Seok Kyu Kang, Carlos G. Vanoye, Sunita N. Misra, Dennis M. Echevarria-Cooper, Jeffrey D. Calhoun, John B. O’Connor, Katarina L. Fabre, Dianalee McKnight, Laurie Demmer, Paula Goldenberg, Lauren Grote, Isabelle Thiffault, Carol Saunders, Kevin A. Strauss, Ali Torkamani, Jasper van der Smagt, Koen L.I. van Gassen, Robert P. Carson, Jullianne Diaz, Eyby Leon, Joseph E. Jacher, Mark C. Hannibal, Jessica Litwin, Neil Friedman, Allison Schreiber, Bryan Lynch, Annapurna Poduri, Eric D. Marsh, Ethan M. Goldberg, J Gordon Millichap, Alfred L. George, Jennifer A. Kearney,
... in KCNB1, encoding the voltage-gated potassium channel KV 2.1, are associated with developmental and epileptic encephalopathy ( ... biophysical properties and cell-surface expression of variant KV 2.1 channels expressed in heterologous cells using high- ... as homotetramers or when coexpressed with wild-type KV 2.1. Quantification of protein expression also identified variants with reduced total KV 2.1 expression or deficient cell-surface expression.Our study establishes a platform for rapid screening of KV 2.1 functional defects caused by KCNB1 variants associated ...
Tópico(s): Epilepsy research and treatment
2019 - Wiley | Annals of Neurology
Yuk‐Man Leung, Youhou Kang, Xiao‐Dong Gao, Fuzhen Xia, Huanli Xie, Laura Sheu, Sharon Tsuk, Ilana Lotan, Robert G. Tsushima, Herbert Y. Gaisano,
Voltage-gated K+(Kv) 2.1 is the dominant Kv channel that controls membrane repolarization in rat islet औ-cells and downstream insulin exocytosis. ... directly binds and modulates rat islet औ-cell Kv 2.1 channel protein at the cytoplasmic N terminus. ... between different Kv channel families. Voltage-gated K+(Kv) 2.1 is the dominant Kv channel that controls ... directly binds and modulates rat islet औ-cell Kv 2.1 channel protein at the cytoplasmic N terminus. ... corresponding to N-terminal region (1–182) of Kv 2.1 were amplified by polymerase chain reaction (PCR) ...
Tópico(s): Erythrocyte Function and Pathophysiology
2003 - Elsevier BV | Journal of Biological Chemistry
Susumu Ohya, Mamiko Tanaka, Minoru Watanabe, Yuji Imaizumi,
... 1.2, Kv 1.5, Kv 1.6, Kv 2.1, Kv 2.2, Kv 3.1, and Kv 3.2), ... channel (Kv 1.2, Kv 1.5, and Kv 2.1) transcripts was observed in these SMs. To ... subtypes (Kv 1.2, Kv 1.5, and Kv 2.1) were determined by competitive PCR. In vascular ... whereas in visceral SM tissues, UB and VD, Kv 2.1 transcripts were expressed at the relatively high ...
Tópico(s): Neuroscience and Neuropharmacology Research
2000 - Japan Society of Smooth Muscle Research | Journal of Smooth Muscle Research
Somayeh Taghian Dinani, Michel Havet,
... s, 0 kV–0.4 m/s, 30 kV–2.2 m/s, 25 kV–2.2 m/s, 20 kV–2.2 m/s and, 0 kV–2.2 m/s) were carried out at 45 ° ...
Tópico(s): Microbial Inactivation Methods
2015 - Elsevier BV | Industrial Crops and Products
Somayeh Taghian Dinani, Michel Havet,
... drying rate and final moisture content to 0 kV-2.2 m/s, 20 kV-2.2 m/s, 25 kV-2.2 m/s, and 30 kV-2.2 m/s treatments, but it represented considerably ...
Tópico(s): Microbial Inactivation Methods
2015 - Elsevier BV | Journal of Cleaner Production
G. Jönsson, C. Levinson, Sune Svanberg,
... α0(4p2 1S0) = -32.2(16) MHz (cm/kV)2, α0(4p2 1D2) = 1.8(2) MHz (cm/kV)2 and α2(4p2 1D2) = 1.15(10) MHz (cm/kV)2. Additional measurements yielded τ(4s5f1F3) = 60(3) ns, ... and α0 (4s6s1S0) = 6.98(35) MHz (cm/kV)2.
Tópico(s): Mass Spectrometry Techniques and Applications
1984 - IOP Publishing | Physica Scripta
R. Madavan, Sujatha Balaraman, S. Saroja,
... inhibited and uninhibited MO samples are from 52 kV/2.5 mm to 55 kV/2.5 mm. When the samples are aged, BDV ... uninhibited sample (S1) is reduced about 53% (24 kV/2.5 mm), and the reduction range of inhibited ...
Tópico(s): High voltage insulation and dielectric phenomena
2017 - Institution of Engineering and Technology | IET Generation Transmission & Distribution
Ali Torkamani, Kevin Bersell, Benjamin S. Jorge, R. L. Bjork, Jennifer Friedman, Cinnamon S. Bloss, Julie S. Cohen, Siddharth Gupta, Sakkubai Naidu, Carlos G. Vanoye, Alfred L. George, Jennifer A. Kearney,
... novo missense mutation in KCNB1 that encodes the KV 2.1 voltage-gated potassium channel. Functional studies demonstrated a deleterious effect of the mutation on KV 2.1 function leading to a loss of ion ... missense mutations that cause a similar pattern of KV 2.1 dysfunction.Our genetic and functional evidence demonstrate ...
Tópico(s): Neuroscience and Neuropharmacology Research
2014 - Wiley | Annals of Neurology
Giovanni Borasi, Andrea Nitrosi, P. Ferrari, Davide Tassoni,
... selenium based detector is very high (at 70 kV, 2 cycles/mm, 2.5 μGy, about 0.80). ... panels exhibit a comparable (lower) resolution (at 70 kV, 2 cycles/mm, 2.5 μGy, MTF is about ... the frequency dependence is significantly different. At 70 kV, 2.5 μGy, 0.5 cycles/mm detective quantum ...
Tópico(s): Radiation Detection and Scintillator Technologies
2003 - Wiley | Medical Physics
Osuke Miura, Satoru Tanaka, K. Miyoshi, N. Ichiyanagi, Y. Tanaka, Hideo Ishii, T. Hara,
... the next step, we have designed a 66 kV-2 kA superconducting cable of outer diameter 124 mm ... have been able to successfully perform a 66 kV-2 kA withstand test on an oxide superconducting power ...
Tópico(s): HVDC Systems and Fault Protection
1996 - Elsevier BV | Cryogenics
James A. Dodd, Steven Lipson, Dorothy J. Flanagan, W. A. M. Blumberg, James C. Person, Byron David Green,
... 1): kv=1(N2)=1.2±0.5, kv=2(N2)=3.8±1.5, kv=3(N2)= ... 5; kv=1(Ar)=0.2±0.1, kv=2(Ar)=0.5±0.2, kv=3(Ar)=0.8±0.3; kv=1(H2)≤50, kv=2(H2)≤100, kv=3(H2)≤150. In addition, ...
Tópico(s): Atmospheric chemistry and aerosols
1991 - American Institute of Physics | The Journal of Chemical Physics
... Salmonella. Under the determined conditions (CP: 24.5 kV, 2 min; IPL: 1.5 kV, 2 min), the inactivation levels of Salmonella, Escherichia coli ...
Tópico(s): Radiation Effects and Dosimetry
2022 - Elsevier BV | International Journal of Food Microbiology
Dragan Jovcic, Stefan Kovacevic,
... design and to analyse operating principles. A 5 kV, 2 kA hardware demonstrator with 1.5 ms disconnector ...
Tópico(s): Silicon Carbide Semiconductor Technologies
2021 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Delivery
Qingquan Qiu, Liye Xiao, Jingye Zhang, Zhifeng Zhang, Naihao Song, Liwei Jing, Wenhan Zha, Xiaoji Du, Yuping Teng, Zhihao Zhou, Guomin Zhang, Dong Xia,
... this article, a general scheme of a 40-kV/2-kA resistive type dc superconducting fault current limiter ( ...
Tópico(s): Electrical Fault Detection and Protection
2020 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
Amir Heidary, Kumars Rouzbehi, Morteza Hesami, Mehdi Bigdeli, Carlos Bordons,
... kA 1 packaged IGBT and diode, 4.5 kV, 2.9 kA MB 134 series IGBT, 4.5 ... mH arresters metal oxide arrester, peak voltage 600 kV, 2.75 MJ Metal oxide arrester, peak voltage 360 ...
Tópico(s): Superconductivity in MgB2 and Alloys
2020 - Institution of Engineering and Technology | IET Generation Transmission & Distribution
Mohammad Reza Barzegar‐Bafrooei, Asghar Akbari Foroud, Jamal Dehghani Ashkezari, Mohsen Niasati,
... budget for Ampacity project (HTS cable plus 12 kV/2.3 kA RSFCL) was about €13.5 million [ ... 05 kA UK/bus-bar coupling 2015 12 kV/2.3 kA Germany/HTS cable protection 2014 13. ...
Tópico(s): Power Systems Fault Detection
2019 - Institution of Engineering and Technology | IET Generation Transmission & Distribution
Hossein Jafari, Morteza Habibi,
... 84 nF, 48 nH, and PF-225: 15 kV, 2 μF, 50 nH), operating at repetitive discharges with the following specifications: 20 kV, 2.0 kW, and maximum pulse repetition rate up ...
Tópico(s): Silicon Carbide Semiconductor Technologies
2019 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Claire Bar, Giulia Barcia, Mélanie Jennesson, Gwenaël Le Guyader, Amy L. Schneider, Cyril Mignot, Gaëtan Lesca, Delphine Breuillard, Martino Montomoli, Boris Keren, Diane Doummar, Thierry Billette de Villemeur, Alexandra Afenjar, Isabelle Marey, Marion Gérard, Hervé Isnard, Alice Poisson, S. Dupont, Patrick Berquin, Pierre Meyer, David Geneviève, Anne de Saint Martin, Salima El Chehadeh, Jamel Chelly, Agnès Guët, Emmanuel Scalais, Nathalie Dorison, Candace T. Myers, Heather C. Mefford, Katherine B. Howell, Carla Marini, Jeremy L. Freeman, Anca Nica, Gaetano Terrone, Tayeb Sékhara, Anne-Sophie Lèbre, Sylvie Odent, Lynette G. Sadleir, Arnold Munnich, Renzo Guerrini, Ingrid E. Scheffer, Edor Kabashi, Rima Nabbout,
... of the delayed rectifier voltage-dependent potassium channel Kv 2.1. We review the 37 previously reported patients ... the voltage sensor and the pore domain of Kv 2.1. We also report the first inherited variant ( ...
Tópico(s): Genomics and Rare Diseases
2019 - Wiley | Human Mutation
M. Ramesh, C. Vanniarajan, Ravikesavan, K. Eraivan Arutkani Aiyanathan, P.P. Mahendran,
... mutagen gamma ray in barnyard millet variety Co(Kv) 2. Genetically pure seeds were treated with different doses ...
Tópico(s): Magnetic and Electromagnetic Effects
2019 - Indian Society of Plant Breeders | Electronic Journal of Plant Breeding
Kaizheng Wang, Feipeng Wang, Qi Zhao, Jian Li, Ziyi Lou, Qiuhuang Han, Kelin Hu,
... shows higher AC breakdown voltage (Vb, 72.6 kV/2.5 mm) than that of FR3 (65 kV/2.5 mm). TME oil is readily biodegradable whose ...
Tópico(s): Corrosion Behavior and Inhibition
2019 - Institute of Electrical and Electronics Engineers | IEEE Access
Olga Zavaritskaya, Srikanth Dudem, Dongyu Ma, Kaneez E. Rabab, Sarah Albrecht, D Tsvetkov, Mario Kaßmann, K. D. Thornbury, Mitko Mladenov, Claire Kammermeier, Gerard P. Sergeant, Nicholas D. Mullins, Ornella Wouappi, Hannah Wurm, Aimo Kannt, Maik Gollasch, Mark A. Hollywood, Rudolf Schubert,
... their effects considerably, but neither Kv 1 nor Kv 2 channel blockers altered the inhibitory effects of GoSlo- ... Kv 7.5 channels. Activation of Kv 1, Kv 2 or Kv 7.1 channels or other vasodilator ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Wiley | British Journal of Pharmacology
Xianshuang Wang, An Li, Nasrullah Wazir, Shiqi Huang, Shuai Guo, Liang Liang, Zhang Min, Bingsuo Zou, Yan Hao, Feng He, Yufeng Bai, Weipeng Sun, Hu Mu-lin, Ruibin Liu,
... 1 kV to 1.5 kV, 1.75 kV, 2 kV, 2.5 kV and 2.8 kV. The discharge ...
Tópico(s): Mercury impact and mitigation studies
2018 - Optica Publishing Group | Optics Express
Shiqi Jin, Bo Zhang, Lina Zhang, Shu Li, Songbai Li, Peiling Li,
... yielded optimal clinical diagnostic value for both 80 kV (2.35±0.054) and 120 kV (2.51±0.053) scanning methods, with a strong ...
Tópico(s): Advanced X-ray and CT Imaging
2018 - AME Publishing Company | Quantitative Imaging in Medicine and Surgery
... PDMS (0.5 phr) system was 60.0 kV/2 mm, which was 13.6% higher than that ... PEM-PDMS (0.5 phr) system, 52.8 kV/2 mm. The contact angle of neat epoxy was ...
Tópico(s): Lightning and Electromagnetic Phenomena
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Dielectrics and Electrical Insulation
Donatella Termini, Alice Di Leonardo,
... The dominant mechanism of exchange obtained for h/kv < 2 is different from that obtained for h/kv > 2. Quadrant analysis has been also applied to investigate ...
Tópico(s): Hydraulic flow and structures
2017 - Elsevier BV | Advances in Water Resources
Hongfa Ding, Yuan Yang, Yun Xu, Chengxi Jiang, Liang Li, Xianzhong Duan, Yuan Pan, Jihui Hu,
... to provide no-load voltages of 3.2 kV (2.7 kV) and full-load voltages of 2.7 kV (2.25 kV) at the rated current of 25 ...
Tópico(s): Magnetic confinement fusion research
2014 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
Mietek Bakowski, Per Ranstad, Jang‐Kwon Lim, Wlodek Kaplan, Sergey A. Reshanov, Adolf Schöner, Florian Giezendanner, Anton Ranstad,
10 kV, 2 A SiC p-i-n diodes have been designed and fabricated. The devices feature excellent stability of ...
Tópico(s): Advanced DC-DC Converters
2014 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electron Devices
Essa Mayyas, Indrin J. Chetty, M Chetvertkov, Ning Wen, T Neicu, Teamor Nurushev, Lei Ren, Mei Lü, Hans Stricker, Deepak Pradhan, Benjamin Movsas, Mohamed A. Elshaikh,
... 3.2, 2.2, 2.5) mm], [ μ kV = (−2.9, −0.4, 0.5) mm, Σ kV = (3.4, 3.1, 2.6) mm, σ kV = (2.9, 2.0, 2.4) mm], and [ μ ...
Tópico(s): Radiation Dose and Imaging
2013 - Wiley | Medical Physics
Radka Kodešová, Marcela Rohošková, Anna Žigová,
... from fast wetting (KV 1) and slow wetting (KV 2) tests showed similar trends of the soil aggregate ... was obtained between the WSA index and the KV 2 value, which depended on the organic matter content ...
Tópico(s): Soil Management and Crop Yield
2009 - Springer Nature | Biologia
S. D. Korovin, A. A. Eltchaninov, В. В. Ростов, V. G. Shpak, M. I. Yalandin, N. S. Ginzburg, A. S. Sergeev, I. V. Zotova,
... using the SINUS-150 accelerator (4 ns, 330 kV, 2.6 kA) 0.6-0.8 ns superradiance ... on the RADAN-303 accelerator (1 ns, 290 kV, 2.5 kA) demonstrated production of the superradiance (SR) ...
Tópico(s): Crystallography and Radiation Phenomena
2006 - American Physical Society | Physical Review E