Miguel Salinas, Fabrice Duprat, Catherine Heurteaux, Jean‐Philippe Hugnot, Michel Lazdunski,
... in electrophysiological properties of Kv2 subunits induced by Kv5.1 and Kv6.1, two other modulatory subunits. ... in electrophysiological properties of Kv2 subunits induced by Kv5.1 and Kv6.1, two other modulatory subunits. ... recently been cloned which constitute three new subfamilies (Kv5.1 (IK8), Kv6.1 (K13) (20Drewe J.A. ... activity by themselves. The study also shows that Kv5.1 and Kv6.1 are also potent regulators ... Kv2.α heteromultimers are compared with those of Kv5.1/Kv2.α and Kv6.1/Kv2.α ... The coding sequences of Kv9.1, Kv9.2, Kv5.1 (IK8) and Kv6.1 (K13) were amplified ...
Tópico(s): Receptor Mechanisms and Signaling
1997 - Elsevier BV | Journal of Biological Chemistry
Glenn Regnier, Elke Bocksteins, Gerda Van de Vijver, Dirk J. Snyders, Pierre‐Paul van Bogaert,
... Kv2 and silent Kv (KvS) subunits (i.e., Kv5-Kv6 and Kv8-Kv9). However, little is known ... 1995). On the other hand, members of the Kv5, Kv6, Kv8, and Kv9 subfamilies do not form ... that spanned intron boundaries (except for the intronless Kv5.1) (Table 1). Glyceraldehyde 3-phosphate dehydrogenase (G3PDH) ... Kv2.2 5′-TTGATAACACCTGCTGCCCG-3′ 5′-TGGCGAGTTTCAGTATCCTGA-3′ Kv5.1 5′-CTGGTGGGCTATCATCACCA-3′ 5′-CGGGTCCTATGATGCTTCTC-3′ Kv6. ... has been demonstrated that different KvS (i.e., Kv5, Kv6, Kv8 and Kv9) subunits are expressed in ...
Tópico(s): Neuroscience and Neuropharmacology Research
2016 - Wiley | Physiological Reports
James Kramer, Marc Post, Arthur Brown, Glenn E. Kirsch,
... of coexpression of Kv2.1 with electrically silent Kv5.1 or Kv6.1 α-subunits in Xenopus ... evoked by high-frequency trains of short pulses. Kv5.1 coexpression also slowed deactivation of Kv2.1. ... tail currents. Support for the notion that the Kv5.1’s effects stem from coassembly of α- ... heterogeneity in unitary conductance. Our results show that Kv5.1 and Kv6.1 function as regulatory α- ...
Tópico(s): Coordination Chemistry and Organometallics
1998 - American Physical Society | AJP Cell Physiology
Daniel Kerschensteiner, Francisco J. Monje, Martin Stocker,
... regulated by its association with modulatory α-subunits (Kv5, Kv6, Kv8, and Kv9). For instance, Kv9.3 ... regulated by its association with modulatory α-subunits (Kv5, Kv6, Kv8, and Kv9). For instance, Kv9.3 ... mammalian modulatory α-subunits so far consists of Kv5.1, Kv6.1–6.4, Kv8.1–2, ... acid sequences of all of modulatory α-subunits (Kv5.1, Kv6.1–6.4, Kv8.1–8. ...
Tópico(s): Neuroscience and Neuropharmacology Research
2003 - Elsevier BV | Journal of Biological Chemistry
... the tomb of the Sons of Ramesses II (KV5). It is, in fact, one of the largest ... of the tomb of Sons of Ramsses II (KV5) under their present conditions, against unfavorable environmental (i. ... mass classification indicated the rock mass where the KV5 is excavated is poor rock, with RMR 39 ... provided and detailed illustrated with the case of KV5 in this study.
Tópico(s): Tunneling and Rock Mechanics
2018 - Springer Nature | Geoenvironmental Disasters
Kevin S. Thorneloe, Mark T. Nelson,
... V ) subunits revealed the expression of Kv2.1, Kv5.1, Kv6.1, Kv6.2 and Kv6.3 ... V) with those reported for Kv2.1 and Kv5.1 and/or Kv6 heteromultimeric channels demonstrated a ... heteromultimeric channel complexes composed of Kv2.1 and Kv5.1 and/or Kv6 subunits form the molecular ...
Tópico(s): Neuroscience and Neuropharmacology Research
2003 - Wiley | The Journal of Physiology
Cem İ̇smail Küçükali, Büşra Şengül, Duygu Gezen‐Ak, Erdinç Dursun, Ece Erdağ, Gürler Akpınar, Murat Kasap, Zerrin Karaaslan, Nermi̇n Görkem Şi̇ri̇n, Pınar Tektürk, Betül Baykan, Erdem Tüzün,
... potassium channel modifier subfamily F member 1 (KCNF1, Kv5.1) as the single common cell surface antigen ... assays and co-localization (serum IgG and commercial Kv5.1-antibody) studies done with non-fixed Kv5.1-transfected HEK293 cells and primary neuronal cultures confirmed the presence of Kv5.1-antibody in 4 epilepsy patients identified by ... The herein described novel neuronal surface antibody to Kv5.1 appears to be associated with treatment-resistant ...
Tópico(s): Epilepsy research and treatment
2022 - Elsevier BV | Epilepsy Research
... level changes made during the construction of tomb KV5 in the Valley of the Kings. The construction ...
Tópico(s): Conservation Techniques and Studies
2008 - Elsevier BV | Tunnelling and Underground Space Technology
Jeroen I. Stas, Elke Bocksteins, Alain J. Labro, Dirk J. Snyders,
... interacting with the electrically silent Kv (KvS) subunits Kv5−Kv6 and Kv8−Kv9, into functional heterotetrameric Kv2/ ... properties of these heterotetrameric complexes. We demonstrate that Kv5.1, Kv8.1 and Kv9.3 currents were ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Public Library of Science | PLoS ONE
... the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, collectively identified as electrically ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2016 - Rockefeller University Press | The Journal of General Physiology
Elke Bocksteins, Alain J. Labro, Evy Mayeur, Tine Bruyns, Jean‐Pierre Timmermans, Dirk Adriaensen, Dirk J. Snyders,
... heterotetramers with members of the silent Kv subfamilies (Kv5, Kv6, Kv8, and Kv9). The T1 domain contains ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2009 - Elsevier BV | Journal of Biological Chemistry
Natacha Ottschytsch, Adam Raes, Diane Van Hoorick, Dirk J. Snyders,
... showed interactions with Kv2.1, Kv3.1, and Kv5.1. Co-expression of each of the previously ...
Tópico(s): Neuroscience and Neuropharmacology Research
2002 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Xi Zhong, Khaled S. Abd‐Elrahman, Chiu‐Hsiang Liao, Ahmed F. El‐Yazbi, Emma Walsh, Michael P. Walsh, William C. Cole,
... Kv2 subunits associate with 'silent' subunits from the Kv5, Kv6, Kv8 or Kv9 subfamilies to form heterotetrameric ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2010 - Wiley | The Journal of Physiology
Amy L. Firth, Carmelle V. Remillard, Oleksandr Platoshyn, Ivana Fantozzi, Eun‐A Ko, Jason X.‐J. Yuan,
... Kv3.3, Kv3.4, Kv4.1, Kv4.2, Kv5.1, Kv 6.1-Kv6.3, Kv9.1, ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2011 - SAGE Publishing | Pulmonary Circulation
Mulugu V. Brahmajothi, Michael J. Morales, Shuguang Liu, Randall L. Rasmusson, Donald L. Campbell, Harold C. Strauss,
... transcripts for Kv1.3, Kv2.2, Kv4.1, Kv5.1, and members of the Kv3 family. Kv1. ...
Tópico(s): Cardiomyopathy and Myosin Studies
1996 - Lippincott Williams & Wilkins | Circulation Research
Christoforos Tsantoulas, Stephen B. McMahon,
... and Kv10-Kv12 are pore-forming subunits, whereas Kv5, Kv6, Kv8, and Kv9 members do not form ...
Tópico(s): Neuroscience and Neuropharmacology Research
2014 - Elsevier BV | Trends in Neurosciences
Jens‐Peter David, Jeroen I. Stas, Nicole Schmitt, Elke Bocksteins,
... of the modulatory so-called silent Kv subfamilies (Kv5-Kv6 and Kv8-Kv9). However, it has not ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Nature Portfolio | Scientific Reports
Xiantao Li, Xi-Mu Hu, Xiaoqing Li, Xuran Hao,
... KCNH4, but no significant alteration was observed for Kv5.1 and KCNQ4. Furthermore, the macroscopic currents through ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Public Library of Science | PLoS ONE
Glenn Regnier, Elke Bocksteins, Waleed F. A. Marei, Isabel Pintelon, Jean‐Pierre Timmermans, Jo Leroy, Dirk J. Snyders,
... voltage-gated potassium (KvS) channel subunits (i.e. Kv5-Kv6 and Kv8-Kv9) do not form functional ...
Tópico(s): Insect and Pesticide Research
2016 - CSIRO Publishing | Reproduction Fertility and Development
Da Hye Hong, Hongliang Li, Hye Won Kim, Han Sol Kim, Youn Kyoung Son, Se‐Ran Yang, Jeong‐Ran Park, Kwon‐Soo Ha, Eun‐Taek Han, Seok‐Ho Hong, Amy L. Firth, Sung Hun Na, Won Sun Park,
... Kv2.1, Kv3.2, Kv4.1, Kv4.3, Kv5.1, Kv6.2, Kv8.1, Kv9.3, and ...
Tópico(s): Nitric Oxide and Endothelin Effects
2016 - Wiley | Clinical and Experimental Pharmacology and Physiology
... subfamilies. Among them, subunits in the Kv1 to Kv5 subfamily are capable of functional homomeric channels in ...
Tópico(s): Neuroscience and Neuropharmacology Research
1997 - Elsevier BV | Journal of Biological Chemistry
Mulugu V. Brahmajothi, Michael J. Morales, Randall L. Rasmusson, Donald L. Campbell, Harold C. Strauss,
... transcripts for Kv1.3, Kv2.2, Kv4.1, Kv5.1, and members of the Kv3 family, Kv1. ...
Tópico(s): Cardiomyopathy and Myosin Studies
1997 - Wiley | Pacing and Clinical Electrophysiology
Aditya Pisupati, Keith J. Mickolajczyk, W. J. Horton, Damian B. van Rossum, Andriy Anishkin, Sree V. Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory W. Busey, William O. Hancock, Timothy Jegla,
... but a group of mammalian Kv2-related genes (Kv5.1, Kv6s, Kv8s, and Kv9s) encodes subunits that ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Rockefeller University Press | The Journal of General Physiology
Melek Akçay, Durmuş Etiz, Kerem Duruer, Ozge Bozdogan, Alaattin Özen,
... esophagus Dmean were lower in IMRT technique and kV5-10 was lower in the 2PA-VMAT technique. ...
Tópico(s): Radiation Therapy and Dosimetry
2021 - BioMed Central | Journal of Cancer Research and Therapeutics
... pulmonary arterial smooth muscle (Kv1, Kv2, Kv3, Kv4, Kv5, Kv6, and Kv9). Among them, several candidate channels ...
Tópico(s): Neuroscience and Neuropharmacology Research
2002 - Oxford University Press | Cardiovascular Research
Kirk W. Beisel, N.C. Lofton, Philip M. Kelley,
... novel voltage-gated potassium ion channel (designated as Kv5.1) using the both RT-PCR with degenerative ... found in other members of this gene family. Kv5.1 has an amino acid sequence homology of ... unique tissue distribution, we have tentatively assigned the Kv5.1 gene as a new subfamily. Both the ... gene and are now determining chromosomal location of Kv5.1 by in situ hybridization and PCR analysis ...
Tópico(s): RNA Research and Splicing
1994 - Elsevier BV | The American Journal of Human Genetics
Michael Ferns, Deborah van der List, Nicholas C. Vierra, Taylor Lacey, Karl D. Murray, Michael Kirmiz, Robert G. Stewart, Jon T. Sack, James S. Trimmer,
Tópico(s): Receptor Mechanisms and Signaling
2025 - Society for Neuroscience | Journal of Neuroscience
Debanjan Tewari, Christian Sattler, Klaus Benndorf,
... transmembrane segments (S1-S6). Silent Kv (KvS), includes Kv5.1, Kv6.1-6.4, Kv8.1-8. ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2024 - Elsevier BV | Biochemical and Biophysical Research Communications
Jeroen I. Stas, Elke Bocksteins, Alain J. Labro, Dirk J. Snyders,
... Kv1-Kv6, Kv8-Kv9. The silent (KvS) subunits (Kv5-Kv9) cannot form homotetramers but assemble with Kv2 ... 1) inhibited 17%, 60%, 82% and 13% of Kv5.1, Kv6.3, Kv8.1 and Kv9.3- ...
Tópico(s): Neuroscience and Neural Engineering
2014 - Elsevier BV | Biophysical Journal