Charles B. Hicks, Patrick G. Clay, Robert Redfield, Jay Lalezari, Ralph Liporace, Stefan Schneider, Michael Sension, MaryPeace McRae, Jean‐Pierre Laurent,
... virus, thereby inducing viral extinction. One such drug, KP-1461, was tested in a population of HIV-infected ... patients who received at least one dose of KP-1461, 13 completed the planned 4 months of monotherapy. ... achieved. There were no new mutations induced by KP-1461 that changed viral susceptibility to standard antiretroviral agents. ... alterations were consistent with an effect resulting from KP-1461's proposed mechanism of action. These findings suggest ...
Tópico(s): HIV/AIDS Research and Interventions
2012 - Mary Ann Liebert, Inc. | AIDS Research and Human Retroviruses
Patrick G. Clay, MaryPeace McRae, Jean‐Pierre Laurent,
Background: KP-1461 is a prodrug to KP-1212. KP-1212 is a viral mutagen designed to increase viral error ... study in 42 non-HIV-infected participants) and KP-1461-102 (double-blind placebo-controlled dose escalation 14- ... characterize KP-1212 effects on viral load. Results: KP-1461 was well tolerated. Majority of adverse events were ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2011 - SAGE Publishing | Journal of the International Association of Physicians in AIDS Care
Kevin S. Harris, Dmitri S. Sergueev, John M. Reno,
KP-1461 is a deoxycytidine analogue that is randomly inserted into HIV DNA by reverse transcriptase where it ... alpha and beta have a high Km for KP-1461 triphosphate that could preclude incorporation into nuclear DNA.KP-1461 has successfully completed preclinical testing including animal toxicology ...
Tópico(s): DNA and Nucleic Acid Chemistry
2006 - BioMed Central | Retrovirology
KP-1461, an experimental HIV drug already in a phase II trial, works so differently from other antiretrovirals ... science that goes back at least 25 years. KP-1461 is the only antiretroviral in human use or ...
Tópico(s): HIV/AIDS Research and Interventions
2007 - | AIDS treatment news
Most of the antiretrovirals in development represent additions to the currently available drug classes. Agents with different mechanisms of action are
Tópico(s): DNA and Nucleic Acid Chemistry
2013 - Massachusetts Medical Society | Journal watch
Edward Fox, Jiang‐Cheng Shen, Lawrence A. Loeb,
... II clinical studies, administration of a cytidine analog, KP-1461, to individuals infected with HIV results in increased ...
Tópico(s): Cancer-related Molecular Pathways
2011 - American Association for Cancer Research | Cancer Research