING CORRESPONDENT, From Our Geneva Correspondent, FROM A SPECIAL CORRESPONDENT, From Our Correspondent, From Our Labour Correspondent, From Our Political Correspondent, FROM OUR CITY EDITOR, TOBY LOW, D. G. GREIG., W. T. BLAKE., ARTHUR BEACHAM, M. ZVEGINTZOV, GRAHAM HALLETT, H. DRUMMOND, RUTH SERTIN., By Cedric Collyer, W. BEVAN WHITNEY., JAMES THOMSON., WILLIAM DOUGLAS HOME, WILLIAM J. CLARK., N. JENKINS., BRYAN ANSTEY, BERNARD C. SHRUBSOLE, RACHEL D. THOMAS, JULIET RHYS WILLIAMS, D. M. RICHES, A. L. DIAMOND, FROM OUR MEDICAL CORRESPONDENT, FROM OUR MUSEUMS CORRESPONDENT, Sir Geoffrey Crowther, Major A. L. Holt, Lord Chorley, Sir Fergus Graham, From Our Special Correspondents, From Our Own Correspondents, FROM OUR OWN CORRESPONDENTS, From Our Racing Correspondent, From Our Northern Correspondent, FROM OUR RACING CORRESPONDENT, FROM OUR NORTHERN CORRESPONDENT, From Our Rugby Football Correspondent, FROM A STAFF REPORTER, FROM OUR RIFLE SHOOTING CORRESPONDENT, By Our City Editor, From a Correspondent, FROM OUR SHIPPING CORRESPONDENT,
... Some Help Needed, Japanese Group To Visit U.K., On Other City Pages, Calcutta Jute Prices Rise Sharply, ...
1960 - Gale Group | TDA
Yunxi Yao, Jason P. Coyle, Seán T. Barry, Francisco Zaera,
... threshold for this chemistry varies wildly, from 270 K on Ni(110) to 430 K on O/Cu(110), 470 K on Cu(110), 500 K on NiO/Ni(110), and 570 K on SiO2/Ta. Copper reduction is also observed in ... VV Auger (AES) spectra, reaching completion by 300 K on Ni(110) but occurring only between 500 and 600 K on Cu(110). On NiO/Ni(110), both Cu( ... required for ALD between approximately 300 and 450 K on both Ni(110) and NiO/Ni(110); the ...
Tópico(s): Electronic and Structural Properties of Oxides
2016 - American Institute of Physics | The Journal of Chemical Physics
John Huxley, Lew Baxter, Gillian Tindall, Malcolm Brown, John Coleman, William Kay, Victoria Glendinning, Harry Watson Linlithgow, Will Ellsworth-Jones, Bel Mooney, Jon Swain, Chris Ryder, Peter Gillman, John Vincent, Chris Tighe, Christopher Hird, John Pargeter, Donald MacIntyre Labour Editor, Emmett O'Connell, Robin Morgan, Bojang Meftah, Anne Redmon, Nick Pitt, John Huxley Industrial Editor, John Whale, Henry Porter, Jason Tomas, Mark Hosenball, Deborah Moggach, Joan Rivers, Robert Gray, John Coates, Liz Bellamy, Milk Brearley, Robert Hewison, Deryk Brown, Mick Brown, David Dougill, Fellx Aprahamian, Joe Irving, Veronica Horwell, Peter Shear-Lock, Derek Jewell, Johnny Black, Gareth Daniels, David Caims, Poul-Erik Fabricius, Ray Charles, Susan Crosland, Peter Kemp, Julian Desser, John Ballantine, Adrianne Blue, Peter Forster, Geoff Whitten, Lionel Barber, Michael Jones, Pearson Phillips, Fiona Malcolm, George Perry, Byron Rogers, Tony Willard, Andrew Wiseman, Joyce Hopkirk, Bruce Main-Smith, Donald MacIntyre, Roger Eglin, Peter Shearlock, James Stirling, Peter Lennon, K. Sutherland, R. Wyles, Isobel Hilton, Philip Vaughan, Richard Brooks, George Rosie, Muriel Bowen Local Government Correspondent, David Hughes, Raghu Gaind, Brian Jackman, Claire Tomalin, Judith Jackson, Richard Girling, Jill Jolliffe, Nick Gilbert, Roy Lancaster, John Hopkins, Shirley MacLaine, Jill Neville, John Barnes, Geoffrey Young, Stephen Wood, Jonathan Raban, Hugo Young Political Editor, Raymond Keene, Simon Freeman, Gareth Huw Davies, Brian Murphy, James Wilson, Peter Hall, Simon Frith, Stephen Fay charts, Hirsh Goodman, Stephen Jones, Desmond Shawe-Taylor, Brian Deer, Meriel McCooey, David Pelham, John Ryle, Tom Williamson, Russell Davies, David Howell Mp (Con), Gloria Cottesloe, Martin Kettle, Stephen Aris, Peter Wilsher Foreign Editor, Professor Anthony Flew, David Lipsey, Brough Scott, Deyan Sudjic, Oliver Gillie Medical Correspondent, Mira Bar-Hillel, Simon Winchester, Dudley Doust, Brian Glanvile, John Shirley Chief Reporter, Peter Shearlock City Editor, Peter Clarke, Godfrey Smith, Steve Coppell's, Richard Burnell, Anthony Mascarenhas, Dr David Owen, Mike Johnson, Brian Glanville, John Carey, Norman Macrae, James Fenton, Michael Green, Ian Hamilton, Michael Jones Political Correspondent, Jon Connell Defence Correspondent, Marina Vaizey, Amir Taheri, Elizabeth Dunn, Phillip Knightley, Germaine Greer, Tony Hetherington, Donald Fields, Peter Wilby Education Correspondent, Beverly Hayne, Patience Wheatcroft, John Marshall, Bernard Black, Jon Connell, Leslie Geddes-Brown, Isabel Hilton, Boris Schapiro, Professor Philip Collins,
... K. and Jackie's… Jackie and J. F. K. on holiday at Hyannis Port, 1958 Picture Gallery Horris ...
1983 - Gale Group | Sunday Times HA GDA
Marleen L. A. Kortenoeven, Cristina Esteva‐Font, Henrik Dimke, Søren Brandt Poulsen, Sathish K. Murali, Robert A. Fenton,
... PubMed Scopus (82) Google Scholar). The effects of K+ on BP are blunted in NCC knockout mice, highlighting ... 15Frindt G. Palmer L.G. Effects of dietary K on cell-surface expression of renal ion channels and ... gland. To assess if the effects of high K+ on NCC expression were still apparent with aldosterone present, ... Supporting such a mechanism, the effects of high K+ on NCC were absent when tubules were simultaneously incubated ... for modulating the long-term effects of high K+ on NCC, tubules were incubated for 24 h in ...
Tópico(s): Magnesium in Health and Disease
2021 - Elsevier BV | Journal of Biological Chemistry
... Items, The … Bill Dead, Manly Words Hon. J. K. … on the Greenwood Tragedy, The Kansas Red-Neck He ...
1890 - Gale Group | SAS Part 1
Réka Kovács, László Bodai, A. Dobozy, Lajos Kemény,
... R et al.The effects of topical vitamin K on bruising after laser treatment.J Am Acad Dermatol. ... certain days.To evaluate the effects of vitamin K on the prevention and clearing of purpuras, we designed ... R et al.The effects of topical vitamin K on bruising after laser treatment.J Am Acad Dermatol. ... R et al.The effects of topical vitamin K on bruising after laser treatment.J Am Acad Dermatol. ... certain days. To evaluate the effects of vitamin K on the prevention and clearing of purpuras, we designed ... R et al.The effects of topical vitamin K on bruising after laser treatment.J Am Acad Dermatol. ...
Tópico(s): Nail Diseases and Treatments
2004 - Elsevier BV | Journal of the American Academy of Dermatology
From Our Association Football Correspondent-, FROM OUR ROWING CORRESPONDENT, From Our Shipping Correspondent, From Our Golf Correspondent, FROM OUR SCOTTISH CORRESPONDENT, FROM OUR LABOUR STAFF, FROM A RACKETS CORRESPONDENT, FROM OUR CORRESPONDENT, FROM A STAFF REPORTER, FROM OUR MEDICAL CORRESPONDENT, From a Staff Reporter, From Our Own Correspondent, FROM OUR DIPLOMATIC CORRESPONDENT, FROM OUR AIR CORRESPONDENT, From Our Commonwealth Staff, From Our Correspondent, From Our Special Correspondent, FROM OUR OWN CORRESPONDENT, FROM OUR LABOUR CORRESPONDENT, From Monitor, FROM A SPECIAL CORRESPONDENT, From Our Motoring Correspondent, From Our Labour Correspondent, From Our Parliamentary Correspondent, FROM OUR CITY EDITOR, FROM OUR POLITICAL CORRESPONDENT, FROM OUR UNITED NATIONS CORRESPONDENT, From Our Middle East Correspondent, MARGARET COWAN., A. J. CHISLETT., A. J. B. RUTHERFORD, F. G. WEDELL., KENNET. House of Lords, March 7., DRUMALBYN, Chairman, The Advertising Standards Authority Limited, KENNETH PICKTHORN. House of Commons, March 8., G. N. SANDERSON., FRANCES BOYD. 3 Alma Square. N.W.8, March 3., Mr. John Gawsworth, FROM A CORRESPONDENT, From Our Sale Room Correspondent, John Willett, From Our Film Critic, From a Correspondent, From Our Music Critic, From Our Art Critic, From Our Drama Critic, By Our City Editor, From Our European Economic Correspondent, From a Special Correspondent,
... Spurt By G. & J. Weir, Agreement With U.K. On Double Tax, Chrysler Offer This Month, Rolls-Royce ...
1966 - Gale Group | TDA
Jędrzej Małecki, Agnieszka Polit, Zygmunt Wasylewski,
... of allostery and is described by rate constants:k on = 28 ± 1.5 s−1 andk off = 75. ... of allostery and is described by rate constants:k on = 28 ± 1.5 s−1 andk off = 75. ... is the equilibrium constant between these two states, k on and k off are rate constants that describe ... equation to yield the kinetic and thermodynamic parameters k on, k off, andKsyn . kobs=kon+koffKsyn2Ksyn2+2Ksyn[cAMP]+[ ... following values of the fitted parameters were obtained: k on = 28 ± 1.5 s−1, for the forward ... following values of the estimated parameters were obtained: k on = 28.5 ± 2.0 s−1, k off = ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2000 - Elsevier BV | Journal of Biological Chemistry
From Our Racing Correspondent, FROM OUR NORTHERN CORRESPONDENT, FROM OUR NEWMARKET CORRESPONDENT, From Our Special Correspondent, From Our Rugby Football Correspondent, FROM OUR SCHOOLS RUGBY CORRESPONDENT, From a Staff Reporter, FROM OUR ROWING CORRESPONDENT, From Our Association Football Correspondent, FROM A STAFF REPORTER, FROM OUR HOCKEY CORRESPONDENT, FROM OUR CORRESPONDENT, FROM OUR LABOUR CORRESPONDENT, FROM OUR SPECIAL CORRESPONDENT, From Our Agricultural Correspondent, From a Correspondent, From Our Political Correspondent, From Our Correspondent, FROM OUR OWN CORRESPONDENT, From Our United Nations Correspondent, FROM OUR CHESS CORRESPONDENT, From Our Diplomatic Correspondent, From Our Athens Correspondent, From Our Own Correspondent, LAURENCE WILKINSON., CHORLEY., E. SWINFEN GREEN., FRANK MEDLICOTT., GEORGE PARGITER, FRANK McLEAVY., ELIZABETH WISKEMANN, H. A. WILLIAMS., T. E. SMITH, JOHN B. FRANCEY, FROM A CORRESPONDENT, FROM A CORRESPONDENT IN NEW YORK, FROM A SPECIAL CORRESPONDENT, FROM OUR FILM CRITIC, FROM OUR ART CRITIC, By Our City Editor, A friend, FROM OUR ESTATES CORRESPONDENT,
... Aircraft For Businessmen Growing Potential Market In U.K., On Other Ciyy Pages. Business Appointments: Business Changes. Stock ...
1960 - Gale Group | TDA
Timothy Myles, Frank Church, Herbert C. Whinna, Denis Monard, Stuart R. Stone,
... In the absence of glycosaminoglycan, association rate constant ( k on ) values for the inhibition of the mutant thrombins ( ... similar to wild-type recombinant thrombin (rIIa), whereas k on values were decreased 2–3-fold for HCII ... on heparin-accelerated inhibition by ATIII with maximal k on values similar to rIIa. A small effect was ... R67Q, R73Q, R75Q, and R77 a Q, where k on values were decreased 2–4-fold, compared with rIIa. For HCII/heparin, k on values for inhibition of the exosite-I mutants ( ... 3-fold lower than rIIa. Larger decreases in k on values for HCII/heparin were found for R67Q ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
1998 - Elsevier BV | Journal of Biological Chemistry