Shunsuke Nakae, Takema Kato, Kazuhiro Murayama, Hikaru Sasaki, Masato Abe, Masanobu Kumon, Tadashi Kumai, Kei Yamashiro, Joji Inamasu, Mitsuhiro Hasegawa, Hiroki Kurahashi, Yuichi Hirose,
... 4 , Masato Abe 5 , Masanobu Kumon 1 , Tadashi Kumai 1 , Kei Yamashiro 1 , Joji Inamasu 1 , Mitsuhiro Hasegawa 1 , ...
Tópico(s): Ocular Oncology and Treatments
2017 - Impact Journals LLC | Oncotarget
Toshihiro Nagato, Takayuki Ohkuri, Kenzo Ohara, Yui Hirata, Kan Kishibe, Yuki Komabayashi, Seigo Ueda, Miki Takahara, Takumi Kumai, Kei Ishibashi, Akemi Kosaka, Naoko Aoki, Kensuke Oikawa, Yuji Uno, Naoko Akiyama, Masatoshi Sado, Hidehiro Takei, Esteban Celis, Yasuaki Harabuchi, Hiroya Kobayashi,
Tópico(s): Cancer Immunotherapy and Biomarkers
2017 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Takumi Kumai, Kei Ishibashi, Kensuke Oikawa, Yoshinari Matsuda, Naoko Aoki, Shoji Kimura, Satoshi Hayashi, Masahiro Kitada, Yasuaki Harabuchi, Esteban Celis, Hiroya Kobayashi,
Posttranslational modifications regulate the function and stability of proteins, and the immune system is able to recognize some of these modifications. Therefore, the presence of posttranslational modifications increases the diversity of potential immune responses to a determinant antigen. The stimulation of tumor-specific CD4(+) helper T lymphocytes (HTLs) is considered important for the production of anti-tumor antibodies by B cells and for the generation and persistence of CD8(+) cytotoxic T ...
Tópico(s): Peptidase Inhibition and Analysis
2014 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Katsuya Sakai, Keisuke Goto, Rui Watanabe, Junpei Tanabe, Kazu Amimoto, Ken Kumai, Kei-ichiro Shibata, Kenji Morikawa, Yumi Ikeda,
Visual–motor illusion (VMI) is to evoke a kinesthetic sensation by viewing images of oneself performing physical exercise while the body is at rest. Previous studies demonstrated that VMI activates the motor association brain areas; however, it is unclear whether VMI immediately alters the resting-state functional connectivity (RSFC). This study is aimed to verify whether the VMI induction changed the RSFC using functional near-infrared spectroscopy (fNIRS). The right hands of 13 healthy adults underwent ...
Tópico(s): Heart Rate Variability and Autonomic Control
2020 - Elsevier BV | Brain and Cognition
Akemi Kosaka, Yuki Yajima, Mayumi Hatayama, Katsuya Ikuta, Takaaki Sasaki, Noriko Hirai, Syunsuke Yasuda, Marino Nagata, Ryusuke Hayashi, Shohei Harabuchi, Kenzo Ohara, Mizuho Ohara, Takumi Kumai, Kei Ishibashi, Yui Hirata‐Nozaki, Toshihiro Nagato, Kensuke Oikawa, Yasuaki Harabuchi, Esteban Celis, Toshikatsu Okumura, Yoshinobu Ohsaki, Hiroya Kobayashi, Takayuki Ohkuri,
Abstract Recent studies have revealed that tumor cells decrease their immunogenicity by epigenetically repressing the expression of highly immunogenic antigens to survive in immunocompetent hosts. We hypothesized that these epigenetically hidden “stealth” antigens should be favorable targets for cancer immunotherapy due to their high immunogenicity. To identify these stealth antigens, we treated human lung cell line A549 with DNA methyltransferase inhibitor 5‐aza‐2′‐deoxycytidine (5Aza) and its prodrug ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2021 - Wiley | Cancer Science
Mari Kasai, Tomohiro Sugawara, Junko Takada, Keiichi Kumai, Kei Nakamura, Kenichi Meguro,
To assess cognitive impairment, self-awareness is an important issue. The Ascertain Dementia 8 questionnaire (AD8) is a brief observation checklist for detecting mild cognitive impairment (MCI) and dementia. After analyzing the reliability and validity of a self-reported Japanese version of the AD8 (AD8-J), we compared self- and informant-reported versions of the AD8-J.A total of 93 community residents aged 75 years or older living in Wakuya, Northern Japan, agreed to participate in this study; 35 ...
Tópico(s): Dementia and Cognitive Impairment Research
2021 - Karger Publishers | Dementia and Geriatric Cognitive Disorders Extra
Y. Shibata, Madoka Kumai, Kiyomasa Nishii, Kei‐ichiro Nakamura,
Tópico(s): Heat shock proteins research
2001 - Springer Science+Business Media | Medical Electron Microscopy
Cast plates of the AC4CH aluminum alloy with different thickness were fabricated by rheocasting and squeeze casting. Tear tests were performed for the as cast and heat treated products (T5 and T6) and effects of solidified structure and heat treatment on the unit crack propagation energy (UEp) were examined. Increase of the cooling rate (corresponding to the decrease in plate thickness) resulted in refined solidified structure and enlarged UEp values for as cast samples. Both spheroidized eutectic ...
Tópico(s): Advanced Welding Techniques Analysis
2006 - Japan Institute of Light Metals | Journal of Japan Institute of Light Metals
Kenzo Ohara, Takayuki Ohkuri, Takumi Kumai, Toshihiro Nagato, Yui Nozaki, Kei Ishibashi, Akemi Kosaka, Marino Nagata, Shohei Harabuchi, Mizuho Ohara, Kensuke Oikawa, Naoko Aoki, Yasuaki Harabuchi, Esteban Celis, Hiroya Kobayashi,
The human T cell receptor is capable of distinguishing between normal and post-translationally modified peptides. Because aberrant phosphorylation of cellular proteins is a hallmark of malignant transformation, the expression of the phosphorylated epitope could be an ideal antigen to combat cancer without damaging normal tissues. p53 activates transcription factors to suppress tumors by upregulating growth arrest and apoptosis-related genes. In response to DNA damage, p53 is phosphorylated at multiple ...
Tópico(s): Immunotherapy and Immune Responses
2018 - Landes Bioscience | OncoImmunology
Keiichi Kumai, Kenichi Meguro, Mari Kasai, Kei Nakamura, Masahiro Nakatsuka,
Recently, the concept of motoric cognitive risk (MCR) syndrome was proposed, where slow gait is considered a risk factor for conversion to dementia.To retrospectively investigate the characteristics of MCR among a population aged 75+ years, focusing on the aspects of epidemiology and neurobehavioral characteristics.The participants were 590 residents aged 75+ years living in Kurihara who underwent MRI and neurobehavioral assessments including walking velocity. The prevalence of MCR and conversion ...
Tópico(s): Balance, Gait, and Falls Prevention
2016 - Karger Publishers | Dementia and Geriatric Cognitive Disorders Extra
Shinji Kumai, Kei Kobayashi, Hong Zhu, Kenta Suzuki, Toshio Haga,
Vacuum die-cast and high-speed twin-roll cast products were fabricated using a heat-treatable Al-Si-Mg base alloy (A) and a non-heat-treatable Al-Mg base alloy (B). These alloys have almost equivalent tensile strength and ductility but different solidified structure. Tear toughness tests were performed using a small-size specimen and the unit crack propagation energy, UEp, was obtained from the load-displacement curve. For the vacuum die-cast products, both A and B exhibited macroscopically plane ...
Tópico(s): Advanced ceramic materials synthesis
2005 - Japan Institute of Light Metals | Journal of Japan Institute of Light Metals
Takayuki Ohkuri, Akemi Kosaka, Kei Ishibashi, Takumi Kumai, Yui Hirata, Kenzo Ohara, Toshihiro Nagato, Kensuke Oikawa, Naoko Aoki, Yasuaki Harabuchi, Esteban Celis, Hiroya Kobayashi,
Tópico(s): Inflammasome and immune disorders
2017 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Kei Ishibashi, Takumi Kumai, Takayuki Ohkuri, Akemi Kosaka, Toshihiro Nagato, Yui Hirata, Kenzo Ohara, Kensuke Oikawa, Naoko Aoki, Naoko Akiyama, Masatoshi Sado, Masahiro Kitada, Yasuaki Harabuchi, Esteban Celis, Hiroya Kobayashi,
Tumor immune escape has been a major problem for developing effective immunotherapy. The human leukocyte antigen G (HLA-G) is a non-classical MHC class I molecule whose primary function is to protect the fetus from the mother's immune system. While HLA-G is hardly found in normal adult tissues, various tumor cells are known to express it, aiding their escape from the immune system. Thus, HLA-G is an attractive immunotherapy target. CD4+ helper T lymphocytes (HTLs) play an important role in the immune ...
Tópico(s): Immunotherapy and Immune Responses
2016 - Landes Bioscience | OncoImmunology
Takumi Kumai, Yoshinari Matsuda, Takayuki Ohkuri, Kensuke Oikawa, Kei Ishibashi, Naoko Aoki, Shoji Kimura, Yasuaki Harabuchi, Esteban Celis, Hiroya Kobayashi,
Background: The expression of c-Met and its ligand HGF plays a critical role in cell proliferation and is involved in numerous malignancies. Because c-Met expression and its role in NK/T-cell lymphoma remain unclear, we studied the expression and function of c-Met in NK/T-cell lymphoma cells. In addition, we investigated the possibility that c-Met could function as a tumor-associated antigen for helper T lymphocytes (HTLs).Methods: We evaluated whether HGF and c-Met were expressed in NK/T-cell lymphoma ...
Tópico(s): Liver physiology and pathology
2015 - Landes Bioscience | OncoImmunology
K Egashira, Kiyomasa Nishii, Kei‐ichiro Nakamura, Madoka Kumai, Sachio Morimoto, Yosaburo Shibata,
Abstract In early‐stage heart, the cardiac impulse does not propagate through the specialized conduction system but spreads from myocyte to myocyte. We hypothesized that the gap junction protein connexin45 (Cx45) regulates early‐stage contractions, because it is the only gap junction protein described in early hearts. Cx45‐deficient (Cx45 −/− ) mice die of heart failure, concomitantly displaying other complex defects in the cardiovascular system. In order to determine the specific cardiac muscular function ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2004 - Wiley | The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology
Shu‐ichi Hashimoto, Noriyuki Sakakibara, Hideshi Kumai, Midori Nakai, Sadatoshi Sakuma, S Chiba, Kei Fujinaga,
Human adenovirus type 40 (Ad40) cannot propagate in conventional established human cell lines such as KB or HeLa cells. However, it has been shown that Ad40 DNA replicates in KB18 cells which express Ad2 E1B genes, suggesting that Ad40 is defective in the E1B gene function in KB or HeLa cells. We show here that Ad40 can propagate and produce plaques on A549 cells which do not contain Ad E1B genes. Our experiments show that the levels of replication of Ad40 DNA and production of infectious Ad40 virus ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
1991 - American Society for Microbiology | Journal of Virology
Keiichi Kumai, Kei Nakamura, Kenichi Meguro,
... very mild Alzheimer's disease Keiichi Kumai, Keiichi Kumai Division of Geriatric Behavioral Neurology, Tohoku University CYRIC, Sendai, JapanSearch for more papers by this authorKei Nakamura, Kei Nakamura Division of Geriatric Behavioral Neurology, Tohoku University ... more papers by this author Keiichi Kumai, Keiichi Kumai Division of Geriatric Behavioral Neurology, Tohoku University CYRIC, Sendai, JapanSearch for more papers by this authorKei Nakamura, Kei Nakamura Division of Geriatric Behavioral Neurology, Tohoku University ...
Tópico(s): Dementia and Cognitive Impairment Research
2016 - Wiley | Psychogeriatrics
Yui Hirata‐Nozaki, Takayuki Ohkuri, Kenzo Ohara, Takumi Kumai, Marino Nagata, Shohei Harabuchi, Akemi Kosaka, Toshihiro Nagato, Kei Ishibashi, Kensuke Oikawa, Naoko Aoki, Mizuho Ohara, Yasuaki Harabuchi, Yuji Uno, Hidehiro Takei, Esteban Celis, Hiroya Kobayashi,
Head and neck squamous cell carcinoma (HNSCC) originates from squamous epithelium of the upper aerodigestive tract and is the most common malignancy in the head and neck region. Among HNSCCs, oropharynx squamous cell carcinoma (OSCC) has a unique profile and is associated with human papillomavirus infection. Recently, anti-programmed cell death-1 monoclonal antibody has yielded good clinical responses in recurrent and/or metastatic HNSCC patients. Therefore, programmed death-ligand 1 (PD-L1) may be ...
Tópico(s): Immunotherapy and Immune Responses
2019 - BioMed Central | Journal of Translational Medicine
Tópico(s): African history and culture analysis
1996 - Brill | Images
Ayako Shimada, Koji Fujita, Minoru Kitago, Shunsuke Ichisaka, Kei‐ichi Ishikawa, Hiroyuki Kikunaga, Koichiro Kumai, Hiroshi Miura,
Abstract Background Perforation of a duodenal diverticulum is a rare complication that may become fatal with a delay in appropriate treatment. However, the optimal treatment for perforated duodenal diverticulum remains controversial, ranging from conservative therapy to surgery including pancreatoduodenectomy. Case presentation The patient was a 60-year-old woman with no particular medical history who visited our hospital with chief complaints of continuous fever and right dorsal pain. Upon arrival, ...
Tópico(s): Diverticular Disease and Complications
2020 - Springer Nature | Surgical Case Reports
Saeko Higashiguchi, Akiyo Sadato, Ichiro NAKAHARA, Shoji Matsumoto, Motoharu Hayakawa, Kazuhide Adachi, Akiko Hasebe, Yoshio Suyama, Tatsuo Omi, Kei Yamashiro, Akira Wakako, Takuma Ishihara, Yushi Kawazoe, Tadashi Kumai, Jun Tanabe, Kenichiro Suyama, Sadayoshi Watanabe, Takeya Suzuki, Yuichi Hirose,
Background Thromboembolic complications (TECs) are frequent during the endovascular treatment of unruptured aneurysms. To prevent TECs, dual antiplatelet therapy using aspirin and clopidogrel is recommended for the perioperative period. In patients with a poor response, clopidogrel is a risk factor for TECs. To prevent TECs, our study assessed the stratified use of prasugrel. Methods Patients who underwent endovascular therapy for unruptured cerebral aneurysms from April 2017 to August 2019 were ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2021 - BMJ | Journal of NeuroInterventional Surgery
Kyoko Akanuma, Kei Nakamura, Kenichi Meguro, Masanori Chiba, Sergio Ramón Gutiérrez Úbeda, Keiichi Kumai, Yuka Kato, Jiro Oonuma, Mari Kasai, Masahiro Nakatsuka, Takashi Seki, Hiroaki Tomita,
After the Great East Japan Earthquake of 2011, we investigated the safety of residents in the affected communities. Most of the people requiring help were elderly and had previously been assessed as Clinical Dementia Rating (CDR) 0.5 (i.e. as having mild cognitive impairment (MCI)). We examined how well they understood the television news and whether they could make appropriate decisions.This community-based study of dementia and difficulties following a disaster started in Tome, northern Japan. The ...
Tópico(s): Traumatic Brain Injury Research
2016 - Wiley | Psychogeriatrics
Mika Kumai, Keiichi Kumai, Kei Nakamura, Shigeo Kinomura, Kenichi Meguro,
Abstract: A 59-year-old, right-handed woman made many mistakes in her job in a pharmacy, despite having considerable experience working in this setting. She had a can-do attitude, but also showed no sign of remorse when she failed. Other staff grew impatient with her and she was diagnosed with frontotemporal dementia based on clinical and brain imaging findings. After diagnosis, other staff understood that the disease was the cause of her difficulties, and her work tasks and hours were changed to ...
Tópico(s): Healthcare Decision-Making and Restraints
2021 - Dove Medical Press | International Medical Case Reports Journal
Junko Takada, Hiromi Nakanome, Shoko Sasaki, Yukiko Kanzaki, Keiichi Kumai, Kei Nakamura, Takanori Aonuma, Kenichi Meguro,
The “New Orange Plan” aims to make a society in which they can live in a familiar and good environment for as long as possible. To keep living at home, managing risk conditions is necessary. We previously reported that older community residents with the Clinical Dementia Rating (CDR) 0.5 (very mild dementia) or CDR 1; (dementia, confirmed by DSM) with cerebrovascular disease (CVD) (vascular cognitive impairment, VCI) were easily involved in various risk conditions as well as progressed to severe dementia. ...
Tópico(s): Dementia and Cognitive Impairment Research
2018 - Wiley | Alzheimer s & Dementia
Keiichi Kumai, Mika Kumai, Junko Takada, Jiro Oonuma, Kei Nakamura, Kenichi Meguro,
<b><i>Introduction:</i></b> The aim of this study is to clarify the association between repeated falls and the dominant/nondominant side in the open-eyed one-leg standing (OLS) test among people who are healthy or have mild cognitive impairment (MCI) or dementia in a community setting. We recruited 180 participants from 39 areas in the town of Wakuya. <b><i>Methods:</i></b> This is a cross-sectional study. Participants were classified into 3 Clinical Dementia ...
Tópico(s): Stroke Rehabilitation and Recovery
2021 - Karger Publishers | Dementia and Geriatric Cognitive Disorders Extra
Takuya Minagawa, Shoichi Dowaki, Hiroyuki Kikunaga, Koji Fujita, Kei‐ichi Ishikawa, Katsuaki Mori, Tadayuki Sakuragawa, Shunsuke Ichisaka, Hiroshi Miura, Koichiro Kumai, Shuji Mikami, Yuko Kitagawa,
Choledochal cyst (CC)-a congenital anomaly of the bile duct-is rare. We report a 28-year-old woman complaining of epigastralgia who was transferred to our hospital. Physical examination revealed severe tenderness to abdominal palpation without symptoms of diffuse peritonitis. Urgent contrast-enhanced abdominal computed tomography indicated the dilated common bile duct (CBD) was perforated, with a presumed diagnosis of perforated CC. Endoscopic external biliary drainage was performed immediately as ...
Tópico(s): Congenital Anomalies and Fetal Surgery
2015 - Springer Nature | Surgical Case Reports
Akemi Kosaka, Kei Ishibashi, Toshihiro Nagato, Hidemitsu Kitamura, Yukio Fujiwara, Syunsuke Yasuda, Marino Nagata, Shohei Harabuchi, Ryusuke Hayashi, Yuki Yajima, Kenzo Ohara, Takumi Kumai, Naoko Aoki, Yoshihiro Komohara, Kensuke Oikawa, Yasuaki Harabuchi, Masahiro Kitada, Hiroya Kobayashi, Takayuki Ohkuri,
Activation of STING signaling plays an important role in anti-tumor immunity, and we previously reported the anti-tumor effects of STING through accumulation of M1-like macrophages in tumor tissue treated with a STING agonist. However, myeloid cells express SIRPα, an inhibitory receptor for phagocytosis, and its receptor, CD47, is overexpressed in various cancer types. Based on our findings that breast cancer patients with highly expressed CD47 have poor survival, we evaluated the therapeutic efficacy ...
Tópico(s): interferon and immune responses
2021 - Rockefeller University Press | The Journal of Experimental Medicine
Keiichi Kumai, Mika Kumai, Junko Takada, Jiro Oonuma, Kei Nakamura, Takanori Aonuma, Kenichi Meguro,
Fall is a major risk for fractures which will surely result in decreased daily activities for older adults. The Timed-Up-and-Go Test (TUG) is commonly used to detect older residents with the risk of fall accidents in quite a few communities but no academic background has been applied. The Wakuya Project (2014–2015) was performed to focus on the older residents aged 65 years or older, for the prevention of stroke, dementia and bed-confinement in Wakuya, a typical agricultural town in Miyagi Prefecture, ...
2017 - Wiley | Alzheimer s & Dementia
Yuki Yajima, Akemi Kosaka, Kei Ishibashi, Shunsuke Yasuda, Hiroki Komatsuda, Toshihiro Nagato, Kensuke Oikawa, Masahiro Kitada, Masanori TAKEKAWA, Takumi Kumai, Kenzo Ohara, Takayuki Ohkuri, Hiroya Kobayashi,
Although neoantigens are one of the most favorable targets in cancer immunotherapy, it is less versatile and costly to apply neoantigen-derived cancer vaccines to patients due to individual variation. It is, therefore, important to find highly immunogenic antigens between tumor-specific or associated antigens that are shared among patients. Considering the cancer immunoediting theory, immunogenic tumor cells cannot survive in the early phase of tumor progression including two processes: elimination ...
Tópico(s): Immune Cell Function and Interaction
2022 - Wiley | Cancer Science
J. Donald Easton, Maria Aunes, Gregory W. Albers, Pierre Amarenco, Sara Bokelund-Singh, Hans Denison, Scott R. Evans, Peter Held, Maria Jahreskog, Jenny Jonasson, Kazuo Minematsu, Yongjun Wang, K.S. Lawrence Wong, S. Claiborne Johnston, Sebastiá Ameriso, Geoffrey Donnan, Ayrton Massaro, Michael D. Hill, Norio Tanahashi, Ludmila Stakhovskaya, Jong-Sung Kim, Nils Wahlgren, Tsong Hai Lee, Kursad Kutluk, Sergii Moskovko, Scott Kasner, Daniel Laskowitz, Wayne Clark, Huy Thang Nguyen, Sebastian Ameriso, Sandra Lepera, Marina Romano, David Paulon, Pablo Ioli, Cristina Zurru, Guadalupe Bruera, Lorena Jure, Francisco Klein, Guillermo Povedano, Christopher Levi, Thanh Viet Phan, Romesh Markus, Craig Anderson, Arman Sabet, Stephen M. Davis, Andrew Lee, Timothy Klein, Andrew Wong, Martín Krause, Jim Jannes, Tissa Wijeratne, Robin Lemmens, Dimitri Hemelsoet, André Peeters, Philippe Tack, Peter Vanacker, Patrice Laloux, William van Landegem, Geert Vanhooren, Philippe Desfontaines, Marc van Orshoven, Fábio Oliveira, Mauricio Friedrich, Rosane Brondani, Rubens Gagliardi, Fabio Fabio, Maria Dracoulakis, Rodrigo Bazan, Luiz Marrone, Octavio Pontes Neto, Gisele Silva, Pedro Kowacs, Ekaterina Titianova, Paraskeva Stamenova, Marin Daskalov, Ivan Staikov, Dimo Baldaranov, Dimitar Maslarov, Hristo Lilovski, Plamen Petkov, Neli Petrova, Radoslav Mavrov, Veska Markova, Valeria Petrova, Tanya Beleva, Borislav Kralev, Nikolay Sotirov, Veska Lekova, Hristo Hristov, Vera Ermenkova, Lyudmil Mateev, Rumeliya Mitkova, Liybomir Haralanov, Rosen Ikonomov, Margarita Mihailova, Ivan Georgiev, Ashfaq Shuaib, Vladimir Hachinski, Martin Boulanger, Sharan Mann, Ayman K.M. Hassan, Ariane Mackey, Bijoy Menon, Jeffrey Minuk, Muzaffar Siddiqui, Marsha Eustace, Lucia Vieira, Daniel Selchen, Grant Stotts, Pablo Lavados, Angel Castro, Kristo Gasic, Rodrigo Rivas, Pablo Sánchez, Andres Roldan, Ingrid Grossmann, Christian Figueroa, Jim Li, Xiaolin Xu, Huisheng Chen, Xiaohong Li, Yi Yang, Chunsheng Zhang, Baojun Wang, Guanglai Li, Dong Wang, Hong Li, Yamei Tang, Anding Xu, Yanjiang Wang, Hong Hong, Zhi Song, Xiaoping Jin, Fuling Yan, Weihong Zheng, Xiaoping Wang, Dong Dong, Zhongxin Zhao, Baorong Zhang, Wangtao Wang, Guoqiang Wen, Guozhong Li, Dong Xu, Xiangyang Tian, Zhaohui Zhang, Xu Xu, Kaixiang Li, Jun Chen, Ondrej Skoda, David Skoloudik, Edvard Ehler, Daniel Vaclavik, Daniel Sanak, Sylva Klimosova, Eva Vitkova, Jan Fiksa, Robert Mikulik, Jiri Neumann, Richard Plny, Didier Leys, Igor Sibon, Jean-Louis Mas, Sonia Alamowitch, Fernando Pico, Marie-Hélène Mahagne, Emmanuel Touzé, Wilfried Vadot, Stephane Vannier, Norbert Norbert, Yves Samson, Pierre Garnier, Emmanuel Ellie, Benoit Guillon, Serge Timsit, Maurice Giroud, Philippe Philippeau, Aude Bagan-Triquenot, Valérie Wolff, Nicolas Raposo, Severine Debiais, Jérôme Grimaud, Stéphane Illouz, Didier Smadja, Cédric Urbanczyk, Joachim Röther, Jörg Berrouschot, Christian Weimar, Georg Gahn, Hassan Hassan, Sven Klimpe, Darius Nabavi, Jörg Glahn, Martin Köhrmann, Lars Krause, Christoph Terborg, Peter Urban, Thorsten Steiner, Andreas Ferbert, Rainer Dziewas, Günter Seidel, Götz Thomalla, Chen Li, Wing Chi Fong, Raymond Cheung, Szegedi Norbert, Krisztián Pozsegovits, Attila Valikovics, Gyula Pánczél, Csilla Rózsa, László Németh, Péter Diószeghy, Csaba Óváry, Attila Csányi, Levente Kerényi, Valéria Nagy, Sámuel Komoly, Dániel Bereczki, Sándor Molnár, István Kondákor, David Tanné, Guy Raphaeli, Gregory Telman, Natan Bornstein, Ronen Leker, Yair Lampl, Giancarlo Agnelli, Francesco Corea, Donata Guidetti, Giovanni Malferrari, Marc Marcheselli, Giuseppe Micieli, Andrea Zini, Vincenzo Di Lazzaro, Carlo Gandolfo, Andrea Salmaggi, Rossana Tassi, Maurizia Rasura, Giovanni Orlandi, Giancarlo Comi, Stefano Ricci, Michel Michel, Maria Delodovici, Paolo Bovi, Domenico Consoli, Kimiaki Kim, Tsuneo Fujita, Hideyuki Kurihara, Chikashi Maruki, Takeshi Hayashi, Tsuneaki Ogiichi, Morio Kumagai, Katsunobu Takenaka, Kazunori Toyoda, Kazuhiro Takamatsu, Ryo Ogami, Shigenari Kin, Takeshi Aoki, Katsumi Takizawa, Shigehiro Omori, Takehiko Umezawa, Yasuyuki Toba, Yutaka Nonoyama, Hidemitsu Nakagawa, Takashi Naka, Masanori Mas, Shuichi Matsumoto, Tsutomu Hitotsumatsu, Tatsuya Shingaki, Satoshi Okuda, Mamoru Ota, Nobuyuki Sakai, Takeshi Yamada, Jun Niwa, Hitoshi Fujita, Akihito Moriki, Yoshihisa Fukushima, Takahisa Mori, Atsushi Sato, Yoshikazu Kusano, Michiya Kubo, Masashi Mas, Takao Ooasa, Takafumi Nishizaki, Naoki Kitagawa, Yasuhiro Manabe, Akira Yoshioka, Takato Kagawa, Toshikazu Ichihashi, Hideki Matsuoka, Yasuhiro Ito, Hitonori Takaba, Hisatoshi Saito, Kazumasa Fukuda, En Endo, Minoru Kidooka, Toshitaka Umemura,
Background: Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes) was the first trial with ticagrelor in patients with acute ischemic ...
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