Benjarong Thongbai, Frank Surup, Kathrin I. Mohr, Eric Kuhnert, Kevin D. Hyde, Marc Stadler,
A chlorinated isocoumarin with an acetylenyl side chain and its 3,4-dihydro derivative, named gymnopalynes A (1) and B (2), were isolated from cultures of a basidiomycete originating from the rain forest of Northern Thailand. The producing organism was identified as a species of Gymnopus (Marasmiaceae). Their structures were elucidated by spectroscopic methods including UV/vis and NMR spectroscopy as well as high-resolution mass spectrometry as 3-(3-chloroprop-1-yn-1-yl)-1H-isochromen-1-one (1) and ...
Tópico(s): Marine Sponges and Natural Products
2013 - American Chemical Society | Journal of Natural Products
Enge Sudarman, Eric Kuhnert, Kevin D. Hyde, Esteban B. Sir, Frank Surup, Marc Stadler,
From stromata (fruiting bodies) of three xylariaceous fungi belonging to the genus Annulohypoxylon (A. leptascum, A. cf. truncatum and an unidentified Annulohypoxylon sp.), truncatone A (1), three unprecedented derivatives named truncatones B–D (2–4) besides the known 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl (BNT, 5), hypoxylonol C (6) and hypoxylonol F (7) were isolated. Planar structures of the new benzo[j]fluoranthene derivatives 2–4 were determined on the basis of NMR and HRESIMS data. While the relative ...
Tópico(s): Lichen and fungal ecology
2016 - Elsevier BV | Tetrahedron
Frank Surup, Benjarong Thongbai, Eric Kuhnert, Enge Sudarman, Kevin D. Hyde, Marc Stadler,
Bioassay-guided fractionation of antibacterial extracts from cultures of a basidiomycete from Northern Thailand, which represents a new species of the genus Deconica, yielded the terpenoid deconin A (1), whose structure was elucidated by spectral methods (NMR, HRMS) as a cuparenic/mevalonic acid conjugate. The absolute configuration of 1 was determined after saponification and comparison of specific rotations of the resulting cuparenic acid and mevalonolactone with authentic standards and literature ...
Tópico(s): Phytochemical compounds biological activities
2015 - American Chemical Society | Journal of Natural Products
Esteban B. Sir, Eric Kuhnert, Frank Surup, Kevin D. Hyde, Marc Stadler,
A specimen of the Hypoxylon rubiginosum complex featuring unusual bicoloured stromata was collected in northern Thailand and examined by means of classical morphological methodology, complemented by studies of its secondary metabolites using high performance liquid chromatography coupled with diode array and electrospray mass spectrometric detection (HPLC-DAD/MS), and molecular phylogenetic analysis of its ITS and partial beta-tubulin DNA sequences. In addition, the ultrastructure of its ascospores ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2015 - Springer Science+Business Media | Mycological Progress
Babra Moyo, Yolanda Novokoza, Nikita Tawanda Tavengwa, Nikolai Kuhnert, Kevin A. Lobb, Ntakadzeni E. Madala,
Rationale Although mass spectrometry (MS) is a powerful tool in structural elucidation of unknown flavonoids based on their unique fragmentation patterns, proposing the correct fragmentation mechanism is still a challenge from tandem mass spectrometry data only. In recent years, computational tools such as molecular networking and MS2LDA have played a major role in the identification of structurally related compounds through an in‐depth survey of their fragmentation patterns. Methods Therefore, in ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2023 - Wiley | Rapid Communications in Mass Spectrometry
Eric Kuhnert, Jorge C. Navarro-Muñoz, Kevin Becker, Marc Stadler, Jérôme Collemare, Russell J. Cox,
To date little is known about the genetic background that drives the production and diversification of secondary metabolites in the Hypoxylaceae . With the recent availability of high-quality genome sequences for 13 representative species and one relative ( Xylaria hypoxylon ) we attempted to survey the diversity of biosynthetic pathways in these organisms to investigate their true potential as secondary metabolite producers. Manual search strategies based on the accumulated knowledge on biosynthesis ...
Tópico(s): Microbial Natural Products and Biosynthesis
2021 - Elsevier BV | Studies in Mycology
Frank Surup, Eric Kuhnert, Erik E. Lehmann, Simone Heitkämper, Kevin D. Hyde, Jacques Fournier, Marc Stadler,
During the course of a screening for novel anti-infective agents from cultures of tropical Xylariaceae originating from French Guiana and Thailand, pronounced antifungal activity was noted in extracts of cultures of Hypoxylon monticulosum. A bioassay-guided fractionation led to the known metabolite sporothriolide as active principle. In addition, three new derivatives of sporothriolide were isolated, for which we propose the trivial names sporothric acid, isosporothric acid and dihydroisosporothric ...
Tópico(s): Fungal Infections and Studies
2014 - Taylor & Francis | Mycology: An International Journal on Fungal Biology
Eric Kuhnert, Esteban B. Sir, Christopher Lambert, Kevin D. Hyde, Adriana I. Hladki, Andrea I. Romero, Manfred Rohde, Marc Stadler,
Tópico(s): Yeasts and Rust Fungi Studies
2016 - Springer Science+Business Media | Fungal Diversity
Kevin Wei, Frank Kuhnert, Calvin J. Kuo,
Tópico(s): CAR-T cell therapy research
2007 - Springer Science+Business Media | Journal of Molecular Medicine
Eric Kuhnert, Frank Surup, Esteban B. Sir, Christopher Lambert, Kevin D. Hyde, Adriana I. Hladki, Andrea I. Romero, Marc Stadler,
Seven new azaphilone pigments named lenormandins A–G were isolated from stromata (fruiting bodies) of the xylariaceous fungus, Hypoxylon lenormandii using preparative High Performance Liquid Chromatography (HPLC) and their structures were elucidated by NMR spectroscopy, high resolution mass spectrometry and other spectral methods. Their occurrence in herbarium specimens (including various type materials collected in the 19th and early 20th century) and several fresh collections was studied by analytical ...
Tópico(s): Fungal Biology and Applications
2015 - Springer Science+Business Media | Fungal Diversity
Yunlong Sun, Jennifer Gerke, Kevin Becker, Eric Kuhnert, Bart Verwaaijen, Daniel Wibberg, Jörn Kalinowski, Marc Stadler, Russell J. Cox,
Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae .
Tópico(s): Enzyme Catalysis and Immobilization
2023 - Royal Society of Chemistry | Chemical Science
Chongqing Wang, Kevin Becker, Sebastian Pfütze, Eric Kuhnert, Marc Stadler, Russell J. Cox, Elizabeth Skellam,
Tailoring enzymes in cytochalasan biosynthesis are relatively promiscuous. Exploiting this property, we deduced the function of four cryptic cytochrome P450 monooxygenases via heterologous expression of six cytochrome P450-encoding genes, originating from Hypoxylon fragiforme and Pyricularia oryzae, in pyrichalasin H ΔP450 strains. Three cryptic cytochrome P450 enzymes (HffD, HffG, and CYP1) restored pyrichalasin H production in mutant strains, while CYP3 catalyzed a site-selective epoxidation leading ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2019 - American Chemical Society | Organic Letters
Kevin Becker, Sebastian Pfütze, Eric Kuhnert, Russell J. Cox, Marc Stadler, Frank Surup,
The diversity of azaphilones in stromatal extracts of the fungus Hypoxylon fragiforme was investigated and linked to their biosynthetic machineries by using bioinformatics. Nineteen azaphilone-type compounds were isolated and characterized by NMR spectroscopy and mass spectrometry, and their absolute stereoconfigurations were assigned by using Mosher ester analysis and electronic circular dichroism spectroscopy. Four unprecedented bis-azaphilones, named hybridorubrins A-D, were elucidated, in addition ...
Tópico(s): Plant Pathogens and Fungal Diseases
2020 - Wiley | Chemistry - A European Journal
David J. DiLillo, Kara Olson, Katja Mohrs, T. Craig Meagher, Kevin Bray, Olga Sineshchekova, Thomas Startz, Jessica Kuhnert, Marc W. Retter, Stephen Godin, Prachi Sharma, Frank J. Delfino, John Lin, Eric Smith, Gavin Thurston, Jessica R. Kirshner,
CD3-engaging bispecific antibodies (bsAbs) and chimeric antigen receptor (CAR) T cells are potent therapeutic approaches for redirecting patient T cells to recognize and kill tumors. Here we describe a fully human bsAb (REGN5458) that binds to B-cell maturation antigen (BCMA) and CD3, and compare its antitumor activities vs those of anti-BCMA CAR T cells to identify differences in efficacy and mechanism of action. In vitro, BCMAxCD3 bsAb efficiently induced polyclonal T-cell killing of primary human ...
Tópico(s): Nanowire Synthesis and Applications
2021 - Elsevier BV | Blood Advances
Kevin Becker, Eric Kuhnert, Russell J. Cox, Frank Surup,
Abstract We report new stromatal azaphilone pigments rubiginosins Z‐X from the ascomycete Hypoxylon rubiginosum , as well as rubiginosins Z and W from H. texense , which were isolated along with known monomeric and dimeric congeners. Structures were elucidated using comprehensive HRMS, NMR, and ECD analysis, revealing azaphilones from both fungi to be exclusively C‐8( S )‐configured. The orsellinic acid (OA)‐carrying rubiginosins A, Z and dimeric rutilins A‐B exhibited cytotoxicity. Rubiginosins X‐W bearing ...
Tópico(s): Microbial Metabolism and Applications
2021 - Wiley | European Journal of Organic Chemistry
Esteban B. Sir, Kevin Becker, Christopher Lambert, Gerald F. Bills, Eric Kuhnert,
Two new species and a new combination of Hypoxylon from Texas were identified and described based on morphological, multigene phylogenetic (ITS [nuc rDNA internal transcribed spacer region ITS1-5.8S-ITS2], 28S [5′ 1200 bp of nuc 28S rDNA], RPB2 [partial second largest subunit of the DNA-directed RNA polymerase II], TUB2 [partial β-tubulin]), and chemotaxonomic data. Hypoxylon olivaceopigmentum is characterized by its pulvinate to glomerate stromata, olivaceous KOH-extractable pigments, equilateral ascospores, ...
Tópico(s): Lichen and fungal ecology
2019 - Taylor & Francis | Mycologia
Houda Ennaceri, Kristina Fischer, Kevin Hanus, A. Chemseddine, Andrea Prager, Jan Griebel, Mathias Kühnert, Agnes Schulze, Bernd Abel,
In the present work, highly ordered titanium dioxide (TiO2) nanotube anodes were grown using a rapid anodization process. The photoelectrochemical performances of these electrodes strongly depend on the anodization conditions. Parameters such as electrolyte composition, anodization potential and anodization time are shown to affect the geometrical parameters of TiO2 nanotubes. The optimal anodization parameters are determined by photocurrent measurements, linear sweep voltammetry and electrochemical ...
Tópico(s): Anodic Oxide Films and Nanostructures
2020 - Multidisciplinary Digital Publishing Institute | Catalysts
Kevin Lamkiewicz, Luis Roger Esquivel Gomez, Denise Kühnert, Manja Marz,
Coronaviruses have a broad host range and exhibit high zoonotic potential. In this chapter, we describe their genomic organization in terms of encoded proteins and provide an introduction to the peculiar discontinuous transcription mechanism. Further, we present evolutionary conserved genomic RNA secondary structure features, which are involved in the complex replication mechanism. With a focus on computational methods, we review the emergence of SARS-CoV-2 starting with the 2019 strains. In that ...
Tópico(s): Animal Virus Infections Studies
2023 - Springer Science+Business Media | Current topics in microbiology and immunology
Die Daseinsvorsorge in offentlicher Hand dient mehr als der Bereitstellung wichtiger Guter und Dienstleistungen. Sie zahmt den Kapitalismus, dampft die Ungleichheit und starkt, richtig gemacht, Tei...
Tópico(s): Public Administration and Political Analysis
2020 - Wochenschau Verlag | Politikum
Katharina Schmidt, Esteban Charria‐Girón, Tatiana E. Gorelik, Christian Kleeberg, Jackson M. Muema, Simone Heitkämper, Bart Verwaaijen, Eric Kuhnert, Jennifer Gerke, Jörn Kalinowski, Kevin D. Hyde, Marc Stadler, Russell J. Cox, Frank Surup,
Tópico(s): Cancer Treatment and Pharmacology
2025 - Wiley | ChemBioChem
Anita Patel, Daniel B. Jernigan,
... for Emerging and Zoonotic Infectious Diseases CDC; Wendi Kuhnert-Tallman, Deputy Director for Infectious Diseases, CDC; Stephanie ...
Tópico(s): COVID-19 epidemiological studies
2020 - Elsevier BV | American Journal of Transplantation
Anita Patel, Daniel B. Jernigan, Fatuma Abdirizak, Glen R. Abedi, Sharad Aggarwal, Denise Albina, Elizabeth S. Allen, Lauren M. Andersen, Jade Anderson, Megan Anderson, Tara C. Anderson, Kayla N. Anderson, Ana C. Bardossy, Vaughn Barry, Karlyn D. Beer, Michael Bell, Sherri Berger, Joseph Bertulfo, Holly M. Biggs, Jennifer Bornemann, Josh Bornstein, Willie Bower, Joseph S. Bresee, Clive Brown, Alicia Budd, Jennifer Buigut, S. Bürke, Rachel M. Burke, Erin Burns, Jay C. Butler, Russell Cantrell, Cristina V. Cardemil, Jordan Cates, Marty Cetron, Kevin Chatham‐Stephens, Kevin Chatham-Stevens, Nora Chea, Bryan Christensen, Victoria Chu, Kevin R. Clarke, Angela A. Cleveland, Nicole J. Cohen, Max Cohen, Amanda Cohn, Jennifer Collins, Rebecca M. Dahl, W. Randolph Daley, Vishal Dasari, Elizabeth Davlantes, Patrick Dawson, Lisa Delaney, Matthew Donahue, Chad Dowell, Jonathan Dyal, William Christopher Edens, Rachel B. Eidex, Lauren Epstein, Mary E. Evans, Ryan Fagan, Kevin Farris, Leora R. Feldstein, LeAnne M. Fox, Mark Frank, Brandi Freeman, Alicia M. Fry, James A. Fuller, Romeo R. Galang, Sue Gerber, Runa H. Gokhale, S. Goldstein, Sue Gorman, William J. Gregg, William Greim, Steven Grube, Aron J. Hall, Amber Haynes, Sherrasa Hill, Jennifer Hornsby‐Myers, Jennifer C. Hunter, Christopher Ionta, Cheryl Isenhour, Max W. Jacobs, Kara Jacobs Slifka, Daniel B. Jernigan, Michael A. Jhung, Jamie Jones-Wormley, Anita Kambhampati, Shifaq Kamili, Pamela Kennedy, Charlotte Kent, Marie E. Killerby, Lindsay Kim, Hannah L. Kirking, Lisa M. Koonin, Ram Koppaka, Christine Kosmos, David T. Kuhar, Wendi Kuhnert-Tallman, Stephanie Kujawski, Archana Kumar, Alexander Landon, Leslie Lee, Jessica Leung, Stephen Lindstrom, Ruth Link‐Gelles, Joana Y Lively, Xiaoyan Lu, Brian Lynch, Lakshmi Malapati, Samantha Mandel, Brian J. Manns, Nina Marano, Mariel Marlow, Barbara J. Marston, Nancy McClung, Liz McClure, Emily G. McDonald, Oliva McGovern, Nancy Messonnier, Claire Midgley, Danielle Moulia, Janna Murray, Kate C. Noelte, Michelle Noonan-Smith, Kristen Nordlund, Emily Norton, Sara E. Oliver, Mark A. Pallansch, Umesh D. Parashar, Anita Patel, Manisha Patel, Kristen Pettrone, Taran Pierce, Harald Pietz, Satish K. Pillai, Lewis J. Radonovich, Sarah Reagan-Steiner, Amy Reel, Heather E. Reese, Brian Rha, Philip Ricks, Melissa A. Rolfes, Shahrokh Roohi, Lauren Roper, Lisa D. Rotz, Janell Routh, Senthil Kumar K. Sakthivel, Luisa Sarmiento, Jessica Schindelar, Eileen Schneider, Anne Schuchat, Sarah Scott, Varun Shetty, Caitlin Shockey, Jill Shugart, Mark Stenger, Matthew J. Stuckey, Brittany Sunshine, Tamara Sykes, Jonathan Trapp, Timothy M. Uyeki, Grace M. Vahey, Amy L. Valderrama, Julie Villanueva, Tunicia Walker, Megan Wallace, Lijuan Wang, John T. Watson, Angie Weber, Cindy M. Weinbaum, William C. Weldon, Caroline Westnedge, Brett Whitaker, Michael Whitaker, Alcia Williams, Holly Ann Williams, Ian Willams, Karen K. Wong, Amy Xie, Anna Yousef,
On December 31, 2019, Chinese health officials reported a cluster of cases of acute respiratory illness in persons associated with the Hunan seafood and animal market in the city of Wuhan, Hubei Province, in central China. On January 7, 2020, Chinese health officials confirmed that a novel coronavirus (2019-nCoV) was associated with this initial cluster (1). As of February 4, 2020, a total of 20,471 confirmed cases, including 2,788 (13.6%) with severe illness,* and 425 deaths (2.1%) had been reported ...
Tópico(s): COVID-19 epidemiological studies
2020 - Centers for Disease Control and Prevention | MMWR Morbidity and Mortality Weekly Report
Produção Nacional
Revisado por pares
Guo Jie Li, Kevin D. Hyde, Rui-Lin Zhao, Sinang Hongsanan, Faten A. Abdel-Aziz, Mohamed A. Abdel‐Wahab, Pablo Alvarado, Genivaldo Alves-Silva, Joseph F. Ammirati, Hiran A. Ariyawansa, Abhishek Baghela, Ali H. Bahkali, Michael Beug, D. Jayarama Bhat, Dimitar Bojantchev, Thitiya Boonpratuang, Timur S. Bulgakov, Erio Camporesi, Marcela Castilho Boro, Oldriska Ceska, Dyutiparna Chakraborty, Jia Jia Chen, K. W. Thilini Chethana, Putarak Chomnunti, Giovanni Consiglio, Bao‐Kai Cui, Dong Qin Dai, Yu‐Cheng Dai, Dinushani A. Daranagama, Kanad Das, Monika C. Dayarathne, Eske De Crop, Rafael José Vilela de Oliveira, Carlos Alberto Fragoso de Souza, José Ivanildo de Souza, Bryn T. M. Dentinger, Asha J. Dissanayake, Mingkwan Doilom, Elisandro Ricardo Drechsler‐Santos, Masoomeh Ghobad‐Nejhad, Sean Gilmore, Aristóteles Goés‐Neto, Michał Gorczak, Charles H. Haitjema, Kalani Kanchana Hapuarachchi, Akira Hashimoto, Mao He, John K. Henske, Kazuyuki Hirayama, María Josefina Iribarren, Subashini C. Jayasiri, Ruvishika S. Jayawardena, Sun Jeong Jeon, Gustavo Henrique Jerônimo, Ana Lúcia de Jesus, E. B. Gareth Jones, Ji Chuan Kang, Samantha C. Karunarathna, Paul M. Kirk, Sirinapa Konta, Eric Kuhnert, Ewald Langer, Haeng Sub Lee, Hyang Burm Lee, Wen Jing Li, Xing Hong Li, Kare Liimatainen, Diogo Xavier Lima, Chuan-Gen Lin, Jian‐Kui Liu, Xings Zhong Liu, Zuo Yi Liu, Janet Jennifer Luangsa-ard, Robert Lücking, H. Thorsten Lumbsch, Saisamorn Lumyong, Eduardo M. Leaño, Agostina V. Marano, Misato Matsumura, Eric H. C. McKenzie, Suchada Mongkolsamrit, Peter E. Mortimer, Thi Thuong Thuong Nguyen, Tuula Niskanen, Chada Norphanphoun, Michelle O’Malley, Sittiporn Parnmen, Julia Pawłowska, Rekhani H. Perera, Rungtiwa Phookamsak, Chayanard Phukhamsakda, Carmen Lidia Amorim Pires‐Zottarelli, Olivier Raspé, Mateus Arduvino Reck, Sarah C. O. Rocha, André Luiz Cabral Monteiro de Azevedo Santiago, Indunil C. Senanayake, Ledo Setti, Qiu-Ju Shang, Sanjay K. Singh, Esteban B. Sir, Kevin Solomon, Jie Song, Prasert Srikitikulchai, Marc Stadler, Satinee Suetrong, H. Takahashi, Takumasa Takahashi, Kazuaki Tanaka, Li Tang, Kasun M. Thambugala, Donnaya Thanakitpipattana, Michael K. Theodorou, Benjarong Thongbai, Tuksaporn Thummarukcharoen, Qing Tian, Saowaluck Tibpromma, Annemieke Verbeken, Alfredo Vizzini, Josef Vlasák, Kerstin Voigt, Dhanushka N. Wanasinghe, Yong Wang, Gothamie Weerakoon, Hua Wen, Ting‐Chi Wen, Nalin N. Wijayawardene, Sarunyou Wongkanoun, Marta Wrzosek, Yuan Xiao, Jian Xu, Ji Yan, Jing Yang, Shu Da Yang, Yu Hu, Jin Feng Zhang, Jie Zhao, Li Zhou, Derek Peršoh, Alan J. L. Phillips, Sajeewa S. N. Maharachchikumbura,
Notes on 113 fungal taxa are compiled in this paper, including 11 new genera, 89 new species, one new subspecies, three new combinations and seven reference specimens. A wide geographic and taxonomic range of fungal taxa are detailed. In the Ascomycota the new genera Angustospora (Testudinaceae), Camporesia (Xylariaceae), Clematidis, Crassiparies (Pleosporales genera incertae sedis), Farasanispora, Longiostiolum (Pleosporales genera incertae sedis), Multilocularia (Parabambusicolaceae), Neophaeocryptopus ( ...
Tópico(s): Lichen and fungal ecology
2016 - Springer Science+Business Media | Fungal Diversity
Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim M Kaiser, Gereon Rieke, Jenny Bischoff, Malte B. Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans Dieter Nischalke, Christian P. Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason D. Goldman, Philip Rosenstiel, Susanne V. Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J. Ball, Joseph M. Johnson, Paul-Albert Koenig, Florian I. Schmidt, Muzlifah Haniffa, James R. Heath, Beate M. Kümmerer, Verena Keitel, Björn‐Erik Ole Jensen, Paula Stubbemann, Florian Kurth, Leif Erik Sander, Birgit Sawitzki, Anna C. Aschenbrenner, Joachim L. Schultze, Jacob Nattermann, Janine Altmüller, Angel Angelov, Anna C. Aschenbrenner, Robert Bals, Alexander Bartholomäus, Anke Becker, Matthias Becker, Daniela Bezdan, Michael Bitzer, Conny Blumert, Ezio Bonifacio, Peer Bork, Boyke Bunk, Helmut Blum, Nicolas Casadei, Thomas Clavel, Maria Colomé‐Tatché, Markus Cornberg, Inti Alberto De La Rosa Velázquez, Andreas Diefenbach, Alexander Dilthey, Nicole Fischer, Konrad U. Förstner, Sören Franzenburg, Julia-Stefanie Frick, Gisela Gabernet, Julien Gagneur, Tina Ganzenmueller, Marie Gauder, Janina Geißert, Alexander Goesmann, Siri Göpel, Adam Grundhoff, Hajo Grundmann, Torsten Hain, Frank Hanses, Ute Hehr, André Heimbach, Marius M. Hoeper, Friedemann Horn, Daniel Hübschmann, Michael Hummel, Thomas Iftner, Angelika Iftner, Thomas Illig, Stefan Janssen, Jörn Kalinowski, René Kallies, Birte Kehr, Andreas Keller, Oliver T. Keppler, Sarah Kim-Hellmuth, Christoph Klein, Michael Knop, Oliver Kohlbacher, Karl Köhrer, Jan O. Korbel, Peter G. Kremsner, Denise Kühnert, Ingo Kurth, Markus Landthaler, Yang Li, Kerstin U. Ludwig, Oliwia Makarewicz, Fédérico Marini, Manja Marz, Alice C. McHardy, Christian Mertes, Maximilian Münchhoff, Sven Nahnsen, Markus M. Nöthen, Francine Ntoumi, Peter Nürnberg, Stephan Ossowski, Jörg Overmann, Silke Peter, Klaus Pfeffer, Isabell Pink, Anna R. Poetsch, Ulrike Protzer, Alfred Pühler, Nikolaus Rajewsky, Markus Ralser, Kristin Reiche, Olaf Rieß, Stephan Ripke, Ulisses Nunes da Rocha, Philip Rosenstiel, Antoine‐Emmanuel Saliba, Leif Erik Sander, Birgit Sawitzki, Simone Scheithauer, Philipp H. Schiffer, Jonathan L. Schmid‐Burgk, Wulf Schneider, Eva C. Schulte, Joachim L. Schultze, Alexander Sczyrba, Mariam L. Sharaf, Yogesh Preet Singh, Michael Sonnabend, Oliver Stegle, Jens Stoye, Fabian J. Theis, Thomas Ulas, Jörg Janne Vehreschild, Thirumalaisamy P. Velavan, Jörg Vogel, Sonja Volland, Max von Kleist, Andreas Walker, Jörn Walter, Dagmar Wieczorek, Sylke Winkler, John Ziebuhr,
Longitudinal analyses of the innate immune system, including the earliest time points, are essential to understand the immunopathogenesis and clinical course of coronavirus disease (COVID-19). Here, we performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies. We found elevated interferon (IFN)-α plasma levels in early ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Cell Press | Immunity
Franziska Hufsky, Kevin Lamkiewicz, Alexandre Almeida, Abdel Aouacheria, Cecilia Arighi, Alex Bateman, Jan Baumbach, Niko Beerenwinkel, Christian Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, ROBERT FINN, Adrian Fritz, Stephan Fuchs, Georges Hattab, Anne-Christin Hauschild, Dominik Heider, Marie Hoffmann, Martin Hölzer, Stefan Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, Renó Kmiecinski, Denise Kühnert, Gorka Lasso, Pieter Libin, Markus List, Hannah F. Löchel, María Martin, Roman Martin, Julian Matschinske, Alice C. McHardy, Pedro Mendes, Jaina Mistry, Vincent Navratil, Eric P. Nawrocki, Áine O’Toole, Nancy Ontiveros‐Palacios, Anton I. Petrov, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Alejandro Reyes, Lorna Richardson, David S. Robertson, Sepideh Sadegh, Joshua B. Singer, Kristof Theys, Chris Upton, Marius Welzel, Lowri Williams, Manja Marz,
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools designed explicitly for SARS-CoV-2 have only recently been developed as a rapid reaction to the need for fast detection, understanding and treatment of COVID-19. To control the ongoing COVID-19 pandemic, it is of utmost importance to get insight ...
Tópico(s): Cell Image Analysis Techniques
2020 - Oxford University Press | Briefings in Bioinformatics
Joseph M. Vinci, David L. Horwitz, Randall M. Zusman, John J. Pisano, Kevin Catt, Harry R. Keiser,
... publication date: 1-Mar-1983.Holland O, von Kuhnert L, Campbell W and Anderson R (1983) Synergistic ...
Tópico(s): Renin-Angiotensin System Studies
1979 - Lippincott Williams & Wilkins | Hypertension
P. Mendes-Ferreira, C. Maia-Rocha, Rui Adão, Ana Paula Lourenço, Clícia Grazielly de Lima Moura, Sirlaine de Pinho, J. C. Areias, Gilles W. De Keulenaer, Adelino Leite‐Moreira, C. Bras-Silva, Luise Holzhauser, D. Lindner, Anika Jenke, Heinz‐Peter Schultheiß, Diedrich Westermann, Carsten Skurk, T. Misaka, S. Suzuki, M Miyata, Akio Kobayashi, S. Saitoh, Yasuchika Takeishi, M. Czolbe, V. Pekarek, Trevor Williams, F. Panther, J. Strassen, Oliver Ritter, Stefan Voß, Holger Nef, S. Szardien, C. Troidl, B. Kojonazarov, D. Visser, J Hoffmann, M. Willmer, C. Hamm, H. Moellmann, Suzana Ljubojević, S. Sedej, M. Sacherer, G. Leitinger, J. Kockskaemper, Burkert Pieske, N. M. Vorobyeva, A. B. Dobrovolsky, E. V. Titaeva, A. I. Kirienko, Е. П. Панченко, R. Nakamura, Yuya Matsue, Akiko Mizukami, M. Ohno, M. Suzuki, Akira Matsumura, Yasuhiro Hashimoto, M. Rosiak, Marek Postuła, Agnieszka Kapłon‐Cieślicka, E. Trzepla, A. Czlonkowski, Krzysztof J. Filipiak, Grzegorz Opolski, Dariusz A. Kosior, Tommy Andersson, Pola Nagy, Maha Niazi, S. Nylander, Lars Wallentin, Joshua T. Mendell, Lee J Johnson, Glyneva Bradley Ridout, Longtao He, S. Chen, M. Petrkova, P. Schneiderova, E. Kriegova, Zdeněk Kolář, Miloš Táborský, Martin Petřek, N. Khuseyinova, Renate B. Schnabel, Thomas Zeller, Tommaso Gori, A. Schulz, Christine Espinola‐Klein, K Lackner, Stefan Blankenberg, T. Muenzel, P. S. Wild, Nicolas Amabile, SiMin Cheng, M. G. Larson, A. Ghorbani, E. Mc Cabe, G. Griffin, K. S. Cohen, A. Tedgui, Carole Boulanger, T. J. Wang, Marish I.F.J. Oerlemans, A. Mosterd, Mireille Dekker, E. A. De Vrey, Annette H M van der Helm–van Mil, Gerard Pasterkamp, Pieter A. Doevendans, A. W. Hoes, Joost P. G. Sluijter, C. Besler, Raisa Laaksonen, K. Ekroos, K. Tarasov, R. Hurme, T. F. Luescher, Arnold von Eckardstein, Ulf Landmesser, M. Ohno, Shaw Watanabe, Y. Hiraoka, Tatsuomi Matsuoka, Kazuhiko Nishi, Shigeru Saijo, Tomoko Kita, E. Nishi, T. Kimura, Keith Robertson, Jing Hu, R. A. Mcdonald, Keith G. Oldroyd, Stephanie Jessica Wan, Andrew H. Baker, Diane Jones, Krishnaraj S. Rathod, John Howard, Stuart J. Gallagher, A. K. Jain, Charles H. Knight, Sam Mohiddin, A. Mathur, Erin Smith, A. Wragg, Marije M. Vis, Marcel A.M. Beijk, Maik J. Grundeken, Janneke Baan, Klaus Koch, Joanna J. Wykrzykowska, J. G. P. Tijssen, Robbert J. de Winter, Jan J. Piek, José P.S. Henriques, T. Bauer, R Schiele, R. Zahn, S. Schneider, Bernhard Rauch, G. Sabin, Gunnar Steineck, J. Senges, Uwe Zeymer, Étienne Puymirat, E. Durand, K. Khalife, B. De Breyne, Vanda M. Lucke, Gillian H. Levy, Yves Cottin, J. Ferrrieres, Trevor W. Simon, Nicolas Danchin, Y. M. Lopatin, O. V. Ilyukhin, M. V. Ilyukhina, E. L. Kalganova, D. L. Tarasov, V. Ivanenko, Yves Devaux, Naser Ahmed Razvi, M. Vausort, Ged McCann, Dorothy H. Kelly, L. Zhang, Lavrova Ng, David R. Wagner, Iain Squire, Y. Ozaki, Aiko Tanaka, Kanji Ishibashi, T Tanimoto, Toshinao Yamano, Y. Ino, T. Yamaguchi, Takeshi Kubo, T. Imanishi, T Akasaka, Masahiko Takahata, Takeshi Kubo, T. Wada, Masahiro Orii, Toshinao Yamano, T Tanimoto, Y. Ino, T. Yamaguchi, T. Imanishi, T Akasaka, F. Imola, M. T. Mallus, V. Ramazzotti, M. Manzoli, Andrea A. Pappalardo, M. Occhipinti, L. Di Vito, Francesco Prati, Terue Okamura, Junichi Yamada, T. Nao, T. Suetomi, T Maeda, A. Hino, Takako Nakashima, Oda T, Tetsuji Miura, Masayo Matsuzaki, S Umemura, H. Kamihata, Shuji Nakamura, T. Sugiura, Tadashi Seno, K. Manabe, Saburo Tsujimoto, Miura Motohiro, T Iwasaka, Kenya Kusunose, A. Dahiya, M. Chadi Alraies, Diana Kwon, T. Marwick, Abbie Klein, T. Butz, L. Penfield Faber, Crystal Piper, G. Plehn, Dieter Horstkotte, H.-J. Trappe, R. M. Jimenez, J. M. Serrano, C Cristóbal, Pablo Talavera, P. Awanleh, Catherine Graupner, Antonio Curcio, J. J. Alonso Martin, A. Cresti, E. Capati, G. Guerrieri, Sauro Severi, C. Mornos, A. Ionac, D. Cozma, A. Mornos, S. Pescariu, S. Petrescu, S. Rekhraj, B. Szwejkowski, Adnan Nadir, S. Gandy, Jill George, Chim C. Lang, Allan D. Struthers, T. Yingchoncharoen, Sangita Agarwal, T. Marwick, Kiyohiro Takigiku, Masao Takeuchi, S. Nakatani, Chisato Izumi, S. Yuda, Kenji Sakata, N. Ohte, Kumiko Tanabe, Kohei Kaku, Masao Takeuchi, Kiyohiro Takigiku, S. Yasukouchi, Victor Mor‐Avi, Robin Lang, Y. Otsuji, S. A. Kleijn, Natesa G. Pandian, Leopoldo Pérez de Isla, O. Kamp, Michel Züber, P. Nyhoyannopoulos, Tim Forster, H. J. Nesser,
Oxford University Press
Anne Purfield, Jay C. Butler, Kevin P. Cain, Wendi L. Kuhnert, Atis Muehlenbachs, Monica E. Parise, Jim Pirkle,
Tópico(s): Viral Infections and Vectors
2022 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Faeq Husain‐Syed, Fiorenza Ferrari, Horst-Walter Birk, Rolf Weimer, Claudio Ronco, Kevin Poll, Matthias Hecker, Hans-Dieter Walmrath, Werner Seeger, Stefan Kuhnert, Konstantin Mayer,
Post–lung transplantation (LTx) progressive chronic kidney disease (CKD) is associated with increased morbidity and mortality. 1 Khush KK Cherikh WS Chambers DC et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-fifth adult heart transplantation report-2018; focus theme: multiorgan transplantation. J Heart Lung Transplant. 2018; 37: 1155-1168 Abstract Full Text Full Text PDF PubMed Scopus (230) Google Scholar Comorbidities ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2020 - Elsevier BV | The Journal of Heart and Lung Transplantation
Franziska Hufsky, Kevin Lamkiewicz, Alderrosy Fragoso Rodrigues Almeida, Abdel Aouacheria, Cecilia Arighi, Allen C. Bateman, Jan Baumbach, Niko Beerenwinkel, Carl D. Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, ROBERT FINN, A. Fritz, Simon Fuchs, Georges Hattab, Ashleigh Hauschild, D. Heider, Marcin Hoffmann, Martin Hölzer, Susan L. Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, Denise Kühnert, Gorka Lasso, Pieter Libin, Monica List, Hannah F. Löchel, Macarena Martín, R MARTIN, Julian Matschinske, Alice C. McHardy, Paulo Vinícius Braga Mendes, Jayna J. Mistry, Vincent Navratil, Eric P. Nawrocki, Áine O’Toole, Nancy Ontiveros‐Palacios, А. И. Петров, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Arturo Reyes, Lisa Richardson, D L Robertson, Sepideh Sadegh, Justin Singer, Kristof Theys, Chris Upton, Markus Welzel, Lawrence K. Williams, Manja Marz,
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2021 - Oxford University Press | Briefings in Bioinformatics