Sota Asaga, Takayuki Kinoshita, Takashi Hojo, Junko Suzuki, Kenjiro Jimbo, Hitoshi Tsuda,
Tópico(s): Cancer Cells and Metastasis
2012 - Elsevier BV | Clinical Breast Cancer
Yasunari Ando, Tomoki Sugihara, Kenjiro Kimura, Akihiko Tsuda,
An anthracene derivative, having benzamide substituents bearing optically active alkyl chains, in hexane forms one-handedly biased helical supramolecular nanofibres, which show unequal linear dichroism (LD) in right- and left-handed vortex flows.
Tópico(s): Supramolecular Self-Assembly in Materials
2011 - Royal Society of Chemistry | Chemical Communications
Takashi Shigekawa, Nobuhiro Ijichi, Kazuhiro Ikeda, Kuniko Horie‐Inoue, Chikako Shimizu, Shigehira Saji, Kenjiro Aogi, Hitoshi Tsuda, Akihiko Osaki, Toshiaki Saeki, Satoshi Inoue,
Breast cancer is primarily a hormone-dependent tumor that can be regulated by the status of steroid hormones, including estrogen and progesterone. Forkhead box P1 (FOXP1) is a member of the forkhead box transcription factor family and has been reported to be associated with various types of tumors. In the present study, we investigated the expression of FOXP1 in 133 human invasive breast cancers, obtained by core biopsy, by immunohistochemical analysis. Nuclear immunoreactivity of FOXP1 was detected ...
Tópico(s): FOXO transcription factor regulation
2011 - Springer Science+Business Media | Hormones and Cancer
Tetsuya Noguchi, Takashi Matozaki, Kenjiro Inagaki, Masahiro Tsuda, Kaoru Fukunaga, Yukari Kitamura, Tadahiro Kitamura, Kozui Shii, Yuji Yamanashi, Masato Kasuga,
Tópico(s): Cell Adhesion Molecules Research
1999 - Springer Nature | The EMBO Journal
Jun’ichi Kobayashi, Kenjiro Inaba, Masashi Tsuda,
Two new bromopyrrole alkaloids, tauroacidins A (1) and B (2), with tyrosine kinase inhibitory activity have been isolated from an Okinawan marine sponge Hymeniacidon sp. and the structures were elucidated on the basis of spectral data and chemical means. Tauroacidins A (1) and B (2) are rare bromopyrrole alkaloids possessing a taurine residue.
Tópico(s): Synthesis and Reactions of Organic Compounds
1997 - Elsevier BV | Tetrahedron
Nobuhiro Ijichi, Takashi Shigekawa, Kazuhiro Ikeda, Kuniko Horie‐Inoue, Chikako Shimizu, Shigehira Saji, Kenjiro Aogi, Hitoshi Tsuda, Akihiko Osaki, Toshiaki Saeki, Satoshi Inoue,
Breast cancer is primarily a hormone-dependent tumor that can be regulated by the status of the steroid hormones estrogen and progesterone. Forkhead box A1 (FOXA1) is a member of the forkhead box transcription factor family and functions as a pioneer factor of the estrogen receptor (ER) in breast cancer. In the present study, we demonstrate that FOXA1 mRNA was upregulated by estrogen and that estrogen receptor-α (ERα) recruitment to ER-binding sites in the vicinity of the FOXA1 gene was increased by ...
Tópico(s): Cancer Cells and Metastasis
2012 - Springer Science+Business Media | Hormones and Cancer
Ryota Tanaka, Yuko Sasajima, Hitoshi Tsuda, Kenjiro Namikawa, Akira Takahashi, Arata Tsutsumida, Yasuhiro Fujisawa, Manabu Fujimoto, Naoya Yamazaki,
Tópico(s): Nonmelanoma Skin Cancer Studies
2016 - Springer Science+Business Media | Clinical & Experimental Metastasis
Ryota Tanaka, Yuko Sasajima, H. Tsuda, Kenjiro Namikawa, Arata Tsutsumida, Fuminori Otsuka, Naoya Yamazaki,
Background Several recent studies have reported on the overexpression of human epidermal growth factor receptor (HER)2 in extramammary Paget disease (EMPD). However, there are only a few cases in which both overexpression and gene amplification of HER2 have been examined. Objectives To evaluate the overexpression and gene amplification of HER2 using a standardized method with a large number of cases of EMPD. Methods Immunohistochemically, the overexpression of the HER2 protein was examined in 104 ...
Tópico(s): Hedgehog Signaling Pathway Studies
2013 - Oxford University Press | British Journal of Dermatology
Masashi Tsuda, Kenjiro Inaba, Naoko Kawasaki, Kaori Honma, Jun’ichi Kobayashi,
Both enantiomers of keramaphidin B (1) were separated by using chiral HPLC, of which one may be a plausible biogenetic precursor of ircinals A (4) and B (5) and manzamines A (2) and B (3), while the other may be associated with antipodes of manzamine alkaloids such as ircinols A (6) and B (7). Isolation and structure elucidation of a new manzamine congener, manzamine L (8), and absolute configurations at C-1 of 8 and manzamines D (10) and H (9) deduced from the Cotton effects are also described.
Tópico(s): Chemical synthesis and alkaloids
1996 - Elsevier BV | Tetrahedron
Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, K. Ishíbashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda, Yasuyuki Ishibashi,
Abstract Background Osteoarthritis (OA) is one of the costliest and most disabling forms of arthritis, and it poses a major public health burden; however, its detailed etiology, pathophysiology, and metabolism remain unclear. Therefore, the purpose of this study was to investigate the key plasma metabolites and metabolic pathways, especially focusing on radiographic OA severity and synovitis, from a large sample cohort study. Methods We recruited 596 female volunteers who participated in the Iwaki ...
Tópico(s): Gout, Hyperuricemia, Uric Acid
2022 - BioMed Central | Arthritis Research & Therapy
Kenjiro Inaba, Hiroyasu Sato, Masashi Tsuda, Jun’ichi Kobayashi,
Four new bromopyrrole alkaloids, spongiacidins A-D (1-4), have been isolated from an Okinawan marine sponge Hymeniacidon sp. and the structures elucidated on the basis of spectral data and chemical means.
Tópico(s): Microbial Natural Products and Biosynthesis
1998 - American Chemical Society | Journal of Natural Products
Nobuhiro Ijichi, Takashi Shigekawa, Kazuhiro Ikeda, Toshiaki Miyazaki, Kuniko Horie‐Inoue, Chikako Shimizu, Shigehira Saji, Kenjiro Aogi, Hitoshi Tsuda, Akihiko Osaki, Toshiaki Saeki, Satoshi Inoue,
Abstract Introduction Breast cancer is primarily a hormone-dependent tumor that is regulated by the status of the estrogen and progesterone receptors. We previously identified EBAG9 as an estrogen-responsive gene in MCF-7 human breast carcinoma cells. Upregulation of EBAG9 expression has been observed in several malignant tumors such as advanced breast cancers, indicating that EBAG9 might contribute to tumor progression. Patients and Methods In the present study, we generated a monoclonal antibody against ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2013 - Elsevier BV | Clinical Breast Cancer
Junichi Kurebayashi, Naoki Kanomata, Toshiro Shimo, Tetsumasa Yamashita, Kenjiro Aogi, Rieko Nishimura, Chikako Shimizu, Hitoshi Tsuda, Takuya Moriya, Hiroshi Sonoo,
Tópico(s): Estrogen and related hormone effects
2012 - Springer Science+Business Media | Breast Cancer
Sho Shiino, Takayuki Kinoshita, Masayuki Yoshida, Kenjiro Jimbo, Sota Asaga, Shin Takayama, Hitoshi Tsuda,
Recent retrospective studies have reported discordance rate of hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) statuses between primary and recurrent tumors and prognostic values of discordance. However, the results of these reports may possibly include analytical error.We analyzed 153 patients from whom pathological specimens of tumor tissues were available from both primary and recurrent sites. For all specimens, immunohistochemistry was performed for these statuses with ...
Tópico(s): Estrogen and related hormone effects
2016 - Elsevier BV | Clinical Breast Cancer
Sho Shiino, Hitoshi Tsuda, Masayuki Yoshida, Kenjiro Jimbo, Sota Asaga, Takashi Hojo, Takayuki Kinoshita,
Intraductal papillary lesions of the breast constitute a heterogeneous entity, including benign intraductal papilloma ( IDP ) with or without atypia and malignant papillary carcinoma. Differentiating between these diagnoses can be challenging. We re‐evaluated core biopsy specimens that were diagnosed as IDP and the corresponding surgical excision specimens, and assessed the potential risk for the diagnosis to be modified to malignancy based on excision. By sorting the pathology database of the National ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2015 - Wiley | Pathology International
Yuya Sato, Takayuki Kinoshita, Junko Suzuki, Kenjiro Jimbo, Sota Asaga, Takashi Hojo, Masayuki Yoshida, Hitoshi Tsuda,
Tópico(s): Colorectal Cancer Surgical Treatments
2015 - Springer Science+Business Media | Breast Cancer
Kenjiro Inagaki, Tetsuya Noguchi, Takashi Matozaki, Tatsuya Horikawa, Kaoru Fukunaga, Masahiro Tsuda, Masamitsu Ichihashi, Masato Kasuga,
SHP-2, a SRC homology 2 domain-containing protein tyrosine phosphatase, mediates activation of Ras and mitogen-activated protein kinase by various mitogens and cell adhesion. Inhibition of endogenous SHP-2 by overexpression of a catalytically inactive (dominant negative) mutant in Chinese hamster ovary cells or Rat-1 fibroblasts has now been shown to induce a marked change in cell morphology (from elongated to less polarized) that is accompanied by substantial increases in the numbers of actin stress ...
Tópico(s): Cell Adhesion Molecules Research
2000 - Springer Nature | Oncogene
Hasuka Kanno, Shuji Moriguchi, Yuto Tsuda, Ikumasa Yoshida, Shoji Iwanaga, Kenjiro Terada,
The purpose of this study is to introduce a novel framework that aids in the installation of rockfall protection structures for the risk reduction of rockfall-related damage. In this study, we propose a computational method that performs risk analysis for a road and plans an optimal arrangement of rockfall protection structures. First, a rockfall trajectory simulation is performed using a three-dimensional numerical analysis method to obtain sufficient data for risk analysis. Then, the risk to motorized ...
Tópico(s): Dam Engineering and Safety
2023 - Elsevier BV | Engineering Geology
Taizo Hirata, Kan Yonemori, Masashi Ando, Akihiro Hirakawa, Hitoshi Tsuda, Tadashi Hasegawa, Hirokazu Chuman, Kenjiro Namikawa, Naoya Yamazaki, Yasuhiro Fujiwara,
The purpose of this study was to evaluate the efficacy of taxane regimens in patients with metastatic angiosarcoma. Forty-one patients with metastatic angiosarcoma treated at the National Cancer Center Hospital between January 1982 and January 2009 were retrospectively classified into 3 groups according to the treatment type: (i) taxane (n=11), (ii) non-taxane (n=14), and (iii) best supportive care (BSC; n=16) groups. The taxane group received paclitaxel (n=6), docetaxel (n=4), or albumin-bound paclitaxel ( ...
Tópico(s): Sarcoma Diagnosis and Treatment
2011 - John Libbey Eurotext | European Journal of Dermatology
Tetsuya Noguchi, Masahiro Tsuda, Hitoshi Takeda, Toshiyuki Takada, Kenjiro Inagaki, Takuji Yamao, Kaoru Fukunaga, Takashi Matozaki, Masato Kasuga,
SAP-1 (stomach cancer-associated protein-tyrosine phosphatase-1) is a transmembrane-type protein-tyrosine phosphatase that is abundant in the brain and certain cancer cell lines. With the use of a "substrate-trapping" approach, p130cas, a major focal adhesion-associated phosphotyrosyl protein, has now been identified as a likely physiological substrate of SAP-1. Expression of recombinant SAP-1 induced the dephosphorylation of p130cas as well as that of two other components of the integrin-signaling ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2001 - Elsevier BV | Journal of Biological Chemistry
Sadahiro Amemori, Hiro‐o Yamano, Yoshihito Tanaka, Kenjiro Yoshikawa, Hiro‐o Matsushita, Ryo Takagi, Eiji Harada, Yuko Yoshida, Kazunori Tsuda, Kato Bun'ichiro, Eri Tamura, Makoto Eizuka, Tamotsu Sugai, Yasushi Adachi, Eiichiro Yamamoto, Hiromu Suzuki, Hiroshi Nakase,
Based on the concept of the adenoma‐carcinoma sequence, most colorectal cancers are considered to arise from conventional adenomas. However, recent studies suggested that a subset of colorectal cancers develop through the serrated neoplastic pathway. It has also been documented that serrated polyps can rapidly transform into invasive cancers even when they are small in size. We now describe a case of a sessile serrated adenoma/polyp which had been followed up for 4 years but eventually showed rapid ...
Tópico(s): Colorectal Cancer Treatments and Studies
2019 - Wiley | Digestive Endoscopy
Kenjiro Jimbo, Takayuki Kinoshita, Junko Suzuki, Sota Asaga, Takashi Hojo, Masayuki Yoshida, Hitoshi Tsuda,
Clinical significance of intraoperative sentinel lymph node (SLN) metastases detection using one-step nucleic acid amplification (OSNA) has not been thoroughly investigated. The aim of this study was to assess the usefulness of using a combination of OSNA and conventional histological examinations.We included 772 consecutive patients with clinical node-negative cTis-cT3 primary breast cancer who underwent SLN biopsy with intraoperative OSNA and multi-section histological examination at our institution. ...
Tópico(s): Breast Implant and Reconstruction
2013 - Elsevier BV | The Breast
Daisuke Yotsumoto, Yasuaki Sagara, Hiraku Kumamaru, Naoki Niikura, Hiroaki Miyata, Chizuko Kanbayashi, Hitoshi Tsuda, Yutaka Yamamoto, Kenjiro Aogi, Makoto Kubo, Kenji Tamura, Naoki Hayashi, Minoru Miyashita, Takayuki Kadoya, Shigehira Saji, Masakazu Toi, Shigeru Imoto, Hiromitsu Jinno,
Tópico(s): Breast Implant and Reconstruction
2021 - Springer Science+Business Media | Breast Cancer
Shin-ichi Tsuda, Takashi Tokumasu, Kenjiro Kamijo,
The present study investigates bubble nucleation in liquid oxygen with dissolved impurities (nitrogen or helium molecules) using molecular dynamics simulations. When the mole fraction of impurities is 0.05, there is a fundamental difference in the bubble nucleation mechanism between the two dissolved impurities cases; vaporization in the homogeneous bulk makes a bubble in the case of a nitrogen-dissolved liquid while phase separation of impurities and liquid molecules makes a nucleus in the case ...
Tópico(s): Gas Dynamics and Kinetic Theory
2005 - Wiley | Heat Transfer-Asian Research
Minoru Miyashita, Naoki Niikura, Hiraku Kumamaru, Hiroaki Miyata, Takayuki Iwamoto, Masaaki Kawai, Keisei Anan, Naoki Hayashi, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Shinobu Masuda, Koichiro Tsugawa, Takayuki Kinoshita, Hitoshi Tsuda, Seigo Nakamura, Yutaka Tokuda,
Tópico(s): Breast Implant and Reconstruction
2019 - Springer Science+Business Media | Annals of Surgical Oncology
Sho Shiino, Masayuki Yoshida, Kenjiro Jimbo, Sota Asaga, Shin Takayama, Akiko Miyagi Maeshima, Hitoshi Tsuda, Takayuki Kinoshita, Nobuyoshi Hiraoka,
Tópico(s): Breast Lesions and Carcinomas
2019 - Springer Science+Business Media | Virchows Archiv
Kenji Hashimoto, Chikako Shimizu, Hitoshi Tsuda, Shigehira Saji, Akihiko Osaki, Takashi Shigekawa, Kenjiro Aogi,
<i>Background:</i> Breast cancer stem cells are rich in triple negative or human epidermal growth factor receptor-2-positive breast cancers. The role of these stem cells in hormone receptor-positive breast cancers is unknown. Therefore, we launched this retrospective biomarker analysis to clarify the role of stem cells in relation with endocrine therapy in hormone receptor-positive breast cancer. <i>Methods:</i> Formalin-fixed paraffin-embedded tissue samples from primary stage ...
Tópico(s): Metastasis and carcinoma case studies
2012 - Karger Publishers | Oncology
Hiroki Ito, Yu Kawamata, Mako Kamiya, Kayoko Tsuda‐Sakurai, Shinji Tanaka, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Shigeo Okabe, Masayuki Miura, Yasuteru Urano,
Abstract The Escherichia coli lac Z gene encoding β‐galactosidase is a widely used reporter, but few synthetic substrates are available for detecting its activity with single‐cell resolution in living samples. Our recently reported fluorogenic substrate SPiDER‐βGal is suitable for this purpose, but its hydrolysis product shows green fluorescence emission, and a red‐shifted analogue is therefore required for use in combination with green fluorescent protein (GFP) markers. Herein, we describe the development ...
Tópico(s): Biosensors and Analytical Detection
2018 - Wiley | Angewandte Chemie International Edition
Kenjiro Jimbo, Hitoshi Tsuda, Masayuki Yoshida, Akiko Miyagi‐Maeshima, Yuka Sasaki‐Katsurada, Sota Asaga, Takashi Hojo, Yuko Kitagawa, Takayuki Kinoshita,
We investigated whether some mucinous carcinomas ( MUCs ) are associated with lobular neoplasia ( LN ) components, and if so, whether this subset has any distinct biological properties. MUC specimens from 41 patients were stratified into pure and mixed types. The LN components adjacent to MUC lesions were examined histopathologically. We also tested immunohistochemically for E ‐cadherin, β‐catenin, and the neuroendocrine markers chromogranin A and synaptophysin; and compared results between MUCs with and ...
Tópico(s): Breast Cancer Treatment Studies
2014 - Wiley | Pathology International
Hajime SUGIE, Mitsuru Yoshida, Kenjiro KAWASAKI, Hiroshi Noguchi, Seiichi Moriya, Kazuo TAKAGI, Hiroshi Fukuda, Azusa Fujiie, Masahiro Yamanaka, Y. Ohira, Takafumi TSUTSUMI, Katsuo Tsuda, Katsuhiko Fukumoto, Miyoshi Yamashita, Hiroshi Suzuki,
Tópico(s): Research on scale insects
1996 - Springer Science+Business Media | Applied Entomology and Zoology