Michael Stilkerich, Isabella Thomm, Christian Wawersich, Wolfgang Schröder‐Preikschat,
... the lacking language features for low-level programming. KESO is a Java Virtual Machine (JVM) that was ... a fixed subset of the Java standard functionality, KESO uses the available ahead-of-time knowledge to ... towards the particular application. A key feature of KESO is its Multi-JVM architecture, which allows the ... to compare the cost of an application using KESO to its C counterpart. Our results show that ... consumption of applications developed on the base of KESO is comparable to C applications, and its mechanisms ...
Tópico(s): Distributed systems and fault tolerance
2011 - Wiley | Concurrency and Computation Practice and Experience
... which consists of a Kalman extended state observer (KESO) with an adaptive sliding mode controller (ASMC). First, ... software. The results conclusively demonstrate that the proposed KESO-ASMC achieves significantly improved trajectory tracking performance, even ...
Tópico(s): Adaptive Control of Nonlinear Systems
2024 - Institute of Electrical and Electronics Engineers | IEEE Access
Mohd Hafis Yuswan, Nurul Hanani A. Jalil, Haslina Mohamad, Shamsidah Keso, Nurhidayatul Asma Mohamad, Tengku Shahrul Tengku Md. Yusoff, Nor Falahiah Ismail, Yanty Noorzianna Abdul Manaf, Amalia Mohd Hashim, Mohd Nasir Mohd Desa, Yus Aniza Yusof, Shuhaimi Mustafa,
Gelatin and collagen are considered halal-critical ingredients as they are typically derived from either bovine or porcine animals. Current analytical methods for determining the sources of gelatin and collagen suffer from limitations in terms of robustness and false positives in peptide matching. Thus, the aim of this study was to investigate the utility of monitoring hydroxyproline, a signature amino acid for gelatin and collagen, for identifying potentially haram foodstuffs. To determine the ...
Tópico(s): Halal products and consumer behavior
2020 - Elsevier BV | Food Chemistry
Cécilia Veraar, Harald Rinösl, Karina Kühn, Keso Skhirtladze‐Dworschak, Alessia Felli, M. Mouhieddine, Johannes Menger, Ekaterina Pataraia, Hendrik Jan Ankersmit, Martin Dworschak,
Systemic blood flow in patients on extracorporeal assist devices is frequently not or only minimally pulsatile. Loss of pulsatile brain perfusion, however, has been implicated in neurological complications. Furthermore, the adverse effects of absent pulsatility on the cerebral microcirculation are modulated similarly as CO2 vasoreactivity in resistance vessels. During support with an extracorporeal assist device swings in arterial carbon dioxide partial pressures (PaCO2) that determine cerebral oxygen ...
Tópico(s): Mechanical Circulatory Support Devices
2019 - BioMed Central | Critical Care
Keso Skhirtladze‐Dworschak, Doris Hutschala, Georg Reining, Peter Dittrich, Anna Bartunek, Martin Dworschak, Edda Tschernko,
Surgical site infections contribute to morbidity and mortality after surgery. The authors hypothesized that higher antibiotic tissue concentrations can be reached for a prolonged time span by continuous administration of prophylactic cefuroxime compared to bolus administration.Twelve patients undergoing elective cardiac surgery were investigated. Group A received 1.5 g cefuroxime as bolus infusions before surgery, and 12 and 24 hours thereafter. In group B, a continuous infusion of 3.0 g cefuroxime ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2019 - Wiley | British Journal of Clinical Pharmacology
Sebastian Schnaubelt, Patrick Sulzgruber, Johannes Menger, Keso Skhirtladze‐Dworschak, Fritz Sterz, Martin Dworschak,
Abstract Introduction Regional cerebral oxygen saturation (rSO2) can be measured non-invasively even at no- or low-flow states. It thus allows assessment of brain oxygenation during CPR. Certain rSO2 values had been associated with return of spontaneous circulation (ROSC) and neurological outcome in the past. Clear-cut thresholds for the prediction of beneficial outcome, however, are still lacking. Methods We conducted a database search to extract all available investigations on rSO2 measurement during CPR. ...
Tópico(s): Hemodynamic Monitoring and Therapy
2018 - Elsevier BV | Resuscitation
Isabella Stilkerich, Clemens Lang, Christoph Erhardt, Christian Bay, Michael Stilkerich,
... we explore the application of escape analysis in KESO [Stilkerich et al. 2012], a Java ahead-of- ...
Tópico(s): Distributed systems and fault tolerance
2017 - Association for Computing Machinery | ACM Transactions on Embedded Computing Systems
The paper aims at understanding the post-transition period from a modernization theoretical point of view by reinterpreting various empirical researches.The analytical framework was elaborated in the essay A unified theory of classical and late modernity based on the theories of Bourdieu, Habermas, Giddens and Lash.Based on the empirical review, we may conclude that in Hungary the integration logics of classical and late modernity strengthen each other's pathological tendencies instead of counterbalancing ...
Tópico(s): Social Policy and Reform Studies
2015 - | Socio hu
Cheng Yang, Regina Fischer-Kešo, Tanja Schlechter, Philipp Ströbel, Alexander Marx, Ilse Hofmann,
Plakophilin (PKP) 1 is frequently downregulated in prostate cancer and therefore may play a tumor-suppressive role. In the present study, we stably knocked down PKP1 in the non-neoplastic, prostatic BPH-1 cell line. In the PKP1-deficient cells, the expression of keratin 14 was lost, and the apoptosis rate was significantly reduced indicating that the cells acquired new biological capabilities. Moreover, we analyzed the gene expression profile of the PKP1-deficient BPH-1 cells. Among the genes that ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2015 - SAGE Publishing | Tumor Biology
Regina Fischer-Kešo, Sonja Breuninger, Sarah Hofmann, Manuela Henn, Theresa Röhrig, Philipp Ströbel, Georg Stoecklin, Ilse Hofmann,
Plakophilins 1 and 3 (PKP1/3) are members of the arm repeat family of catenin proteins and serve as structural components of desmosomes, which are important for cell-cell-adhesion. In addition, PKP1/3 occur as soluble proteins outside desmosomes, yet their role in the cytoplasm is not known. We found that cytoplasmic PKP1/3 coprecipitated with the RNA-binding proteins FXR1, G3BP, PABPC1, and UPF1, and these PKP1/3 complexes also comprised desmoplakin and PKP2 mRNAs. Moreover, we showed that the interaction ...
Tópico(s): RNA and protein synthesis mechanisms
2014 - Taylor & Francis | Molecular and Cellular Biology
Kirsi Väyrynen, Kati Kortelainen, Heikki Numminen, Katja Miettinen, Anna Keso, M. Tenhunen, Heini Huhtala, Sari‐Leena Himanen,
In acute stroke, OSA has been found to impair rehabilitation and increase mortality but the effect of central apnea is more unclear. The aim of the present study was to evaluate the feasibility of using limited ambulatory recording system (sleep mattress to evaluate nocturnal breathing and EOG-electrodes for sleep staging) in sleep disordered breathing (SDB) diagnostics in mild acute cerebral ischemia patients and to discover the prevalence of various SDB-patterns among these patients. 42 patients ...
Tópico(s): Cardiovascular and Diving-Related Complications
2014 - Hindawi Publishing Corporation | Sleep Disorders
Keso Skhirtladze‐Dworschak, Martin Dworschak,
Cerebral oximetry is a Food and Drug Administration–approved technology that allows monitoring of brain oxygen saturation in accessible superficial brain cortex regions, which are amongst the most vulnerable in regard to ischemic or hypoxic injury. Since most oxygen in the area of interest is located in the venous compartment, the determined regional brain oxygen saturation approximately reflects the local balance between oxygen delivery and oxygen consumption. Major systemic alterations in blood ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2013 - SAGE Publishing | Seminars in Cardiothoracic and Vascular Anesthesia
Keso Skhirtladze, Eva Base, Andrea Lassnigg, Alexandra Kaider, S. Linke, Martin Dworschak, M. Hiesmayr,
BackgroundInfusion of 5% human albumin (HA) and 6% hydroxyethyl starch 130/0.4 (HES) during cardiac surgery expand circulating volume to a greater extent than crystalloids and would be suitable for a restrictive fluid therapy regimen. However, HA and HES may affect blood coagulation and could contribute to increased transfusion requirements.MethodsWe randomly assigned 240 patients undergoing elective cardiac surgery to receive up to 50 ml kg−1 day−1 of either HA, HES, or Ringer’s lactate (RL) as the ...
Tópico(s): Trauma and Emergency Care Studies
2013 - Elsevier BV | British Journal of Anaesthesia
Bruno Mora, Ismail Ince, Beatrice Birkenberg, Keso Skhirtladze, Elisabeth Pernicka, Hendrik Jan Ankersmit, Martin Dworschak,
Summary After cardiac surgery, patients with low left ventricular ejection fraction probably benefit the most from accurate monitoring of continuous cardiac output. Thirty patients with impaired ventricular function were studied, and intermittent bolus thermodilution and continuous pulse contour (LiDCO plus TM ) cardiac output compared. Following lithium dilution calibration, a total of 220 paired results were recorded. Thermodilution and LiDCO measurements ranged from 2.3 to 11.0 and 2.6 to 10.8 l. ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2011 - Wiley | Anaesthesia
Eva Base, Thomas Standl, Andrea Lassnigg, Keso Skhirtladze, Cornelius Jungheinrich, Daniela Gayko, M. Hiesmayr,
Objective The infusion of large amounts of saline-based solutions may contribute to the development of hyperchloremic metabolic acidosis and the use of a balanced carrier for colloid solutions might improve postoperative acid-base status. The equivalence of 2 hydroxyethyl starch (HES) solutions and the influence on chloride levels and acid-base status by selectively changing the carrier of rapidly degradable modern 6% HES 130/0.4 were studied in cardiac surgery patients. Design A prospective, randomized, ...
Tópico(s): Hemodynamic Monitoring and Therapy
2011 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
Keso Skhirtladze, Bruno Mora, Andrea Moritz, Beatrice Birkenberg, Hendrik Jan Ankersmit, Martin Dworschak,
Early defibrillation clearly improves survival from malignant arrhythmia. However, in some cases the cause of death will only be altered from arrhythmic to nonarrhythmic. We evaluated the impact of left ventricular ejection fraction (LVEF) on trend and recovery profile of beat-to-beat cardiac output (CO) and mean arterial blood pressure (MAP) after successful defibrillation.We investigated 63 NYHA class I-III patients undergoing threshold testing in the course of insertion of an implantable cardioverter ...
Tópico(s): Cardiac pacing and defibrillation studies
2010 - Elsevier BV | Resuscitation
Ulla Hoppu, Jenni Lehtisalo, Johanna Kujala, Teija Keso, Sini Garam, Heli Tapanainen, Antti Uutela, Tiina Laatikainen, Ulla Rauramo, Pirjo Pietinen,
Abstract Objective To decrease the intake of sucrose, increase the intake of fibre and the consumption of fruit and vegetables among secondary-school pupils. Design Intervention study among eighth grade pupils during one school year. Data were collected by questionnaires and from a subgroup of pupils by 48 h dietary recall at baseline in spring 2007 and after the intervention in 2008. Setting Twelve secondary schools were randomly allocated to intervention (IS) and control schools (CS) within three ...
Tópico(s): Child Nutrition and Water Access
2010 - Cambridge University Press | Public Health Nutrition
Doris Hutschala, Christian Kinstner, Keso Skhirdladze, Florian Thalhammer, Markus Müller, Edda Tschernko,
Vancomycin is frequently used in clinical practice to treat severe wound and systemic infections caused by Gram-positive bacteria after cardiac surgery. The drug is excreted almost entirely by glomerular filtration and might exhibit nephrotoxic side effects. This study compared the nephrotoxic impact of vancomycin during continuous versus intermittent administration.The authors analyzed 149 patients admitted to the intensive care unit during a 5-yr period. All patients were treated at the intensive ...
Tópico(s): Acute Kidney Injury Research
2009 - Lippincott Williams & Wilkins | Anesthesiology
Keso Skhirtladze, Beatrice Birkenberg, Bruno Mora, Andrea Moritz, Ismail Ince, Hendrik Jan Ankersmit, Barbara Szeinlechner, Martin Dworschak,
Objective: To determine the impact of brief periods of cardiac arrest (CA) on regional cerebral oxygen saturation (rSo2) in patients with low left ventricular ejection fraction (LVEF 50%), moderately impaired (LVEF 30%–50%), or severely reduced (LVEF <30%). Interventions: None. Measurements and Main Results: rSo2 was determined during threshold testing with concomitant induction of CA. In patients with LVEF <30%, mean baseline rSo2 (59%) was already below the lower range of normal despite normal arterial ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2009 - Lippincott Williams & Wilkins | Critical Care Medicine
Doris Hutschala, Christian Kinstner, Keso Skhirtladze, Bernhard-Xaver Mayer-Helm, Markus Zeitlinger, Wilfried Wisser, Markus Müller, Edda Tschernko,
Tópico(s): Mechanical Circulatory Support Devices
2008 - Springer Science+Business Media | Intensive Care Medicine
Conrad Iber, Sonia Ancoli‐Israel, Andrew L. Chesson, Stuart F. Quan,
... UnitVäyrynen K, Kortelainen K, Numminen H, Miettinen K, Keso A, Tenhunen M, Huhtala H and Himanen S ...
Tópico(s): Sleep and Work-Related Fatigue
2007 - American Academy of Sleep Medicine | Journal of Clinical Sleep Medicine
Doris Hutschala, Keso Skhirtladze, Christian Kinstner, Bernhard Mayer‐Helm, Markus Müller, Ernst Wolner, Edda Tschernko,
Wound infections remain an important problem after cardiac surgery despite antimicrobial prophylaxis, causing increased mortality, morbidity, and costs. Penetration properties of antibiotics are altered by extracorporeal circulation, fluid resuscitation, surgery, and postoperative treatment measures. So far, interstitial antibiotic concentration has not been measured continuously during surgery. It remains uncertain whether the concentration of the prophylactic antibiotic is sufficient in interstitial ...
Tópico(s): Central Venous Catheters and Hemodialysis
2007 - Elsevier BV | The Annals of Thoracic Surgery
Keso Skhirtladze, Doris Hutschala, Tatjana Fleck, Florian Thalhammer, Marek Ehrlich, Thomas Vukovich, Markus Müller, Edda Tschernko,
Soft tissue infections constitute a serious complication following surgery in diabetic patients and frequently require the administration of vancomycin. However, despite antibiotic treatment, mortality of patients with postoperative infections remains high and might be related to an impaired penetration of anti-infective agents to target tissues. Therefore, the present study was designed to measure vancomycin tissue concentrations in six diabetic and six nondiabetic patients after cardiac surgery. ...
Tópico(s): Surgical site infection prevention
2006 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Doris Hutschala, Keso Skhirtladze, Andreas Zuckermann, Wilfried Wisser, Péter Jaksch, Bernhard Mayer‐Helm, Heinz Burgmann, Ernst Wolner, Markus Müller, Edda Tschernko,
Nosocomial pneumonia is a severe complication after cardiac surgery (CS). Levofloxacin, a fluoroquinolone, qualifies for the therapy of postoperative pneumonia. However, penetration properties of levofloxacin into the lung tissue could be substantially affected by CS: atelectasis, low cardiac output after CS, high volume loads, and inflammatory capillary leak potentially influence drug distribution. The aim of our study was to gain information on interstitial antibiotic concentrations in lung tissue ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2005 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Manuela Weigl, Giacomo Tenze, Barbara Steinlechner, Keso Skhirtladze, Georg Reining, Mario Bernardo, Elisa Pedicelli, Martin Dworschak,
We conducted a Medline search for controlled studies evaluating currently available drugs for pharmacological neuroprotection. They had to be administered prior to transient global cerebral ischaemia without further non-pharmacological measures. We deliberately excluded focal ischaemia since its pathophysiology is substantially different from global ischaemia. A total of 45 articles conducted exclusively in laboratory animals met these criteria. The following classes of agents were evaluated: anaesthetics, ...
Tópico(s): Anesthesia and Neurotoxicity Research
2005 - Elsevier BV | Resuscitation
T Keso, Markus Perola, Pékka Laippala, Erkki Ilveskoski, Tarja Kunnas, Jussi Mikkelsson, Antti Penttilä, Mikko Hurme, Pekka J. Karhunen,
Tumor necrosis factor (TNF) is an important cytokine in the inflammation process of atherosclerosis and is also involved in lipid metabolism. Two biallelic polymorphisms within TNF gene locus-TNFA at the position −308 in the promoter region of the TNF gene and TNFB in the first intron of the lymphotoxin-α (LT-α) have been reported to be associated with TNF production and with susceptibility to inflammatory diseases. We studied the association of these polymorphisms within the major histocompatibility ...
Tópico(s): Cell Adhesion Molecules Research
2001 - Elsevier BV | Atherosclerosis
Mika Klemettinen, Heikki Mannila, A. Inkeri Verkamo,
... using a simple query language implemented in the KESO data mining system. Our results emphasize the importance ...
Tópico(s): Algorithms and Data Compression
1999 - Springer Science+Business Media | Lecture notes in computer science
Sanna Talja, Heidi Keso, Tarja Pietiläinen,
Context is hot in information science as well as in numerous other disciplines, but what exactly does this mean in and for research? The paper discusses the differences between objectified and interpretative approaches to context. It is argued that in information needs and seeking research (INS), the former approach has thus far been more common. Contextual entities are usually described to provide a background for the study of individuals' or groups' information behavior, not in order to point out ...
Tópico(s): Library Science and Administration
1999 - Elsevier BV | Information Processing & Management
Tópico(s): Rough Sets and Fuzzy Logic
1996 - Springer Science+Business Media | Lecture notes in computer science
The first randomized clinical trial on the Hazelden‐type of treatment showed that this AA‐oriented treatment for alcoholism can result in significant improvement in drinking behavior as compared to a more traditional form of treatment. One hundred forty‐one employed alcoholics were randomized to either Hazelden‐type treatment ( N = 74) or to traditional‐type treatment ( N = 67). The treatment groups were highly comparable. The bimonthly follow‐up lasted one year. According to the COPES‐questionnaire (short ...
Tópico(s): Alcohol Consumption and Health Effects
1990 - Wiley | Alcoholism Clinical and Experimental Research