... 2130-2134Crossref PubMed Scopus (442) Google Scholar, 18.Kaseda K. Higuchi H. Hirose K. Alternate fast and ... using recombinant constructs of Drosophila kinesin. Work by Kaseda et al. (18.Kaseda K. Higuchi H. Hirose K. Alternate fast and ...
Tópico(s): Cellular Mechanics and Interactions
2007 - Elsevier BV | Biophysical Journal
H. Tsuda, T. Noguchi, R. Kido,
... biol. Chem. 245, 1699. Kido R., Nogwchi T., Kaseda H., Kawamoto M. and Matsumura Y. (1968) Archs ... 1954) J. biol. Chem. 210, 139. Noguchi T., Kaseda H., Kido R. and Matsumura Y. (1970a) J. Biochem. 68, 245. Noguchi T., Kaseda H., Kido R. and Matsumura Y. (1970b) J. ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
1972 - Wiley | Journal of Neurochemistry
H. Kaseda, Tomoo Noguchi, Ryo Kido,
... and 2-Amino-3-hydroxyacetophenone Get access Hiroki KASEDA, Hiroki KASEDA Department of Biochemistry, Wakayama Medical CollegeWakayama 640 Search ...
Tópico(s): Plant biochemistry and biosynthesis
1973 - Oxford University Press | The Journal of Biochemistry
Takahiro Inoue, Tokushi Koga, Shigeru Kaseda, Yasuo Kaizuka, Nobuyuki Kawazoe, Seizo Sadoshima, Mituru Kinjo,
... Aorta Takahiro Inoue, MD, Tokushi Koga, MD, Shigeru Kaseda, MD, Yasuo Kaizuka, MD, Nobuyuki Kawazoe, MD, Seizo ... Steel Yawata Memorial Hospital, Fukuoka, Japan. , Shigeru KasedaShigeru Kaseda From the Division of Cardiology, Nippon Steel Yawata ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2004 - Lippincott Williams & Wilkins | Circulation
Takumi Chinen, Shohei Yamamoto, Yutaka Takeda, Koki Watanabe, Kanako Kuroki, Kaho Hashimoto, Daisuke Takao, Daiju Kitagawa,
... the radial array of microtubules during early mitosis (Kaseda et al, 2012). At the G2/M transition, ... Bertran et al, 2011; Smith et al, 2011; Kaseda et al, 2012; Hata et al, 2019). In ...
Tópico(s): 14-3-3 protein interactions
2019 - Springer Nature | The EMBO Journal
Kiyoko Hosaka, T. Takeda, Noriaki Iino, Michihiro Hosojima, Hiroyoshi Sato, Ryohei Kaseda, Keiko Yamamoto, Asako Kobayashi, Fumitake Gejyo, Akihiko Saito,
... 522-531Crossref PubMed Scopus (82) Google Scholar, 38.Kaseda R. Iino N. Hosojima M. et al.Megalin- ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2009 - Elsevier BV | Kidney International
Sosuke Iwai, Daisuke Hanamoto, Shigeru Chaen,
... fragment of pTIKLOES1 (17Uyeda T.Q. Tokuraku K. Kaseda K. Webb M.R. Patterson B. Biochemistry. 2002; ... from solution studies (17Uyeda T.Q. Tokuraku K. Kaseda K. Webb M.R. Patterson B. Biochemistry. 2002; ...
Tópico(s): Muscle Physiology and Disorders
2006 - Elsevier BV | Journal of Biological Chemistry
Xuchen Zhang, Peiying Shan, Dianhua Jiang, Paul W. Noble, Nader G. Abraham, Attallah Kappas, Patty J. Lee,
... to the best of our knowledge (9Hasuwa H. Kaseda K. Einarsdottir T. Okabe M. FEBS Lett. 2002; ... used to deliver siRNA in vivo (9Hasuwa H. Kaseda K. Einarsdottir T. Okabe M. FEBS Lett. 2002; ...
Tópico(s): Mechanical Circulatory Support Devices
2004 - Elsevier BV | Journal of Biological Chemistry
Anuj K. Dalal, John D. Harding, Ralph J. Verdino,
... sustained monomorphic ventricular tachycardia.16Bailie DS Inoue H Kaseda S Ben-David J Zipes DP Magnesium suppression ... cesium chloride in dogs.16Bailie DS Inoue H Kaseda S Ben-David J Zipes DP Magnesium suppression ...
Tópico(s): Nephrotoxicity and Medicinal Plants
2004 - Elsevier BV | Mayo Clinic Proceedings
Kohji Ito, Taro Q.P. Uyeda, Yoshikazu Suzuki, Kazuo Sutoh, Keiichi Yamamoto,
... of S1 forms (26Uyeda T.Q. Tokuraku K. Kaseda K. Webb M.R. Patterson B. Biochemistry. 2002; ... nm for S1 (26Uyeda T.Q. Tokuraku K. Kaseda K. Webb M.R. Patterson B. Biochemistry. 2002; ...
Tópico(s): Viral Infections and Immunology Research
2003 - Elsevier BV | Journal of Biological Chemistry
... in sheep. J. anim. Sci. 27, 117– 121. Kaseda, Y. (1981) The structure of the groups of ... Cape. Jap. J. Zootech. Sci. 52, 227– 235. Kaseda, Y., Ogawa, H. and Khalil, A.M. (1997) ...
Tópico(s): Wildlife Ecology and Conservation
1997 - Wiley | Equine Veterinary Journal
Rosalía B. Frydman, Marı́a L. Tomaro, Benjamín Frydman,
... colleagues. Learn more.Copy URL References 1 H. Kaseda, T. Noguchi, N. Konishi, R. Kido, Experientia, 27, ... Dalgliesh, Biochem. J., 61, (1955), 334– 3 H. Kaseda, T. Noguchi, R. Kido, Y. Matsumura, Experientia, 26, ( ...
Tópico(s): Synthesis of Indole Derivatives
1971 - Wiley | FEBS Letters
Shizuka Kaseda, Teruhiro Aoki, Nanae Hangai, Shuzo Yamamoto, Mitsuhide Kitano, Yuichi Yajima,
Kaseda, Shizuka MD; Aoki, Teruhiro MD; Hangai, Nanae MD; Yamamoto, Shuzo MD; Kitano, Mitsuhide MD; Yajima, Yuichi ...
Tópico(s): Trauma Management and Diagnosis
1997 - Lippincott Williams & Wilkins | Journal of Trauma and Acute Care Surgery
Tomoo Noguchi, H. Kaseda, Ryō Kido, Yuichi MATSUMURA,
... author on: Oxford Academic PubMed Google Scholar Hiroki KASEDA, Hiroki KASEDA The Department of Biochemistry, Wakayama Medical CollegeWakayama Search ...
Tópico(s): Plant biochemistry and biosynthesis
1970 - Oxford University Press | The Journal of Biochemistry
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian‐Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai,
Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis. However, the ability of metformin to improve non-diabetic glomerular disease and chronic kidney disease (CKD) has not been explored. To investigate the effect of metformin on non-diabetic glomerular disease, we used a mouse model of Alport syndrome (Col4a5 G5X) which were treated with metformin or losartan, ...
Tópico(s): Chronic Kidney Disease and Diabetes
2021 - Nature Portfolio | Scientific Reports
Misato Kamura, Tomohiko Yamamura, Kohei Omachi, Mary Ann Suico, Kandai Nozu, Shota Kaseda, Jun Kuwazuru, Tsuyoshi Shuto, Kazumoto Iijima, Hirofumi Kai,
IntroductionAlport syndrome is a hereditary glomerulonephritis that results from the disruption of collagen α345(IV) heterotrimerization caused by mutation in COL4A3, COL4A4 or COL4A5 genes. Many clinical studies have elucidated the correlation between genotype and phenotype, but there is still much ambiguity and insufficiency. Here, we focused on the α345(IV) heterotrimerization of α5(IV) missense mutant as a novel factor to further understand the pathophysiology of Alport syndrome.MethodsWe selected ...
Tópico(s): Platelet Disorders and Treatments
2020 - Elsevier BV | Kidney International Reports
Erin T. Kaseda, Andrew J. Levine,
Objective: SARS-CoV-2 infection and its oft-associated illness COVID-19 may lead to neuropsychological deficits, either through direct mechanisms (i.e., neurovirulance) or indirect mechanisms, most notably complications caused by the virus (e.g., stroke) or medical procedures (e.g., intubation). The history of past human coronavirus outbreaks resulting in similar health emergencies suggests there will be a substantial prevalence of post-traumatic stress disorder (PTSD) among COVID-19 survivors. To prepare ...
Tópico(s): COVID-19 and Mental Health
2020 - Taylor & Francis | The Clinical Neuropsychologist
Tomoya Hirota, Takumi Nagayama, Mareki Honma, Y. Adachi, Ross A. Burns, James O. Chibueze, Yoon Kyung Choi, Kazuya Hachisuka, Kazuhiro Hada, Yoshiaki Hagiwara, Shota Hamada, Toshihiro Handa, Mao Hashimoto, Ken Hirano, Yushi Hirata, Takanori Ichikawa, Hiroshi Imai, Daichi Inenaga, Toshio Ishikawa, Takaaki Jike, Osamu Kameya, Daichi Kaseda, Jeong Sook Kim, Jungha Kim, Mi Kyoung Kim, Hideyuki Kobayashi, Yusuke Kono, Tomoharu Kurayama, Masako Matsuno, Atsushi Morita, Kazuhito Motogi, Takeru Murase, Akiharu Nakagawa, Hiroyuki Nakanishi, Kotaro Niinuma, Junya Nishi, Chung Sik Oh, Toshihiro Omodaka, Miyako Oyadomari, Tomoaki Oyama, Daisuke Sakai, Nobuyuki Sakai, Satoko Sawada‐Satoh, Katsunori M. Shibata, Makoto Shizugami, Jumpei Sudo, Koichiro Sugiyama, Kazuyoshi Sunada, Syunsaku Suzuki, K. Takahashi, Yoshiaki Tamura, Fumie Tazaki, Yuji Ueno, Yuri Uno, Riku Urago, Koji Wada, Yuanwei Wu, Kazuyoshi Yamashita, Yuto Yamashita, Aya Yamauchi, Akito Yuda,
We present the first astrometry catalog from the Japanese VLBI (very long baseline interferometer) project VERA (VLBI Exploration of Radio Astrometry). We have compiled all the astrometry results from VERA, providing accurate trigonometric annual parallax and proper motion measurements. In total, 99 maser sources are listed in the VERA catalog. Among them, 21 maser sources are newly reported while the rest of 78 sources are referred to previously published results or those in preparation for forthcoming ...
Tópico(s): Astrophysics and Star Formation Studies
2020 - Oxford University Press | Publications of the Astronomical Society of Japan
Lung cancer is the leading cause of cancer-related deaths around the world, the most common type of which is non-small-cell lung cancer (NSCLC). Computed tomography (CT) is required for patients with NSCLC, but often involves diagnostic issues and large intra- and interobserver variability. The anatomic data obtained using CT can be supplemented by the metabolic data obtained using fluorodeoxyglucose F 18 (FDG) positron emission tomography (PET); therefore, the use of FDG-PET/CT for staging NSCLC is ...
Tópico(s): Medical Imaging Techniques and Applications
2020 - Multidisciplinary Digital Publishing Institute | Diagnostics
Masao Higo, Yuya Tatewaki, Kento Gunji, Akari Kaseda, Katsunori Isobe,
Understanding the role of communities of arbuscular mycorrhizal fungi (AMF) in agricultural systems is imperative for enhancing crop production. The key variables influencing change in AMF communities are the type of cover crop species or the type of subsequent host crop species. However, how maize and soybean performance is related to the diversity of AMF communities in cover cropping systems remains unclear. We therefore investigated which cover cropping or host identity is the most important factor ...
Tópico(s): Plant Pathogens and Fungal Diseases
2019 - PeerJ, Inc. | PeerJ
Yuki Higuchi, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Sawako Goto, Koji Toba, Ryohei Kaseda, Takahiro Tanaka, Nobutaka Kitamura, Hayato Takihara, Shujiro Okuda, Masayuki Taniguchi, Hitoshi Arao, Ichiei Narita, Akihiko Saito,
Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidney disease in animal models. However, the effects of REP intake during childhood on adulthood health are unclear. Therefore, we used a mouse model to experimentally investigate the preconditioning effects ...
Tópico(s): Nutritional Studies and Diet
2019 - Multidisciplinary Digital Publishing Institute | Nutrients
Koji Toba, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Toshiko Murayama, Keiko Yamamoto-Kabasawa, Ryohei Kaseda, Eri Wada, Reiko Watanabe, Naohito Tanabe, Yoshiki Suzuki, Ichiei Narita, Akihiko Saito,
Dietary acid load has been suggested to mediate the progression of chronic kidney disease (CKD). However, it is unclear what kinds of foods are actually associated with dietary acid load in patients with CKD. The self-administered diet history questionnaire (DHQ), which semi-quantitatively assesses the dietary habits of Japanese individuals through 150 question items, can estimate average daily intake of various foods and nutrients during the previous month. Using the DHQ, we investigated the association ...
Tópico(s): Gastroesophageal reflux and treatments
2019 - BioMed Central | BMC Nephrology
Ryohei Kaseda, Yohei Tsuchida, Hai-Chun Yang, Patricia G. Yancey, Jianyong Zhong, Tao Huan, Aihua Bian, Agnes B. Fogo, Mac Rae F. Linton, Sergio Fazio, T. Alp İkizler, Valentina Kon,
Background: Our aim was to evaluate lipid trafficking and inflammatory response of macrophages exposed to lipoproteins from subjects with moderate to severe chronic kidney disease (CKD), and to investigate the potential benefits of activating cellular cholesterol transporters via liver X receptor (LXR) agonism.Methods: LDL and HDL were isolated by sequential density gradient ultracentrifugation of plasma from patients with stage 3-4 CKD and individuals without kidney disease (HDL CKD and HDL Cont , respectively). ...
Tópico(s): Liver Disease Diagnosis and Treatment
2018 - BioMed Central | BMC Nephrology
Kohei Omachi, Misato Kamura, Keisuke Teramoto, Haruka Kojima, Tsubasa Yokota, Shota Kaseda, Jun Kuwazuru, Ryosuke Fukuda, Kosuke Koyama, Shingo Matsuyama, Keishi Motomura, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai,
Alport syndrome is a hereditary glomerular disease caused by mutation in type IV collagen α3–α5 chains (α3–α5(IV)), which disrupts trimerization, leading to glomerular basement membrane degeneration. Correcting the trimerization of α3/α4/α5 chain is a feasible therapeutic approach, but is hindered by lack of information on the regulation of intracellular α(IV) chain and the absence of high-throughput screening (HTS) platforms to assess α345(IV) trimer formation. Here, we developed sets of split NanoLuc- ...
Tópico(s): Complement system in diseases
2018 - Elsevier BV | Cell chemical biology
Tomonari Kinoshita, Chie Kudo‐Saito, Reiko Muramatsu, Tomonobu Fujita, Miyuki Saito, Haruna Nagumo, Toshiharu Sakurai, Shinobu Noji, Emi Takahata, Tomonori Yaguchi, Nobuo Tsukamoto, Yuichiro Hayashi, Kaoru Kaseda, Ikuo Kamiyama, Takashi Ohtsuka, Kenji Tomizawa, Masaki Shimoji, Tetsuya Mitsudomi, Hisao Asamura, Yutaka Kawakami,
We have previously demonstrated that the prognostic significance of tumour-infiltrating CD8+ T cells significantly differs according to histological type and patient smoking habits in non-small cell lung cancer (NSCLC). This work suggested that infiltrating CD8+ T cells may not be activated sufficiently in the immunosuppressive microenvironment in non-smokers with adenocarcinoma. To understand the immunogenic microenvironment in NSCLC, we characterised immune cells comprehensively by performing an ...
Tópico(s): Immunotherapy and Immune Responses
2017 - Elsevier BV | European Journal of Cancer
Tsubasa Yokota, Kohei Omachi, Mary Ann Suico, Misato Kamura, Haruka Kojima, Ryosuke Fukuda, Keishi Motomura, Keisuke Teramoto, Shota Kaseda, Jun Kuwazuru, Toru Takeo, Naomi Nakagata, Tsuyoshi Shuto, Hirofumi Kai,
Alport syndrome (AS) is a hereditary, progressive nephritis caused by mutation of type IV collagen. Previous studies have shown that activation of signal transducer and activator of transcription 3 (STAT3) exacerbates other renal diseases, but whether STAT3 activation exacerbates AS pathology is still unknown. Here we aim to investigate the involvement of STAT3 in the progression of AS.Phosphorylated STAT3 expression was assessed by immunoblotting analysis of kidneys and glomeruli of an AS mouse model ( ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2017 - Oxford University Press | Nephrology Dialysis Transplantation
Shankhajit De, Shoji Kuwahara, Michihiro Hosojima, Tomomi Ishikawa, Ryohei Kaseda, Piyali Sarkar, Yusuke Yoshioka, Hideyuki Kabasawa, Tomomichi Iida, Sawako Goto, Koji Toba, Yuki Higuchi, Yoshiki Suzuki, Masanori Hara, Hiroyuki Kurosawa, Ichiei Narita, Yoshiaki Hirayama, Takahiro Ochiya, Akihiko Saito,
Efficient biomarkers for diabetic nephropathy (DN) have not been established. Using ELISA, we found previously that urinary levels of full-length megalin (C-megalin), a multiligand endocytic receptor in proximal tubules, was positively correlated with DN progression in patients with type 2 diabetes mellitus (T2DM). Here, we found that urinary extracellular vesicle (UEV) excretion and C-megalin content in UEVs or in their exosomal fraction increased along with the progression of the albuminuric stages ...
Tópico(s): Mosquito-borne diseases and control
2017 - American Diabetes Association | Diabetes
Katsuya Kajimoto, Yuichiro Minami, Shigeru Otsubo, Naoki Sato, Naoki Sato, Kuniya Asai, Ryo Munakata, Toshiyuki Aokage, Asuka Yoshida, Yuichiro Minami, Dai Yumino, Masayuki Mizuno, Erisa Kawada, Kentaro Yoshida, Yuri Ozaki, Tomohito Kogure, Shintaro Haruki, Masayuki Mizuno, Katsuya Kajimoto, Kōichi Nakao, Tadashi Sawamura, Toshiaki Nuki, Ryoji Ishiki, Shigeki Yokota, Hiroyuki Fujinaga, Takashi Yamamoto, Kenji Harada, Akihiro Saito, Norihito Kageyama, Takanobu Okumura, Noritake Hata, Koji Murai, Ayaka Nozaki, Hidekazu Kawanaka, Jun Tanabe, Yukihito Sato, Katsuhisa Ishii, Hitoshi Oiwa, Tomoaki Matsumoto, Daisuke Yoshida, Nobuo Kato, Hiroshi Suzuki, Nobuyuki Shimizu, Takehiko Keida, Masaki Fujita, Kentaro Nakamura, Toshiya Chinen, Kentaro Meguro, Tatsuro Kikuchi, Toshiyuki Nishikido, Marohito Nakata, Tatsuya Yamashita, Masaya Nakata, Akitoshi Hirono, Kazuaki Mitsudo, Kazushige Kadota, Noriko Makita, Nagisa Watanabe, Masaaki Kawabata, Kenichi Fujii, Shinichi Okuda, Shigeki Kobayashi, Ikuo Moriuchi, Kiyo-o Mizuno, Kazuo Osato, Tatsuaki Murakami, Yoshifumi Shimada, Katsushi Misawa, Hiromasa Kokado, Takashi Fujita, Yoshitomo Fukuoka, Syu Takabatake, Yoshifumi Takata, Manabu Miyagi, Nobuhiro Tanaka, Akira Yamashina, Shinji Sudo, Koichi Shimamura, Michitaka Nagashima, Tomoya Kaneda, Kosei Ueda, Hiromasa Kato, Toshinori Higashikata, Kanichi Fujimori, Hiroshi Kobayashi, Shinya Fujii, Masahiro Yagi, Yuri Ozaki, Jyunko Takaki, Eiji Yamashita, Takuji Toyama, Tetsuo Hirata, Kazuho Kamisihima, Toshiaki Oka, Ryushi Komatsu, Itoh Akira, Takahiko Naruko, Yukio Abe, Eiichirou Nakagawa, Atsuko Furukawa, Naoto Kinou, Shoko Uematsu, Isao Tabuchi, Taku Imai, Takafumi Sakamoto, Koji Todaka, Yuji Koide, Koji Maemura, Koichiro Yoshioka, Akiomi Yoshihisa, Takamasa Sato, Yasuchika Takeishi, Toshiaki Ebina, Kazuo Kimura, Masaaki Konishi, Masahiko Kato, Yoshiharu Kinugasa, Katsunori Ishida, Shinobu Sugihara, Kiyotaka Yanagihara, Toshiharu Takeuchi, Motoi Okada, Naoyuki Hasebe, Tetsuo Sakai, Taku Asano, Yoshino Minoura, Tsutomu Toshida, Takatoshi Sato, Yuya Yokota, Seita Kondo, Yasushi Sakata, Issei Komuro, Kinya Otsu, Shizuya Yamashita, Yoshihiro Asano, Asuka Yoshida, Katsuya Kajimoto, Kazunori Kashiwase, Yasunori Ueda, Taizo Kondo, Katsuhiro Kawaguchi, Akinori Sawamura, Taro Saito, Toru Higa, Hiroo Noguchi, Yoko Yanagita, Keita Nakamura, Tomo Komaki, Toshihiro Muramatsu, Tomomi Koizumi, Yoshie Nakajima, Toshihiko Kikutani, Yoshifimi Ikeda, Toru Tamaki, Shuhei Funada, Harumi Ogawa, Koichiro Sakuragawa, Shun Kohsaka, Shin‐ichi Ando, Toshiaki Kadokami, Eiko Ishida, katsumi ide, Yohei Sotomi, Yoshiharu Higuchi, Motoko Uehara, Toshihiko Goto, Nobuyuki Ohte, Masanobu Miura, Nobuyuki Shiba, Kotaro Nochioka, Hiroaki Shimokawa, Shiro Ishihara, Tokushi Koga, Shinichiro Fujishima, Shigeru Kaseda, Yoshie Haga, Keisuke Kida, Kazuho Kamisihima, Makiko Nakamura, Osahiko Sunagawa, Takafumi Miyara, Youji Taba, Takashi Touma, Osamu Shinjo, Yoshioki Nishimura, Kazuomi Kario, Hayato Shimizu, Takahiro Uchida, Kenichi Amitani, Naoki Sato, Katsunori Shimada,
The aim of this study was to evaluate the association of functional mitral regurgitation (FMR), preserved or reduced ejection fraction (EF), and ischemic or nonischemic origin with outcomes in patients discharged alive after hospitalization for acute decompensated heart failure (HF). Of the 4,842 patients enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, 3,357 patients were evaluated to assess the association of FMR, preserved or reduced EF, and ischemic or nonischemic origin ...
Tópico(s): Cardiac pacing and defibrillation studies
2017 - Elsevier BV | The American Journal of Cardiology
Masaya Yotsukura, Hiroyuki Yasuda, Takao Shigenobu, Kaoru Kaseda, Kyohei Masai, Yuichiro Hayashi, Tomoyuki Hishida, Takashi Ohtsuka, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku, Hisao Asamura,
Objectives Over the past decade, the biological and clinical characteristics of lung cancer with epidermal growth factor receptor (EGFR) mutation have been well studied. However, most studies have focused on advanced inoperable cancer, and not on resected early-stage lung adenocarcinoma. We aimed to elucidate the differences in the clinicopathological characteristics and postoperative prognosis according to the EGFR mutation status in early-stage lung adenocarcinoma. Materials and methods We retrospectively ...
Tópico(s): Lung Cancer Research Studies
2017 - Elsevier BV | Lung Cancer
Y Hori, Nobumasa Aoki, Shoji Kuwahara, Michihiro Hosojima, Ryohei Kaseda, Sawako Goto, Tomomichi Iida, Shankhajit De, Hideyuki Kabasawa, Reika Kaneko, Hiroyuki Aoki, Yoshinari Tanabe, Hiroshi Kagamu, Ichiei Narita, Toshiaki Kikuchi, Akihiko Saito,
Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem. Megalin, an endocytic receptor expressed at the apical membranes of proximal tubules, mediates the nephrotoxicity of aminoglycosides and colistin, key antimicrobials for multidrug-resistant organisms. The mechanisms underlying the nephrotoxicity induced by vancomycin, an antimicrobial for methicillin-resistant Staphylococcus aureus, and cisplatin, an important anticancer drug, are unknown, although the nephrotoxicity ...
Tópico(s): Drug Transport and Resistance Mechanisms
2017 - American Society of Nephrology | Journal of the American Society of Nephrology