... 9, XXI. Hitopadeça, Ed. Schl. Und Lass, III. Krçâ Gautami (Kandjur XI. Blatt 122—130), XLIX. Çântiçataka, ...
1876 - Gale Group | NCCO AsiaWest
Chi Hoon Park, Hyeonjeong Choe, In-Young Jang, So Yeong Kwon, Muhammad Latif, Heung Kyoung Lee, Hyeon Ji Lee, Eun Hye Yang, Jeong In Yun, Chong Hak Chae, Sung Yun Cho, Sang Un Choi, Jae Du Ha, Heejung Jung, Hyoung Rae Kim, Pilho Kim, Chong Ock Lee, Chang‐Soo Yun, Kwang‐Ho Lee,
... relationship to anaplastic lymphoma kinase (ALK) is presented. KRCA-0008 is selective and potent to ALK and ... and displays drug-like properties without hERG liability. KRCA-0008 demonstrates in vivo efficacy comparable to Crizotinib ...
Tópico(s): Synthesis and Biological Evaluation
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Zhanmei Yang, Jingyong Zhang, Ye Liu, Kai Li,
... 42 °N–50 °N, 62 °E–80°E, KRCA) from Noah, Mosaic, CLM and ERA-interim datasets ... experiments. Warmer soil temperature in May over the KRCA can keep to the summer and cause positive ...
Tópico(s): Cryospheric studies and observations
2022 - Springer Science+Business Media | Climate Dynamics
B. Kureleć, Smiljana Britvić, Sanja Krča, Rudolf K. Ζahn,
Tópico(s): Toxic Organic Pollutants Impact
1986 - Springer Science+Business Media | Marine Biology
Branko Kurelec, Achal Garg, Sanja Krča, Mary Chacko, Ramesh C. Gupta,
Measurement of specific DNA adduct concentrations in target tissues of organisms may provide a key biologic end-point of exposure to environmental carcinogens. Using a general and highly sensitive assay with 32P-postlabeling, we found that natural populations of freshwater fish species chub, barbel, bream and crap, as well as a marine fish mugil, revealed the presence of four to nine qualitatively similar adducts irrespective of whether they were caught from unpolluted or polluted waters. No statistically ...
Tópico(s): Toxic Organic Pollutants Impact
1989 - Oxford University Press | Carcinogenesis
Branko Kurelec, Achal Garg, Sanja Krča, Ramesh C. Gupta,
The presence of ‘natural’ (‘pre-existing’) DNA adducts in indicator organisms may complicate the use of pollution-related DNA-adduct measurements as a biomarker in the assessment of both the biologically relevant exposure to carcinogens and the pathobiological consequences of that exposure. Here, we present data demonstrating that detection and identification of exposure-related DNA adducts in marine and freshwater organisms (sponge, mussel and fish) is possible despite the presence, sometimes, of great ...
Tópico(s): Environmental Toxicology and Ecotoxicology
1989 - Elsevier BV | Marine Environmental Research
Branko Kurelec, Sanja Krča, Branka Pivčević, Đurđica Ugarković, Michael Bachmann, Georg Imsiecke, Wernér E.G. Müller,
In the present paper it is shown that the marine sponges Geodia cydonium and Verongia aerophoba contain the gene coding for P-glycoprotein P170, also known as a multidrug-resistance gene. Western blot studies revealed that polyclonal antibodies raised against hamster P170 cross-react with the sponge polypeptide of Mr 125,000. After endoglycosidase F treatment, the sponge P125 is converted to a polypeptide of Mr 105,000. Northern blot studies, using the human P170 cDNA probe, revealed a size of 4. ...
Tópico(s): Antimicrobial Peptides and Activities
1992 - Oxford University Press | Carcinogenesis
Achal Garg, Sanja Krča, Branko Kurelec, Ramesh C. Gupta,
1. Novel DNA modifications were detected in the aquatic organisms belonging to the phyla Porifera, Arthropoda, Echinodermata, Protochordata and Pisces by a generally applicable 32P-post-labeling technique. 2. These modifications are lipophilic and different to 5-methylcystosine. They are unrelated to trace RNA contamination. 3. Up to 5-fold interorganism and 1100-fold interspecies variations were observed in the level of modifications, the highest being in P. lividus (Echinodermata), and lowest in ...
Tópico(s): Echinoderm biology and ecology
1992 - Elsevier BV | Comparative Biochemistry and Physiology Part B Comparative Biochemistry
Branko Kurelec, Achal Garg, Sanja Krča, Smiljana Britvić, Davor Lučıć, Ramesh C. Gupta,
In attempts to mimic field exposure, oil slicks prepared from diesel-2 oil/water emulsions were poured onto the surface of water in tanks prepared fresh every day and liver DNA adducts were analyzed by 32P-postlabeling in carp free-swimming in these tanks. ‘Clusters’ of lipophilic DNA adducts were detected, with five major and numerus minor adducts. Essentially a similar adduct pattern was found in the liver DNA of carp exposed to crude oil-polluted water. Diesel-2 adduct induction was observed slowly ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
1992 - Elsevier BV | European Journal of Pharmacology Environmental Toxicology and Pharmacology
Reaction of 1-substituted 5-hydroxy-1H-pyrazoles (pyrazolones) with trans-cinnamoyl chloride / calcium hydroxide in dioxane affords the corresponding 4-cinnamoyl-5-hydroxy-1H-pyrazoles.Cyclization of the latter into 5,6-dihydropyrano[2,3-c]pyrazol-4-ones proceeds in very low yields upon treatment with concentrated sulfuric acid.1,6-Diphenyl-1H-pyrano[2,3c]pyrazol-4-one was synthesized by reaction of of 4-acetyl-5-hydroxy-1-phenyl-1H-pyrazole with benzoyl chloride and lithium bis(trimethylsilyl)amide ...
Tópico(s): Synthesis and biological activity
2003 - Elsevier BV | Heterocycles
S. Tomić, Sanja Dolanski Babić, Tomislav Vuletić, Sanja Krča, Dušica Ivanković, Lorena Griparić, Rudolf Podgornik,
We report on a detailed characterization of complex dielectric response of Na-DNA aqueous solutions by means of low-frequency dielectric spectroscopy (40 Hz - 110 MHz). Results reveal two broad relaxation modes of strength 20<\Delta\epsilon_LF<100 and 5<\Delta\epsilon_HF<20, centered at 0.5 kHz<\nu_LF<70 kHz and 0.1 MHz<\nu_HF<15 MHz. The characteristic length scale of the LF process, 50<L_LF<750nm, scales with DNA concentration as c_DNA^{-0.29\pm0.04} and is independent of the ionic strength in the low ...
Tópico(s): Material Dynamics and Properties
2007 - American Physical Society | Physical Review E
Sanja Krča, Roko Žaja, Violeta Čalić, Senka Terzić, Miloš Saša Grubešić, Marijan Ahel, Tvrtko Smital,
Abstract As a widely spread cyprinid fish species, the European chub ( Leuciscus cephalus ) has been used extensively in bio‐monitoring programs. However, no laboratory dose‐response and/or time course studies related to applied biomarkers have been reported on chub yet. In order to address this issue, specimens of juvenile chub caught in September 2005 in the Sava River, Croatia, were laboratory exposed to various (0.25–50 mg/kg) doses of either model polycyclic aromatic hydrocarbons (PAH) premutagen ...
Tópico(s): Reproductive biology and impacts on aquatic species
2007 - Wiley | Environmental Toxicology and Chemistry
S. Tomić, Tomislav Vuletić, Sanja Dolanski Babić, Sanja Krča, Dušica Ivanković, Lorena Griparić, Rudolf Podgornik,
The fundamental length scales in semidilute Na-DNA aqueous solutions have been investigated by dielectric spectroscopy. The low- and the high-frequency relaxation modes are studied in detail. The length scale of the high-frequency relaxation mode at high DNA concentrations can be identified with the de Gennes-Pfeuty-Dobrynin correlation length of polyelectrolytes in semidilute solution, whereas at low DNA concentrations and in the low added salt limit the length scale shows an unusual exponent reminiscent ...
Tópico(s): DNA and Nucleic Acid Chemistry
2006 - American Physical Society | Physical Review Letters
B. Kureleć, Sanja Krča, Davor Lučıć,
The gills of mussel Mytilus galloprovincialis express a multixenobiotic resistance mechanism (MXRM) mediated by P-glycoprotein activity, as evidenced by the rate of (G-3H) vincristine accumulation and its sensitivity to verapamil, as well as by the direct immunochemical detection of P-glycoprotein by Western blotting analysis. The MXRM is induced at polluted sites: gills from mussels living at polluted sites accumulate less vincristine, the vincristine accumulation is less sensitive to verapamil, ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
1996 - Elsevier BV | Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology
Tvrtko Smital, Roberta Sauerborn, Branka Pivčević, Sanja Krča, Branko Kurelec,
Tópico(s): Pharmacological Effects and Toxicity Studies
2000 - Elsevier BV | Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology
B. Kureleć, Davor Lučıć, Branka Pivčević, Sanja Krča,
Tópico(s): Pharmacological Effects and Toxicity Studies
1995 - Springer Science+Business Media | Marine Biology
Chung Hyo Kang, Jeong In Yun, Kwangho Lee, Chong Ock Lee, Heung Kyoung Lee, Chang‐Soo Yun, Jong Yeon Hwang, Sung Yun Cho, Heejung Jung, Pilho Kim, Jae Du Ha, Jeong Hee Jeon, Sang Un Choi, Hye Gwang Jeong, Hyoung Rae Kim, Chi Hoon Park,
... and potent ALK inhibitor having similar scaffold to KRCA-0008, which was reported previously, and its molecular ... wild type enzyme assay, we selected two compounds, KRCA-0080 and KRCA-0087, which have trifluoromethyl instead of chloride in ... and in vivo assays. Enzyme assay shows that KRCA-0080 is more potent against various ALK mutants, ... which are seen in crizotinib-resistant patients, than KRCA-0008 is. Cell based assays demonstrate our compounds ... In vivo H3122 xenograft assay, we found that KRCA-0080 shows significant reduction in tumor size compared ...
Tópico(s): Cancer therapeutics and mechanisms
2015 - Elsevier BV | Biochemical and Biophysical Research Communications
Ga Ae Kang, Minji Lee, Dawn Song, Heung Kyoung Lee, Sunjoo Ahn, Chi Hoon Park, Chong Ock Lee, Chang Soo Yun, Heejung Jung, Pilho Kim, Jae Du Ha, Sung Yun Cho, Hyoung Rae Kim, Jong Yeon Hwang,
... and cell-based ALK assays. Amongst compounds synthesized, KRCA-0445 showed very promising results in pharmacokinetic study ...
Tópico(s): Synthesis and Biological Evaluation
2015 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
B. Kureleć, Sanja Krča, Ajay Garg, Ramesh C. Gupta,
We have investigated the formation of DNA adducts in starved, fed and 5,6-benzoflavone-pretreated carp following i.p. administration of benzo(a)pyrene. 32P-postlabeling analysis of the liver DNAs showed the presence of one predominant (>92%) adduct in all three groups. Cochromatography experiments revealed that the main adduct was identical to authentic BPDEI-dG (10β-(deoxyguanosin-N2-yl)-7β,8α,9α-trihydroxy-7,8,9,10 -tetrahydrobenzo[a]pyrene). The formation of the adduct was evident as early as 1.5 ...
Tópico(s): DNA and Nucleic Acid Chemistry
1991 - Elsevier BV | Cancer Letters
B. Kureleć, Smiljana Britvić, Sanja Krča, Wernér E.G. Müller, Rudolf K. Ζahn,
Postmitochondrial fractions from marine sponges Geodia cydonium, Tethya aurantium, Verongia aerophoba and Pellina semitubulosa activate precarcinogenic aromatic amine 2-aminoanthracene, but not precarcinogenic polycyclic aromatic hydrocarbon benzo(a)pyrene, to Salmonella typhimurium TA 98 mutagens. All four sponge species lack a benzo(a)pyrene monooxygenase activity, but possesses the enzyme activity whose characteristics (selective activation of aromatic amines, NADPH-dependency, pH optimum at 8. ...
Tópico(s): Chemistry and Chemical Engineering
1987 - Elsevier BV | Comparative Biochemistry and Physiology Part C Comparative Pharmacology
S. Tomić, Sanja Dolanski Babić, Tomislav Ivek, Tomislav Vuletić, Sanja Krča, F. Livolant, Rudolf Podgornik,
Dielectric spectroscopy is used to investigate fundamental length scales of 146 bp short-fragment (nucleosomal) dilute Na-DNA solutions. Two relaxation modes are detected: the high- and the low-frequency mode. Dependence of the corresponding length scales on the DNA and on the (uni-valent) salt concentration is studied in detail, being different from the case of long, genomic DNA, investigated before. In low-added-salt regime, the length scale of the high-frequency mode scales as the average separation ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2008 - Institute of Physics | EPL (Europhysics Letters)
1. The mode of activation of 2-aminofluorene (AF), 2-acetylaminofluorene (AAF) and N-hydroxy-acetylaminofluorene (OH-AAF) to Salmonella typhimurium TA 98 mutagens was investigated in subcellular fractions from the digestive gland of the mussel Mytilus galloprovincialis and from the liver of carp Cyprinus carpio. 2. In carp liver microsomes the activation of OH-AAF was due to very active deacetylase, in contrast to undetectable deacetylase-dependent activation in mussel microsomes. 3. AF and AAF are ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
1987 - Elsevier BV | Comparative Biochemistry and Physiology Part C Comparative Pharmacology
Rohit Raj Jha, Kavita Isvaran,
... of conservation concern in the Krishnasaar Conservation Area (KrCA) in Nepal. Here, blackbuck Antilope cervicapra , a generalist ... 250 × 250 m grid cells in the entire KrCA and carried out indirect sign surveys with three ...
Tópico(s): Primate Behavior and Ecology
2022 - Wiley | Ecology and Evolution
Đurđica Ugarković, B. Kureleć, Sanja Krča, R. Batel, Andrea A. Robitzki, Wernér E.G. Müller, Heinz C. Schröder,
Tópico(s): Environmental Toxicology and Ecotoxicology
1990 - Springer Science+Business Media | Marine Biology
Jungjoong Hwang, Insuk Song, Kwang Ho Lee, Hyoung Rae Kim, Eun‐Hye Hong, Jung Soon Hwang, Sung‐Hoon Ahn, Jong‐Kook Lee,
Tópico(s): Lung Cancer Treatments and Mutations
2020 - Springer Science+Business Media | Investigational New Drugs
1. The in vitro incubation of mussel digestive gland with 1 mM aminofluorene resulted in the formation of glucuronides that (a) became mutagenic with carp liver S9, and (b) liberated S9-dependent mutagenic aglucones after beta-glucuronidase treatment. 2. Natural populations of mussels from unpolluted and polluted sites, as well as mussels exposed to 3 ppm of aminofluorene or to used engine oil, did not accumulate detectable amounts of premutagens, mutagens, or mutagenic glucuronides/aglucones either ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1989 - Elsevier BV | Comparative Biochemistry and Physiology Part C Comparative Pharmacology
Ali H. Kashmar, Eddie Shahril Ismail,
... ciphers, termed Auto-Key Round Combiner Algorithm A-KRCA, applied as a nonlinear invertible round function to perform the encryption/decryption process. A-KRCA was implemented and its cryptanalysis demonstrated that the ...
Tópico(s): Chaos-based Image/Signal Encryption
2014 - American Institute of Physics | AIP conference proceedings
... 78C: 363–367. 19 Kurelec, B. and S. Krca. 1987. Metabolic activation of 2-aminofluorene, 2-acetylaminofluorene ...
1990 - Wiley | Environmental Toxicology and Chemistry
Elena Janiczeková, Jana Lauková, Denisa Ivaničová, Daniela Beňadiková,
Súhrn Úvod: Kolorektálny karcinóm (KRCa) je jedným z mála karcinómov, kde je možná účinná sekundárna prevencia, pretože tá ho môže vo väčšine prípadov včas odhaliť ... Cieľ: Cieľom prehľadovej štúdie je zmapovať prevalenciu výskytu KRCa u jedincov v kontexte s odkladom skríningu kolorektálneho ... viacerých európskych krajinách spomalila až zastavila skríningové programy KRCa. Dočasným pozastavením skríningových programov počas lockdownu sa zvýšil výskyt KRCa, aj miera detekcie "vysoko rizikových" adenómov bola významne ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2023 - University of South Bohemia in České Budějovice | Kontakt
Kwang Ho Lee, Hyoung Rae Kim, Sung Yun Cho, Hee Jung Jung, Jae Du Ha, Chang‐Soo Yun, Pilho Kim, Chi Hoon Park, Chong Ock Lee,
... matched with crizotinib and LDK378 in docking study. KRCA-0008 has been identified as a highly potent ... L1196M cell line. PK profiles were excellent and KRCA-0008 was safe in Ames test, chromosomal aberration ... micronucleus asssay, and acute toxicity. Also, we observed KRCA-0008 is chemically and metabolically very stable and ... vivo xenograft mouse model (H3122 NSCLC) model study, KRCA-0008 shows moderate tumor growth inhibition without significant ...
Tópico(s): Lung Cancer Treatments and Mutations
2013 - American Association for Cancer Research | Molecular Cancer Therapeutics