Produção Nacional
Revisado por pares
José Marcos Sanches, Laura Migliari Branco, Gustavo Henrique Bueno Duarte, Sônia Maria Oliani, Karina Ramalho Bortoluci, Vanessa Moreira, Cristiane Damas Gil,
Annexin A1 (AnxA1) is a potent anti-inflammatory protein that downregulates proinflammatory cytokine release. This study evaluated the role of AnxA1 in the regulation of NLRP3 inflammasome activation and lipid release by starch-elicited murine peritoneal macrophages. C57bl/6 wild-type (WT) and AnxA1-null (AnxA1-/-) mice received an intraperitoneal injection of 1.5% starch solution for macrophage recruitment. NLRP3 was activated by priming cells with lipopolysaccharide for 3 h, followed by nigericin ( ...
Tópico(s): Neonatal Respiratory Health Research
2020 - Multidisciplinary Digital Publishing Institute | Cells
Produção Nacional
Revisado por pares
José Marcos Sanches, Rebeca D. Correia-Silva, Gustavo Henrique Bueno Duarte, Anna Maria A. P. Fernandes, Salvador Sánchez-Vinces, Patrícia de Oliveira Carvalho, Sônia Maria Oliani, Karina Ramalho Bortoluci, Vanessa Moreira, Cristiane Damas Gil,
This study evaluated the role of endogenous and exogenous annexin A1 (AnxA1) in the activation of the NLRP3 inflammasome in isolated peritoneal neutrophils. C57BL/6 wild-type (WT) and AnxA1 knockout mice (AnxA1-/-) received 0.3% carrageenan intraperitoneally and, after 3 h, the peritoneal exudate was collected. WT and AnxA1-/- neutrophils were then stimulated with lipopolysaccharide, followed by the NLRP3 agonists nigericin or ATP. To determine the exogenous effect of AnxA1, the neutrophils were pretreated ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2021 - Multidisciplinary Digital Publishing Institute | Cells
Produção Nacional
Revisado por pares
Carolina Games Bensi, Arinilda Silva Campos, Renata Midori Harada, Karina Ragazzo Oliani, Rodrigo Perez Ranzatti, Eliana Sueco Tibana Samano, Marina Gonçalves, Auro del Giglio,
INTRODUÇÃO: O câncer de mama é o segundo tipo de câncer mais incidente e a primeira causa de morte por câncer entre as mulheres brasileiras. Na perspectiva do médico, a indicação da quimioterapia adjuvante como parte de seu tratamento deve se pautar pelos seus riscos e benefícios. Do ponto de vista da paciente, entretanto, em nosso meio, há poucos dados acerca de suas opiniões quanto à magnitude dos benefícios e riscos associados a este tratamento. OBJETIVOS: Avaliar o benefício mínimo necessário ...
Tópico(s): Science and Education Research
2006 - Brazilian Medical Association | Revista da Associação Médica Brasileira
Produção Nacional
Revisado por pares
Laise Nayana Sala Elpídio, Amarilis Giaretta de Moraes, Ieda Bernadete Volkweis Langer, Greicy Cezar do Amaral, Maria Luíza Moretti, Márcia Teixeira Garcia, Rodrigo Nogueira Angerami, José Luiz Proença‐Módena, Karina Bispo-dos-Santos, Matheus Cavalheiro Martini, Pierina Lorencini Parise, Christiane Maria Ayo, Luíz Carlos de Mattos, Cinara Cássia Brandão de Mattos, Maurício Lacerda Nogueira, Denise Cristina Mós Vaz Oliani, Lígia Cosentino Junqueira Franco Spegiorin, Quirino Alves de Lima Neto, Jeane Eliete Laguila Visentainer,
BACKGROUND Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV. During ZIKV infection, cytokines are produced and natural killer (NK) cells are recruited, whose activation depends on signaling pathways activated by specific ...
Tópico(s): Immune Cell Function and Interaction
2022 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz