Nancy Blüthgen, Nicole Meili, Geraldine Chew, Alex Odermatt, Karl Fent,
Wide application of the UV-filter octocrylene (OC) in cosmetics leads to contamination of the aquatic environment, but effects of OC remain unclear. Here we determine bioaccumulation and molecular effects of OC. Adult male zebrafish were exposed to 22, 209 and 383 μg/L and embryos to 69, 293 and 925 μg/L OC. OC accumulated in fish up to 17 μg/g. Calculated BCF varied between 41 and 136. Microarray analysis in brain and liver following exposure to 383 μg/L OC revealed alteration of 628 and 136 transcripts, ...
Tópico(s): Animal testing and alternatives
2014 - Elsevier BV | The Science of The Total Environment
Nancy Blüthgen, John P. Sumpter, Alex Odermatt, Karl Fent,
Here, we analyzed the transcriptional effects of the antiprogestin mifepristone (MIF, RU486) and progesterone (P4) in zebrafish as well as their in vitro activities in yeast-based reporter gene assays. This study is associated with the reproduction study in adult zebrafish and embryos exposed for 21 days to 5, 39, 77 ng/L MIF, and 25 ng/L P4 (Blüthgen et al., 2013a). The in vitro activities of MIF and P4 were investigated using a series of recombinant yeast-based assays (YES, YAS, YPS) and compared ...
Tópico(s): Hormonal Regulation and Hypertension
2013 - Elsevier BV | Aquatic Toxicology
Nguyen Thi Minh Hai, Jan Odermatt, Valentine Grimaudo, Karl W. Krämer, Alexander Fluegel, Marco Arnold, Dieter Mayer, Peter Broekmann,
Polymerizates of imidazole and epichlorohydrin (Imep) serve as one of the benchmarks for today's chemistry development of leveler additives in context of the industrial copper Damascene process. We therefore studied the synergistic and antagonistic interplay of the Imep polymer with other additives, commonly present in copper plating baths used for the state-of-the-art IC manufacturing. Characteristic oscillations in the applied electrode potential appear in galvanostatic copper electrodeposition ...
Tópico(s): Copper Interconnects and Reliability
2012 - American Chemical Society | The Journal of Physical Chemistry C
Erika A. Crane, Wolfgang Heydenreuter, Katharina R. Beck, Petra Strajhar, Jan Vomacka, Martin Smieško, Elma Mons, Lydia Barth, Markus Neuburger, Angelo Vedani, Alex Odermatt, Stephan A. Sieber, Karl Gademann,
To identify new potential therapeutic targets for neurodegenerative diseases, we initiated activity-based protein profiling studies with withanolide A (WitA), a known neuritogenic constituent of Withania somnifera root with unknown mechanism of action. Molecular probes were designed and synthesized, and led to the discovery of the glucocorticoid receptor (GR) as potential target. Molecular modeling calculations using the VirtualToxLab predicted a weak binding affinity of WitA for GR. Neurite outgrowth ...
Tópico(s): Medicinal Plants and Neuroprotection
2019 - Elsevier BV | Bioorganic & Medicinal Chemistry
Reinhold A. Lang, Petra Baumann, Claudia Schmoor, Erich K. Odermatt, Moritz N. Wente, Karl‐Walter Jauch,
Intra-abdominal surgical intervention can cause the development of intra-peritoneal adhesions. To reduce this problem, different agents have been tested to minimize abdominal adhesions; however, the optimal adhesion prophylaxis has not been found so far. Therefore, the A-Part(®) Gel was developed as a barrier to diminish postsurgical adhesions; the aim of this randomized controlled study was a first evaluation of its safety and efficacy.In this prospective, controlled, randomized, patient-blinded, ...
Tópico(s): Surgical Sutures and Adhesives
2015 - BioMed Central | Annals of Surgical Innovation and Research
Sandrine Joly, Mike Francke, Elke Ulbricht, Susanne Beck, Matthias Seeliger, Petra G. Hirrlinger, Johannes Hirrlinger, Karl S. Lang, Martin S. Zinkernagel, Bernhard Odermatt, Marijana Samardzija, Andreas Reichenbach, Christian Grimm, Charlotte E. Remé,
Phagocytosis is essential for the removal of photoreceptor debris following retinal injury. We used two mouse models, mice injected with green fluorescent protein-labeled bone marrow cells or green fluorescent protein-labeled microglia, to study the origin and activation patterns of phagocytic cells after acute blue light-induced retinal lesions. We show that following injury, blood-borne macrophages enter the eye via the optic nerve and ciliary body and soon migrate into the injured retinal area. ...
Tópico(s): Retinal Development and Disorders
2009 - Elsevier BV | American Journal Of Pathology
Benjamin Odermatt, Kerstin Wellershaus, Anke Wallraff, Gerald Seifert, Joachim Degen, Carsten Euwens, Babette Fuss, Heinrich Büssow, Karl Schilling, Christian Steinhäuser, Klaus Willecke,
To further characterize the recently described gap junction gene connexin 47 (Cx47), we generated Cx47-null mice by replacing the Cx47 coding DNA with an enhanced green fluorescent protein (EGFP) reporter gene, which was thus placed under control of the endogenous Cx47 promoter. Homozygous mutant mice were fertile and showed no obvious morphological or behavioral abnormalities. Colocalization of EGFP fluorescence and immunofluorescence of cell marker proteins revealed that Cx47 was mainly expressed ...
Tópico(s): Biochemical effects in animals
2003 - Society for Neuroscience | Journal of Neuroscience
Philipp A. Lang, Haifeng C. Xu, Melanie Grusdat, David R. McIlwain, Aleksandra A. Pandyra, Isaac S. Harris, Namir Shaabani, Nadine Honke, Sathish Kumar Maney, Elisabeth Lang, Vitaly I. Pozdeev, Mike Recher, Bernhard Odermatt, Dirk Brenner, Dieter Häussinger, Pamela S. Ohashi, Hans Hengartner, Rolf M. Zinkernagel, Tak W. Mak, Karl S. Lang,
Cluster of differentiation (CD)8+ T cells are like a double edged sword during chronic viral infections because they not only promote virus elimination but also induce virus-mediated immunopathology. Elevated levels of reactive oxygen species (ROS) have been reported during virus infections. However, the role of ROS in T-cell-mediated immunopathology remains unclear. Here we used the murine lymphocytic choriomeningitis virus to explore the role of ROS during the processes of virus elimination and ...
Tópico(s): Immune cells in cancer
2013 - Springer Nature | Cell Death and Differentiation
Barbara Teubner, Benjamin Odermatt, Martin Güldenagel, Goran Söhl, Joachim Degen, Feliksas F. Bukauskas, Jack Kronengold, Vytas K. Verselis, Yong Tae Jung, Christine A. Kozak, Karl Schilling, Klaus Willecke,
A new mouse gap junction gene that codes for a protein of 46,551 Da has been identified and designated connexin47 (Cx47). It mapped as a single-copy gene to mouse chromosome 11. In human HeLa cells and Xenopus oocytes, expression of mouse Cx47 or a fusion protein of Cx47 and enhanced green fluorescent protein induced intercellular channels that displayed strong sensitivity to transjunctional voltage. Tracer injections in Cx47-transfected HeLa cells revealed intercellular diffusion of neurobiotin, ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2001 - Society for Neuroscience | Journal of Neuroscience
Philipp A. Lang, Claudio Contaldo, Panco Georgiev, Ashraf Mohammad El‐Badry, Mike Recher, Michael Kurrer, Luisa Cervantes‐Barragán, Burkhard Ludewig, Thomas Calzascia, Beatrice Bolinger, Doron Merkler, Bernhard Odermatt, Michael Bäder, Rolf Graf, Pierre A. Clavien, Ahmed N. Hegazy, Max Löhning, Nicola L. Harris, Pamela S. Ohashi, Hans Hengartner, Rolf M. Zinkernagel, Karl S. Lang,
More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus1. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stage liver failure or hepatocellular carcinoma. Virus-specific T cells are a major determinant of the outcome of hepatitis, as they contribute to the early control of chronic hepatitis viruses, but they also ...
Tópico(s): Liver Disease Diagnosis and Treatment
2008 - Nature Portfolio | Nature Medicine
Alexander A. Navarini, Karl S. Lang, Admar Verschoor, Mike Recher, Annelies S. Zinkernagel, Victor Nizet, Bernhard Odermatt, Hans Hengartner, Rolf M. Zinkernagel,
Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defense function against bacterial pathogens before development of a specific immune response. These specialized phagocytes are short lived (12–24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of Listeria monocytogenes, neutrophils are depleted despite high granulocyte-colony stimulating factor induction. In contrast to a low-dose innocuous ...
Tópico(s): Sepsis Diagnosis and Treatment
2009 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Karl S. Lang, Mike Recher, Tobias Junt, Alexander A. Navarini, Nicola L. Harris, Stefan Freigang, Bernhard Odermatt, Curdin Conrad, Lars M. Ittner, Stefan Bauer, Sanjiv A. Luther, Satoshi Uematsu, Shizuo Akira, Hans Hengartner, Rolf M. Zinkernagel,
Autoimmune diabetes mellitus in humans is characterized by immunological destruction of pancreatic beta islet cells. We investigated the circumstances under which CD8+ T cells specific for pancreatic beta-islet antigens induce disease in mice expressing lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP) as a transgene under the control of the rat insulin promoter. In contrast to infection with LCMV, immunization with LCMV-GP derived peptide did not induce autoimmune diabetes despite large ...
Tópico(s): Immune Cell Function and Interaction
2005 - Nature Portfolio | Nature Medicine
C Thalhammer, Markus Aschwanden, UA Baumann, Angela Odermatt, Karl‐Heinz Labs, KA Jaeger,
Purpose: Information concerning increased venous pressure is crucial in pathologic situations like cardiac failure, liver disease or chronic venous insufficiency. However, the measurement of venous pressure requires punction of the vein and is not suited for routine or repeated examinations. A non invasive technique to determine venous pressure would be helpful in various situations.
Tópico(s): Cardiac Imaging and Diagnostics
2005 - Georg Thieme Verlag | Ultraschall in der Medizin - European Journal of Ultrasound
Alexander A. Navarini, Mike Recher, Karl S. Lang, Panco Georgiev, Susanne Meury, Andreas Bergthaler, Lukas Flatz, Jacques Billé, Régine Landmann, Bernhard Odermatt, Hans Hengartner, Rolf M. Zinkernagel,
The reason why severe localized or systemic virus infections enhance and aggravate bacterial superinfection is poorly understood. Here we show that virus-induced IFN type I caused apoptosis in bone marrow granulocytes, drastically reduced granulocyte infiltrates at the site of bacterial superinfection, caused up to 1,000-fold higher bacterial titers in solid organs, and increased disease susceptibility. The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense ...
Tópico(s): Viral gastroenteritis research and epidemiology
2006 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Karl S. Lang, Alexander A. Navarini, Mike Recher, Philipp A. Lang, Mathias Heikenwälder, Barbara Stecher, Andreas Bergthaler, Bernhard Odermatt, Shizuo Akira, Kenya Honda, Hans Hengartner, Rolf M. Zinkernagel,
MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/-) mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the ...
Tópico(s): Immunotherapy and Immune Responses
2007 - Wiley | European Journal of Immunology
Karl S. Lang, Panco Georgiev, Mike Recher, Alexander A. Navarini, Andreas Bergthaler, Mathias Heikenwälder, Nicola L. Harris, Tobias Junt, Bernhard Odermatt, Pierre-Alain Clavien, Hanspeter Pircher, Shizuo Akira, Hans Hengartner, Rolf M. Zinkernagel,
The liver is known to be a classical immunoprivileged site with a relatively high resistance against immune responses. Here we demonstrate that highly activated liver-specific effector CD8+ T cells alone were not sufficient to trigger immune destruction of the liver in mice. Only additional innate immune signals orchestrated by TLR3 provoked liver damage. While TLR3 activation did not directly alter liver-specific CD8+ T cell function, it induced IFN-α and TNF-α release. These cytokines generated ...
Tópico(s): Immunotherapy and Immune Responses
2006 - American Society for Clinical Investigation | Journal of Clinical Investigation
Reinhold A. Lang, Petra Baumann, Karl‐Walter Jauch, Claudia Schmoor, Christine Weis, Erich K. Odermatt, Hanns‐Peter Knaebel,
Abstract Background Postoperative adhesions occur when fibrous strands of internal scar tissue bind anatomical structures to one another. The most common cause of intra-abdominal adhesions is previous intra-abdominal surgical intervention. Up to 74% of intestinal obstructions are caused by post surgical adhesions. Although a variety of methods and agents have been investigated to prevent post surgical adhesions, the problem of peritoneal adhesions remains largely unsolved. Materials serving as an ...
Tópico(s): Minimally Invasive Surgical Techniques
2010 - BioMed Central | BMC Surgery
Karl S. Lang, Mike Recher, Tobias Junt, Alexander A. Navarini, Nicola L. Harris, Stefan Freigang, Bernhard Odermatt, Curdin Conrad, Lars M. Ittner, Stefan Bauer, Sanjiv A. Luther, Satoshi Uematsu, Shizuo Akira, Hans Hengartner, R M Zinkernagel,
Nat. Med. 11, 138–145 (2005) During preparation of Figure 5c, a naive islet was inadvertently reproduced in place of an LPS-treated islet. The corrected version of Figure 5c is shown below. Different doses and sources of LPS induced varying degrees of MHC I expression in islet cells of C57BL/6 or 129Sv mice, but LPS-induced MHC class I upregulation was not seen in type I interferon receptor–deficient (Ifnar−/−) mice.
Tópico(s): Immune Cell Function and Interaction
2005 - Nature Portfolio | Nature Medicine
Mike Recher, Karl S. Lang, Alexander A. Navarini, Lukas Hunziker, Philipp A. Lang, Katja Fink, Stefan Freigang, Panco Georgiev, Lars Hangartner, Raphaël M. Zellweger, Andreas Bergthaler, Ahmed N. Hegazy, Bruno Eschli, Alexandre Theocharides, Lukas T. Jeker, Doron Merkler, Bernhard Odermatt, Martin Hersberger, Hans Hengartner, Rolf M. Zinkernagel,
T helper cells can support the functions of CD8+ T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV. These viruses often resist complete elimination and remain detectable at sanctuary sites, such as the kidneys and other extralymphatic organs. The mechanisms underlying this persistence are not well understood. Here we show that mice with potent virus-specific T-cell responses have reduced levels and delayed ...
Tópico(s): T-cell and B-cell Immunology
2007 - Nature Portfolio | Nature Medicine
Klaus D. Bornemann, Karl‐Heinz Wiederhold, Chantal Pauli, Florian Ermini, Martina Stalder, Lisa Schnell, Bernd Sommer, Mathias Jucker, Matthias Staufenbiel,
... supplied by Drs. R. M. Zinkernagel and B. Odermatt, University of Zürich, Zürich, Switzerland); rat monoclonal FA- ...
Tópico(s): Advanced Glycation End Products research
2001 - Elsevier BV | American Journal Of Pathology
Charlotte E. Remé, Karl S. Lang, B Odermatt, Sandrine Joly, Marijana Samardzija, K. Schwerdfeger, Christian Grimm,
Tópico(s): Photoreceptor and optogenetics research
2007 - Cadmus Press | Investigative Ophthalmology & Visual Science
Jami E. Milam, John R. Erb‐Downward, Gwo-Hsiao Chen, Marcin F. Osuchowski, Roderick A. McDonald, Stephen W. Chensue, Galen B. Toews, Gary B. Huffnagle, Michal A. Olszewski,
... 3282-3286PubMed Google Scholar, 15Probst HC Tschannen K Odermatt B Schwendener R Zinkernagel RM Van Den Broek ... Grayson MH Swanson PE Drewry AM Chang KC Karl IE Hotchkiss RS Sepsis induces apoptosis and profound ...
Tópico(s): Immunotherapy and Immune Responses
2009 - Elsevier BV | American Journal Of Pathology
... and among many others such as Max Bill, Karl Gerstner, Hans Hartmann, Armin Hofmann, Gottfried Honegger and Warja Honegger-Lavater, Richard Paul Lohse, Therese Moll, Ruth Napflin, Hans Neuburg, Siegfried Odermatt, Emil Ruder, Nelly Rudin, Max Schmid, Anton Stankowski, ...
Tópico(s): Visual Culture and Art Theory
2010 - Routledge | Visible Language
Karl S. Lang, Mike Recher, Alexander A. Navarini, Stefan Freigang, Nicola L. Harris, Maries van den Broek, Bernhard Odermatt, Hans Hengartner, Rolf M. Zinkernagel,
Abstract Bone marrow transplantation (BMT) is commonly used in the treatment of leukemia, however its therapeutic application is partly limited by the high incidence of associated opportunistic infections. We modeled this clinical situation by infecting mice that underwent BMT with lymphocytic choriomeningitis virus (LCMV) and investigated the potential of immunotherapeutic strategies to counter such infections. All mice that received BMT survived LCMV infection and developed a virus carrier status. ...
Tópico(s): Parvovirus B19 Infection Studies
2005 - American Association of Immunologists | The Journal of Immunology
... Nordmann Ângela Novais Eric Nuermberger Origène Nyanguile Alex Odermatt J. Nicholas O’Donnell Nancy Odurowah Duah-Quashie ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2021 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy