Benjamin V. Treadwell, Christine A. Towle, Kenneth K. Ishizue, Keith P. Mankin, Michele Pavia, Felicia M. Ollivierre, Donald H. Gray,
We have purified a low molecular weight protein from medium conditioned by calf synovium with physical and biological properties similar to the leukocyte cytokine interleukin 1 (IL-1). The factor is active in stimulating the synthesis (three- to fivefold) of collagenase activator protein (CAP) by the surface (1–2 mm) of articular cartilage while CAP synthesis in the deeper zones of articular cartilage is not affected. Recombinant mouse IL-1 and commercially available purified human IL-1 are also capable ...
Tópico(s): Protease and Inhibitor Mechanisms
1986 - Elsevier BV | Archives of Biochemistry and Biophysics
Enchi Liu, Mark E. Schmidt, Richard Margolin, Reisa A. Sperling, Robert A. Koeppe, N. Scott Mason, William E. Klunk, Chester A. Mathis, Stephen Salloway, Nick C. Fox, David Hill, Andrea S. Les, Peter Collins, Keith M. Gregg, Jianing Di, Yuan Lü, Iulia Cristina Tudor, Bradley T. Wyman, Kevin Booth, S Broome, Eric Yuen, Michael Grundman, H. Robert Brashear, Stephen Salloway, Reisa A. Sperling, Murray A. Raskind, Marwan N. Sabbagh, Lawrence S. Honig, Anton P. Porsteinsson, Steven H. Ferris, David Weisman, Lynne Harris, Betty Diamond, A. Casher, Thomas Vincent, Daniel R. Rhodes, Celine Olivia, Andrea Years, Anthony Rosenzweig, Ronald Klein, Steven E. Arnold, V. Boruta, A Blue-Schaller, James McGowan, J. Wurziger, Özkan Yalkinoglu, J. Wurziger, Martina Kirsch, Christian Schindler, Arthur Spirling, M. Ohnesorge, Andreas Kluge, Martha McCartney, Thomas Stubbs, K. J. Sweeney, Keith A. Johnson, Roberto Santangelo, Benjamin K.P. Woo, Marcelo F. DiCarli, Steven Williams, J. M. Passler, D. Cheng, Wendy J. Ingram, S. Jutras, Moshe Shay, A. McGlew, S. Warner-Coviello, R. Nandan, Paul Rees, Varun Mehra, Juliana Velosa Porras, S. Bryant, E. Bartolomé, Carl K. Hoh, Jennifer M. Murphy, Salmaan Sharif, Monte S. Buchsbaum, K E Kortman, István Kovács, Neelee Chini, Lisa Brown, Gus Alva, Ajjai Alva, J. Kellogg, Mathilde Lykke, Markus Rabe, B. Shih, Joseph C. Wu, Carl K. Hoh, Monte S. Buchsbaum, Pierre N. Tariot, R. Yaari, Scott A. Small, M. Chavira, Eric M. Reiman, H. Brand, Lisa Cooper, W. Dennis-Busier, Dan Bandy, James D. Seward, John M. Weir, Carlos N. Monarrez, D. Ware Branch, J.B. Langbaum, A. Mohammand, Christopher A. Ross, Louise Mullen, S. Goodwin, Adam Fleisher, A. Burke, Laura Jakimovich, D. Costanzo, T. Drimer-Kagan, Cheryl L. Holt, Nellie High, Kathy Wright, Stephanie Reeder, Katherine H. Saunders, Nils Richter, Sheila Vadovicky, E. Salomon, R. Lopez, Megan Frantz, Jose Isidro Minero, Carolyn Langlois, Gursharan Chana, Erika Hamilton, S. Media-Rodriguez, D. Lefranc, Milan Luk, A. Herrero San Martín, Kay Weiler, M. Baker, L. Martinez-Lujan, Marwan N. Sabbagh, Sandra A. Jacobson, CM Belden, David A. Holladay, R. Cottam, Holly A. Shill, Jerri D. Edwards, Donald J. Connor, Keith L. Davis, D. Allinich, Joan Sala, Markus W. Covert, Joanne Ceimo, C. Molnar, M. Malek-Ahmadi, E. Schwartz, P. A. Conrad, Jean Lopez, E. Karoll, Mónica Dias-Teixeira, Cristina Delcò, Zoran Obradov, Katrin Kohl, B M Montalvo, Dan Bandy, Chong Chen, Robert A. Stern, Anil K. Nair, R. Green, Ilona M. Kopits, Glenn D. Barest, Rohini N. Nadgir, A. Mandell, Noyan Gokce, Jane Mwicigi, Asad Mian, J. Wang, Carlo Rossi, Shirley Poon, J. Callaghan, Osamu Sakai, Hui Hong, Sheelakumari Raghavan, Prajakta Joshi, E. Francis Cook, Keith A. Johnson, Eric Steinberg, Thomas McGowan, Marcelo F. DiCarli, Patricia Lynn Johnson, W. Qui, Guillermo Marshall, Dorene M. Rentz, Scott McGinnis, Keith A. Johnson, Lauren E. Olson, Mark R. Frey, Alireza Atri, Meghan Searl, Reisa A. Sperling, James M. Mountz, Katherine Frishe, Ottavio V. Vitolo, Rebecca E. Amariglio, Marcelo F. Di Carli, Martha Vander Vliet, Laura Horkey, Mykol Larvie, Nancy J. Donovan, Natacha Lorius, B. Boot, D. G. Sapir, Krishna Chandra Roy, S. Kim, Stephen Salloway, Dieter Lederer, W. Fennelly, B. Blackham, Joel R. Primack, Diane Monast, C. Kechichian, Paul Malloy, V. Sofios, Steven A. Weinman, Roberto Santoro, Kathryn Bandeira de Mello, Colleen J. Maxwell, Martin J. Gardner, Kenneth C. Rickler, Nicole McLaughlin, Keith A. Johnson, Lincoln Tirpaeck, D. Jerue, Irene Piryatinsky, Marcelo F. Di Carli, D. Cheng, Richard Marsland, Phillip Read, Ania Mikos, Desiree Medeiros, Fiona Kinney, Deborah Dahl, Adrian H. Thurstin, Richard May, Helen L. Reeves, R. Colin Garner, Timothy A. Steele, Lelland C. Tolbert, K. Lindbergh, Michael D. Redwine, Jeffrey Hammel, Ronald E. Savage, Stuart C. White, Neil Kirby, X. Wang, Sebastian Berg, Gary A. Rosenberg, Michèle Campopiano, L. Dobkin, S. Richard-Aasen, Jérôme Champ, Chris Dutka, Marina Celanovic, Jared Minkel, John Wilson, N. Belt, Leon Flamm, Richard Kasdan, Douglas I. Katz, L.P. Chandler, R. T. Clegg, H Duncan, J. Moutz, Jay R. Harris, C. Gautier, L. Champ, Victoria Louise Reid, C. Ravella, Pradeep Garg, Christopher W. Jones, Karen Pulford, Maria DeSantis, T. Annas, Carol Moore, J Kunze, Pramod Kumar Garg, Jennifer Lail, Katharine A. Kirby, C. Doherr, Juliet N. Barker, X. Wang, Sebastian Berg, Gary A. Rosenberg, Michèle Campopiano, L. Dobkin, S. Richard-Aasen, Jérôme Champ, Chris Dutka, Marina Celanovic, Jared Minkel, John Wilson, N. Belt,
Objective: To evaluate the effects of bapineuzumab on brain β-amyloid (Aβ) burden using 11 C-Pittsburgh compound B ( 11 C-PiB)-PET. Methods: Two phase 3 clinical trials, 1 each in apolipoprotein APOE ε4 carriers and noncarriers, were conducted in patients with mild to moderate Alzheimer disease dementia. Bapineuzumab, an anti-Aβ monoclonal antibody, or placebo, was administered by IV infusion every 13 weeks for 78 weeks. PET substudies assessed change in brain fibrillar Aβ over 71 weeks using an 11 C-PiB-PET ...
Lippincott Williams & Wilkins
Robert J. Simpson, Andrew T. McKie,
... et al., 2009Zhang D.L. Hughes R.M. Ollivierre-Wilson H. Ghosh M.C. Rouault T.A. ... paper, Mastrogiannaki et al., 2009Mastrogiannaki M. Matak P. Keith B. Simon M.C. Vaulont S. Peyssonnaux C. ...
Tópico(s): Folate and B Vitamins Research
2009 - Cell Press | Cell Metabolism