Julie Hubbard, Khumbo Phiri, Corrina Moucheraud, Kaitlyn McBride, Ashley R. Bardon, Kelvin Balakasi, Eric Lungu, Kathryn Dovel, Gift Kakwesa, Risa M. Hoffman,
ABSTRACT Introduction: Multimonth dispensing (MMD) of antiretroviral therapy (ART) is a differentiated model of care that can help overcome health system challenges and reduce the burden of HIV care on clients. Although 3-month dispensing has been the standard of care, interest has increased in extending refill intervals to 6 months. We explored client and provider experiences with MMD in Malawi as part of a cluster randomized trial evaluating 3- versus 6-month ART dispensing. Methods: Semi-structured in- ...
Tópico(s): HIV, Drug Use, Sexual Risk
2020 - Johns Hopkins University Press | Global Health Science and Practice
Eve Schoen, Calvin Leung, Kiyoshi W. Masui, Daniele Michilli, Pragya Chawla, Aaron B. Pearlman, Kaitlyn Shin, Ashley Stock,
Abstract We describe a pipeline to measure scintillation in fast radio bursts (FRBs) detected by CHIME/FRB in the 400–800 MHz band by analyzing the frequency structure of the FRB's spectrum. We use the pipeline to measure the characteristic frequency bandwidths of scintillation between 4–100 kHz in 12 FRBs corresponding to timescales of ∼2–40 μ s for 10 FRBs detected by CHIME/FRB. For the other two FRBs, we did not detect scintillation in the region our analysis is sensitive. We compared the measured ...
Tópico(s): Astrophysical Phenomena and Observations
2021 - IOP Publishing | Research Notes of the AAS
Maria I. Carlo, Vignesh Ravichandran, Preethi Srinavasan, Chaitanya Bandlamudi, Yelena Kemel, Özge Ceyhan-Birsoy, Semanti Mukherjee, Diana Mandelker, Joshua Chaim, Andrea Knežević, Satshil Rana, Zarina Fnu, Kelsey Breen, Angela G. Arnold, Aliya Khurram, Kaitlyn Tkachuk, C Cipolla, Ashley Marie Regazzi, A. Ari Hakimi, Hikmat Al‐Ahmadie, Guido Dalbagni, Karen A. Cadoo, Michael F. Walsh, Min Yuen Teo, Samuel A. Funt, Jonathan Coleman, Bernard H. Bochner, Gopa Iyer, David B. Solit, Zsofia K. Stadler, Liying Zhang, Jonathan E. Rosenberg, Barry S. Taylor, Mark E. Robson, Michael F. Berger, Joseph Vijai, Dean F. Bajorin, Kenneth Offit,
Urothelial cancers (UCs) have a substantial hereditary component, but, other than their association with Lynch syndrome, the contribution of genetic risk factors to UC pathogenesis has not been systematically defined. We sought to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in patients with UC and identify associated clinical factors.Overall, 586 patients with UC underwent prospective, matched tumor-normal DNA sequencing. Seventy-seven genes associated with cancer ...
Tópico(s): Urinary and Genital Oncology Studies
2019 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Malathi Narayan, Juan Zhang, Kaitlyn Braswell, Chelsea L. Gibson, Ashley Zitnyar, Daniel C. Lee, Sheeba Varghese-Gupta, Umesh K. Jinwal,
Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multi-domain protein that has been found to be mutated in patients with familial and sporadic Parkinson's disease, Alzheimer's disease and Crohn's disease. While the functions of LRRK2 are still largely unclear and mutations in LRRK2 are associated with adverse gain-of-function activities such as increased kinase activity, increased levels of LRRK2 alone are associated with toxicity in neurons. Consequently, exploring mechanisms to decrease levels ...
Tópico(s): Phytochemicals and Medicinal Plants
2015 - Bentham Science Publishers | Current Aging Science
Molly Kent, Massimo Bardi, Ashley Hazelgrove, Kaitlyn Sewell, Emily R. Kirk, Brooke Thompson, Kristen R. Trexler, Brennan Terhune-Cotter, Kelly G. Lambert,
Coping strategies have been associated with differential stress responsivity, perhaps providing a valuable neurobiological marker for susceptibility to the emergence of depressogenic symptoms or vulnerability to other anxiety-related disorders. Rats profiled with a flexible coping phenotype, for example, exhibit increased neurobiological markers of emotional regulation compared to active and passive copers (Bardi et al., 2012; Lambert et al., 2014). In the current study, responses of male and female ...
Tópico(s): Tryptophan and brain disorders
2017 - Elsevier BV | Hormones and Behavior
Kenneth J. Woodside, Sarah Bell, Purna Mukhopadhyay, Kaitlyn Repeck, Ian T. Robinson, Ashley Eckard, Sudipta Dasmunshi, Brett Plattner, Jeffrey Pearson, Douglas E. Schaubel, Ronald L. Pisoni, Rajiv Saran,
Arteriovenous fistulas (AVFs) are the preferred form of hemodialysis vascular access, but maturation failures occur frequently, often resulting in prolonged catheter use. We sought to characterize AVF maturation in a national sample of prevalent hemodialysis patients in the United States.Nonconcurrent observational cohort study.Prevalent hemodialysis patients having had at least 1 new AVF placed during 2013, as identified using Medicare claims data in the US Renal Data System.Demographics, geographic ...
Tópico(s): Vascular Procedures and Complications
2018 - Elsevier BV | American Journal of Kidney Diseases
David Shin, Kaitlyn Melnick, David D. Tran, Ashley Ghiaseddin,
Tópico(s): Brain Metastases and Treatment
2020 - Springer Science+Business Media | Journal of Neuro-Oncology
Nori Bradley, Ashley DiPasquale, Kaitlyn Dillabough, Prism S. Schneider,
KEY POINTS On Mar. 27, 2020, the United Nations issued a statement warning that rates of widespread intimate partner violence (IPV) will increase owing to the coronavirus disease 2019 (COVID-19) pandemic, including intimate partner femicides.[1][1] Measures to minimize the spread of severe acute
Tópico(s): Homicide, Infanticide, and Child Abuse
2020 - Canadian Medical Association | Canadian Medical Association Journal
Kaitlyn H. Hajdarovic, Doudou Yu, Ashley E. Webb,
The hypothalamus is a brain region that integrates signals from the periphery and the environment to maintain organismal homeostasis. To do so, specialized hypothalamic neuropeptidergic neurons control a range of processes, such as sleep, feeding, the stress response, and hormone release. These processes are altered with age, which can affect longevity and contribute to disease status. Technological advances, such as single-cell RNA sequencing, are upending assumptions about the transcriptional ...
Tópico(s): Stress Responses and Cortisol
2022 - Elsevier BV | Trends in Neurosciences
Kevin Drace, Adam M. Kiefer, Marcello M. Veiga, Matt K. Williams, Benjamin Ascari, Kassandra A. Knapper, Kaitlyn M. Logan, Vanessa M. Breslin, Ashley Skidmore, Daniel A. Bolt, Grant Geist, Lorlyn Reidy, James V. Cizdziel,
Artisanal and small-scale gold mining accounts for a significant portion of the current global gold market. Many artisanal gold miners use mercury to amalgamate gold and separate it from undesired gangue minerals, because it is relatively inexpensive and readily available. Unfortunately, the inappropriate handling and use of mercury has created environmental and health concerns in artisanal mining camps throughout the world. While the vast majority of artisanal and small-scale gold mines in Mozambique ...
Tópico(s): Hydropower, Displacement, Environmental Impact
2012 - Elsevier BV | Journal of Cleaner Production
Khumbo Phiri, Kaitlyn McBride, Zumbe Siwale, Julie Hubbard, Ashley R. Bardon, Corrina Moucheraud, Mwiza Haambokoma, Pedro T. Pisa, Crispin Moyo, Risa M. Hoffman,
Multi-month dispensing of antiretroviral therapy (ART) has been taken to scale in many settings in sub-Saharan Africa with the benefits of improved client satisfaction and decreased client costs. Six-month ART dispensing may further increase these benefits; however, data are lacking. Within a cluster-randomized trial of three- versus six-month dispensing in Malawi and Zambia, we performed a sub-study to explore Zambian provider experiences with multi-month dispensing. We conducted 18 in-depth interviews ...
Tópico(s): Adolescent Sexual and Reproductive Health
2020 - Taylor & Francis | AIDS Care
Kaitlyn Clark, Asma Sheikh, Jennifer Swartzenberg, Ashley Gleason, Cody Cummings, Jonathan Dominguez, Michelle Mailhot, Christina G. Collison,
Historically, deaf and hard-of-hearing students (D/HH) who solely rely on an interpreter during organic chemistry lecture courses at the Rochester Institute of Technology consistently performed below the average in the class. A barrier attributed to this D/HH student performance is the lack of standardized methods in sign language to effectively communicate the organic chemistry terminology. As such, our group worked to address this challenge through a deliberate effort to develop a lexicon of insightful ...
Tópico(s): Safety Warnings and Signage
2021 - American Chemical Society | Journal of Chemical Education
Avigail T. Erlich, Liam D. Tryon, Matthew J. Crilly, Jonathan M. Memme, Zahra S. Mesbah Moosavi, Ashley N. Oliveira, Kaitlyn Beyfuss, David A. Hood,
Skeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a number of proteins have been identified to be important for the maintenance of mitochondria in quiescent muscle, the requirement for these appears to decrease with the activation of multiple overlapping signaling events that are triggered by exercise. This makes exercise a valuable therapeutic tool for the treatment of mitochondrially based metabolic ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2016 - Elsevier BV | Integrative Medicine Research
Thilina Jayarathne, Chelsea E. Stockwell, Ashley A. Gilbert, Kaitlyn Daugherty, Mark A. Cochrane, Kevin C. Ryan, Erianto Indra Putra, Bambang Hero Saharjo, Ati Dwi Nurhayati, Israr Albar, R. J. Yokelson, Elizabeth A. Stone,
Abstract. Fine particulate matter (PM2.5) was collected in situ from peat smoke during the 2015 El Niño peat fire episode in Central Kalimantan, Indonesia. Twenty-one PM samples were collected from 18 peat fire plumes that were primarily smoldering with modified combustion efficiency (MCE) values of 0.725–0.833. PM emissions were determined and chemically characterized for elemental carbon (EC), organic carbon (OC), water-soluble OC, water-soluble ions, metals, and organic species. Fuel-based PM2.5 ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2018 - Copernicus Publications | Atmospheric chemistry and physics
Elizabeth A. Walsh, Joel R. Deye, Wesley Baas, Kaitlyn Sullivan, Ashley Lancaster, Keith A. Walters,
A new ligand has been designed that provides a relatively simple framework to build supramolecular systems containing both fullerene and transition metal moieties. The modular framework of the ligand allows for the easy design of more complex systems. Analysis of absorption and emission spectra suggests significant photoinduced charge transfer between the two moieties. More complex systems and the excited-state photophysics of the presented systems are being studied.
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2013 - Elsevier BV | Journal of Photochemistry and Photobiology A Chemistry
Catherine A. Staton, Kaitlyn Friedman, Ashley J. Phillips, Mary Catherine Minnig, Francis Sakita, Kennedy Ngowi, Brian Suffoletto, Jon Mark Hirshon, Monica H. Swahn, Blandina T. Mmbaga, João Ricardo Nickenig Vissoci,
Introduction Low-resourced settings often lack personnel and infrastructure for alcohol use disorder treatment. We culturally adapted a Brief Negotiational Interview (BNI) for Emergency Department injury patients, the “Punguza Pombe Kwa Afya Yako (PPKAY)” (“Reduce Alcohol For Your Health”) in Tanzania. This study aimed to evaluate the feasibility of a pragmatic randomized adaptive controlled trial of the PPKAY intervention. Materials and methods This feasibility trial piloted a single-blind, parallel, ...
Tópico(s): Diabetes Management and Education
2023 - Public Library of Science | PLoS ONE
Alyssa L. Kennedy, Kasiani C. Myers, James R. Bowman, Christopher J. Gibson, Nicholas D. Camarda, Elissa Furutani, Gwen M. Muscato, Robert H. Klein, Kaitlyn Ballotti, Shanshan Liu, Chad E. Harris, Ashley Galvin, Maggie Malsch, David C. Dale, John M. Gansner, Taizo A. Nakano, Alison A. Bertuch, Adrianna Vlachos, Jeffrey M. Lipton, Paul Castillo, James A. Connelly, Jane E. Churpek, John Edwards, Nobuko Hijiya, Richard Ho, Inga Hofmann, James N. Huang, Sioḃán Keel, Adam J. Lamble, Bonnie Lau, Maxim Norkin, Elliot Stieglitz, Wendy Stock, Kelly Walkovich, Steffen Boettcher, Christian Brendel, Mark D. Fleming, Stella M. Davies, Edie Weller, Christopher D. Bahl, Scott L. Carter, Akiko Shimamura, R. Coleman Lindsley,
Abstract To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. To define the mechanistic basis of clonal hematopoiesis in SDS, we investigate somatic mutations acquired by patients with SDS followed longitudinally. Here we report that multiple independent somatic hematopoietic clones arise early in life, most ...
Tópico(s): Acute Myeloid Leukemia Research
2021 - Nature Portfolio | Nature Communications
Kaitlyn Jones, Evelyn C. Tocco, Ashley N. Marshall, Tamara C. Valovich McLeod, Cailee E. Welch Bacon,
Clinical Scenario : Low back pain is widely prevalent in the general population as well as in athletes. Therapeutic exercise is a low-risk and effective treatment option for chronic pain that can be utilized by all rehabilitation clinicians. However, therapeutic exercise alone does not address the psychosocial aspects that are associated with chronic low back pain. Pain education is the umbrella term utilized to encompass any type of education to the patient about their chronic pain. Therapeutic exercise ...
Tópico(s): Opioid Use Disorder Treatment
2020 - Human Kinetics | Journal of Sport Rehabilitation
Kaitlyn G. Holden, Ashley R. Hedrick, Eric J. Gangloff, Steven J. Hall, Anne M. Bronikowski,
Abstract Temperature affects nearly every aspect of how organisms interact with and are constrained by their environment. Measures of organismal energetics, such as metabolic rate, are highly temperature‐dependent and governed through temperature effects on rates of biochemical reactions. Characterizing the relationships among levels of biological organization can lend insight into how temperature affects whole‐organism function. We tested the temperature dependence of cellular oxygen consumption ...
Tópico(s): Amphibian and Reptile Biology
2021 - Wiley | Journal of Experimental Zoology Part A Ecological and Integrative Physiology
Ashley N. Lough, Kaitlyn M. Faries, Dal-Hoe Koo, Abid Hussain, Leah Roark, Tiffany Langewisch, Teresa Backes, Karl A. Kremling, Jiming Jiang, James A. Birchler, Kathleen J. Newton,
Abstract The transfer of mitochondrial DNA (mtDNA) into nuclear genomes is a regularly occurring process that has been observed in many species. Few studies, however, have focused on the variation of nuclear-mtDNA sequences (NUMTs) within a species. This study examined mtDNA insertions within chromosomes of a diverse set of Zea mays ssp. mays (maize) inbred lines by the use of fluorescence in situ hybridization. A relatively large NUMT on the long arm of chromosome 9 (9L) was identified at approximately ...
Tópico(s): Genomics and Phylogenetic Studies
2015 - Genetics Society of America | G3 Genes Genomes Genetics
Ashley Ghiaseddin, David Shin, Kaitlyn Melnick, David D. Tran,
Malignant gliomas remain a challenging cancer to treat due to limitations in both therapeutic and efficacious options. Tumor treating fields (TTFields) have emerged as a novel, locoregional, antineoplastic treatment modality with favorable efficacy and safety being demonstrated in the most aggressive type of malignant gliomas, glioblastoma (GBM). In 2 large randomized, controlled phase 3 trials, the addition of TTFields was associated with increased overall survival when combined with adjuvant temozolomide ( ...
Tópico(s): Neuroblastoma Research and Treatments
2020 - Springer Science+Business Media | Current Treatment Options in Oncology
Robert West, Carl T. Ash, Ashley Dapore, Bridget Kirby, Kaitlyn Malley, Shasha Zhu,
The widespread adoption of smartphones has been associated with the emergence of problematic smartphone use. Problematic smartphone use is consistently associated with increased levels of depression and lower self-control, and pathological technology use more generally may be associated with reduced activity in the reward system, an effect that is also observed in depression and with poor self-control. The current study sought to examine the association between problematic smartphone use and event- ...
Tópico(s): Child Development and Digital Technology
2021 - Elsevier BV | Addictive Behaviors
Megan N. Perez, Christina Sharkey, Alayna P. Tackett, Alexandria M. Delozier, Dana M. Bakula, Kaitlyn L. Gamwell, Sunnye Mayes, Rene McNall, John M. Chaney, Ashley H. Clawson, Larry L. Mullins,
Caregivers of pediatric cancer patients are at risk for posttraumatic stress symptoms (PTSS). Previous literature has identified caregiver illness uncertainty as a predictor of PTSS, yet little is known about the mechanism by which illness uncertainty may affect PTSS. Rumination, or perseverations about the cause and consequences of an event, has been related to posttraumtic stress disorder in other populations. However, limited research of this relationship exists for pediatric cancer caregivers. ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2018 - Taylor & Francis | Pediatric Hematology and Oncology
Ashley R. Deutsch, Edwin Dickinson, Kaitlyn C. Leonard, Juan Francisco Pastor, Magdalena N. Muchlinski, Adam Hartstone‐Rose,
By combining muscle architectural data with biomechanical variables relating to the jaw, we produce anatomically derived maximum bite force estimations for 23 species of catarrhine and platyrrhine primates. We investigate how bite force scales across the sample as a whole (and within each parvorder) relative to two size proxies, body mass and cranial geometric mean, and the effect of diet upon bite force. Bite force is estimated at three representative bite points along the dental row: the first ...
Tópico(s): Evolution and Paleontology Studies
2019 - Wiley | The Anatomical Record
Clare Grady, Kaitlyn Melnick, Ken Porche, Farhad Dastmalchi, Daniel J. Hoh, Maryam Rahman, Ashley Ghiaseddin,
Spinal cord gliomas are rare entities that often have limited surgical options. Immunotherapy has shown promise in intracranial gliomas with some research suggesting benefit for spinal cord gliomas. A focused review of immunotherapies that have been investigated in spinal cord gliomas was performed. The primary methods of immunotherapy investigated in spinal cord gliomas include immune checkpoint inhibitors, adoptive T-cell therapies, and vaccine strategies. There are innumerable challenges that ...
Tópico(s): Immunotherapy and Immune Responses
2022 - Korean Spinal Neurosurgery Society | Neurospine
Daniel J. Hellenbrand, Kaitlyn Reichl, Benjamin J. Travis, Mallory Filipp, Andrew Khalil, Domenic J. Pulito, Ashley V. Gavigan, Elizabeth R. Maginot, Mitchell Arnold, Alexander G. Adler, William L. Murphy, Amgad S. Hanna,
The anti-inflammatory cytokine interleukin-10 (IL-10) has been explored previously as a treatment method for spinal cord injury (SCI) due to its ability to attenuate pro-inflammatory cytokines and reduce apoptosis. Primary limitations when using systemic injections of IL-10 are that it is rapidly cleared from the injury site and that it does not cross the blood-spinal cord barrier.Here, mineral-coated microparticles (MCMs) were used to obtain a local sustained delivery of IL-10 directly into the injury ...
Tópico(s): Mesenchymal stem cell research
2019 - BioMed Central | Journal of Neuroinflammation
Katherine B. Peters, Jessica W. Templer, Elizabeth R. Gerstner, Thomas Wychowski, Anette Storstein, Karan Dixit, Tobias Walbert, Kaitlyn Melnick, Maya Hrachova, Sonia Partap, Nicole J. Ullrich, Ashley Ghiaseddin, Maciej Mrgula,
Patients with brain tumors will experience seizures during their disease course. While providers can use antiseizure medications to control these events, patients with brain tumors can experience side effects, ranging from mild to severe, from these medications. Providers in subspecialties such as neurology, neuro-oncology, neurosurgery, radiation oncology, and medical oncology often work with patients with brain tumor to balance seizure control and the adverse toxicity of antiseizure medications. ...
Tópico(s): Neuroscience and Neuropharmacology Research
2024 - Lippincott Williams & Wilkins | Neurology
Amanda Maisel, Abigail Waldman, Karina Furlan, Alexandra Weil, Kaitlyn Sacotte, Jake M. Lazaroff, Katherine A. Lin, Diana Aranzazu, Mathew M. Avram, Ashley Bell, Todd V. Cartee, Alex Cazzaniga, Anne Chapas, Milène K. Crispin, Jennifer A. Croix, Catherine M. DiGiorgio, Jeffrey S. Dover, David J. Goldberg, Mitchel P. Goldman, Jeremy B. Green, Charmaine L. Griffin, Adele Haimovic, Amelia K. Hausauer, Shannon Hernandez, Sarah H. Hsu, Omer Ibrahim, Derek Jones, Joely Kaufman, Suzanne L. Kilmer, Nicole Y. Lee, David H. McDaniel, Joel Schlessinger, Elizabeth L. Tanzi, Eduardo Weiss, Robert A. Weiss, Douglas C. Wu, Emily Poon, Murad Alam,
Despite the growing popularity of cosmetic procedures, the sociocultural and quality-of-life factors that motivate patients to undergo such procedures are not well understood. To estimate the relative importance of factors that motivate patients to seek minimally invasive cosmetic procedures. This prospective, multicenter observational study was performed at 2 academic and 11 private dermatology practice sites that represented all US geographic regions. Adult patients presenting for cosmetic consultation ...
Tópico(s): Global Healthcare and Medical Tourism
2018 - American Medical Association | JAMA Dermatology
Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, D. Abdo, Basir Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Amina Abdulle, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Sara J. Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Lisa C. Adams, Richard Adams, Tim Adams, Kirsty Adcock, Jemaimah Addai, Ade Adebiyi, Ken Adegoke, Vicki Adell, Debo Ademokun, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Dominic Affron, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Penny Agent, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Humayun Ahmad, Mohammad Ahmad, Syed A. Ahmad, Asim A. Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Iram Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Sophia Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Giulia Airoldi, Myriam Aissa, Lindianne Aitken, Bini Ajay, Francis Ajeneye, Abdulakeem Ajibode, Ayesha Ajmi, Tahir Akbar, Naim Akhtar, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Olajide Akinwumiju, Olugbenro Aktinade, Ahmad Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Karina Al-Asadi, Kyriaki S. Alatzoglou, Manaf Al-Bayati, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter Alexander, Charlotte Alford, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Asad Ali, Fawzia R Ali, Hoodo Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sabira Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Allameddine Allameddine, Fiona Allan, Rachel Allan, Alison Allanson, Robert Allcock, B. Allen, Eireann Allen, Jess Allen, Kerry Allen, Laura K. Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Sara Altaf, Mary Alvarez, Balaal Alyas, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Kenneth Amenyah, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Mariam Ammoun, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Rekha Anand, Samantha Anandappa, Julie Anderson, Kevin L. Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy G. Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Susan Andrews, Gregory Andrikopoulos, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, George Apostolides, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia Aquino, Bianca Araba, Samuel Aransiola, Mariana E. G. de Araújo, Emily Arbon, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Sylvia Armstrong‐Fisher, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold,
BackgroundMany patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. ...
Elsevier BV
Sanjay Srivatsan, Sarah Heidl, Brian Pfau, Beth Martin, Peter D. Han, Weizhi Zhong, Katrina van Raay, Evan McDermot, Jordan Opsahl, Luis Fernando Gamboa, Nahum Smith, Melissa Truong, Shari Cho, Kaitlyn A. Barrow, Lucille M. Rich, Jeremy Stone, Caitlin R. Wolf, Denise J. McCulloch, Ashley E. Kim, Elisabeth Brandstetter, Sarah L Sohlberg, Misja Ilcisin, Rachel E. Geyer, Wei Chen, Jase Gehring, Helen Y. Chu, Michael Boeckh, Janet A. Englund, Michael Famulare, Christina M. Lockwood, Barry R. Lutz, Deborah A. Nickerson, Mark J. Rieder, Lea M. Starita, Matthew Thompson, Cécile Viboud, Jay Shendure, Trevor Bedford, Sriram Kosuri, Trevor Bedford, Mark J. Rieder, Deborah A. Nickerson, Helen Y. Chu, Eric Q. Konnick, Jason S. Debley, Jay Shendure, Christina M. Lockwood, Lea M. Starita,
The urgent need for massively scaled clinical testing for SARS-CoV-2, along with global shortages of critical reagents and supplies, has necessitated development of streamlined laboratory testing protocols. Conventional nucleic acid testing for SARS-CoV-2 involves collection of a clinical specimen with a nasopharyngeal swab in transport medium, nucleic acid extraction, and quantitative reverse-transcription PCR (RT-qPCR). As testing has scaled across the world, the global supply chain has buckled, ...
Tópico(s): Biosensors and Analytical Detection
2021 - American Association for Clinical Chemistry | Clinical Chemistry