... the Wisteria at Ushijima (Present-Day Ushijima in Kasukabe City, Saitama Prefecture), but This Is Not Certain. ...
0000 - Gale Group | NCCO Photography
Roel Willems, Dirk R. Van Bockstaele, Filip Lardon, Marc Lenjou, Griet Nijs, Hans‐Willem Snoeck, Zwi Berneman, Herman Slegers,
... by Okabe-Kado et al. (13Okabe-Kado J. Kasukabe T. Honma Y. Hayashi M. Henzel W.J. ... mutants lacking the enzymatic activity (13Okabe-Kado J. Kasukabe T. Honma Y. Hayashi M. Henzel W.J. ... PubMed Scopus (111) Google Scholar, 14Okabe-Kado J. Kasukabe T. Hozumi M. Honma Y. Kimura N. Baba ... PubMed Scopus (68) Google Scholar, 15Okabe-Kado J. Kasukabe T. Baba H. Urano T. Shiku H. Honma ... Kaneko Y. Hino K. Tomoyasu S. Tsuruoka N. Kasukabe T. Honma Y. Blood. 1996; 88: 3555-3561Crossref ... independently of their enzymatic activity (13Okabe-Kado J. Kasukabe T. Honma Y. Hayashi M. Henzel W.J. ...
Tópico(s): Metastasis and carcinoma case studies
1998 - Elsevier BV | Journal of Biological Chemistry
... hydrophilized ceramide Jun Yajima, Corresponding Author Jun Yajima Kasukabe Dermatology Clinic, Saitama, JapanJun Yajima Kasukabe Dermatology Clinic 3-11-15, Chuoh Kasukabe-Shi Saitama 344-0067 JapanSearch for more papers ... this author Jun Yajima, Corresponding Author Jun Yajima Kasukabe Dermatology Clinic, Saitama, JapanJun Yajima Kasukabe Dermatology Clinic 3-11-15, Chuoh Kasukabe-Shi Saitama 344-0067 JapanSearch for more papers ...
Tópico(s): Ocular Surface and Contact Lens
2002 - Wiley | Contact Dermatitis
Ikuko Abe, T. Ochiai, Akira Kawamura, R. Muto, Yohei Hirano, Makoto Ogawa,
... Surugadai Nihon University Hospital, Tokyo, Japan; Hirano Clinic, Kasukabe‐shi, Saitama, Japan Search for other works by ... Surugadai Nihon University Hospital, Tokyo, Japan; Hirano Clinic, Kasukabe‐shi, Saitama, Japan Search for other works by ... Surugadai Nihon University Hospital, Tokyo, Japan; Hirano Clinic, Kasukabe‐shi, Saitama, Japan Search for other works by ... Surugadai Nihon University Hospital, Tokyo, Japan; Hirano Clinic, Kasukabe‐shi, Saitama, Japan Search for other works by ... Surugadai Nihon University Hospital, Tokyo, Japan; Hirano Clinic, Kasukabe‐shi, Saitama, Japan Search for other works by ...
Tópico(s): Genetic Neurodegenerative Diseases
2006 - Oxford University Press | Clinical and Experimental Dermatology
Maho Oishi, Yukiko Inoue, R. Kagatsume, Takehito Shukuya, R. Kasukabe, Hiroshi Oya, Shigeyuki HOSHINO, S. Ushiku, Y. Fujiwara, Y. Motokura, Yoshiaki Maeda,
... Oishi, Y. Inoue, R. Kagatsume, T. Shukuya, R. Kasukabe, H. Oya, S. Hoshino, S. Ushiku, Y. Fujiwara, ... protected], Y. Inoue, R. Kagatsume, T. Shukuya, R. Kasukabe, H. Oya, S. Hoshino, S. Ushiku, Y. Fujiwara, ... Oishi † Y. Inoue R. Kagatsume T. Shukuya R. Kasukabe H. Oya S. Hoshino S. Ushiku Y. Fujiwara ...
Tópico(s): Herpesvirus Infections and Treatments
2017 - American Phytopathological Society | Plant Disease
Sung‐Jen Wei, Carol S. Trempus, Robin C. Ali, Laura A. Hansen, Raymond W. Tennant,
... Scopus (145) Google Scholar), differentiation (14Okabe-Kado J. Kasukabe T. Hozumi M. Honma Y. Kimura N. Baba ... PubMed Scopus (68) Google Scholar, 15Okabe-Kado J. Kasukabe T. Honma Y. Leukemia Res. 2002; 26: 569- ...
Tópico(s): Metastasis and carcinoma case studies
2004 - Elsevier BV | Journal of Biological Chemistry
Levon M. Khachigian, Roger G. Fahmy, Guishui Zhang, Yuri V. Bobryshev, Anastasia Kaniaros,
... to c-jun, Kanatani and colleagues (25Kanatani Y. Kasukabe T. Okabe-Kado J. Hayashi S. Yamamoto- Yamaguchi ... tumor growth factor-β and dexamethasone (25Kanatani Y. Kasukabe T. Okabe-Kado J. Hayashi S. Yamamoto- Yamaguchi ...
Tópico(s): Molecular Biology Techniques and Applications
2002 - Elsevier BV | Journal of Biological Chemistry
Atsuo Kondo, Eiji Yokoyama, Ken Koshiba, Junnosuke Fukui, Momokazu Gotoh, Yoko Yoshikawa, Takumi Yamada, Mineo Takei,
... s International Hospital, Tokyo, Hekinan Municipal Hospital, Hekinan, Kasukabe Municipal Hospital, Kasukabe and Hara-Sansin General Hospital, Fukuoka, Japan© 1997 ...
Tópico(s): Urinary Tract Infections Management
1997 - Lippincott Williams & Wilkins | The Journal of Urology
Ichiroh Kato, Takashi Kasukabe, Shunichi Kumakura,
Menin‑mixed‑lineage leukemia (MLL) inhibitors have potential for use as therapeutic agents for MLL‑rearranged leukemia. They are also effective against solid cancers, such as breast cancer. The present study demonstrated that menin‑MLL inhibitors, such as MI‑463, unexpectedly induced the ferroptotic cell death of several cancer cell lines. MI‑463 at a double‑digit nM concentration markedly decreased the viable number of OVCAR‑8 ovarian cancer cells for 3 days. Ferrostatin‑1 (a ferroptosis inhibitor) ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Spandidos Publishing | International Journal of Oncology
Pawan Boonyoung, Takatoshi Kasukabe, Yasuto Hoshikawa, Ángel Berenguer‐Murcia, Diego Cazorla‐Amorós, Bundet Boekfa, Hirotomo Nishihara, Takashi Kyotani, Khanin Nueangnoraj,
Schwarzites have a three-dimensional sp2 carbon structure with negative Gaussian curvatures. They can be synthesized through the deposition of carbon by chemical vapor deposition on a zeolite template and may be formed by increasing the amount of carbon. In this research, the amount of carbon deposition was increased by shortening the length of the diffusion pathways of the template through the use of nano-sized zeolite Y (nano-FAU). It was found that significantly larger quantities of carbon could ...
Tópico(s): Concrete and Cement Materials Research
2019 - Frontiers Media | Frontiers in Materials
Yuki Yamaguchi, Takashi Kasukabe, Shunichi Kumakura,
Pancreatic cancer is one of the most lethal types of cancer with a mortality rate of almost 95%. Treatment with current chemotherapeutic drugs has limited success due to poor responses. Therefore, the development of novel drugs or effective combination therapies is urgently required. Piperlongumine (PL) is a natural product with cytotoxic properties restricted to cancer cells by significantly increasing intracellular reactive oxygen species (ROS) levels. In the present study, we demonstrated that ...
Tópico(s): MicroRNA in disease regulation
2018 - Spandidos Publishing | International Journal of Oncology
Kumiko Eguchi, Tomohiko Shindo, Kenta Ito, Tsuyoshi Ogata, Ryo Kurosawa, Yuta Kagaya, Yuto Monma, Sadamitsu Ichijo, Sachie Kasukabe, Satoshi Miyata, Takeo Yoshikawa, Kazuhiko Yanai, Hirofumi Taki, Hiroshi Kanai, Noriko Osumi, Hiroaki Shimokawa,
Therapeutic focused-ultrasound to the hippocampus has been reported to exert neuroprotective effects on dementia. In the present study, we examined whether the whole-brain LIPUS (low-intensity pulsed ultrasound) therapy is effective and safe in 2 mouse models of dementia (vascular dementia, VaD and Alzheimer's disease, AD), and if so, to elucidate the common underlying mechanism(s) involved.We used bilateral carotid artery stenosis (BCAS) model with micro-coils in male C57BL/6 mice as a VaD model and ...
Tópico(s): Ultrasound and Hyperthermia Applications
2018 - Elsevier BV | Brain stimulation
Takatoshi Kasukabe, Hirotomo Nishihara, K. Kimura, Taketoshi Matsumoto, Hikaru Kobayashi, M. Okai, Takashi Kyotani,
Nowadays, ca. 176,640 tons/year of silicon (Si) (>4N) is manufactured for Si wafers used for semiconductor industry. The production of the highly pure Si wafers inevitably includes very high-temperature steps at 1400-2000 °C, which is energy-consuming and environmentally unfriendly. Inefficiently, ca. 45-55% of such costly Si is lost simply as sawdust in the cutting process. In this work, we develop a cost-effective way to recycle Si sawdust as a high-performance anode material for lithium-ion batteries. ...
Tópico(s): Semiconductor materials and devices
2017 - Nature Portfolio | Scientific Reports
Taketoshi Matsumoto, K. Kimura, Hirotomo Nishihara, Takatoshi Kasukabe, Takashi Kyotani, Hikaru Kobayashi,
Si nanopowder is expected as a high capacity anode active material for Li-ion batteries (LIBs) due to its superior theoretical capacity of ∼3600 mA h/g, which is approximately one order of magnitude higher than that of conventional graphitic materials. We have succeeded in fabrication of Si nanopowder from Si swarf using the cost-effective beads milling method. The Si nanopowder consists of Si nano-crystals having flake-like shape with two largely different sizes, i.e., several hundred nm sizes and ...
Tópico(s): Advanced Battery Technologies Research
2017 - Elsevier BV | Journal of Alloys and Compounds
Takatoshi Kasukabe, Hirotomo Nishihara, Shinichiroh Iwamura, Takashi Kyotani,
Si nanoparticles prepared by ball-milling (BM-Si) are expected as practical negative-electrode materials for lithium-ion batteries, but their performance is much lower than those of more expensive Si nanomaterials, such as chemical-vapor-deposition derived Si nanoparticles (CVD-Si) having a tight network structure. It is found that carbon-coating of aggregations of BM-Si forms a quasi-network structure, thereby making the performance comparable to that of CVD-Si under capacity restriction (to 1500 ...
Tópico(s): Graphene research and applications
2016 - Elsevier BV | Journal of Power Sources
Alberto Castro‐Muñiz, Yasuto Hoshikawa, Takatoshi Kasukabe, Hiroshi Komiyama, Takashi Kyotani,
The main aim of the present work is to precisely understand the sole effect of nitrogen doping on the electrochemical performance of porous carbon materials. To achieve this objective, the whole surface of mesoporous silica (SBA-15) was coated with a thin layer of carbon (about 0.4 nm) with and without N-doping by using acetonitrile and acetylene chemical vapor deposition, respectively. The resulting N-doped and nondoped carbon-coated silica samples have mesopore structures identical to those in the ...
Tópico(s): Mesoporous Materials and Catalysis
2016 - American Chemical Society | Langmuir
Tomohiko Shindo, Kenta Ito, Tsuyoshi Ogata, Kazuaki Hatanaka, Ryo Kurosawa, Kumiko Eguchi, Yuta Kagaya, Kenichiro Hanawa, Kentaro Aizawa, Takashi Shiroto, Sachie Kasukabe, Satoshi Miyata, Hirofumi Taki, Hideyuki Hasegawa, Hiroshi Kanai, Hiroaki Shimokawa,
Objective— Left ventricular (LV) remodeling after acute myocardial infarction still remains an important issue in cardiovascular medicine. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) therapy improves myocardial ischemia in a pig model of chronic myocardial ischemia through enhanced myocardial angiogenesis. In the present study, we aimed to demonstrate whether LIPUS also ameliorates LV remodeling after acute myocardial infarction and if so, to elucidate the underlying ...
Tópico(s): Elasticity and Material Modeling
2016 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Takashi Kasukabe, Yoshio Honma, Junko Okabe‐Kado, Yusuke Higuchi, Nobuo Kato, Shunichi Kumakura,
The treatment of pancreatic cancer, one of the most aggressive gastrointestinal tract malignancies, with current chemotherapeutic drugs has had limited success due to its chemoresistance and poor prognosis. Therefore, the development of new drugs or effective combination therapies is urgently needed. Cotylenin A (CN-A) (a plant growth regulator) is a potent inducer of differentiation in myeloid leukemia cells and exhibits potent antitumor activities in several cancer cell lines. In the present study, ...
Tópico(s): Ferroptosis and cancer prognosis
2016 - Elsevier BV | Oncology Reports
Yasuhisa Maniwa, Takashi Kasukabe, Shunichi Kumakura,
Although all-trans retinoic acid (ATRA) is a standard and effective drug used for differentiation therapy in acute promyelocytic leukemia, ATRA-resistant leukemia cells ultimately emerge during this treatment. Therefore, the development of new drugs or effective combination therapy is urgently needed. We demonstrate that the combined treatment of vitamin K2 and cotylenin A synergistically induced monocytic differentiation in HL-60 cells. This combined treatment also synergistically induced NBT-reducing ...
Tópico(s): Protein Degradation and Inhibitors
2015 - Spandidos Publishing | International Journal of Oncology
Takashi Kasukabe, Junko Okabe‐Kado, Nobuo Kato, Yoshio Honma, Shunichi Kumakura,
Arsenic trioxide (ATO) is an approved treatment for acute promyelocytic leukemia (APL). It has also shown potential for treatment of multiple myeloma and various solid tumors including breast cancer. The requirement of high, toxic concentrations for the induction of apoptosis in non-APL and solid tumor cells is a major limitation for its use in other hematological malignancies and solid tumors. We have examined whether inducers of differentiation of leukemia cells can control the growth of solid tumor ...
Tópico(s): 14-3-3 protein interactions
2014 - Spandidos Publishing | International Journal of Oncology
Takashi Kasukabe, Junko Okabe‐Kado, Yu Haranosono, Nobuo Kato, Yoshio Honma,
Cotylenin A, a plant growth regulator, and rapa-mycin, an inhibitor of the mammalian target of rapamycin, are potent inducers of differentiation in myeloid leukemia cells and also synergistically inhibit the proliferation of several human breast cancer cell lines including MCF-7 in vitro and in vivo. However, the mechanisms of the combined effects of cotylenin A and rapamycin are still unknown. Activated Akt induced by rapamycin has been suggested to attenuate the growth-inhibitory effects of rapamycin, ...
Tópico(s): Phytochemical compounds biological activities
2012 - Spandidos Publishing | International Journal of Oncology
Joohyun Lee, Teresa H. Burns, Ginger G. Light, Yan Sun, Mohamed Fokar, Yoshihisha Kasukabe, Koichi Fujisawa, Yoshihiko Maekawa, Randy D. Allen,
Tópico(s): Plant Gene Expression Analysis
2010 - Springer Science+Business Media | Planta
Yuki Hagiwara, Takashi Kasukabe, Yasuhiko Kaneko, Nozomi Niitsu, Junko Okabe‐Kado,
Tópico(s): Biological Activity of Diterpenoids and Biflavonoids
2010 - Springer Science+Business Media | International Journal of Hematology
Kimitaka Kawamura, Hideki Kasukabe, Leonard A. Barrie,
Water‐soluble dicarboxylic acids (C 2 ‐C 12 ), ketocarboxylic acids (C 2 ‐C 6 , C 9 ), and α ‐dicarbonyls (glyoxal and methylglyoxal) were determined in the Arctic aerosols collected in winter to early summer, as well as aerosol total carbon (TC) and water‐soluble organic carbon (WSOC). Concentrations of TC and WSOC gradually decreased from late February to early June with a peak in spring, indicating a photochemical formation of water‐soluble organic aerosols at a polar sunrise. We found that total (C 2 ‐C 11 ) diacids ( ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2010 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Junko Okabe‐Kado, Takashi Kasukabe, Yoshio Honma, Hirofumi Kobayashi, Nobuo Maseki, Yasuhiko Kaneko,
An elevated serum level of NM23-H1 protein is found in acute myelogenous leukemia (AML), and predicts a poor treatment outcome in AML patients. To investigate the potential pathological link between the elevated serum level of this protein and poor prognosis, we examined the extracellular effects of recombinant NM23-H1 protein on the in vitro growth and survival of primary cultured AML cells at concentrations equivalent to the levels found in the serum of AML patients. Extracellular NM23-H1 protein ...
Tópico(s): Enzyme function and inhibition
2009 - Wiley | Cancer Science
Takashi Kasukabe, Junko Okabe‐Kado, Yoshio Honma,
Cotylenin A, a plant growth regulator, and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), are potent inducers of differentiation of myeloid leukemia cells. Recently, we found that cotylenin A and rapamycin effectively inhibited the proliferation of several human breast cancer cell lines including MCF‐7. Herein, we demonstrate that cotylenin A and rapamycin rapidly and markedly induced the cyclin G2 gene expression in several cancer cells including MCF‐7 cells. The growth arrest ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2008 - Wiley | Cancer Science
Daniel Smrž, Pavel Lebduška, Lubica Dráberová, Jan Korb, Petr Dráber,
... Tomoyasu S. Kimura F. Motoyoshi K. Honma Y. Kasukabe T. Leuk. Res. 2004; 28: 149-157Crossref PubMed ...
Tópico(s): Cellular transport and secretion
2008 - Elsevier BV | Journal of Biological Chemistry
Yoshihisa Kasukabe, Lixiong He, Yuriko Watakabe, Motoyasu Otani, Takiko Shimada, Shoji Tachibana,
With the purpose of enhancing environmental stress tolerance of sweet potato (Ipomoea batatas, cv. Kokei 14), we transformed this plant with spermidine synthase genes derived from Cucurbita ficifolia (FSPD1). The FSPD1-transgenic plants showed twice as high spermidine content as the wild type (WT) counterpart in both leaves and storage roots. One of the most characteristic features of the transgenic plants was the increase in the number of storage roots formed under both non-stress and stressful environments. ...
Tópico(s): Plant Virus Research Studies
2006 - Japanese Society for Plant Biotechnology | Plant Biotechnology
Junko Okabe‐Kado, Takashi Kasukabe, Yoshio Honma, Ryoji Hanada, Akira Nakagawara, Yasuhiko Kaneko,
We have previously reported that NM23 genes are overexpressed in various hematological malignancies and that serum NM23‐H1 protein levels are useful for predicting patient outcomes. In this study we assessed the clinical implications of serum NM23‐H1 protein on neuroblastoma. We examined serum NM23‐H1 protein levels in 217 patients with neuroblastoma, including 131 found by mass‐screening and 86 found clinically by an enzyme‐linked immunosorbent assay, and determined the association between levels ...
Tópico(s): Neuroendocrine Tumor Research Advances
2005 - Wiley | Cancer Science
Takashi Kasukabe, Junko Okabe‐Kado, Nobuo Kato, Takeshi Sassa, Yoshio Honma,
Abstract Introduction Rapamycin, an inhibitor of the serine/threonine kinase target of rapamycin, induces G 1 arrest and/or apoptosis. Although rapamycin and its analogues are attractive candidates for cancer therapy, their sensitivities with respect to growth inhibition differ markedly among various cancer cells. Using human breast carcinoma cell line MCF-7 as an experimental model system, we examined the growth-inhibitory effects of combinations of various agents and rapamycin to find the agent ...
Tópico(s): 14-3-3 protein interactions
2005 - BioMed Central | Breast Cancer Research