Rika Kosaki, Toshiki Takenouchi, Noriko Takeda, Masayo Kagami, Kazuhiko Nakabayashi, Kenichiro Hata, Kenjiro Kosaki,
Simpson–Golabi–Behmel syndrome is a rare overgrowth syndrome caused by the GPC3 mutation at Xq26 and is clinically characterized by multiple congenital abnormalities, intellectual disability, pre/postnatal overgrowth, distinctive craniofacial features, macrocephaly, and organomegaly. Although this syndrome is known to be associated with a risk for embryonal tumors, similar to other overgrowth syndromes, the pathogenetic basis of this mode of tumorigenesis remains largely unknown. Here, we report ...
Tópico(s): Hedgehog Signaling Pathway Studies
2014 - Wiley | American Journal of Medical Genetics Part A
Toshiki Takenouchi, Rika Kosaki, Takahiro Niizuma, Kenichiro Hata, Kenjiro Kosaki,
The combinatory phenotype of thrombocytopenia and developmental delay has been described for two genetic conditions: a chromosome 11q deletion that is referred to as Jacobsen syndrome, and a 21q22 microdeletion syndrome. Herein, we report a young girl who presented with persistent macrothrombocytopenia and a developmental delay. Whole exome sequencing revealed a de novo amino acid substitution in CDC42, a critical regulator of the cytoskeleton. Our observation recapitulates observations in mice ...
Tópico(s): Blood properties and coagulation
2015 - Wiley | American Journal of Medical Genetics Part A
Keisuke Ohno, Hidefumi Nishimori, Takahiro Yasoshima, Kenjiro Kamiguchi, Fumitake Hata, Rika Fukui, Koichi Okuya, Yasutoshi Kimura, Ryuichi Denno, Shigeyuki Kon, Toshimitsu Uede, Noriyuki Sato, Koichi Hirata,
Tópico(s): Oral and Maxillofacial Pathology
2010 - Springer Science+Business Media | Surgery Today
Akiharu Kubo, Aiko Shiohama, Takashi Sasaki, Kazuhiko Nakabayashi, Hiroshi Kawasaki, Toru Atsugi, Showbu Sato, Atsushi Shimizu, Shuji Mikami, Hideaki Tanizaki, M Uchiyama, Tatsuo Maeda, Taisuke Ito, Jun‐ichi Sakabe, Toshio Heike, Torayuki Okuyama, Rika Kosaki, Kenjiro Kosaki, Jun Kudoh, Kenichiro Hata, Akihiro Umezawa, Y. Tokura, Akira Ishiko, Hironori Niizeki, Kenji Kabashima, Yoshihiko Mitsuhashi, Masayuki Amagai,
"Nagashima-type" palmoplantar keratosis (NPPK) is an autosomal recessive nonsyndromic diffuse palmoplantar keratosis characterized by well-demarcated diffuse hyperkeratosis with redness, expanding on to the dorsal surfaces of the palms and feet and the Achilles tendon area. Hyperkeratosis in NPPK is mild and nonprogressive, differentiating NPPK clinically from Mal de Meleda. We performed whole-exome and/or Sanger sequencing analyses of 13 unrelated NPPK individuals and identified biallelic putative ...
Tópico(s): Dermatologic Treatments and Research
2013 - Elsevier BV | The American Journal of Human Genetics
Jun Onagi, Toru Komatsu, Yuki Ichihashi, Yugo Kuriki, Mako Kamiya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Tetsuo Nagano, Yasuteru Urano,
Cellular homeostasis is maintained by a complex network of reactions catalyzed by enormous numbers of enzymatic activities (the enzymome), which serve to determine the phenotypes of cells. Here, we focused on the enzymomics of proteases and peptidases because these enzymes are an important class of disease-related proteins. We describe a system that (A) simultaneously evaluates metabolic activities of peptides using a series of exogenous peptide substrates and (B) identifies the enzymes that metabolize ...
Tópico(s): Glycosylation and Glycoproteins Research
2017 - American Chemical Society | Journal of the American Chemical Society
Haruki Senoo, Ryu‐Ichiro Hata, Yutaka Nagai, Kenjiro Wake,
A cell fraction enriched with lipid droplet-containing cells (perisinusoidal stellate cells, vitamin A-storing cells, or fat-storing cells), and freed from contamination of parenchymal cells, was prepared by low speed centrifugation followed by Percoll density gradient centrifugation. Cells in this fraction were found to take up and store the largest amount of vitamin A per cell among the liver cells including parenchymal cells, when [3H]retinol was injected through the portal vein of rats. Analysis ...
Tópico(s): Liver physiology and pathology
1984 - Allied Academies | Biomedical Research
Harumi Fujita, Takashi Sasaki, Tatsuo Miyamoto, Silvia Natsuko Akutsu, Showbu Sato, Takehiko Mori, Kazuhiko Nakabayashi, Kenichiro Hata, Hisato Suzuki, Kenjiro Kosaki, Shinya Matsuura, Yoichi Matsubara, Masayuki Amagai, Akiharu Kubo,
Abstract Damage to the genome can accelerate aging. The percentage of aneuploid cells, that is, cells with an abnormal number of chromosomes, increases during aging; however, it is not clear whether increased aneuploidy accelerates aging. Here, we report an individual showing premature aging phenotypes of various organs including early hair loss, atrophic skin, and loss of hematopoietic stem cells; instability of chromosome numbers known as mosaic variegated aneuploidy (MVA); and spindle assembly ...
Tópico(s): Genomics and Chromatin Dynamics
2020 - Wiley | Aging Cell
Takeshi Itoh, Yuko Hata, Hitomi Nishinakamura, Kenjiro Kumano, Hiroyuki Takahashi, Shohta Kodama,
Abstract Background Clinical allogeneic islet transplantation has become an attractive procedure for type 1 diabetes mellitus treatment. However, there is a severe shortage of human donors. Microencapsulated neonatal porcine islet ( NPI ) xenotransplantation may be an alternative transplantation procedure. Currently, the efficacy of microencapsulated NPI xenotransplantation into the peritoneal cavity is limited because of early non‐function resulting from inflammation, which is a serious hindrance to ...
Tópico(s): Xenotransplantation and immune response
2016 - Wiley | Xenotransplantation
Yukitaka Tanaka, Hideaki Imai, Kenjiro Konno, Takaaki Miyagishima, Chisato Kubota, Sandra Puentes, Takeo Aoki, Hidekazu Hata, Kuniaki Takata, Yuhei Yoshimoto, Nobuhito Saito,
Background and Purpose— Lacunar infarction accounts for 25% of ischemic strokes, but the pathological characteristics have not been investigated systematically. A new experimental model of lacunar infarction in the miniature pig was developed to investigate the pathophysiological changes in the corticospinal tract from the acute to chronic phases. Methods— Thirty-five miniature pigs underwent transcranial surgery for permanent anterior choroidal artery occlusion. Animals recovered for 24 hours (n= ...
Tópico(s): Glaucoma and retinal disorders
2007 - Lippincott Williams & Wilkins | Stroke
Takayuki Kondo, Norikazu Hara, Satoshi Koyama, Yuichiro Yada, Kayoko Tsukita, Ayako Nagahashi, Takeshi Ikeuchi, Kenji Ishii, Takashi Asada, Tetsuaki Arai, Ryo Yamada, Michael W. Weiner, Paul Aisen, Ronald C. Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John C. Morris, Leslie M. Shaw, Jeffrey Kaye, Joseph F. Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James B. Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne Lord, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva‐Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau M. Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik D. Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo‐Morrell, Ranjan Duara, Daniel Varón, Maria T. Greig, Peggy Roberts, Marilyn Albert, Chiadi U. Onyike, Daniel D’Agostino, Stephanie Kielb, James E. Galvin, Brittany Cerbone, Christina A. Michel, Dana M. Pogorelec, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges‐Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Gregory A. Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana G. Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po H. Lu, George Bartzokis, Neill R. Graff‐Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Cynthia Hunt, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Curtis Caldwell, Ging‐Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Diana Kerwin, Chuang‐Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Jerome A. Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil W. Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan J. Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T.-Y. Lee, Robert Bartha, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Pierre N. Tariot, Anna Burke, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David C. Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Z. Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Takeshi Iwatsubo, Takashi Asada, Hiroyuki Arai, Morihiro Sugishita, Hiroshi Matsuda, Kengo Ito, Michio Senda, Kenji Ishii, Ryozo Kuwano, Takeshi Ikeuchi, Noriko Sato, Hajime Sato, Shun Shimohama, Masaki Saitoh, Rika Yamauchi, Takashi Hayashi, Seiju Kobayashi, Norihito Nakano, Junichiro Kanazawa, Takeshi Ando, Chiyoko Takanami, Masato Hareyama, Masamitsu Hatakenaka, Eriko Tsukamoto, Shinji Ochi, Mikio Shoji, Etsuro Matsubara, Takeshi Kawarabayashi, Yasuhito Wakasaya, Takashi Nakata, Naoko Nakahata, Shuichi Ono, Yoshihiro Takai, Satoshi Takahashi, Hisashi Yonezawa, Junko Takahashi, Masako Kudoh, Makoto Sasaki, Yutaka Matsumura, Yohsuke Hirata, Tsuyoshi Metoki, Susumu Hayakawa, Yuichi Sato, Masayuki Takeda, Toshiaki Sasaki, K. Sera,
Genome-wide association studies have demonstrated that polygenic risks shape Alzheimer's disease (AD). To elucidate the polygenic architecture of AD phenotypes at a cellular level, we established induced pluripotent stem cells from 102 patients with AD, differentiated them into cortical neurons and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ). Using such a cellular dissection of polygenicity (CDiP) approach, we identified 24 significant genome-wide loci associated with ...
Nature Portfolio
Toshiki Takenouchi, Rika Kosaki, Kazuhiko Nakabayashi, Kenichiro Hata, Takao Takahashi, Kenjiro Kosaki,
The juvenile form of GM1 gangliosidosis lacks specific physical findings and thus is often a diagnostic challenge for clinicians. T2 hypodensity in the globus pallidus is a characteristic radiographic sign of neurodegeneration with iron accumulation in the brain that is observed in GM1 gangliosidosis, but the exact timing when this radiographic sign becomes apparent remains to be elucidated.Two male siblings had normal development until 2 years of age and then developed psychomotor regression with ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2014 - Elsevier BV | Pediatric Neurology
Kenjiro Koga, Akira Kaji, Kenichi HIROSAKI, Yukako Hata, Tsutomu Ogura, Osamu Fujishita, Kazuhiro Shintani,
The aim of this study was to evaluate the cytotoxicity of cubic boron nitride (cBN), a component of surgical cutting tools. The small quantities of cBN that typically remain on implants as a result of the manufacturing process may act as abrasives, injuring tissues surrounding the implant. To determine how cBN affects cells, we treated human neuroblastoma cells (NB-1) and human articular chondrocytes (nHAC-kn) with different concentrations of cBN powder and assessed cell growth and cell survival using ...
Tópico(s): Orthopaedic implants and arthroplasty
2006 - Elsevier BV | Toxicology in Vitro
Hideharu Okanobu, Jiro Hata, Ken Haruma, Mutsuhiro Hara, Kenjiro Nakamura, Shinji Tanaka, Kazuaki Chayama,
To evaluate ultrasonographic (US) features in the differential diagnosis of giant gastric folds.One hundred sixty-five patients with giant gastric folds at transabdominal US examination (five with Ménétrier disease, 24 with anisakiasis, 61 with acute gastric mucosal lesion [AGML], 13 with gastric lymphoma, and 62 with scirrhous carcinoma) were examined. With 3-6-MHz curved and 5-11-MHz linear-array transducers, the authors evaluated gastric wall thickness, wall stratification, main thickened layer, ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2003 - Radiological Society of North America | Radiology
Akiharu Kubo, Takashi Sasaki, Hisato Suzuki, Aiko Shiohama, Satomi Aoki, Showbu Sato, Harumi Fujita, Noriko Ono, Noriko Umegaki‐Arao, Tomoko Kawai, Kazuhiko Nakabayashi, Kenichiro Hata, Daisuke Yamada, Yoichi Matsubara, Kenjiro Kosaki, Masayuki Amagai,
Patients with disseminated superficial actinic porokeratosis (DSAP) and linear porokeratosis (LP) exhibit monoallelic germline mutations in genes encoding mevalonate pathway enzymes, such as MVD or MVK. Here, we showed that each skin lesion of DSAP exhibited an individual second hit genetic change in the wild-type allele of the corresponding gene specifically in the epidermis, indicating that a postnatal second hit triggering biallelic deficiency of the gene is required for porokeratosis to develop. ...
Tópico(s): Genetic and rare skin diseases.
2019 - Elsevier BV | Journal of Investigative Dermatology
Mitsunobu Nakamura, Hideaki Imai, Kenjiro Konno, Chisato Kubota, Koji Seki, Sandra Puentes, Ahmad Faried, Hideaki Yokoo, Hidekazu Hata, Yuhei Yoshimoto, Nobuhito Saito,
Object Encephalomyosynangiosis (EMS) is a surgical treatment for moyamoya disease that is widely used to provide increased intracranial blood flow via revascularization by arterial anastomosis from the external carotid artery. However, the angiogenic mechanism responsible for the revascularization induced by EMS has not been systematically evaluated. In this study the authors investigated the chronological angiogenic changes associated with EMS to clarify the favorable factors and identify revascularization ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2009 - | Journal of Neurosurgery Pediatrics
Hiroshi Yoshihashi, Katsuhiro Maeyama, Rika Kosaki, Tsutomu Ogata, Masato Tsukahara, Yu-ichi Goto, Jun-ichi Hata, Nobutake Matsuo, Robert J. Smith, Kenjiro Kosaki,
Documentation of maternal uniparental disomy of chromosome 7 in 10% of patients with Russell-Silver syndrome (RSS), characterized by prenatal and postnatal growth retardation and dysmorphic features, has suggested the presence of an imprinted gene on chromosome 7 whose mutation is responsible for the RSS phenotype. Human GRB10 on chromosome 7, a homologue of the mouse imprinted gene Grb10, is a candidate, because GRB10 has a suppressive effect on growth, through its interaction with either the IGF- ...
Tópico(s): Epigenetics and DNA Methylation
2000 - Elsevier BV | The American Journal of Human Genetics
Masaaki Yamamoto, Toshihiko Torigoe, Kenjiro Kamiguchi, Yoshihiko Hirohashi, Katsuya Nakanishi, Chika Nabeta, Hiroko Asanuma, Tetsuhiro Tsuruma, Takashi Sato, Fumitake Hata, Tousei Ohmura, Koji Yamaguchi, Takehiro Kurotaki, Koichi Hirata, Noriyuki Sato,
Abstract Caspase-associated recruitment domains (CARD) are protein-protein interaction modules found extensively in proteins that play important roles in apoptosis. One of the CARD-containing proteins, TUCAN (CARD8), was reported previously as an antiapoptotic protein with a molecular weight of 48 kDa, which was up-regulated in colon cancer cells. We identified a novel isoform of TUCAN with a molecular weight of 54 kDa. The new variant of TUCAN, termed TUCAN-54, was expressed in gastric, colon, and ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2005 - American Association for Cancer Research | Cancer Research
Ritsuko Harigai, Shigeki Sakai, Hiroyuki Nobusue, Chikako Hirose, Oltea Sampetrean, Noriaki Minami, Yukie Hata, Takashi Kasama, Takanori Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Kazuo Kishi, Hideyuki Saya, Yoshimi Arima,
Neurofibromatosis type 1 (NF1) is caused by germline mutations in the NF1 gene and is characterized by café au lait spots and benign tumours known as neurofibromas. NF1 encodes the tumour suppressor protein neurofibromin, which negatively regulates the small GTPase Ras, with the constitutive activation of Ras signalling resulting from NF1 mutations being thought to underlie neurofibroma development. We previously showed that knockdown of neurofibromin triggers epithelial-mesenchymal transition (EMT) ...
Tópico(s): Melanoma and MAPK Pathways
2018 - Nature Portfolio | Scientific Reports
Shinya Yamamoto, Takaaki Ito, Taku Aizawa, Kenjiro Noda, KIYOKAZU UMEZU, NORIHIKO OHTSURU, Kenichi Hata,
Abstract Background: To investigate retrospectively whether the eight‐core biopsy method improves the prostate cancer detection rate when compared with the standard sextant biopsy method in patients with prostate specific antigen (PSA) levels of 4.1–10 ng/mL. Material and methods: Of 437 patients whose PSA levels ranged from 4.1 to 10 ng/mL, 237 underwent a transrectal ultrasound guided sextant biopsy (sextant group), and 200 underwent an eight‐core biopsy (eight‐core group). Eight core samples were ...
Tópico(s): Urologic and reproductive health conditions
2004 - Wiley | International Journal of Urology
Hideaki Imai, Kenjiro Konno, Mitsunobu Nakamura, Tatsuya Shimizu, Chisato Kubota, Koji Seki, Fumiaki Honda, Shinichiro Tomizawa, Yukitaka Tanaka, Hidekazu Hata, Nobuhito Saito,
The purpose of this set of studies is to design a minimally invasive, reproducible stroke model in the gyrencephalic brain. This paper provides information on both surgical technique and methods of quantification of ischemic damage to both gray and white matter in the miniature pig.Sixteen male miniature pigs were randomly divided into three groups and underwent transcranial surgery involving a frontotemporal approach with orbital rim osteotomy for permanent middle cerebral artery occlusion (MCAO; ...
Tópico(s): Acute Ischemic Stroke Management
2006 - | Journal of Neurosurgery Pediatrics
Hideaki Imai, Kenjiro Konno, Mitsunobu Nakamura, Tatsuya Shimizu, Chisato Kubota, Koji Seki, Fumiaki Honda, Shinichiro Tomizawa, Yukitaka Tanaka, Hidekazu Hata, Nobuhito Saito,
Object The purpose of this set of studies is to design a minimally invasive, reproducible stroke model in the gyrencephalic brain. This paper provides information on both surgical technique and methods of quantification of ischemic damage to both gray and white matter in the miniature pig. Methods Sixteen male miniature pigs were randomly divided into three groups and underwent transcranial surgery involving a frontotemporal approach with orbital rim osteotomy for permanent middle cerebral artery ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2006 - | Journal of Neurosurgery Pediatrics
Koji Haratani, Atsushi Nakamura, Nobuaki Mamesaya, Kenji Sawa, Yasuto Yoneshima, Ryota Saito, Tomohiro Ozaki, Kenjiro Tsuruoka, Akito Hata, Kosuke Tsuruno, Tomohiro Sakamoto, Shunsuke Teraoka, Masahide Oki, Hiroshi Watanabe, Tomoyuki Otani, Kazuko Sakai, Shuta Tomida, Yasutaka Chiba, Akihiko Ito, Kazuto Nishio, Nobuyuki Yamamoto, Kazuhiko Nakagawa, Hidetoshi Hayashi,
... Kenji Sawa, Yasuto Yoneshima, Ryota Saito, Tomohiro Ozaki, Kenjiro Tsuruoka, Akito Hata, Kosuke Tsuruno, Tomohiro Sakamoto, Shunsuke Teraoka, Masahide Oki, ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2023 - American Association for Cancer Research | Cancer Research
Hidefumi Nishimori, Takahiro Yasoshima, Fumitake Hata, Ryuichi Denno, Y Yanai, Hiroki Nomura, Hiroshi Tanaka, Kenjiro Kamiguchi, Noriyuki Sato, Koichi Hirata,
Recently, several mice models have been used for investigating cancer metastasis. However, there are no metastatic and peritoneal dominated variants from the same parental cell line.To elucidate the mechanisms of metastasis, we established highly liver metastatic and peritoneal disseminated models in nude mice, and then characterized several factors related to metastasis in these cells. We established a series of well-characterized sublines that showed metastatic potentials to different organ sites ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2002 - Lippincott Williams & Wilkins | Pancreas
Yūji Takahashi, Hidetoshi Date, Hideki Oi, Takeya Adachi, Noriaki Imanishi, En Kimura, Hotake Takizawa, Shinji Kosugi, Naomichi Matsumoto, Kenjiro Kosaki, Yoichi Matsubara, Yukio Ando, Toshihisa Anzai, Tadashi Ariga, Yoshimitsu Fukushima, Yoshihiko Furusawa, Akira Ganaha, Yu‐ichi Goto, Kenichiro Hata, Masataka Honda, Kazumoto Iijima, Tsunakuni Ikka, Issei Imoto, Tadashi Kaname, Masao Kobayashi, Seiji Kojima, Hiroki Kurahashi, Shigeo Kure, Kenji Kurosawa, Yoshihiro Maegaki, Yoshio Makita, Tomohiro Morio, Ichiei Narita, Fumio Nomura, Tsutomu Ogata, Keiichi Ozono, Akira Oka, Nobuhiko Okamoto, Shinji Saitoh, Akihiro Sakurai, Fumio Takada, Tsutomu TAKAHASHI, Akira Tamaoka, Akihiro Umezawa, Akihiro Yachie, Kouichiro Yoshiura, Yasutsugu Chinen, Mariko Eguchi, Keishi Fujio, Kiminori Hosoda, Tomohiko Ichikawa, Toshitaka Kawarai, Tomoki Kosho, Mitsuo Masuno, Akie Nakamura, Takaya Nakane, Tomoo Ogi, Satoshi Okada, Yasushi Sakata, Toshiyuki Seto, Yoshiyuki Takahashi, Tadao Takano, Mitsuharu Ueda, Hideaki Yagasaki, Toshiyuki Yamamoto, Atsushi Watanabe, Yoshihiro Hotta, Akiharu Kubo, Hirofumi Maruyama, Keiji Moriyama, Eiji Nanba, Norio Sakai, Yoshiki Sekijima, Toru Shimosegawa, Tsutomu Takeuchi, Shin‐ichi Usami, Kazuhiko Yamamoto, Hidehiro Mizusawa,
The identification of causative genetic variants for hereditary diseases has revolutionized clinical medicine and an extensive collaborative framework with international cooperation has become a global trend to understand rare disorders. The Initiative on Rare and Undiagnosed Diseases (IRUD) was established in Japan to provide accurate diagnosis, discover causes, and ultimately provide cures for rare and undiagnosed diseases. The fundamental IRUD system consists of three pillars: IRUD diagnostic ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Springer Nature | Journal of Human Genetics
Hiroki Nomura, Hidefumi Nishimori, Takahiro Yasoshima, Fumitake Hata, Hiroshi Tanaka, Futoshi Nakajima, Toshio Honma, Jun Araya, Kenjiro Kamiguchi, Hiroshi Isomura, Noriyuki Sato, Ryuichi Denno, Koichi Hirata,
Tópico(s): Cancer Research and Treatments
2002 - Springer Science+Business Media | Clinical & Experimental Metastasis
Hiroki Nomura, Hidefumi Nishimori, Takahiro Yasoshima, Fumitake Hata, Katsuya Sogahata, Hiroshi Tanaka, Futoshi Nakajima, Shinichiro Ikeda, Kenjiro Kamiguchi, Hiroshi Isomura, Noriyuki Sato, Ryuichi Denno, Kouichi Hirata,
We established a new cell line, NUGC-3P4T, with high peritoneal metastatic disseminating potential in nude mice. NUGC-3P4T cells were derived from the human gastric carcinoma line NUGC-3, which has low capacity for peritoneal dissemination. NUGC-3P4T cells developed peritoneal dissemination in 10 / 10 (100%) mice, whereas the parental NUGC-3 cells developed dissemination in 1 / 5 (20.0%) mice. The metastatic foci in the peritoneum showed essentially the same histological appearance as those induced by ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2001 - Oxford University Press | Japanese Journal of Cancer Research
Sonoko Saito, Yuki Saito, Showbu Sato, Satomi Aoki, Harumi Fujita, Yoshihiro Ito, Noriko Ono, Takeru Funakoshi, Tomoko Kawai, Hisato Suzuki, Takashi Sasaki, Tomoyo Tanaka, Masukazu Inoie, Kenichiro Hata, Keisuke Kataoka, Kenjiro Kosaki, Masayuki Amagai, Kazuhiko Nakabayashi, Akiharu Kubo,
Porokeratosis is a clonal keratinization disorder characterized by solitary, linearly arranged, or generally distributed multiple skin lesions. Previous studies showed that genetic alterations in MVK, PMVK, MVD, or FDPS—genes in the mevalonate pathway—cause hereditary porokeratosis, with skin lesions harboring germline and lesion-specific somatic variants on opposite alleles. Here, we identified non-hereditary porokeratosis associated with epigenetic silencing of FDFT1, another gene in the mevalonate ...
Tópico(s): Cancer and Skin Lesions
2024 - Elsevier BV | The American Journal of Human Genetics
Kohei Fujita, Osamu Kanai, Hiroaki Hata, Kenjiro Ishigami, Kazutaka Nanba, Naoki Esaka, Koichi Seta, Tadashi Mio, Takao Odagaki,
Molnupiravir is being widely used as a treatment for coronavirus disease 2019 (COVID-19); however, its acceptability and safety in older patients aged ≥ 80 years in real-world clinical practice is not well understood.We conducted a single-centre retrospective study and assessed the outcome of patients with COVID-19 treated with molnupiravir according to the following criteria: (A) discontinuation rate of molnupiravir; (B) type, frequency, and severity of adverse events; (C) all-cause mortality within ...
Tópico(s): Respiratory viral infections research
2023 - Elsevier BV | Aging and Health Research
Kimiko Nakajima, Hisato Suzuki, Mayuko Yamamoto, Tetsuya Yamamoto, Tomoko Kawai, Kazuhiko Nakabayashi, Kenichiro Hata, Kenjiro Kosaki, Hideki Nakajima, Shigetoshi Sano, Akiharu Kubo,
Abstract Periodontal Ehlers–Danlos syndrome (pEDS) is an autosomal‐dominant disorder first described by Stewart in 1977 that is characterized by severe gingival recession and periodontitis that triggers premature loss of permanent teeth and alveolar bone absorption. It was recently shown that pEDS is caused by a heterozygous missense mutation in C1R or C1S , which encode complement 1 proteases. Here, we report a familial case of pEDS with a novel heterozygous missense mutation, c.674G>C (p.R225P), ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2022 - Wiley | The Journal of Dermatology
Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun‐ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Toshiharu Ninomiya, Jun Hata, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Masato Akiyama, Shigeyuki Nakaji, Koichi Murashita, Tatsuya Mikami, Songee Jung, Mina Misawa, Tetsuya Maeda, Naoki Ishizuka, Hiroshi Akasaka, Yasuo Terayama, Hisashi Yonezawa, Junko Takahashi, Kenjiro Ono, Moeko Noguchi‐Shinohara, Junji Komatsu, Shutaro Shibata, Sohshi Yuki-Nozaki, Masaru Mimura, Shogyoku Bun, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Kenji Nakashima, Yasuyo Fukada, Hisanori Kowa, Toshiya Nakano, Kenji Wada, Masafumi Kishi, Tomoki Ozaki, Ayumi Tachibana, Yuta Yoshino, Jun-ichi Iga Shu-ichi Ueno, Minoru Takebayashi, Tomohisa Ishikawa, Seiji Yuki, Asuka Koyama, Naoto Kajitani, Mamoru Hashimoto, Manabu Ikeda, Yoshihiro Kokubo, Kazuhiro Uchida, Midori Esaki, Yasuyuki Taki, Yasuko Tatewaki, Benjamin Thyreau, Koji Yonemoto, Hisako Yoshida, Kaori Muto, Yusuke Inoue, Izen Ri, Yukihide Momozawa, Chikashi Terao, Michiaki Kubo, Yutaka Kiyohara,
Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese.Population- ...
Tópico(s): Nutritional Studies and Diet
2022 - Elsevier BV | Kidney Medicine