1911 - De Gruyter | Kant-Studien
Anita Ongherth, Sebastian Pasch, Christina M. Wuertz, Karolin Nowak, Naim Kittana, Cleo A. Weis, Aline Jatho, Christiane Vettel, Malte Tiburcy, Karl Toischer, Gerd Hasenfuß, Wolfram‐Hubertus Zimmermann, Thomas Wieland, Susanne Lutz,
Cardiac remodeling, a hallmark of heart disease, is associated with intense auto- and paracrine signaling leading to cardiac fibrosis. We hypothesized that the specific mediator of Gq/11-dependent RhoA activation p63RhoGEF, which is expressed in cardiac fibroblasts, plays a role in the underlying processes. We could show that p63RhoGEF is up-regulated in mouse hearts subjected to transverse aortic constriction (TAC). In an engineered heart muscle model (EHM), p63RhoGEF expression in cardiac fibroblasts ...
Tópico(s): Connective tissue disorders research
2015 - Elsevier BV | Journal of Molecular and Cellular Cardiology