Shigeka YOSHIMOTO, Makoto Yamamoto, Kazuyuki TODA,
This paper describes the pressure distribution in the bearing clearance of circular aerostatic thrust bearings with a single air supply inlet. For high air supply pressure, large bearing clearance, and a relatively small bearing outer radius, it was believed that shock waves are caused and that a complex fluid flow structure is formed in the bearing clearance. Accordingly, analytical models based on the occurrence of shock wave in the bearing clearance have been proposed. Recently, very small aerostatic ...
Tópico(s): Rocket and propulsion systems research
2006 - ASM International | Journal of Tribology
Ryosuke Oki, Yuishin Izumi, Koji Fujita, Ryosuke Miyamoto, Hiroyuki Nodera, Yasutaka Sato, Satoshi Sakaguchi, Hiroshi Nokihara, Kazuaki Kanai, Taiji Tsunemi, Nobutaka Hattori, Yuki Hatanaka, Masahiro Sonoo, Naoki Atsuta, Gen Sobue, Toshio Shimizu, Kazumoto Shibuya, Ken Ikeda, Osamu Kano, Kazuto Nishinaka, Yasuhiro Kojima, Masaya Oda, Kiyonobu Komai, Hitoshi Kikuchi, Nobuo Kohara, Makoto Urushitani, Yoshiaki Nakayama, Hidefumi Ito, Makiko Nagai, Kazutoshi Nishiyama, Daisuke Kuzume, Shun Shimohama, Takayoshi Shimohata, Koji Abe, Tomohiko Ishihara, Osamu Onodera, Sagiri Isose, Nobuyuki Araki, Mitsuya Morita, Kazuyuki Noda, Tatsushi Toda, Hirofumi Maruyama, Hirokazu Furuya, Satoshi Teramukai, Tatsuo Kagimura, Kensuke Noma, Hiroaki Yanagawa, Satoshi Kuwabara, Ryuji Kaji, Yusuke Osaki, Hiroki Yamazaki, Shotaro Haji, Yumi Ishida, Akari Futami, Toshiko Miyamoto, Akiyo Akaishi, Kenshi Takechi, K Maeda, Shoko Kurisu, M Yoshizawa, Nozomu Matsuda, Tomoko Nakazato, Ryoichi Nakamura, Naoki Hayashi, Akihiro Kawata, Hideki Kimura, Kota Bokuda, Akiko Tamura, Chiho Ishida, Michi Kawamoto, Hyo Kim, Jun Kawamata, Shin Hisahara, Yuichi Kimura, Toru Yamashita, Yasuyuki Ohta, Kimihito Arai, Takahiro Takeda, Tomoo Ogawa, Shingo Ikari, Yasunori Ono, Yukio Fujino,
Importance The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there is a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin to be a promising agent. Objective To validate the efficacy and safety of ultrahigh-dose methylcobalamin for patients with ALS enrolled within 1 year of onset. Design, Setting, and Participants This was a multicenter, placebo-controlled, double-blind, randomized phase 3 clinical trial with a 12- ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2022 - American Medical Association | JAMA Neurology
Masatake Yamaguchi, Tomohito Tsuru, Ken-ichi Ebihara, Mitsuhiro Itakura, Kenji Matsuda, Kazuyuki Shimizu, Hiroyuki Toda,
From first-principles calculations, we estimated the trapping energy of hydrogen atom at the interstitial site of perfect crystals of Mg2Si and Al7FeCu2 intermetallic compounds in the aluminum matrix. We found that Al7FeCu2 trapped hydrogen atoms strongly, whereas Mg2Si did not. The highest trapping energy in Al7FeCu2 is 0.56 eV/atom. We also found that the density of hydrogen trapping can be increased up to about 13 atoms/nm3 while keeping high trapping energy of about 0.40 eV/atom. We inferred ...
Tópico(s): Aluminum Alloys Composites Properties
2020 - | MATERIALS TRANSACTIONS
Kazuyuki Shimizu, Hiroyuki Toda, Chihiro Kadogawa, Hiro Fujihara, Akihisa Takeuchi,
Al–Zn–Mg alloys are representative high-strength aluminum alloys, but hydrogen embrittlement hinders further strengthening. The role of nanovoids in the hydrogen embrittlement of a hydrogen-charged Al–Zn–Mg–Cu alloy is examined using high-resolution imaging-type synchrotron X-ray tomography. Although nanovoids are initiated during deformation, their growth and coalescence behaviors are limited. Hydrogen partitioning analysis indicates that this is because most of the formed vacancies are not stabilized ...
Tópico(s): Aluminum Alloy Microstructure Properties
2020 - Elsevier BV | Materialia
Artenis Bendo, Kenji Matsuda, Adrian Lervik, Tomohito Tsuru, K. Nishimura, Norio Nunomura, Randi Holmestad, Calin D. Marioara, Kazuyuki Shimizu, Hiroyuki Toda, Masatake Yamaguchi,
Characterization of precipitates in Al-Zn-Mg alloys, using a combination of electron diffraction, bright field transmission electron microscopy and atomic scale scanning transmission electron microscopy imaging revealed the presence of an unreported η13 orientation relationship between the η-MgZn2 phase and the Al lattice with the following orientation relationship (0001)η ∥ (120)Al and (21¯1¯0)η ∥ (001)Al, plate on (120)Al. The precipitate interfaces were observed and analyzed along two projections 90° ...
Tópico(s): Corrosion Behavior and Inhibition
2019 - Elsevier BV | Materials Characterization
Kazuyuki Shimizu, Hiroyuki Toda, Kentaro Uesugi, Akihisa Takeuchi,
The local deformation and fracture behavior of high-Zn Al-Zn-Mg(-Cu) alloys under hydrogen influence were investigated by in situ tests through synchrotron X-ray tomography. Intergranular and quasi-cleavage fractures were induced by hydrogen, and strain localization by the presence of cracks was not observed by 3D strain mapping. These results suggest that the strain localization at the crack tip is smaller than the measurement limit of 3D strain mapping. The average crack-tip-opening displacements, ...
Tópico(s): Corrosion Behavior and Inhibition
2019 - Springer Science+Business Media | Metallurgical and Materials Transactions A
Kazuyuki Shimizu, Hiroyuki Toda, Hiro Fujihara, Kyosuke Hirayama, Kentaro Uesugi, Akihisa Takeuchi,
To develop high strength Al-Zn-Mg alloys, suppression of hydrogen embrittlement is indispensable. The hydrogen embrittlement behavior of different prepared Al-10.1-1.2Mg alloys with various hydrogen trap sites was observed using in situ synchrotron X-ray tomography in this study. Furthermore, we quantified the hydrogen partitioning based on hydrogen occupancies and hydrogen trap site densities in the prepared alloys. The combined analysis of hydrogen embrittlement and hydrogen partitioning showed ...
Tópico(s): Aluminum Alloy Microstructure Properties
2019 - Elsevier BV | Engineering Fracture Mechanics
Kazuyuki Oshita, Satoshi Toda, Masaki Takaoka, Hideki Kanda, Takashi Fujimori, Kazutsugu Matsukawa, Taku Fujiwara,
Livestock manure is an animal waste that is generated worldwide, and is one of the most abundant waste materials generated in Japan. Its excess application as a fertilizer can cause negative environmental problems; i.e., groundwater pollution and greenhouse gas emissions. When livestock manure is used as a solid fuel, a significant amount of energy is required to remove the high water content by conventional heating, and the resulting dry material has a self-ignition risk that makes it difficult ...
Tópico(s): Phosphorus and nutrient management
2015 - Elsevier BV | Fuel
Yoki Mori, Kazuyuki Kamata, Noriko Toda, Hideyuki Hayashi, Koh‐ichi Seki, Shinji Taneda, Shin Yoshino, Akiyo Sakushima, Masakatsu Sakata, Akira K. Suzuki,
The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities.
Tópico(s): Atmospheric chemistry and aerosols
2003 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Artenis Bendo, Kenji Matsuda, K. Nishimura, Norio Nunomura, Taiki Tsuchiya, Seungwon Lee, Calin D. Marioara, Tomohito Tsuru, Masatake Yamaguchi, Kazuyuki Shimizu, Hiroyuki Toda,
Metastable phases in aluminium alloys are the primary nano-scale precipitates which have the biggest contribution to the increase in the tangible mechanical properties. The continuous increase in hardness in the 7xxx aluminium alloys is associated with the phase transformation from clusters or GP-zones to the metastable η′ phase. The high-resolution electron imaging is used to observe the precipitates and reconstruct a kinetic model that might explain the transformation. This work is an attempt ...
Tópico(s): Advanced Materials Characterization Techniques
2020 - Maney Publishing | Materials Science and Technology
Yuantao Xu, Hiroyuki Toda, Kazuyuki Shimizu, Yafei Wang, Baptiste Gault, Wei Li, Kyosuke Hirayama, Hiro Fujihara, Xuejun Jin, Akihisa Takeuchi, Masayuki Uesugi,
The pursuit of strong and ductile Al alloys with superior resistance to hydrogen embrittlement (HE) is practically significant across the aerospace and transportation industries among others. Unfortunately, effective ways to progress on the strength-HE trade-off for Al-alloys remain elusive. A strategy of suppressing HE by introducing intermetallic compound (IMC) particles to achieve hydrogen redistribution in various trapping sites was proposed. Here, we systematically induce the precipitation of ...
Tópico(s): Corrosion Behavior and Inhibition
2022 - Elsevier BV | Acta Materialia
Hang Su, Hiroyuki Toda, Kazuyuki Shimizu, Kentaro Uesugi, Akihisa Takeuchi, Yoshio Watanabe,
Hydrogen repartitioning and the related embrittlement behavior were characterized by studying Al–Zn–Mg–Cu aluminum alloys with different intermetallic particle contents. Using high-resolution X-ray tomography and related microstructural tracking techniques, hydrogen-induced quasi-cleavage cracks and the related strain localization were observed regardless of the content of the intermetallic particles. The area of quasi-cleavage cracks on the fracture surface increased and the strain localization ...
Tópico(s): Corrosion Behavior and Inhibition
2019 - Elsevier BV | Acta Materialia
Yuki Toda, Kazuyuki Takata, Yuko Nakagawa, Hikaru Kawakami, Shusuke Fujioka, Kazuya Kobayashi, Yasunao Hattori, Yoshihisa Kitamura, Kenichi Akaji, Eishi Ashihara,
Exosomes, the natural vehicles of various biological molecules, have been examined in several research fields including drug delivery. Although understanding of the biological functions of exosomes has increased, how exosomes are transported between cells remains unclear. We hypothesized that cell tropism is important for effective exosomal intercellular communication and that parental cells regulate exosome movement by modulating constituent exosomal molecules. Herein, we demonstrated the strong ...
Tópico(s): MicroRNA in disease regulation
2014 - Elsevier BV | Biochemical and Biophysical Research Communications
Masahiro Toda, Kazuyuki Monden, Kazuki Kubo, Kanehisa Morimoto,
This study investigated the associations between the intensity of mobile phone use and health-related lifestyle. For 275 university students, we evaluated health-related lifestyle using the Health Practice Index (HPI; Hagihara & Morimoto, 1991; Kusaka, Kondou, & Morimoto, 1992) and analyzed responses to a questionnaire (MPDQ; Toda, Monden, Kubo, & Morimoto, 2004) designed, with a self-rating scale, to gauge mobile phone dependence. For males, there was a significant relationship between smoking habits and ...
Tópico(s): Child Development and Digital Technology
2006 - Scientific Journal Publishers Limited | Social Behavior and Personality An International Journal
Taneda Shinji, Kamata Kazuyuki, Hideyuki Hayashi, Toda Noriko, Seki Koh-ichi, Sakushima Akiyo, Yoshino Shin, Yamaki Kouya, Sakata Masakatsu, Mori Yoki, Suzuki Akira K.,
MATERIALS AND METHODSDEP ---DEP were collected, as described previously, from the diesel exhaust of a 4JB1-type engine manufactured by Isuzu Automobile Company, Tokyo, Japan. 21)The particles were produced from the diesel exhaust of light oil containing 0.05% sulfur.The DEP were kept in a sealed bottle at -20°C in the dark.Reagents ---Nitrophenols, 3-nitrophenol (7),
Tópico(s): Free Radicals and Antioxidants
2004 - Pharmaceutical Society of Japan | JOURNAL OF HEALTH SCIENCE
Masahiro Toda, Kazuyuki Monden, Kazuki Kubo, Kanehisa Morimoto,
To assess the reliability and validity of a cellular phone dependence questionnaire (CPDQ) we designed.The CPDQ, a 20-item self-rated scale, was given to 168 healthy female university students (mean age, 21.7 years). Each question uses a 0 to 3 response scale; a higher score indicates greater dependence. The reliability and validity of the CPDQ were assessed by an internal consistency estimate and a factor analysis, respectively. Question scores were then summed to provide a cellular phone dependence ...
Tópico(s): Energy and Environmental Systems
2004 - The Japanese Society for Hygiene | Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)
Risaku Toda, Kazuyuki MINAMI, Masayoshi Esashi,
A new process for fabricating thin mechanical beam structures from single-crystal silicon has been developed. Lateral and vertical dimensions of the beam can be precisely defined. The beam is positioned in the middle of a silicon wafer at exactly equal distances from both sides. The beam design is not limited by crystal orientations of silicon. The silicon beam structure is essentially stress free because the whole structure is made of uniformly doped single-crystal silicon. This thin-beam process ...
Tópico(s): Advanced Surface Polishing Techniques
1998 - Elsevier BV | Sensors and Actuators A Physical
Yasushi Ishijima, Tosifusa Toda, Kazuyuki Matsushita, Mitsutaka Yoshida, Narimichi Kimura,
An expression vector was constructed to produce a common region of human thymopoietin family proteins. The recombinant protein was expressed inEscherichia colias a fusion protein with a biotinylated tag region and purified by affinity chromatography on a monomeric avidin resin. The thymopoietin family-specific antibody was induced in rabbits by immunization with the recombinant fusion protein. Western blotting analysis using the antibody revealed that the expression of thymopoietin family proteins ...
Tópico(s): Lipid metabolism and biosynthesis
1996 - Elsevier BV | Biochemical and Biophysical Research Communications
Hiroyuki Toda, Kazuyuki Shimizu, Kentaro Uesugi, Yoshio Suzuki, Masakazu Kobayashi,
Dual-energy K-edge subtraction imaging technique has been employed to analyze the spatial distribution of copper and its change in three-dimensions quantitatively during a solution treatment. In order to realize it, some preliminary investigations on the verification and assurance of accuracy and repeatability have been performed. Inhomogeneous Cu concentration distribution is revealed even after the solution treatment for a sufficiently long period of time at a high temperature in an Al-Cu alloy. ...
Tópico(s): Advanced X-ray Imaging Techniques
2010 - | MATERIALS TRANSACTIONS
Kentaro Yoda, Kazuyuki Kimoto, Takao Toda,
各種金属化合物触媒によるジメチルテレフタレートとエチレングリコールとのエステル交換反応の速度定数を比較した結果, 電気陰性度が1.0～1.7の間にある金属の化合物が最も触媒活性が強いことが明らかとなった。各種金属化合物とエチレングリコールとの反応性を調べ,触媒の活性種や反応機構などについて電気陰性度との関連において検討した結果,解離イオンによる機構を考えるよりも,配位を考慮した,いわゆるPush and Pull機構を考えるのが適当であろう。
Tópico(s): Catalysis and Hydrodesulfurization Studies
1964 - Chemical Society of Japan | The Journal of the Society of Chemical Industry Japan
Junichi Kuki, Kazuyuki TODA, Makoto Yamamoto,
Erosive actions of solid particles within a flow field are very important in a great number of engineering applications such as aircraft, ship, turbo-machinery and so on, which is referred to erosion. We have developed the numerical method to predict sand erosion phenomenon and the temporal change of the eroded surface. Performing iterative computations for the turbulent flow field, the particle trajectories, the mass removed from a wall, and the deformation of the wall, the behavior of sand erosion ...
Tópico(s): Fluid Dynamics and Heat Transfer
2003 - Trans Tech Publications | Key engineering materials
Fumio Toda, Hisakazu Miyamoto, Kazuyuki Kanemoto,
... the Solid State Give (−)- and (+)-Photocyclization Products, RespectivelyFumio Toda, Hisakazu Miyamoto, and Kazuyuki KanemotoView Author Information Department of Applied Chemistry, Faculty ...
Tópico(s): Natural product bioactivities and synthesis
1996 - American Chemical Society | The Journal of Organic Chemistry
After heating a mixture of trimethylsulphonium iodide, t BuOK and an alkyl aryl ketone at 60-70 "C for 1-5 h, vacuum distillation gave
Tópico(s): Chemical Reaction Mechanisms
1997 - Elsevier BV | Heterocycles
Shigeka YOSHIMOTO, Tomomi YAMAZAKI, Kazuyuki TODA, Masaaki Miyatake,
It is experimentally known that a flat surface vibrating at ultrasonic frequencies generates forces in both vertical and parallel directions to a vibrating surface, and these forces can support a floating object without any contact. However, the cause of the force parallel to the vibrating surface (called a holding force in this paper) has not been clarified yet. Therefore, this paper investigates the cause of the parallel force generated by a vibrating surface, experimentally and numerically. In ...
Tópico(s): Modular Robots and Swarm Intelligence
2007 - Japan Society Mechanical Engineers | TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C
Artenis Bendo, Kenji Matsuda, Seungwon Lee, K. Nishimura, Hiroyuki Toda, Kazuyuki Shimizu, Tomohito Tsuru, Masatake Yamaguchi,
Microstructure evolution of alloy with composition Al – 3.4 Zn – 1.9 Mg (at. %) was tracked using high resolution imaging and electron diffraction during ageing at 120 °C after being initially natural aged for 4 days. Hydrogen was charged in microstructure by cutting samples in Electrical Discharge Machine immediately after being quenched from solid solution temperature. Transmission Electron Microscope observations revealed a higher presence of high aspect ratio GPII-zones in microstructure of hydrogen ...
Tópico(s): Corrosion Behavior and Inhibition
2018 - Elsevier BV | Materialia
Hideto Sonoda, Kazuharu Yamamoto, Kazuyuki Ozeki, Humio Inoye, Shuji Toda, Yoshihiko Maehara,
Tópico(s): Organ Donation and Transplantation
2014 - Springer Science+Business Media | Surgery Today
Kanako Bessho‐Uehara, Diane Wang, Tomoyuki Furuta, Anzu Minami, Keisuke Nagai, Rico Gamuyao, Kenji Asano, Rosalyn B. Angeles‐Shim, Yoshihiro Shimizu, Madoka Ayano, Norio Komeda, Kazuyuki Doi, Kotaro Miura, Yosuke Toda, Toshinori Kinoshita, Satohiro Okuda, Tetsuya Higashiyama, Mika Nomoto, Yasuomi Tada, Hidefumi Shinohara, Yoshikatsu Matsubayashi, Anthony J. Greenberg, Jian Wu, Hideshi Yasui, Atsushi Yoshimura, Hitoshi Mori, Susan R. McCouch, Motoyuki Ashikari,
Significance This study investigates a previously unidentified cysteine-rich peptide (CRP). CRPs have diverse roles in plant growth and development, such as control of stomata density and guidance of pollen-tube elongation. Despite numerous studies on CRPs in Arabidopsis thaliana , there are still many peptides with unknown function. We identify a previously unidentified rice CRP named Regulator of Awn Elongation 2 (RAE2) and show that it is cleaved specifically in the spikelet to promote awn elongation. ...
Tópico(s): Plant nutrient uptake and metabolism
2016 - National Academy of Sciences | Proceedings of the National Academy of Sciences
T Yoshida, K Okuda, K-Q Xin, Kazuyuki Tadokoro, Jun Fukushima, Soji Toda, Eri Hagiwara, Kenji Hamajima, Tumihisa Koshino, Tomoyuki Saito,
SUMMARY We constructed a recombinant replication defective adenovirus vector containing the env gene (Ad-Bal) derived from macrophage-trophic HIV-1 (HIV-1 Bal). We then immunized mice with this vector using several administration routes and protocols, and examined the immune response. When the Ad-Bal viral vector (over 1 × 107 pfu) was injected subcutaneously, both humoral and cell-mediated immunities were induced. However, immune response induced by the Ad-Bal vector alone was weaker than that induced ...
Tópico(s): Virus-based gene therapy research
2001 - Oxford University Press | Clinical & Experimental Immunology
Takehiko Yokomizo, Kazuyuki Masuda, Kazuhiko Kato, Akiko Toda, Takashi Izumi, Takao Shimizu,
Leukotriene B 4 (LTB 4 ) is a potent chemotactic compound that is synthesized from arachidonic acid, by the action of 5-lipoxygenase and leukotriene A 4 hydrolase (1-3). While 5-lipoxygenase is present to a limited extent in leukocytes (4), LTA 4 hydrolase is present ubiquitously in many tissues including the lung, kidney, spleen, and gastrointestinal tract (5). Cytosolic phospholipase A 2 (cPLA 2 ) plays a major role in releasing arachidonic acid from membrane phospholipids (6). We have cloned a human LTB ...
Tópico(s): Receptor Mechanisms and Signaling
2000 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Ryosuke Wakabayashi, Yasunao Hattori, Shigekuni Hosogi, Yuki Toda, Kazuyuki Takata, Eishi Ashihara,
The Wnt/β-catenin pathway is an attractive target for the treatment of acute myelogenous leukemia (AML), since aberrant activation of the Wnt/β-catenin pathway contributes to carcinogenesis in various types of cancers including AML. Screening of an in-house compound library, constructed at Kyoto Pharmaceutical University, identified a novel compound designated "31" that was found to be an inhibitor of the Wnt/β-catenin pathway. The compound inhibited T-cell factor (TCF) activity in a TCF firefly luciferase- ...
Tópico(s): Ubiquitin and proteasome pathways
2020 - Elsevier BV | Biochemical and Biophysical Research Communications