Florian Hermes, Katharina Otte, Jessica Brandt, Marlies Gräwert, Hans G. Börner, Helmut Schlaad,
... ISSUEPREVNoteNEXTPolypeptide-Based Organogelators: Effects of Secondary StructureFlorian Hermes†, Katharina Otte†, Jessica Brandt†, Marlies Gräwert†, Hans G. Börner‡, and ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2011 - American Chemical Society | Macromolecules
Sergey A. Dyshlovoy, Katharina Otte, Winfried Alsdorf, Jessica Hauschild, Tobias Lange, Simone Venz, Christiane K. Bauer, Robert Bähring, Kerstin Amann, Ramin Mandanchi, Udo Schumacher, Jennifer Schröder‐Schwarz, Tatyana N. Makarieva, Alla G. Guzii, Kseniya M. Tabakmakher, Sergey N. Fedorov, Larisa K. Shubina, Igor E. Kasheverov, Heimo Ehmke, Thomas Steuber, Valentin A. Stonik, Carsten Bokemeyer, Friedemann Honecker, Gunhild von Amsberg,
// Sergey A. Dyshlovoy 1, 2, 3, * , Katharina Otte 1, * , Winfried H. Alsdorf 1 , Jessica Hauschild 1 , Tobias Lange 4 , Simone Venz 5 , Christiane K. Bauer 6 , Robert Bähring 6 , Kerstin ...
Tópico(s): Cell death mechanisms and regulation
2016 - Impact Journals LLC | Oncotarget
Thomas Braunbeck, Britta Kais, Eva Lammer, Jens C. Otte, Katharina Schneider, Daniel Stengel, Ruben Strecker,
Tópico(s): Advanced biosensing and bioanalysis techniques
2014 - Springer Science+Business Media | Environmental Science and Pollution Research
Manuela Dudeck, Zrinka Sosic-Vasic, Stefanie Otte, Katharina Rasche, Katharina Leichauer, Susanne Tippelt, Riad Shenar, Solveig Klingner, Nenad Vasić, Judith Streb,
Although previous studies in inmates, forensic and psychiatric samples suggest the relation between childhood trauma and suicide behavior as well as between childhood trauma and violent delinquency, the understanding of possible underlying mechanisms is still fragmentary. In a naturalistic study design, we tested if suicidal attempts and violent crimes are differently associated with adverse childhood experiences and levels of appetitive aggression in male forensic psychiatry inpatients. Adverse ...
Tópico(s): Psychopathy, Forensic Psychiatry, Sexual Offending
2016 - Elsevier BV | Psychiatry Research
Alberto Villa, Sebastiano Campisi, Cristina Giordano, Katharina Otte, Laura Prati,
The application of Mo and W carbide (Mo2C and WC respectively) in the liquid phase oxidation of benzyl alcohol has been presented. Mo2C and WC are, indeed, considered among the most suitable candidates to replace noble metals for oxidation reactions because of their well recognized Pt- and Ru-like behavior, respectively. The good activity of metal carbides and their low cost, compared with noble metals, makes them appealing systems, worth of further investigations. Moreover, the peculiar tunability ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2012 - American Chemical Society | ACS Catalysis
Sergey A. Dyshlovoy, Ekaterina S. Menchinskaya, Simone Venz, Stefanie Rast, Kerstin Amann, Jessica Hauschild, Katharina Otte, Vladimir I. Kalinin, Alexandra S. Silchenko, Sergey A. Avilov, Winfried Alsdorf, Ramin Madanchi, Carsten Bokemeyer, Udo Schumacher, Reinhard Walther, Dmitry L. Aminin, Sergey N. Fedorov, Larisa K. Shubina, Valentin A. Stonik, Stefan Balabanov, Friedemann Honecker, Gunhild von Amsberg,
Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (CRPC), outcome of patients remains poor due to the development of drug resistance. Thus, new drugs are urgently needed. We investigated efficacy, toxicity and mechanism of action of marine triterpene glycoside frondoside A (FrA) using CRPC cell lines in vitro and in vivo. FrA revealed high efficacy in human prostate cancer cells, while non-malignant cells were less sensitive. Remarkably, proliferation and ...
Tópico(s): Phytochemical compounds biological activities
2015 - Wiley | International Journal of Cancer
Sergey A. Dyshlovoy, Kseniya M. Tabakmakher, Jessica Hauschild, Regina Shchekaleva, Katharina Otte, Alla G. Guzii, Tatyana N. Makarieva, Ekaterina Kudryashova, Sergey N. Fedorov, Larisa K. Shubina, Carsten Bokemeyer, Friedemann Honecker, Valentin A. Stonik, Gunhild von Amsberg,
Guanidine alkaloids from sponges Monanchora spp. represent diverse bioactive compounds, however, the mechanisms underlying bioactivity are very poorly understood. Here, we report results of studies on cytotoxic action, the ability to inhibit EGF-induced neoplastic transformation, and the effects on MAPK/AP-1 signaling of eight rare guanidine alkaloids, recently isolated from the marine sponge Monanchora pulchra, namely: monanchocidin A (1), monanchocidin B (2), monanchomycalin C (3), ptilomycalin A ( ...
Tópico(s): Synthesis and Characterization of Pyrroles
2016 - Multidisciplinary Digital Publishing Institute | Marine Drugs
Sergey A. Dyshlovoy, Simone Venz, Jessica Hauschild, Ksenya M. Tabakmakher, Katharina Otte, Ramin Madanchi, Reinhard Walther, Alla G. Guzii, Tatyana N. Makarieva, Larisa K. Shubina, Sergey N. Fedorov, Valentin A. Stonik, Carsten Bokemeyer, Stefan Balabanov, Friedemann Honecker, Gunhild von Amsberg,
Monanchocidin A (MonA) is a novel marine alkaloid with promising anti-cancer properties. We recently demonstrated its high efficacy in human urogenital cancers including germ cell tumors. Here, we applied a global proteome screening approach to investigate molecular targets and biological processes affected by MonA in the human cisplatin-resistant germ cell cancer cell line NCCIT-R. Bioinformatical analysis of the proteomics data predicted an effect of MonA on cancer cell migration. Thus, proteins ...
Tópico(s): Phytochemical compounds biological activities
2016 - Wiley | PROTEOMICS
Sergey A. Dyshlovoy, Ramin Madanchi, Jessica Hauschild, Katharina Otte, Winfried Alsdorf, Udo Schumacher, Vladimir I. Kalinin, Alexandra S. Silchenko, Sergey A. Avilov, Friedemann Honecker, Valentin A. Stonik, Carsten Bokemeyer, Gunhild von Amsberg,
Advanced urothelial carcinomas represent a considerable clinical challenge as they are difficult to treat. Platinum-based combination regimens obtain response rates ranging from 40 to 70% in first-line therapy of advanced urothelial carcinoma. In the majority of cases, however, the duration of these responses is limited, and when progression occurs, the outcome is generally poor. Therefore, novel therapeutic strategies are urgently needed. The purpose of the current research is to investigate the ...
Tópico(s): Marine Sponges and Natural Products
2017 - BioMed Central | BMC Cancer
Sergey A. Dyshlovoy, Stefanie Rast, Jessica Hauschild, Katharina Otte, Winfried Alsdorf, Ramin Madanchi, Vladimir I. Kalinin, Alexandra S. Silchenko, Sergey A. Avilov, Judith Dierlamm, Friedemann Honecker, Valentin A. Stonik, Carsten Bokemeyer, Gunhild von Amsberg,
For patients with refractory or relapsed Burkitt lymphoma (BL), no standard therapy is available for second-line treatment to date. Nonfunctional caspases-dependent apoptosis pathways, inactivating p53 mutations and pro-survival autophagy prevent activity of conventional chemotherapy. Thus, new drugs bypassing these mechanisms of resistance are required. Here, we investigated the efficacy of the marine natural compound frondoside A (FrA) in eight BL cell lines. FrA revealed cytotoxic effects in all ...
Tópico(s): Seaweed-derived Bioactive Compounds
2017 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Sergey A. Dyshlovoy, Katharina Otte, Kseniya M. Tabakmakher, Jessica Hauschild, Tatyana N. Makarieva, Larisa K. Shubina, Sergey N. Fedorov, Carsten Bokemeyer, Valentin A. Stonik, Gunhild von Amsberg,
Development of resistance to standard therapies complicates treatment of advanced prostate cancer. Alternative splicing variants of the androgen receptor (AR), e.g. AR-V7 can mediate resistance to AR-targeting substances abiraterone and enzalutamide. Semi-synthetic marine natural compound rhizochalinin decreases the expression of AR-V7 in human castration-resistant prostate cancer cells and thus resensitizes cells to enzalutamide. In the current study, we modified the structure of rhizochalin in ...
Tópico(s): Lipid metabolism and biosynthesis
2018 - Impact Journals LLC | Oncotarget
Bogdan Kurpil, Katharina Otte, Markus Antonietti, Aleksandr Savateev,
The remarkable bioactivity of 1,3,4-oxadiazoles permanently motivates chemists to develop new milder and broader approaches to synthesize new derivatives, as well as to improve the preparation methodologies of the known compounds. Potassium poly(heptazine imide), a well crystallized representative of carbon nitrides family, shows great performance as a heterogeneous and hence recyclable photocatalyst in the visible light driven oxidative cyclization of N-acylhydrazones to the corresponding oxadiazoles. ...
Tópico(s): Sulfur-Based Synthesis Techniques
2018 - Elsevier BV | Applied Catalysis B Environment and Energy
Bogdan Kurpil, Katharina Otte, Artem M. Mishchenko, Paolo Lamagni, Wojciech Lipiński, Nina Lock, Markus Antonietti, Aleksandr Savateev,
Abstract Addition of N -centered radicals to C=C bonds or insertion into C–H bonds is well represented in the literature. These reactions have a tremendous significance, because they afford polyfunctionalized organic molecules. Despite the tetrahydroisoquinoline (THIQ) moiety widely occurring in natural biologically active compounds, N -unsubstituted THIQs as a source of N -centered radicals are not studied. Herein, we report a photocatalytic reaction between tetrahydroisoquinoline and chalcones that ...
Tópico(s): Catalytic C–H Functionalization Methods
2019 - Nature Portfolio | Nature Communications
Sabrina Golde, J. Heine, Jana Pöttgen, Maron Mantwill, Stephanie Lau, Katja Wingenfeld, Christian Otte, Iris‐Katharina Penner, Andreas Engel, Christoph Heesen, Jan‐Patrick Stellmann, Isabel Dziobek, Carsten Finke, Stefan M. Gold,
Objective: Multiple sclerosis (MS) is characterized by impairments in basic cognitive functions such as information processing speed as well as in more complex, higher-order domains such as social cognition. However, as these deficits often co-occur, it has remained challenging to determine whether they have a specific pathological basis or are driven by shared biology. Methods: To identify neural signatures of social cognition deficits in MS, data were analyzed from n = 29 patients with relapsing- ...
Tópico(s): Neural dynamics and brain function
2020 - Frontiers Media | Frontiers in Neurology
Thies Ingwersen, Silke Wolf, G Birke, Eckhard Schlemm, Christian Bartling, Gabriele Bender, Alfons Meyer, Achim Nolte, Katharina Ottes, Oliver Pade, Martin Peller, Jochen Steinmetz, Christian Gerloff, Götz Thomalla,
Impaired motor functions after stroke are common and negatively affect patients' activities of daily living and quality of life. In particular, hand motor function is essential for daily activities, but often returns slowly and incompletely after stroke. However, few data are available on the long-term dynamics of motor recovery and self-reported health status after stroke. The Interdisciplinary Platform for Rehabilitation Research and Innovative Care of Stroke Patients (IMPROVE) project aims to ...
Tópico(s): Cerebral Palsy and Movement Disorders
2021 - BioMed Central | Neurological Research and Practice
Anna Otte, Katharina Mandel, Gesche Reinstrom, Ralf Hass,
Abstract Phorbol ester (TPA) treatment of human U937 myeloid leukemia cells is associated with increasing adherence and monocyte-like maturation whereby the role of β 2 integrin-mediated attachment for subsequent growth properties and the differentiation program remains unclear. Here, stably-transfected U937 cells with a pMTH1 vector containing the β 2 integrin gene of CD11b in antisense orientation (asCD11b-U937) demonstrated a significantly reduced proliferative capacity in contrast to control vector ...
Tópico(s): Ubiquitin and proteasome pathways
2011 - BioMed Central | Cell Communication and Signaling
Bettina Tóth, W. Würfel, Michael K. Bohlmann, Johannes Zschocke, Sabine Rudnik‐Schöneborn, Frank Nawroth, E Schleußner, Nina Rogenhofer, Tewes Wischmann, Michael von Wolff, Katharina Hancke, Sören von Otte, Ruben Kuon, Katharina Feil, Clemens Tempfer,
Abstract Purpose Official guideline of the German Society of Gynecology and Obstetrics (DGGG), the Austrian Society of Gynecology and Obstetrics (ÖGGG) and the Swiss Society of Gynecology and Obstetrics (SGGG). The aim of this guideline was to standardize the diagnosis and treatment of couples with recurrent miscarriage (RM). Recommendations were based on the current literature and the views of the involved committee members. Methods Based on the current literature, the committee members developed the ...
Tópico(s): Endometriosis Research and Treatment
2018 - Thieme Medical Publishers (Germany) | Geburtshilfe und Frauenheilkunde
Stefanie Otte, Judith Streb, Katharina Rasche, Irina Franke, Felix Segmiller, Stefanie Nigel, Nenad Vasić, Manuela Dudeck,
Abstract This study examined whether the associations between self‐aggression and different forms of externalized aggression (reactive and spontaneous aggression) are influenced by self‐esteem and current psychopathological symptoms. For this purpose, we asked 681 participants from the general population (GP) and 282 general psychiatric patients (PPs) to answer the German versions of the Short Questionnaire for Assessing Factors of Aggression (K‐FAF), the Multidimensional Self‐Esteem Scale (MSWS), and ...
Tópico(s): Bullying, Victimization, and Aggression
2019 - Wiley | Aggressive Behavior
Anja Sterner‐Kock, Irmgard S. Thorey, Katri Koli, Frank Wempe, Jürgen Otte, Thorsten Bangsow, Katharina Kuhlmeier, Thomas Kirchner, Shenchu Jin, Jorma Keski‐Oja, Harald von Melchner,
Transforming growth factor-βs (TGF-βs) are multifunctional growth factors that are secreted as inactive (latent) precursors in large protein complexes. These complexes include the latency-associated propeptide (LAP) and a latent transforming growth factor-β binding protein (LTBP). Four isoforms of LTBPs (LTBP-1–LTBP-4) have been cloned and are believed to be structural components of connective tissue microfibrils and local regulators of TGF-β tissue deposition and signaling. By using a gene trap strategy ...
Tópico(s): Congenital heart defects research
2002 - Cold Spring Harbor Laboratory Press | Genes & Development
Sergey A. Dyshlovoy, Katharina Otte, Simone Venz, Jessica Hauschild, Heike Junker, Tatyana N. Makarieva, Stefan Balabanov, Winfried Alsdorf, Ramin Madanchi, Friedemann Honecker, Carsten Bokemeyer, Valentin A. Stonik, Gunhild von Amsberg,
Rhizochalinin (Rhiz) is a novel marine natural sphingolipid‐like compound, which shows promising in vitro and in vivo activity in human castration‐resistant prostate cancer. In the present study, a global proteome screening approach was applied to investigate molecular targets and biological processes affected by Rhiz in castration‐resistant prostate cancer. Bioinformatical analysis of the data predicted an antimigratory effect of Rhiz on cancer cells. Validation of proteins involved in the cancer‐ ...
Tópico(s): Protease and Inhibitor Mechanisms
2017 - Wiley | PROTEOMICS
G Birke, Silke Wolf, Thies Ingwersen, Christian Bartling, Gabriele Bender, Alfons Meyer, Achim Nolte, Katharina Ottes, Oliver Pade, Martin Peller, Jochen Steinmetz, Christian Gerloff, Götz Thomalla,
Stroke and its long-term consequences pose major challenges for the lives of those affected and healthcare systems. Neurological rehabilitation therefore primarily attempts to improve function in order to increase independence in activities of daily living, and to enable social participation. There is only scarce data on dynamics of functional recovery after patients discharge from inpatient neurological rehabilitation. Even less is known about the patient's perspective on long-term recovery from ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2020 - BioMed Central | Neurological Research and Practice
Silke Wolf, Sara E. Holm, Thies Ingwersen, C. Bartling, Gabriele Bender, G Birke, Alfons Meyer, Achim Nolte, Katharina Ottes, Oliver Pade, Martin Peller, J. Steinmetz, Christian Gerloff, Götz Thomalla,
Lower socioeconomic status (SES) is associated with higher mortality rates and the likelihood of receiving less evidence-based treatment after stroke. In contrast, little is known about the impact of SES on recovery after discharge from inpatient rehabilitation. The aim of this study was to investigate the influence of SES on long-term recovery after stroke.In a prospective, observational, multicentre study, inpatients were recruited towards the end of rehabilitation. The 12-month follow-up focussed ...
Tópico(s): Cardiac Health and Mental Health
2022 - Informa | Annals of Medicine
Tolou Maslahati, Katja Wingenfeld, Julian Hellmann‐Regen, Julia Kraft, Jing Lyu, Marie Keinert, Aline Lea Voß, An Bin Cho, Stephan Ripke, Christian Otte, Katharina Schultebraucks, Stefan Roepke,
Abstract Oxytocin administration during a trauma analogue has been shown to increase intrusive memories, which are a core symptom of post-traumatic stress disorder (PTSD). However, it is unknown whether oxytocin influences the acquisition or the consolidation of the trauma. The current study investigates the effect of the activation of the oxytocin system during the consolidation of an analogue trauma on the formation of intrusive memories over four consecutive days and whether this effect is influenced ...
Tópico(s): Attachment and Relationship Dynamics
2023 - Springer Nature | Translational Psychiatry
Felix S. Lichtenegger, Katharina Mueller, Bettina Otte, Barbara Beck, Wolfgang Hiddemann, Dolores J. Schendel, Marion Subklewe,
Background Dendritic cells (DCs) determine the activation and polarization of T cells via expression of costimulatory molecules and secretion of cytokines. The function of DCs derived from monocytes ex vivo strongly depends on the composition of the maturation cocktail used. Methodology/Principal Findings We analyzed the effect of costimulatory molecule expression and cytokine secretion by DCs on T and natural killer (NK) cell activation by conducting a head-to-head comparison of a Toll-like receptor ( ...
Tópico(s): T-cell and B-cell Immunology
2012 - Public Library of Science | PLoS ONE
Katharina Pohl, Jennyfer Otte, Peter Thissen, Miroslaw Giza, Michael Maxisch, Bernd Schuhmacher, Guido Grundmeier,
The adsorption and stability of adhesion promoting organophosphonic acid monolayers on plasma modified Zn–Mg–Al alloy surfaces were investigated by means of microscopic and spectroscopic techniques. A strip hollow cathode (SHC) was chosen for the plasma surface modification. The chemical composition of the plasma treated surfaces and the influence of reducing and oxidizing plasma modifications on the corrosion properties of Zn–Mg–Al alloy surfaces were analyzed by means of X-ray photoelectron spectroscopy ( ...
Tópico(s): Semiconductor materials and interfaces
2013 - Elsevier BV | Surface and Coatings Technology
Marie-Luise Otte, Mike M. Schmitgen, Katharina M. Kubera, Nadine D. Wolf, Stefan Fritze, Lena S. Geiger, Heike Tost, Ulrich Seidl, Andreas Meyer‐Lindenberg, Dušan Hirjak, Robert Christian Wolf,
Abstract Insight into illness in schizophrenia (SZ) patients has a major impact on treatment adherence and outcome. Previous studies have linked distinct deviations of brain structure to illness insight, specifically in frontoparietal and subcortical regions. Some of these abnormalities are thought to reflect aberrant cortical development. In this study, we used cross-sectional data to examine associations between illness insight and two cortical surface markers that are known to follow distinct ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2021 - Springer Science+Business Media | European Archives of Psychiatry and Clinical Neuroscience
Franz Koenig, Cécile Spiertz, Daniel Millar, Sarai Rodríguez, Núria Machín, Ann Van Dessel, Joan Genescà, Juan M. Pericàs, Martin Posch, Adrián Sánchez‐Montalvá, Ana Belén Estevez, Álex Sánchez-Plà, A. McNulty Sanjuan, Elena Sena, Emma Granados, Esther Arévalo de Andrés, Fátima Nuñez, Gara Arteaga, Gabriela Perez Fuentes Ruiz, Guillermo Fernández, Jesús Rivera‐Esteban, Joan Comella, Josep Antoni Ramos‐Quiroga, Joan Genescà, Juan Felipe Espinosa‐Cristia, Juan M. Pericàs, Lada Murcia, Lucinda Cash‐Gibson, Maria de Valles Silvosa, María Fernanda Barroso de Sousa, Olga Sánchez-Maroto Carrizo, Pol Ibañez-Jiménez, Salvador Augustín, Santiago Pérez‐Hoyos, Sarai Rodríguez, Sergio Muñoz, S. Bezner Serres, Susana G. Kalko, Amelie Michon, Anton Ussi, Ben Lydall, Edwin van de Ketterij, Ignacio Quiles, Tamara Carapina, Constantin Kumaus, Д. М. Рамазанова, Elias Laurin Meyer, Franz Koenig, Marta Bofill Roig, Martin Brunner, Martin Posch, Pavla Krotka, Sonja Zehetmayer, Charlotte Carton, Eric Legius, Amina Begum, Carmine M. Pariante, Courtney Worrell, Giulia Lombardo, Luca Sforzini, Mollie Brown, Nancy Gullet, Nare Amasi-Hartoonian, Rosalie E. Ferner, Melisa Kose, Andrea Spitaleri, Arash Ghodousi, Clelia Di Serio, Daniela María Cirillo, Federica Cugnata, Francesca Saluzzo, Francesco Benedetti, Maria Giovanna Scarale, Michela Zini, Paola M. V. Rancoita, Riccardo Alagna, Sara Poletti, Britt A. E. Dhaenens, Johan van der Lei, Jurriaan de Steenwinkel, Maxim Moinat, Rianne Oostenbrink, Witte J.G. Hoogendijk, Michael Hölscher, Norbert Heinrich, Christian Otte, Cornelia Potratz, Dario Zocholl, Eugenia Kulakova, Frank Tacke, Jelena Brasanac, Jonas Leubner, M Krajewska, Michaela Maria Freitag, Stefan M. Gold, Thomas Zöller, Woo Ri Chae, Christel Daniel, Leila Kara, Morgan Vaterkowski, Nicolas Griffon, P. Wolkenstein, Raluca Pais, Vlad Ratziu, David Voets, Christophe Maes, Dipak Kalra, Geert Thienpoint, Jens Deckerck, Nathan Lea, Peter Singleton, Kert Viele, Peter Jacko, Scott Berry, Tom Parke, Amelie Michon, Burç Aydin, Christine Kubiak, Jacques Demotes‐Mainard, Kiyoshi Ueda, Mihaela Matei, Sergio Contrino, Claas Röhl, E. Cordero, Fiona Greenhalgh, Hannes Jarke, Juliana Angelova, Mathieu Boudes, Stephan Dressler, Valentina Strammiello, Quentin M. Anstee, Iñaki Gutiérrez‐Ibarluzea, Maximilian Otte, Natalie Heimbach, Benjamin Hofner, Cora Burgwinkel, Hue Kaestel, Katharina Hees, Quynh Nguyen, Daniel Prieto‐Alhambra, Eng Hooi Tan, Mario Raviǵlione, Pierpaolo de Colombani, Simone Villa, Eduard Maron, D. Gareth Evans, Adam Savitz, Ann Van Dessel, Anna Duca, Anne Kaminski, Bie Wouters, Brandon Porter, Catherine E. Charron, Cécile Spiertz, Christopher Zizzamia, Daniel Millar, Danny M. Hasselbaink, Donald P. Orr, Divya Kesters, E.A. Hubin, Emma Davies, Eva‐Maria Didden, Gabriela Guz, Evelyn Verstraete, Gary Mao, George Capuano, Heddie Martynowicz, Heidi De Smedt, Ingela Larsson, Ines Bruegelmans, Isabelle Coste, J. Moreno, Julia Niewczas, Jiajun Xu, Karin Rombouts, Katherine Woo, Kathleen Wuyts, Kathryn Hersh, Khrista Oldenburg, Lingjiao Zhang, Mark E. Schmidt, Mark Szuch, Marija Todorović, Maartje Mangelaars, Melissa Grewal, Molli Sandor, Nick Di Prospero, Pamela Van Houten, Pansy Minnick, Polyana Bastos, Robert Patrizi, Salvatore Morello, Severijn De Wilde, Tao Sun, Timothy Kline, Tine De Marez, Tobias Mielke, Tom Reijns, В. В. Попова, Yanina Flossbach, Yevgen Tymofyeyev, Zeger De Groote, Alex Sverdlov, Alexandra Bobirca, Annekatrin Krause, Catalin Bobrica, Daniela Heintz, Dominic Magirr, Ekkehard Glimm, Fabienne Baffert, Federica Castiglione, Franca Caruso, Francesco Patalano, Frank Bretz, Guenter Heimann, Ian Carbarns, Ignacio López Rodríguez, Ioana Ratescu, Lisa V. Hampson, Marcos Pedrosa, Mareile Hark, Peter Mesenbrink, Sabina Hernandez Penna, Sarah Bergues-Lang, Susanne Baltes-Engler, Tasneem Arsiwala, Valeria Jordan Mondragon, Hua Guo, Jose Leite Da Costa, Carl‐Fredrik Burman, George G. Kirk, Anders Aaes‐Jørgensen, Jorgen Dirach, Mette Skalshøi Kjær, Alexandra Martin, Diyan Hristov, Florent Rousseaux, Norbert Hittel, Robert Dornheim, Daniel D. Evans, Nick Sykes, Camille Couvert, Catherine Leuven, Loïc Notelet, Madhavi Gidh‐Jain, Mathieu Jouannin, Nadir Ammour, Suzanne Pierre, Volker Haufe, Yingwen Dong, Catherine Dubanchet, Nathalie de Préville, Tania Baltauss, Zhu Jian, Sara Shnider, Tal Bar-El, Annette Bakker, Marco Nievo, Uche Iloeje, Almari Conradie, Ece Auffarrth, Leandra Lombard, Majda Benhayoun, Morounfolu Olugbosi, Stephanie Seidel, Berta Gumí, Claudia García Guzmán, Eva Molero, Gisela Pairó, Núria Machín, Raimon Cardelús, Saira Ramasastry, Saskia Pelzer, Andreas Kremer, Erno Lindfors, C. Lynch,
Platform trials bring the promise of making clinical research more efficient and more patient centric. While their use has become more widespread, including their prominent role during the COVID-19 pandemic response, broader adoption of platform trials has been limited by the lack of experience and tools to navigate the critical upfront planning required to launch such collaborative studies. The European Union-Patient-cEntric clinicAl tRial pLatform (EU-PEARL) initiative has produced new methodologies ...
Elsevier BV | EClinicalMedicine
Katharina Schultebraucks, Katja Wingenfeld, Christian Otte, Marcus Quinkler,
Primary adrenal insufficiency (AI) requires hormone replacement therapy with fludrocortisone and hydrocortisone stimulating glucocorticoid (GR) and mineralocorticoid receptors (MR). Evidence from animal and human studies shows that MR function is crucial for cognitive function and mood. Regarding patients with AI, very little is known about the role of MR in cognitive function and mood.A repeated-measures within-subject design was used to determine whether cognitive function and mood are related to ...
Tópico(s): Stress Responses and Cortisol
2015 - Karger Publishers | Neuroendocrinology
Katharina Rasche, Manuela Dudeck, Stefanie Otte, Solveig Klingner, Nenad Vasić, Judith Streb,
Psychiatrists frequently find themselves faced with aggressive behavior on the part of their patients. A large body of literature indicates that traumatic experiences in the anamnesis might be a risk factor for violent behavior. But, not all maltreated children became perpetrators of violence themselves. The present review assembled actual behavioral studies that focus on factors which might influence the pathway from trauma to aggression. Substance use to cope, occurrence of post-traumatic stress ...
Tópico(s): Posttraumatic Stress Disorder Research
2016 - Elsevier BV | Neurology Psychiatry and Brain Research
Benjamin Schott, Manuel Traub, Cornelia Schlagenhauf, Masanari Takamiya, Thomas Antritter, Andreas Bartschat, Katharina Löffler, Denis Blessing, Jens C. Otte, Andrei Yu Kobitski, G. Ulrich Nienhaus, Uwe Strähle, Ralf Mikut, Johannes Stegmaier,
State-of-the-art light-sheet and confocal microscopes allow recording of entire embryos in 3D and over time (3D+t) for many hours. Fluorescently labeled structures can be segmented and tracked automatically in these terabyte-scale 3D+t images, resulting in thousands of cell migration trajectories that provide detailed insights to large-scale tissue reorganization at the cellular level. Here we present EmbryoMiner, a new interactive open-source framework suitable for in-depth analyses and comparisons ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2018 - Public Library of Science | PLoS Computational Biology