Akihisa Okumura, Kazue Ito, Masaru Kondo, Hideaki Takahashi, Fumio Hayakawa, Akimasa Ogawa, Kuniyoshi Kuno,
Okumura, Akihisa M.D.; Ito, Kazue M.D.; Kondo, Masaru M.D.; Takahashi, Hideaki M.D.; Hayakawa, Fumio M.D.; Ogawa, Akimasa M.D.; Kuno, Kuniyoshi ...
Tópico(s): Bacterial Identification and Susceptibility Testing
1995 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Yūichi Katayose, Hiroyuki Kanamori, Michihiko Shimomura, Hajime Ohyanagi, Hiroshi Ikawa, Hiroshi Minami, Michie Shibata, Tomoko Ito, Kanako Kurita, Kazue Ito, Yasutaka Tsubokura, Akito Kaga, Jianzhong Wu, Takashi Matsumoto, Kyuya Harada, Takuji Sasaki,
Soybean [Glycine max (L) Merrill] is one of the most important leguminous crops and ranks fourth after to rice, wheat and maize in terms of world crop production. Soybean contains abundant protein and oil, which makes it a major source of nutritious food, livestock feed and industrial products. In Japan, soybean is also an important source of traditional staples such as tofu, natto, miso and soy sauce. The soybean genome was determined in 2010. With its enormous size, physical mapping and genome sequencing ...
Tópico(s): Plant pathogens and resistance mechanisms
2012 - Japanese Society of Breeding | Breeding Science
Jian Wu, Harumi Yamagata, Mika Hayashi‐Tsugane, Saori Hijishita, Masaki Fujisawa, Michie Shibata, Yukiyo Ito, Mari Nakamura, Miyuki Sakaguchi, Rie Yoshihara, Harumi Kobayashi, Kazue Ito, Wataru Karasawa, Mayu Yamamoto, Shoko Saji, Satoshi Katagiri, Hiroyuki Kanamori, Nobukazu Namiki, Yūichi Katayose, Takashi Matsumoto, Takuji Sasaki,
Understanding the organization of eukaryotic centromeres has both fundamental and applied importance because of their roles in chromosome segregation, karyotypic stability, and artificial chromosome-based cloning and expression vectors. Using clone-by-clone sequencing methodology, we obtained the complete genomic sequence of the centromeric region of rice (Oryza sativa) chromosome 8. Analysis of 1.97 Mb of contiguous nucleotide sequence revealed three large clusters of CentO satellite repeats (68. ...
Tópico(s): Genomics and Phylogenetic Studies
2004 - Oxford University Press | The Plant Cell
Jianzhong Wu, Hiroshi Mizuno, Mika Hayashi‐Tsugane, Yukiyo Ito, Yoshino Chiden, Masaki Fujisawa, Satoshi Katagiri, Shoko Saji, Shoji Yoshiki, Wataru Karasawa, Rie Yoshihara, Akiko Hayashi, Harumi Kobayashi, Kazue Ito, Masao Hamada, Masako Okamoto, Maiko Ikeno, Yoko Ichikawa, Yūichi Katayose, Masahiro Yano, Takashi Matsumoto, Takuji Sasaki,
Summary We constructed physical maps of rice chromosomes 1, 2, and 6–9 with P1‐derived artificial chromosome (PAC) and bacterial artificial chromosome (BAC) clones. These maps, with only 20 gaps, cover more than 97% of the predicted length of the six chromosomes. We submitted a total of 193 Mbp of non‐overlapping sequences to public databases. We analyzed the DNA sequences of 1316 genetic markers and six centromere‐specific repeats to facilitate characterization of chromosomal recombination frequency ...
Tópico(s): Genomics and Phylogenetic Studies
2003 - Wiley | The Plant Journal
Yu Sugihara, Yoshiko Abe, Hiroki Takagi, Akira Abe, Motoki Shimizu, Kazue Ito, Eiko Kanzaki, Kaori Oikawa, Jiorgos Kourelis, Thorsten Langner, Joe Win, Aleksandra Białas, Daniel Lüdke, Mauricio P. Contreras, Izumi Chuma, Hiromasa Saitoh, Michie Kobayashi, Shuan Zheng, Yukio Tosa, Mark J. Banfield, Sophien Kamoun, Ryohei Terauchi, Koki Fujisaki,
Studies focused solely on single organisms can fail to identify the networks underlying host-pathogen gene-for-gene interactions. Here, we integrate genetic analyses of rice (Oryza sativa, host) and rice blast fungus (Magnaporthe oryzae, pathogen) and uncover a new pathogen recognition specificity of the rice nucleotide-binding domain and leucine-rich repeat protein (NLR) immune receptor Pik, which mediates resistance to M. oryzae expressing the avirulence effector gene AVR-Pik. Rice Piks-1, encoded ...
Tópico(s): Fungal and yeast genetics research
2023 - Public Library of Science | PLoS Biology
Yu Sugihara, Kwabena Darkwa, Hiroki Yaegashi, Satoshi Natsume, Motoki Shimizu, Akira Abe, Akiko Hirabuchi, Kazue Ito, Kaori Oikawa, Muluneh Tamiru‐Oli, Atsushi Ohta, Ryo Matsumoto, Paterne A. Agre, David De Koeyer, Babil Pachakkil, Shinşuke Yamanaka, Satoru Muranaka, H. Takagi, Benjamen White, Robert Asiedu, Hideki Innan, Asrat Asfaw, Patrick Adebola, Ryohei Terauchi,
Significance Guinea yam is an important staple tuber crop in West Africa, where it contributes to the sustenance and sociocultural lives of millions of people. Understanding the genetic diversity of Guinea yam and its relationships with wild relatives is important for improving this important crop using genomic information. A recent genomics study proposed that Guinea yam originated from a wild relative, the rainforest species Dioscorea praehensilis . Our results based on sequencing of 336 Guinea ...
Tópico(s): Genomics and Phylogenetic Studies
2020 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Kouji Satoh, Koji Doi, Toshifumi Nagata, Naoki Kishimoto, Kohji Suzuki, Yasuhiro Otomo, Jun Kawai, Mari Nakamura, Tomoko Hirozane-Kishikawa, Saeko Kanagawa, Takahiro Arakawa, Juri Takahashi-Iida, Mitsuyoshi Murata, Noriko Ninomiya, Daisuke Sasaki, Shiro Fukuda, Michihira Tagami, Harumi Yamagata, Kanako Kurita, Kozue Kamiya, Mayu Yamamoto, Ari Kikuta, Takahito Bito, Nahoko Fujitsuka, Kazue Ito, Hiroyuki Kanamori, Il‐Ryong Choi, Yoshiaki Nagamura, Takashi Matsumoto, Kazuo Murakami, Kenichi Matsubara, Piero Carninci, Yoshihide Hayashizaki, Shoshi Kikuchi,
Rice (Oryza sativa L.) is a model organism for the functional genomics of monocotyledonous plants since the genome size is considerably smaller than those of other monocotyledonous plants. Although highly accurate genome sequences of indica and japonica rice are available, additional resources such as full-length complementary DNA (FL-cDNA) sequences are also indispensable for comprehensive analyses of gene structure and function. We cross-referenced 28.5K individual loci in the rice genome defined ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2007 - Public Library of Science | PLoS ONE
Takafumi Hasegawa, Kazue Ito, Sugi Ueno, S. Kumamoto, Yukio Ando, Akira Yamada, K Nomoto, Y Yasunobu,
Hot water extract of Chlorella vulgaris (CVE) is a biological response modifier (BRM) which enhances resistance to Listeria monocytogenes through augmentation of helper T cell type 1 (Thl) responses producing gamma-interferon (gammaIFN). We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by increased gammaIFN and IL-12 mRNA expression. Oral administration of CVE enhanced Thl response to casein in the spleen of casein ...
Tópico(s): Escherichia coli research studies
1999 - Elsevier BV | International Journal of Immunopharmacology
Shinji Murosaki, Yoshihiro Yamamoto, Kazue Ito, Takeaki Inokuchi, Hiroaki Kusaka, Hitoshi Ikeda, Yasunobu Yoshikai,
Food allergy is caused by production of IgE against dietary antigen induced by T(H2) response. IL-12 inhibits T(H2) responses and strongly suppresses IgE production. We have recently established a murine model for IgE production with a predominant T(H2) response induced by feeding antigen.We here show a suppressive effect of heat-killed Lactobacillus plantarum L-137, a potent inducer of IL-12, on IgE production against naturally fed antigen in a murine model.The ability of L. plantarum L-137 to ...
Tópico(s): Probiotics and Fermented Foods
1998 - Elsevier BV | Journal of Allergy and Clinical Immunology
Kazue Ito, Kyoko Inagaki‐Ohara, Shinji Murosaki, Hitoshi Nishimura, Tomoya Shimokata, Shinnpei Torii, Tukasa Matsuda, Yasunobu Yoshikai,
Abstract Stimulation of systemic antigen‐specific IgE production plays an important role in the mediation of food allergy; however, the mechanism of IgE production against food antigens is not fully understood. The development of relevant animal models may help to elucidate the pathogenesis of food allergy. We here show that DBA/2 mice receiving a casein diet without any adjuvant produced high levels of IgE specific for casein, accompanied by predominant Th2‐like responses in liver lymphocytes, ...
Tópico(s): Mast cells and histamine
1997 - Wiley | European Journal of Immunology
Kazue Ito, Tatsuo Sakamoto, Yoshiki Hayashi, Masashi Morishita, Eiji Shibata, Kiyoshi Sakai, Yasuhiro Takeuchi, Shinpei Torii,
We have investigated the effects of CP-99,994 [(+)-(2s,3s)-3-(2-methoxybenzylamino)-2-phenylpiperidine], a tachykinin NK1 receptor antagonist, HOE 140 (d-Arg[Hyp3,Thi5,d-Tic7,Oic8]bradykinin), a bradykinin B2 receptor antagonist, and ketotifen (4-(1-methyl-4-piperidylidene)4H-benzo[4,5]cycloheptal[1,2-b]thiophen-10(9H)-one hydrogen fumarate), a histamine H1 receptor antagonist with mast cell-stabilizing properties, on microvascular leakage induced by gaseous formaldehyde. Extravasation of Evans blue dye ...
Tópico(s): Mast cells and histamine
1996 - Elsevier BV | European Journal of Pharmacology
Koji Itakura, Takeyasu Matsudate, Takato Sakurai, Shunichi Hashimoto, Kazue Ito, Hirofumi Kanno, M. Hirata, Kaname Nakamura,
An assay of apolipoproteins (Apo) C-II, C-III and E in human sera by single radial immunodiffusion (SRID) is described. The procedure involves pretreatment of the serum sample with surfactant to facilitate diffusion of very low density lipoproteins in agarose. This allowed measurement of apolipoproteins in lipidemic sera by SRID in agarose gel. The intraplate coefficient of variation was less than 2.5%, and the interplate coefficient of variation, less than 3.0%. Correlation with double-antibody radioimmunoassay ...
Tópico(s): RNA Interference and Gene Delivery
1986 - Elsevier BV | Clinica Chimica Acta
Kenji Fukunaga, Akira Abe, Yohei Mukainari, Kaho Komori, Keisuke Tanaka, Akari Fujihara, Hiroki Yaegashi, Michie Kobayashi, Kazue Ito, Takanori Ohsako, Makoto Kawase,
Abstract We constructed recombinant inbred lines (RILs) between a Japanese and a Taiwanese landrace of foxtail millet and employed next-generation sequencing, such as flexible ddRAD-seq and Nanopore sequencing to identify the candidate genes involved in the crop evolution of foxtail millet. We successfully constructed a linkage map using flexible ddRAD-seq with parents and RILs and detected major QTLs for each of three traits: leaf sheath colors, spikelet-tipped bristles (stb), and days to heading ( ...
Tópico(s): Genomics and Phylogenetic Studies
2022 - Nature Portfolio | Scientific Reports
Yuri Ueda, Tomohiro Enokida, Susumu Okano, Takao Fujisawa, Kazue Ito, Makoto Tahara,
Background: Platinum-containing doublet chemotherapy regimens are generally considered the standard first-line systemic therapy for recurrent or metastatic (R/M) nasopharyngeal cancer (NPC). Gemcitabine (GEM) plus cisplatin (CDDP) has become a standard therapy based on a phase 3 study in several countries, yet this regimen sometimes affects quality of life due to nausea or appetite loss. Here, we present the manageable toxicity and promising activity of paclitaxel + carboplatin + cetuximab (PCE) therapy ...
Tópico(s): Brain Metastases and Treatment
2020 - Frontiers Media | Frontiers in Oncology
Hidekazu Yasunaga, Akiko Takahashi, Kazue Ito, Ueda Masahisa, Hiroshi Urakawa,
A novel colourant for hair dyeing was prepared by an enzymatic reaction with (+)-catechin and its characteristics as a hair dyestuff were studied. The study is aimed at inventing the hair dyestuff that is human- and eco-friendly. One potentially powerful dyestuff was obtained from (+)-catechin treated with tyrosinase after screening experiments using biobased materials. The obtained reddish orange colourant, 4-(3,4-dihydro-3α,5,7-trihydroxy-2H-1-benzopyran-2α-yl) 1,2-benzoquinone named “catechinone”, shows ...
Tópico(s): Skin Protection and Aging
2012 - Scientific Research Publishing | Journal of Cosmetics Dermatological Sciences and Applications
Yuji Furuya, Hidemi Sawada, Toshikatsu Hirahara, Kazue Ito, Takashi Ohshiro, Yoshikazu Izumi,
A basidiomycete, Coprinus sp. SF-1, was found to produce an L-Trp-oxidizing enzyme by screening from the culture collection of our laboratory. After solubilization by 1 M NaSCN from the particulate fraction of disrupted cells of the strain, the enzyme was purified about 76-fold to essential homogeneity. The enzyme had a molecular mass of about 420 kDa and the subunit molecular mass was 68 kDa. The enzyme contained 1 mol of non-covalently bound FAD per mol of the subunit. It catalyzed the simultaneous ...
Tópico(s): Biochemical and biochemical processes
2000 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Yoshinori Akiyama, Kazue Kanehara, Koreaki Ito,
... by this author Author Information Yoshinori Akiyama 1, Kazue Kanehara and Koreaki Ito 1Institute for Virus Research, Kyoto University, Kyoto, Japan * ...
Tópico(s): Bacterial Genetics and Biotechnology
2004 - Springer Nature | The EMBO Journal
Chihiro Matsuyama, Tomohiro Enokida, Yuri Ueda, Shinya Suzuki, Takao Fujisawa, Kazue Ito, Susumu Okano, Makoto Tahara,
Background In the phase 3 SELECT study, lenvatinib significantly improved prognostic outcomes vs. placebo in patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC). However, toxicity of lenvatinib is sometimes considerable and requires frequent dose interruptions and modifications. Recently, planned drug holidays have been proposed as a means of avoiding severe adverse events (AEs). Methods We retrospectively reviewed medical records to compare the efficacy and safety of lenvatinib ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2023 - Frontiers Media | Frontiers in Oncology
Kazue Kanehara, Koreaki Ito, Yoshinori Akiyama,
... a Gln-rich region of RseA Kazue Kanehara Kazue Kanehara Institute for Virus Research, Kyoto University, Kyoto, 606-8507 Japan Search for more papers by this author Koreaki Ito Koreaki Ito Institute for Virus Research, Kyoto University, ... for more papers by this author Kazue Kanehara Kazue Kanehara Institute for Virus Research, Kyoto University, Kyoto, 606-8507 Japan Search for more papers by this author Koreaki Ito Koreaki Ito Institute for Virus Research, Kyoto University, Kyoto, 606-8507 Japan Search for more papers by this author Yoshinori Akiyama Corresponding Author Yoshinori Akiyama Institute for Virus Research, Kyoto University, Kyoto, 606-8507 Japan Search for more papers by this author Author Information Kazue Kanehara1, Koreaki Ito1 and Yoshinori Akiyama 1 1Institute ...
Tópico(s): Evolution and Genetic Dynamics
2003 - Springer Nature | The EMBO Journal
Noritaka Onoda, Yoshiyuki Kato, Toshiro Seki, Makiko Kurimoto, Kazue Takano, Yukio Ito, Kanji Sato,
We report two cases with painful Hashimoto's thyroiditis, who developed recurrent fever and painful thyroid. Glucocorticoid treatment was transiently successful but tenderness in the thyroid gland and fever developed when glucocorticoid was tapered. One patient underwent total thyroidectomy uneventfully. As is well known, it is frequently difficult to make differential diagnosis between painful Hashimoto's thyroiditis and subacute thyroiditis particularly at the initial phase. Interestingly, color ...
Tópico(s): Cardiovascular and Diving-Related Complications
2009 - Japan Endocrine Society | Endocrine Journal
Hiroshi Sakagami, Ken Hashimoto, Fumika Suzuki, Takako Ogiwara, Kazue Satoh, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Sei-ichiro Fujisawa,
Lignins are major cell wall components formed by the dehydrogenative polymerization of three monolignols, p-coumaryl, coniferyl and sinapyl alcohols. We prepared lignin–carbohydrate complexes (Fr. VI and Fr. VII) from pine cones by acid and ethanol precipitation, and investigated which part of these molecules is essential for expression of biological activities. They showed potent antiviral activity upon direct interaction with the virus. The antiviral activity of Frs. VI and VII required the higher- ...
Tópico(s): Phytochemicals and Antioxidant Activities
2005 - Elsevier BV | Phytochemistry
Kazue Kanehara, Koreaki Ito, Yoshinori Akiyama,
Escherichia coli YaeL (EcfE) is a homolog of human site-2 protease (S2P), a membrane-bound zinc metalloprotease involved in regulated intramembrane proteolysis. We have shown previously that YaeL, having essential metalloprotease active site motifs in the cytoplasmic domain, is indispensable for viability. Here, we obtained rpoE , encoding an extracytoplasmic stress response ς factor (ς E ), as a multicopy suppressor against the yaeL disruption. Whereas ς E is thought to be activated by regulated cleavage ...
Tópico(s): RNA and protein synthesis mechanisms
2002 - Cold Spring Harbor Laboratory Press | Genes & Development
Daisuke Yamamoto, Kazuko Fujitani, Kazue Usui, Hiroki Ito, Yoshiro Nakano,
The isolation and analysis of Drosophila mutants with altered sexual orientation lead to the identification of novel branches in the sex-determination cascade which govern the sexually dimorphic development of the nervous system. One such example is the fruitless (fru) gene, the mutation of which induces male-to-male courtship and malformation of a male-specific muscle, the muscle of Lawrence (MOL). Since the MOL is formed in wild-type flies when the innervating nerve is male, regardless of the sex ...
Tópico(s): Animal Behavior and Reproduction
1998 - Elsevier BV | Mechanisms of Development
Toshio Ohta, Kazue Kawai, Shigeo Ito, Yoshikazu Nakazato,
1 The effects of depletion of intracellular Ca 2+ stores on muscle tension and the intracellular Ca 2+ concentration ([Ca 2+ ]) i were studied in fura‐2 loaded longitudinal smooth muscle cells of the rat ileum. 2 After exposure to a Ca 2+ ‐free solution, application of Ca 2+ caused a small contraction and a rise in [Ca 2+ ] i , both of which were potentiated when the muscle was challenged with carbachol or caffeine before the addition of Ca 2+ . 3 Cyclopiazonic acid (CPA), a specific inhibitor of sarcoplasmic ...
Tópico(s): Pain Mechanisms and Treatments
1995 - Wiley | British Journal of Pharmacology
Kazue Nagai, Yasuhiko Ito, Nobuaki Otsuka, A Muranaka,
Tópico(s): Orthopedic Infections and Treatments
1982 - Springer Science+Business Media | European Journal of Nuclear Medicine
Yuri Ueda, Susumu Okano, Tomohiro Enokida, Takao Fujisawa, Kazue Ito, Masanobu Sato, Hideki Tanaka, Akihisa Wada, Makoto Tahara,
In CheckMate 141, nivolumab significantly improved overall survival (OS) in patients with platinum-refractory recurrent or metastatic squamous cell carcinomas (R/M SCC) of the head and neck. However, reports on nivolumab for patients with non-SCC and/or a primary subsite excluded from CheckMate 141 are limited.We conducted a retrospective analysis of R/M head and neck cancer patients who received nivolumab. The study subject excluded patients with squamous cell carcinoma of the oral cavity, oropharynx, ...
Tópico(s): Colorectal and Anal Carcinomas
2022 - Elsevier BV | Oral Oncology
Kazue Sakemi, Rieno Ito, Takashi Umemura, Yasuo Ohno, Mitsuhiro Tsuda,
Tópico(s): Carcinogens and Genotoxicity Assessment
2002 - Springer Science+Business Media | Archives of Toxicology
Akiko Ito, Kazue Nishioka, Hiromi Kanto, Akiko Yagami, Shigeki Yamada, Mariko Sugiura, Chihiro Yasunaga, Keiko YOSHII, Hiromi Kobayashi, Atsuko Adachi, Y. Ikezawa, Kumiko Washizaki, Shigeki Inui, Hitoshi Miyazawa, Naoki Oiso, Tokio Nakata, Kayoko Matsunaga,
Summary Background In J apan, allergic contact dermatitis caused by hair colouring agents is a considerable problem for those occupationally exposed and also for consumers. Over the last 20 years, p ‐phenylenediamine ( PPD ) has been a common allergen, with ∼7% positive patch test reactions. Objectives To investigate which ingredients caused allergic contact dermatitis related to hair dye and perming solutions in J apan, to assess whether PPD is suitable for screening for hair dye allergy, and to propose ...
Tópico(s): Skin Protection and Aging
2017 - Wiley | Contact Dermatitis
Kazue Usui‐Aoki, Hiroki Ito, Kumiko Ui‐Tei, Kuniaki Takahashi, Tamás Lukácsovich, Wakae Awano, Hiromi Nakata, Zheng Fu Piao, Eric Nilsson, Junya Tomida, Daisuke Yamamoto,
Tópico(s): Invertebrate Immune Response Mechanisms
2000 - Nature Portfolio | Nature Cell Biology
Yoshitake Satomura, Norio Sawabu, Ikurou Mouri, Osamu Yamakawa, Hiroyuki Watanabe, Yoshiharu Motoo, Takashi Okai, Takako Ito, Kazue Kaneda, Hiroshi Okamoto,
Tópico(s): Nuclear Structure and Function
1995 - Springer Science+Business Media | Journal of Gastroenterology