Brett C. Bookser, Srinivas Rao Kasibhatla, James R. Appleman, Mark D. Erion,
... 7j (AMPDA K(i) = 0.41 microM and ADA K(i) > 1000 microM). These compounds, as well as ...
Tópico(s): Chemical Synthesis and Analysis
2000 - American Chemical Society | Journal of Medicinal Chemistry
Alison Joyce, Christopher R. Shea, Zhiping You, Boris Gorovits, Christopher Lepsy,
... Singulex Erenna ligand-binding assay (LBA) method. Apparent ADA K D values were calculated using a custom R ... ADA in clinical samples. The observed decrease in ADA K D is consistent with evidence of a maturing ...
Tópico(s): Protein purification and stability
2022 - Springer Science+Business Media | The AAPS Journal
Yipei Wang, Xin Liu, Brandon Schneider, Elaina A. Zverina, Kristen A. Russ, Sanjeeva J. Wijeyesakere, Carol A. Fierke, Rudy J. Richardson, Martin A. Philbert,
... mixed inhibition with 1,3-DNB binding to ADA (K I 5 520 ± 100mM, n 5 1 ± 0.6) and the ADA-adenosine complex (K IS 5 262 ± 7mM, n 5 6 ± 0. ...
Tópico(s): Adenosine and Purinergic Signaling
2011 - Oxford University Press | Toxicological Sciences
... membrane. J. gen. Physiol., 48, 279–295. OK Ada, K. & Adachi, M. (1962). Effect of ethylalcohol on the ...
Tópico(s): Neurobiology and Insect Physiology Research
1967 - Wiley | British Journal of Pharmacology and Chemotherapy
... 5, May 1970, pp. 1030– 1039. 3 Jacox, Ada K., “ Issues in Construction of Nursing Theory.” Proceedings of ...
Tópico(s): School Health and Nursing Education
1970 - Wiley | Nursing Forum
FREDERICK SUPPE, ADA K. JACOX,
Tópico(s): Ethics in medical practice
1985 - Springer Nature | Annual Review of Nursing Research
... 1016/j.jebo.2004.03.021Michael J. Dueker, Ada K. Jacox, David E. Kalist, Stephen J. Spurr The ...
Tópico(s): Housing Market and Economics
1992 - University of Chicago Press | The Journal of Law and Economics
Abstract This paper investigates whether the stock return series of Australia, Hong Kong, Singapore and the US are covariance stationary using Omran and McKenzie's (The Statistician, 48, 361–69, 1999) testing procedure which comprises the Loretan and Phillips (1994) test and an intervention analysis. The main objective of the procedure is to ascertain the role of structural breaks on the stochastic properties of the stock return series. It is found that the intervention due to the 1997 Asian financial ...
Tópico(s): Monetary Policy and Economic Impact
2002 - Taylor & Francis | Applied Economics Letters
Raymond Chuen‐Chung Chang, Ada K. Y. Wong, Ho‐Keung Ng, Jacques Hugon,
Inhibition of protein translation is a mode of inducing neuronal apoptosis and neurodegeneration in Alzheimer's disease (AD). Phosphorylation of eukaryotic initiation factor-2α (eIF2α) terminates global protein translation and induces apoptosis. We examined whether this signaling pathway occurs in degenerating neurons of AD. Brain sections from young individuals, age-matched control individuals and AD patients were examined for immunoreactivity of phosphorylated eIF2α by immunohistochemical analysis. ...
Tópico(s): Mitochondrial Function and Pathology
2002 - Lippincott Williams & Wilkins | Neuroreport
Joanna P. Williams, Laura G. Brown, Ada K. Silverstein, John S. de Cani,
These studies describe and evaluate an instructional program designed to help students with learning disabilities learn about the concept of theme, identify themes in stories, and apply themes to real life. Subjects were fifth- and sixth-grade nondisabled students and students with mild learning disabilities (Study 1) and seventh and eighth graders with more severe disabilities (Study 2). In both studies, the program improved comprehension of theme and identification of a specific theme that had been ...
Tópico(s): Educational and Psychological Assessments
1994 - SAGE Publishing | Learning Disability Quarterly
Ada K. H. Pak, Alice Cheng‐Lai, Ivy F. Tso, Hua Shu, Wenling Li, Richard C. Anderson,
Tópico(s): Visual and Cognitive Learning Processes
2005 - Springer Science+Business Media | Reading and Writing
Matthew Salamonsen, Ada K. C Lo, Arnold C.T. Ng, Farzad Bashirzadeh, William Y.S. Wang, David Fielding,
BACKGROUND The presence of entrapped lung changes the appropriate management of malignant pleural effusion from pleurodesis to insertion of an indwelling pleural catheter. No methods currently exist to identify entrapped lung prior to effusion drainage. Our objectives were to develop a method to identify entrapped lung using tissue movement and deformation (strain) analysis with ultrasonography and compare it to the existing technique of pleural elastance (PEL). METHODS Prior to drainage, 81 patients ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2014 - Elsevier BV | CHEST Journal
Abel Negussie, Wondewosen Kassahun, Sahilu Assegid, Ada K. Hagan,
The prevention of child mortality through immunization is one of the most cost-effective and widely applied public health interventions. In Ethiopia, the Expanded Program on Immunization (EPI) schedule is rarely completed as planned and the full immunization rate is only 24 %. The objective of this study was to identify determinant factors of incomplete childhood immunization in Arbegona district, Sidama zone, southern Ethiopia. A community based unmatched case-control study was undertaken among randomly ...
Tópico(s): Influenza Virus Research Studies
2015 - BioMed Central | BMC Public Health
Jessie M. Wall, Ada K. Law, Ma Zhu, David Munro, Filomena Parada, Richard A. Young,
This article describes an alternative framework for conceptualizing and researching emerging adulthood based on the notions of goal-directed processes. Specifically, contextual action theory (CAT) is proposed to add value to understanding transition-to-adulthood processes because of its emphasis on description, intentional action, and relational context. A related naturalistic, longitudinal method, the action-project method (A-PM), is used to study joint, goal-directed actions and projects (multiple ...
Tópico(s): Family Support in Illness
2015 - SAGE Publishing | Emerging Adulthood
Izabela Z. Schultz, Ada K. Law, Leanna C. Cruikshank,
Within the fields of psychiatry, psychology, and neuropsychology, medical examiners are often tasked with providing an opinion about an injured individual's health prognosis and likelihood of returning to work. Traditionally, examiners have conducted such assessments by employing clinical intuition, expert knowledge, and judgment. More recently, however, an accumulation of research on factors predictive of disability has allowed examiners to provide prognostications using specific empirically supported ...
Tópico(s): Occupational Health and Performance
2016 - Elsevier BV | International Journal of Law and Psychiatry
Ada K. Hagan, Paul E. Carlson, Philip C. Hanna,
The dramatic, rapid growth of Bacillus anthracis that occurs during systemic anthrax implies a crucial requirement for the efficient acquisition of iron. While recent advances in our understanding of B. anthracis iron acquisition systems indicate the use of strategies similar to other pathogens, this review focuses on unique features of the major siderophore system, petrobactin. Ways that petrobactin differs from other siderophores include: A. unique ferric iron binding moieties that allow petrobactin ...
Tópico(s): Bacterial biofilms and quorum sensing
2016 - Wiley | Molecular Microbiology
Travis J. Kochan, Madeline Somers, Alyssa M. Kaiser, Michelle S. Shoshiev, Ada K. Hagan, Jessica L. Hastie, Nicole Giordano, Ashley D. Smith, Alyxandria M. Schubert, Paul E. Carlson, Philip C. Hanna,
Clostridium difficile (C. difficile) is an anaerobic gram-positive pathogen that is the leading cause of nosocomial bacterial infection globally. C. difficile infection (CDI) typically occurs after ingestion of infectious spores by a patient that has been treated with broad-spectrum antibiotics. While CDI is a toxin-mediated disease, transmission and pathogenesis are dependent on the ability to produce viable spores. These spores must become metabolically active (germinate) in order to cause disease. ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2017 - Public Library of Science | PLoS Pathogens
Ada K. Hagan, Yael M. Plotnick, Ryan E. Dingle, Zachary I. Mendel, Stephen R. Cendrowski, David H. Sherman, Ashootosh Tripathi, Philip C. Hanna,
Bacillus anthracis is a Gram-positive bacillus that under conditions of environmental stress, such as low nutrients, can convert from a vegetative bacillus to a highly durable spore that enables long-term survival. The sporulation process is regulated by a sequential cascade of dedicated transcription factors but requires key nutrients to complete, one of which is iron. Iron acquisition by the iron-scavenging siderophore petrobactin is required for vegetative growth of B. anthracis under iron-depleted ...
Tópico(s): Bacteriophages and microbial interactions
2018 - American Society for Microbiology | mBio
Ada K. Hagan, Begüm D. Topçuoğlu, Mia E. Gregory, Hazel A. Barton, Patrick D. Schloss,
Despite 50% of biology Ph.D. graduates being women, the number of women that advance in academia decreases at each level (e.g., from graduate to postdoctorate to tenure track). Recently, scientific societies and publishers have begun examining internal submissions data to evaluate representation and evaluation of women in their peer review processes; however, representation and attitudes differ by scientific field, and to date, no studies have investigated academic publishing in the field of microbiology. ...
Tópico(s): Social Media in Health Education
2020 - American Society for Microbiology | mBio
Ada K. Hagan, Rebecca M. Pollet, Josie Libertucci,
Within the field of biomedical research in the United States, the proportion of underrepresented minorities at the Full Professor level has remained consistently low, even though trainee demographics are becoming more diverse. Underrepresented groups face a complex set of barriers to achieving faculty status, including imposter syndrome, increased performance expectations, and patterns of exclusion. Institutionalized racism and sexism have contributed to these barriers and perpetuated policy that ...
Tópico(s): Mentoring and Academic Development
2020 - American Society for Microbiology | Journal of Microbiology and Biology Education
Gordon Ada, K‐N Leung, Hildegund C.J. Ertl,
... Ann. N. Y. Acad. Sci. 83, 578. Leung, K. N. & Ada, G. L. (1980a) Production of DTH in the ... T cells. Scand. J. Immunol. 12, 12. Leung, K. N. & Ada, G. L. (1980b) Generation of influenza virus specific ... Aust. J. Biol. med Sci. 58, 457. Leung, K. N. & Ada, G. L. (1980c) Cells mediating delayed type hypersensitivity ... influenza virus. Scand. J. Immunol. 12, 393. Leung, K. N. & Ada, G. L. (1980d) Two T-cell populations mediate ... virus infection. Scand. J. Immunol. 12, 481. Leung, K. N. & Ada, G. L. (1981) The effect of helper T ...
Tópico(s): T-cell and B-cell Immunology
1981 - Wiley | Immunological Reviews
Izabela Z. Schultz, Catherine M. Chlebak, Ada K. Law,
Aiming to bridge research and practice, evidence-informed best clinical and occupational practices are a necessity to address alarming economic and personal costs associated with workplace disability. Concerning are both high prevalence and adverse occupational impact of nonvisible disabilities arising from musculoskeletal disorders, especially low back pain and temporomandibular joint and muscle disorders, as well as mental health disorders. Notably, low back pain and temporomandibular joint disorders ...
Tópico(s): Agriculture and Farm Safety
2015 - Springer Nature | Handbooks in health, work, and disability
Produção Nacional
Revisado por pares
Gláubia Sartori, Natália Silva Jardim, Marcel Henrique Marcondes Sari, Eduardo Furtado Flores, Marina Prigol, Cristina W. Nogueira,
... and catalase (CAT). The activities of adenosine deaminase (ADA), Na + /K + ‐ATPase (liver and kidney); alanine aminotransferase (ALT), aspartate ... infected mice and also normalized hepatic and renal ADA activity. It recovered the activity of Na + /K + ‐ and was not effective against the increase in urea levels in infected mice. Different from (PhSe) 2 , acyclovir (positive control), caused an increase in ADA activity and a decrease in hepatic CAT activity. ...
Tópico(s): Pharmacological Effects of Natural Compounds
2016 - Wiley | Journal of Cellular Biochemistry
Byung Woo Han, C.A. Bingman, Donna K. Mahnke, Ryan M. Bannen, Sebastian Y. Bednarek, Richard L. Sabina, G.N. Phillips,
... crystal structures are available, including the functionally related ADA (15Wilson D.K. Rudolph F.B. Quiocho F.A. Science. 1991; ... essential catalytic residues in the active site of ADA (15Wilson D.K. Rudolph F.B. Quiocho F.A. Science. 1991; ...
Tópico(s): Plant Reproductive Biology
2006 - Elsevier BV | Journal of Biological Chemistry
Andrew J. Witten, Karin F.K. Ejendal, Lindsey Gengelbach O'Brien, Meghan A. Traore, Xu Wang, David M. Umulis, Sarah Calve, Tamara L. Kinzer‐Ursem,
... t is the time of incubation with 12-ADA, and k is the pseudo-first order rate constant (k = 0.22 h−1). C2C12 cells were incubated with 12-ADA, Myr, or DMSO for 6 h, as described ...
Tópico(s): Cellular transport and secretion
2017 - Elsevier BV | Journal of Lipid Research
M. Sivák, J. Tyršelová, F. Pavelčík, Jaromı́r Marek,
... 1.3–8.6. The MI[VO(O2)ada] · xH2O (MI= K+, Cs+; x = 4 for K+ and 1 for ... decomposition of the crystallohydrate. The crystal structure of K[VO(O2)ada] · 4H2O was determined by X-ray structure analysis. ...
Tópico(s): Polyoxometalates: Synthesis and Applications
1996 - Elsevier BV | Polyhedron
... heterocyclic core, which have been shown to inhibit ADA with K i values in the nanomolar range.Although successful in providing novel ADA inhibitors, authors recognize the difficulty of unveiling their ...
Tópico(s): Peptidase Inhibition and Analysis
2013 - Springer Science+Business Media | Purinergic Signalling
Ada K. Hagan, Nicholas A. Lesniak, Marcy J. Balunas, Lucas Bishop, William L. Close, Matthew K. Doherty, Amanda G. Elmore, Kaitlin J. Flynn, Geoffrey D. Hannigan, Charlie C. Koumpouras, Matthew L. Jenior, Ariangela J. Kozik, Kathryn McBride, Samara Rifkin, Joshua M. A. Stough, Kelly L. Sovacool, Marc A. Sze, Sarah Tomkovich, Begüm D. Topçuoğlu, Patrick D. Schloss,
Exploratory Science Center, Merck & Co , Inc , Cambridge, Massachusetts, United States of America Affiliation: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America ORCID logo http://orcid org/0000-0003-3140-537X Patrick D Schloss * E-mail: pschloss@umich edu Affiliation: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America ORCID logo http://orcid org/0000-0002-6935-4275 Introduction For ...
Tópico(s): Research Data Management Practices
2020 - Public Library of Science | PLoS Computational Biology
Anne M. Cieniewicz, Linley Moreland, Alison E. Ringel, Samuel G. Mackintosh, Ana Raman, Tonya M. Gilbert, Cynthia Wolberger, Alan J. Tackett, Sean D. Taverna,
... of chromatin-associated transcriptional activator complexes SAGA and ADA (23Lee K.K. Sardiu M.E. Swanson S.K. Gilmore J.M. Torok M. Grant P.A. Florens L. Workman J.L. Washburn M.P. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.Mol. Syst. Biol. 2011; 7: ...
Tópico(s): Ubiquitin and proteasome pathways
2014 - Elsevier BV | Molecular & Cellular Proteomics
Irina Gillerman, Bilha Fischer,
... riboside were found to be competitive inhibitors of ADA with K(i) values of 25, 22, 6, and 3 μM, respectively. We concluded that electronic parameters are not major recognition determinants of ADA but rather steric parameters. A C2 substituent which ...
Tópico(s): Click Chemistry and Applications
2010 - American Chemical Society | Journal of Medicinal Chemistry