From Paul Routledge Labour Staff, From Our Correspondent, From Paul Martin, By Our Political Staff, From David Wood, From A Special Correspondent, Our New York Correspondent, From George Clark, From Trevor Fishlock, By Pearce Wright Science Reporter, From Anthony Smith, By Stephen Jessel Education Correspondent, By Stuart Marshall, From Tony Aldous, By a Staff Reporter, By Our Local Government Correspondent, Basil Gingell, By Peter Waymark, From Our Parliamentary Staff, From Ian McDonald, From Our Special Correspondent, From Geraldine Keen, From Michael Leapman, Dan van der Vat, Our Salisbury Correspondent, From Harry Golombek, From Our Own Correspondent, Our Lusaka Correspondent, By A. M. Rendel Diplomatic Correspondent, By David Wilsworth, From Peter Hopkirk, From Moshe Brilliant, Our Geneva Correspondent, From Jerome Caminada, By George Clark, By Nature-Times News Service, Ian Woodward, By Roy Hay, By Basil Gingell, PHS, A. C. SUTTON, D. C. PIMLOTT, BARBARA GOREHAM, M. C. P. Hewitt, RAYMOND LISTER, T. A. LAYTON, David Wood, B. M. CROWTHER, MICHAEL McNAIR-WILSON, JOHN K. WILD, J. A. WAKEFIELD, C. P. O'DONNELL, J. HODGE LLOYD, MICHAEL R. HEARNE, DAVID JAMES, J. F. MARTIN, E. K. SMITH, By Philip Howard, By Leonard Amey, William Mann, Max Harrison, Robert Anderson, Alan Blyth, John Percival, Joan Chissell, Michael Levey, From St. John Donn-Byrne, By Michael Phillips Racing Correspondent, By Our Northern Correspondent, By Our Newmarket Correspondent, By Jim Snow Northern Correspondent, By Lewine Mair, By U. A. Titley Rugby Correspondent, By Pamela Macgregor-Morris, From Peter Ryde Golf Correspondent, From a Special Correspondent, By Geoffrey Green, Football Correspondent, By Neil Allen, Boxing Correspondent, By Neil Allen, Athletics Correspondent, From Brian Lewis, Gerald Ely, By Richard Spiegelberg, By Kenneth Owen, From Peter Jay, Geoffrey Bell, By Maurice Corina Industrial Editor, From Anthony Thomas, By Clive Callow, By Anthony Rowley, From Our US Economics Correspondent, By Giles Smith, By Melvyn Westlake, By Ian Morison, By Ross Davies, By Dennis Dwyer, By Kenneth Owen, Technology Correspondent, By Peter Hill, Berry Ritchie, From Michael Hornsby, FINANCIAL EDITOR, James Greatorex, ROGER YOUNG, Chris Baur, J. G. Orr, F. W. BATCHELOR, P. A. WILLS, AHMAD MINAI, by Anthony Thomas, William Daniel, Edited by Robert Jones, Richard Spiegelberg, Robert Jones, Joe Roeber, by A. M. Rendel Diplomatic Correspondent, by Paul Martin, Middle East Correspondent, by Charles Douglas-Home, by Ian Hoare, by Tony Aldous, by a Special Correspondent, by Friedrich Ragette, by William A. Ward, Dr. Mahmud Ghul, by Vivian Craddock Williams,
... rallying cry of professionalism, Government now considering Miss Khaled's release, 'Arms went to S Africa'. News ... Appointments, Rothmans, Fiat, Banco De Comercio, Stella, Abdul Aziz & Mohammed A. Aljomaih, Ahmed & Mohammad, The British Bank ...
1970 - Gale Group | TDA
Gordon Mao, Michael J. Gigliotti, Khaled Aziz, Khaled Aziz,
Abstract BACKGROUND The classic pterional, pretemporal, and orbitozygomatic approaches achieve large areas of exposure with easy maneuverability. In select cases (eg, some anterior circulation aneurysms), the minimally invasive fronto-orbital craniotomy can yield adequate exposure that must be balanced with its risk of frontalis injury. OBJECTIVE To detail a 10-yr experience using the transpalpebral approach, characterized by an incision whose camouflage is the natural eyelid crease, notably the ...
Tópico(s): Head and Neck Surgical Oncology
2019 - Lippincott Williams & Wilkins | Operative Neurosurgery
Edward Lucie-Smith, Godfrey Hodgson, Terry Delaney, Richard Buckle, James Margach, Abdul Qayyum, William Shaweross, Harold Hobson, Rob Hughes, Francis Wyndham, Leila Khaled, Edmund Cooper, J P McKeone, Kenneth Pearson, Kathleen Eldred, James Poole, Bernard Fergusson, John Whale, Julian Symons, Frederic Raphael, Neville Cardus, Leo Munro, Philip Oakes, Nigel Lawson, Henry Brandon, Richard Milner, David Divine, Malcolm Crawlord, Cliff Temple, Derek Jewell, M H Kostrzewa, John Ballantine, Norman Harris, J. S., Walter Greenwood, (Dr) Francis Pigott, Robin Marlar, Robert Troop, Lesley Garner, Hugh Somerville, Thomas Hickman, Cyril Connolly, Peter Lennon, Michael Howard, Raymond Mortimer, David Holden, Maxwell Boyd, (Miss) A W Morgan, Tony Geraghty, Judith Jackson, Nicholas Carroll, Nicholas Evans, J M McLintock, Elkan Allen, Peter Wilsher, Norman Booth, Aziz Khan-Panni, Bryan Silcock, Roger Mortimer, Eric Jacobs, John Raymond, Michael Pye, Desmond Shawe-Taylor, Alan Brien, Gwen Nuttall, Michael Bateman, Stephen Aris, Duncan Gardiner, Lanning Roper, Jean Robertson, Dilys Powell, Elkan Allan, Patricia Ashdown-Sharp, Bruce Page Peter Pringle, Dudley Doust, Felix Aprahamian, Ian Nairn, Arnold Field, (Mrs) B J Drabble, Henry Longhurst, Stephen Fay, Peter Pringle, Christopher Ricks, A. F. G. L., Christopher Reed, Tony Dawe, M Arif Action Committee Secretary, Benny Green, Paul Pieturs, Lucia van der Post, Graham Searjeant, C. H. O'd. Alexander, Maurice Wiggin, Nicholas Faith, Allan Hall, Brenda Jones, Michael Tennant, Malcolm Crawford, E M Forster, Vincent Hanna, Boris Schapiro,
... Unwanted £1m Unanswered Hospitals: the real issues Leila Khaled: story false Good innings The myth of the ...
1971 - Gale Group | Sunday Times HA GDA
Ifigeneia V. Mavragani, Zacharenia Nikitaki, Maria Souli, Asef Aziz, Somaira Nowsheen, Khaled Aziz, Emmy P. Rogakou, Alexandros G. Georgakilas,
Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage ...
Tópico(s): Effects of Radiation Exposure
2017 - Multidisciplinary Digital Publishing Institute | Cancers
Yair Lotan, Jennifer Stanfield, L. Chinsoo Cho, Jennifer B. Sherwood, Khaled Abdel‐Aziz, Cheng-Hui Chang, Kenneth Forster, Wareef Kabbani, Jer‐Tsong Hsieh, Hak Choy, Robert Timmerman,
... Jennifer Stanfield, L. Chinsoo Cho, Jennifer B. Sherwood, Khaled F. Abdel-Aziz, Cheng-Hui Chang, Kenneth Forster, Wareef Kabbani, Jer- ... Center, Dallas, Texas More articles by this author Khaled F. Abdel-Aziz Department of Urology, University of Texas Southwestern Medical ...
Tópico(s): Molecular Biology Techniques and Applications
2006 - Lippincott Williams & Wilkins | The Journal of Urology
Khaled Aziz, Cynthia J. Sieben, Karthik B. Jeganathan, Masakazu Hamada, Brian A. Davies, Raul O. Fierro Velasco, Nazneen Rahman, David J. Katzmann, Jan M. van Deursen,
A homozygous truncating frameshift mutation in CEP57 (CEP57T/T) has been identified in a subset of mosaic-variegated aneuploidy (MVA) patients; however, the physiological roles of the centrosome-associated protein CEP57 that contribute to disease are unknown. To investigate these, we have generated a mouse model mimicking this disease mutation. Cep57T/T mice died within 24 hours after birth with short, curly tails and severely impaired vertebral ossification. Osteoblasts in lumbosacral vertebrae of ...
Tópico(s): Caveolin-1 and cellular processes
2018 - American Society for Clinical Investigation | Journal of Clinical Investigation
Somaira Nowsheen, Khaled Aziz, Asef Aziz, Min Deng, Bo Qin, Kuntian Luo, Karthik B. Jeganathan, Henan Zhang, Tongzheng Liu, Jia Yu, Yibin Deng, Jian Yuan, Wei Ding, Jan M. van Deursen, Zhenkun Lou,
Cells respond to cytotoxic DNA double-strand breaks (DSBs) by recruiting DNA repair proteins to the damaged site. This recruitment is dependent on ubiquitylation of adjacent chromatin areas by E3 ubiquitin ligases such as RNF8 and RNF168, which are recruited sequentially to the DSBs. However, it is unclear what dictates the sequential order and recruits RNF168 to the DNA lesion. Here, we reveal that L3MBTL2 (lethal(3)malignant brain tumour-like protein 2) is the missing link between RNF8 and RNF168. ...
Tópico(s): Cancer-related Molecular Pathways
2018 - Nature Portfolio | Nature Cell Biology
Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen, Zhenkun Lou,
Abstract Cells respond to cytotoxic DNA double-strand breaks by recruiting repair proteins to the damaged site. Phosphorylation of the histone variant H2AX at S139 and Y142 modulate its interaction with downstream DNA repair proteins and their recruitment to DNA lesions. Here we report ATM-dependent ZNF506 localization to the lesion through MDC1 following DNA damage. ZNF506, in turn, recruits the protein phosphatase EYA, resulting in dephosphorylation of H2AX at Y142, which further facilitates the ...
Tópico(s): PARP inhibition in cancer therapy
2018 - Nature Portfolio | Nature Communications
Tulika Ranjan, Candace M. Howard, Alexander Yu, Linda Xu, Khaled Aziz, David H. Jho, Jodi Leonardo, Muhammad Hameed, Stephen Karlovits, Rodney E. Wegner, Russell Fuhrer, Seth T. Lirette, Krista L. Denning, Jagan Valluri, Pier Paolo Claudio,
Chemotherapy-resistant cancer stem cells (CSC) may lead to tumor recurrence in glioblastoma (GBM). The poor prognosis of this disease emphasizes the critical need for developing a treatment stratification system to improve outcomes through personalized medicine.We present a case series of 12 GBM and 2 progressive anaplastic glioma cases from a single Institution prospectively treated utilizing a CSC chemotherapeutics assay (ChemoID) guided report. All patients were eligible to receive a stereotactic ...
Tópico(s): Brain Metastases and Treatment
2020 - Elsevier BV | Translational Oncology
Andrew P. Carlson, Daniel Hänggi, George K. C. Wong, Nima Etminan, Stephan A. Mayer, François Aldrich, Michael N. Diringer, Erich Schmutzhard, Herbert Faleck, David Ng, Benjamin R. Saville, Thomas P. Bleck, Robert L. Grubb, Michael M. Miller, José I. Suárez, Howard M. Proskin, R. Loch Macdonald, Amal Abou‐Hamden, Rodney Allan, Laith Altaweel, Arun Paul Amar, Sepideh Amin‐Hanjani, Khaled Aziz, Nicholas C. Bambakidis, Michel W. Bojanowski, Ondřej Bradáč, Sherry Chou, Wayne M. Clark, Tim E. Darsaut, Koji Ebersole, Lucas Elijovich, William D. Freeman, Roland Goldbrunner, Carmelo Graffagnino, Gaurav Gupta, Jiřina Habalová, Moshe Hadani, Sagi Harnof, Mark R. Harrigan, Kevin W. Hatton, Raimund Helbok, Tomáš Hrbáč, Hagen B. Huttner, Pascal Jabbour, Babak S. Jahromi, Robert F. James, J. Dedrick Jordan, Michael Kelly, Riku Kivisaari, Nerissa Ko, Juergen Konczalla, David Kung, Shouri Lahiri, David J. Langer, Matthew F. Lawson, Cappi Lay, Didier Ledoux, George Α. Lopez, W.M. Lui, Charles Matouk, Edward Mee, Jürgen Meixensberger, Oliver Müller, Vincent Ng Yew Poh, Juha Öhman, Peter J. Papadakos, Aman B. Patel, Adam Polifka, Wai Sang Poon, Ciarán J. Powers, John Reavey‐Cantwell, Gary Redekop, Jan Regelsberger, Guy Rosenthal, Yu‐Mi Ryang, Eric Sauvageau, Ian Seppelt, Martin Smrčka, Julian Spears, Ajith J. Thomas, Raymond D Turner, Andreas Unterberg, Peter Vajkoczy, Paul Vespa, Daniel E. Walzman, Thomas Westermaier, John H. Wong, Menashe Zaaroor, Joseph M. Zabramski,
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this study to evaluate efficacy and safety of a single intraventricular 600 mg dose of EG-1962 to patients with aneurysmal subarachnoid hemorrhage, compared with standard of care oral nimodipine. Methods— Subjects were World Federation of Neurological ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2020 - Lippincott Williams & Wilkins | Stroke
Somaira Nowsheen, Rebecca L. Wukovich, Khaled Aziz, Peter T. Kalogerinis, C. Richardson, Mihalis I. Panayiotidis, William M. Bonner, Olga A. Sedelnikova, Alexandros G. Georgakilas,
Increased levels of oxidatively induced DNA damage have been reported in various cases of human pathogenesis like age-related and chronic diseases. Advances in experimental carcinogenesis associate high oxidative stress with genome instability and oncogenic transformation. Cancer biomarkers are helpful for early tumor diagnostics, prediction of tumor development, and analysis of individual tumors' response to therapy as well as recurrence. The repair resistant oxidatively induced clustered DNA lesions ( ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2008 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Brandon J. Baird, Jennifer S. Dickey, Asako Nakamura, Christophe E. Redon, Palak R. Parekh, Yuri Griko, Khaled Aziz, Alexandros G. Georgakilas, William M. Bonner, Olga A. Martin,
Hibernation is an established strategy used by some homeothermic organisms to survive cold environments. In true hibernation, the core body temperature of an animal may drop to below 0 °C and metabolic activity almost cease. The phenomenon of hibernation in humans is receiving renewed interest since several cases of victims exhibiting core body temperatures as low as 13.7 °C have been revived with minimal lasting deficits. In addition, local cooling during radiotherapy has resulted in normal tissue ...
Tópico(s): Thermal Regulation in Medicine
2010 - Elsevier BV | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Prakash Peddi, Charles W. Loftin, Jennifer S. Dickey, Jessica M. Hair, Kara J. Burns, Khaled Aziz, David Francisco, Mihalis I. Panayiotidis, Olga A. Sedelnikova, William M. Bonner,
DNA-dependent protein kinase (DNA-PK) is a key non-homologous-end-joining (NHEJ) nuclear serine/threonine protein kinase involved in various DNA metabolic and damage signaling pathways contributing to the maintenance of genomic stability and prevention of cancer. To examine the role of DNA-PK in processing of non-DSB clustered DNA damage, we have used three models of DNA-PK deficiency, i.e., chemical inactivation of its kinase activity by the novel inhibitors IC86621 and NU7026, knockdown and complete ...
Tópico(s): Acute Lymphoblastic Leukemia research
2010 - Elsevier BV | Free Radical Biology and Medicine
Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gajula, Michael Armour, Jillian Phallen, Stephanie A. Terezakis, Lawrence Kleinberg, Kristin J. Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quiñones‐Hinojosa, Phuoc T. Tran, Michael Lim,
Pituitary adenomas with local invasion and high secretory activity remain a therapeutic challenge. The HIV protease inhibitor nelfinavir is a radiosensitizer in multiple tumor models. We tested nelfinavir as a radiosensitizer in pituitary adenoma cells in vitro and in vivo. We examined the effect of nelfinavir with radiation on in vitro cell viability, clonogenic survival, apoptosis, prolactin secretion, cell cycle distribution, and the PI3K-AKT-mTOR pathway. We evaluated tumor growth delay and ...
Tópico(s): Chromatin Remodeling and Cancer
2011 - Taylor & Francis | Cancer Biology & Therapy
Somaira Nowsheen, Khaled Aziz, Mihalis I. Panayiotidis, Alexandros G. Georgakilas,
The last decade has witnessed an emerging role for molecular or biochemical markers indicating a specific cellular mechanism or tissue function, often called 'biomarkers'. Biomarkers such as altered DNA, proteins and inflammatory cytokines are critical in cancer research and strategizing treatment in the clinic. In this review we look at the application of biological indicators to cancer research and highlight their roles in cancer detection and treatment. With technological advances in gene expression, ...
Tópico(s): Cancer Research and Treatments
2011 - Elsevier BV | Cancer Letters
Phuoc T. Tran, Emelyn H. Shroff, Timothy F. Burns, Saravanan Thiyagarajan, Sandhya Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, E. Alejandro Sweet‐Cordero, Sanjiv S. Gambhir, Charles M. Rudin, Dean W. Felsher,
KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in both a novel transgenic mutant Kras lung cancer mouse model and in human lung tumors that the inhibition of Twist1 restores a senescence program inducing the loss of a neoplastic phenotype. The Twist1 gene encodes for a transcription factor that is essential ...
Tópico(s): Epigenetics and DNA Methylation
2012 - Public Library of Science | PLoS Genetics
Somaira Nowsheen, Khaled Aziz, Phuoc T. Tran, Vassilis G. Gorgoulis, Eddy S. Yang, Alexandros G. Georgakilas,
The study of epigenetic mechanisms in cancer, such as DNA methylation and histone modifications, has revealed a plethora of events that contribute to cancer through stable changes in the expression of genes critical to transformation pathways. In this mini review we look at the different epigenetic modifications prevalent in this neoplastic phenotype, focusing on breast cancer. Most encouragingly, research in epigenetics has led to improved survival of patients with certain forms of lymphoma and ...
Tópico(s): RNA modifications and cancer
2012 - Elsevier BV | Cancer Letters
Jing Zeng, Khaled Aziz, Sivarajan T. Chettiar, Blake T. Aftab, Michael Armour, Rajendra P. Gajula, Nishant Gandhi, Tarek Salih, Joseph M. Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales,
Purpose Despite improvements in chemoradiation, local control remains a major clinical problem in locally advanced non-small cell lung cancer. The Hedgehog pathway has been implicated in tumor recurrence by promoting survival of tumorigenic precursors and through effects on tumor-associated stroma. Whether Hedgehog inhibition can affect radiation efficacy in vivo has not been reported. Methods and Materials We evaluated the effects of a targeted Hedgehog inhibitor (HhAntag) and radiation on clonogenic ...
Tópico(s): Epigenetics and DNA Methylation
2012 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Eliah R. Shamir, Elisa Pappalardo, Danielle M. Jorgens, Kester Coutinho, Wen-Ting Tsai, Khaled Aziz, Manfred Auer, Phuoc T. Tran, Joel S. Bader, Andrew J. Ewald,
Dissemination of epithelial cells is a critical step in metastatic spread. Molecular models of dissemination focus on loss of E-cadherin or repression of cell adhesion through an epithelial to mesenchymal transition (EMT). We sought to define the minimum molecular events necessary to induce dissemination of cells out of primary murine mammary epithelium. Deletion of E-cadherin disrupted epithelial architecture and morphogenesis but only rarely resulted in dissemination. In contrast, expression of ...
Tópico(s): Epigenetics and DNA Methylation
2014 - Rockefeller University Press | The Journal of Cell Biology
Aaron T. Wild, Nishant Gandhi, Sivarajan T. Chettiar, Khaled Aziz, Rajendra P. Gajula, Russell D. Williams, Rachit Kumar, Kekoa Taparra, Jing Zeng, Jessica Cades, Esteban Velarde, Siddharth Menon, J.F. Geschwind, David Cosgrove, Timothy M. Pawlik, Anirban Maitra, John Wong, Russell K. Hales, Michael Torbenson, Joseph M. Herman, Phuoc T. Tran,
Sorafenib (SOR) is the only systemic agent known to improve survival for hepatocellular carcinoma (HCC). However, SOR prolongs survival by less than 3 months and does not alter symptomatic progression. To improve outcomes, several phase I-II trials are currently examining SOR with radiation (RT) for HCC utilizing heterogeneous concurrent and sequential treatment regimens. Our study provides preclinical data characterizing the effects of concurrent versus sequential RT-SOR on HCC cells both in vitro ...
Tópico(s): Cancer Mechanisms and Therapy
2013 - Public Library of Science | PLoS ONE
Rajendra P. Gajula, Sivarajan T. Chettiar, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Katō, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana J. Fertig, Shyam Biswal, Timothy F. Burns, Christine H. Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven S. An, Phuoc T. Tran,
Twist1, a basic helix-loop-helix transcription factor, plays a key role during development and is a master regulator of the epithelial-mesenchymal transition (EMT) that promotes cancer metastasis. Structure-function relationships of Twist1 to cancer-related phenotypes are underappreciated, so we studied the requirement of the conserved Twist box domain for metastatic phenotypes in prostate cancer. Evidence suggests that Twist1 is overexpressed in clinical specimens and correlated with aggressive/ ...
Tópico(s): Mechanisms of cancer metastasis
2013 - American Association for Cancer Research | Molecular Cancer Research
Nishant Gandhi, Aaron T. Wild, Sivarajan T. Chettiar, Khaled Aziz, Yoshinori Katō, Rajendra P. Gajula, Russell D. Williams, Jessica Cades, Anvesh Annadanam, Danny Y. Song, Yonggang Zhang, Russell K. Hales, Joseph M. Herman, Elwood P. Armour, Theodore L. DeWeese, Edward M. Schaeffer, Phuoc T. Tran,
Outcomes for poor-risk localized prostate cancers treated with radiation are still insufficient. Targeting the "non-oncogene" addiction or stress response machinery is an appealing strategy for cancer therapeutics. Heat-shock-protein-90 (Hsp90), an integral member of this machinery, is a molecular chaperone required for energy-driven stabilization and selective degradation of misfolded "client" proteins, that is commonly overexpressed in tumor cells. Hsp90 client proteins include critical components ...
Tópico(s): Radiation Therapy and Dosimetry
2013 - Taylor & Francis | Cancer Biology & Therapy
Geniey Yang, Somaira Nowsheen, Khaled Aziz, Alexandros G. Georgakilas,
Breast cancer is a heterogeneous disease affecting thousands of people every year. Multiple factors are responsible in causing breast cancer while a number of treatment options are also available for the disease. Tamoxifen is the most widely used anti-estrogen for the treatment of hormone-dependent breast cancer. The specific drug is used as a hormonal therapy for patients who exhibit estrogen receptor positive breast cancer. The pharmacological activity of Tamoxifen is dependent on its conversion ...
Tópico(s): Cancer Treatment and Pharmacology
2013 - Elsevier BV | Pharmacology & Therapeutics
Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah N. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, Charles M. Rudin,
Abstract A large fraction of non–small cell lung cancers (NSCLC) are dependent on defined oncogenic driver mutations. Although targeted agents exist for EGFR- and EML4-ALK–driven NSCLCs, no therapies target the most frequently found driver mutation, KRAS. Furthermore, acquired resistance to the currently targetable driver mutations is nearly universally observed. Clearly a novel therapeutic approach is needed to target oncogene-driven NSCLCs. We recently showed that the basic helix-loop-helix transcription ...
Tópico(s): Cancer therapeutics and mechanisms
2013 - American Association for Cancer Research | Molecular Cancer Research
Guus M. Bol, Farhad Vesuna, Min Xie, Jing Zeng, Khaled Aziz, Nishant Gandhi, Anne Levine, Ashley Irving, Dorian Korz, Saritha Tantravedi, Marise R. Heerma van Voss, Kathleen L. Gabrielson, Evan A. Bordt, Brian M. Polster, Leslie Cope, Petra van der Groep, Atul Kondaskar, Michelle A. Rudek, Ramachandra S. Hosmane, Elsken van der Wall, P. J. van Diest, Phuoc T. Tran, Venu Raman,
Tópico(s): RNA modifications and cancer
2015 - Springer Nature | EMBO Molecular Medicine
Somaira Nowsheen, Khaled Aziz, Jung Tak Park, Amir Lerman, Hector R. Villarraga, Kathryn J. Ruddy, Joerg Herrmann,
Background Trastuzumab is life-extending therapy for breast cancer patients overexpressing the human epidermal growth factor receptor 2 ( HER 2+), but has known cardiotoxic risk. We sought to determine if trastuzumab can be administered to patients with reduced baseline cardiac function at no higher cardiotoxicity risk than in those with normal cardiac function at baseline. Methods and Results We performed a retrospective study of women treated with trastuzumab for human epidermal growth factor receptor ...
Tópico(s): Peptidase Inhibition and Analysis
2018 - Wiley | Journal of the American Heart Association
Khaled Aziz, Jazeel F. Limzerwala, Ines Sturmlechner, Erin Hurley, Cheng Zhang, Karthik B. Jeganathan, Grace G. Nelson, Steve F. Bronk, Raul O. Fierro Velasco, Erik-Jan van Deursen, Daniel R. O’Brien, Jean‐Pierre Kocher, Sameh A. Youssef, Janine H. van Ree, Alain de Bruin, Hilda van den Bos, Diana C.J. Spierings, Floris Foijer, Bart van de Sluis, Lewis R. Roberts, Gregory J. Gores, Hu Li, Jan M. van Deursen,
The CCNE1 locus, which encodes cyclin E1, is amplified in many types of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected with hepatitis B virus or adeno-associated virus type 2, due to integration of the virus nearby. We investigated cell-cycle and oncogenic effects of cyclin E1 overexpression in tissues of mice.We generated mice with doxycycline-inducible expression of Ccne1 (Ccne1T mice) and activated overexpression of cyclin E1 from age 3 weeks onward. At ...
Tópico(s): Microtubule and mitosis dynamics
2019 - Elsevier BV | Gastroenterology
Seung Baek Lee, Jung‐Jin Kim, Sang‐Ah Han, Yingfang Fan, Li-Sha Guo, Khaled Aziz, Somaira Nowsheen, Sung Sun Kim, Seon‐Young Park, Qifeng Luo, Jin Ook Chung, Sung Il Choi, Asef Aziz, Ping Yin, Seo‐Yun Tong, Fabienne C. Fiesel, Wolfdieter Springer, Jin‐San Zhang, Zhenkun Lou,
Tópico(s): Cancer-related Molecular Pathways
2019 - Nature Portfolio | Nature Cell Biology
Devin Miles, Daniel M. Sforza, John Wong, Kathleen L. Gabrielson, Khaled Aziz, Mahadevappa Mahesh, Jonathan B. Coulter, Ismaeel Siddiqui, Phuoc T. Tran, Akila Viswanathan, Mohammad Rezaee,
Purpose This work describes the first implementation and in vivo study of ultrahigh-dose-rate radiation (>37 Gy/s; FLASH) effects induced by kilovoltage (kV) x-ray from a rotating-anode x-ray source. Methods and Materials A high-capacity rotating-anode x-ray tube with an 80-kW generator was implemented for preclinical FLASH radiation research. A custom 3-dimensionally printed immobilization and positioning tool was developed for reproducible irradiation of a mouse hind limb. Calibrated Gafchromic (EBT3) film ...
Tópico(s): Nuclear Physics and Applications
2023 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Tracey Wilson, Khaled Aziz, Dolores Vazques, Lisa‐Ann Wuermser, Victor K. Lin, Gary E. Lemack,
Abstract Aims Smooth muscle myosin heavy chain (SMMHC) isoform composition has been shown to be developmentally regulated and to be associated with functional changes in smooth muscle activity. In this study, we sought to determine expression patterns of SMMHC isoforms in a murine model of spinal cord injury (SCI) and to compare these expression patterns to neurologic, cytometric, and morphometric findings. Materials and Methods Baseline cystometry was performed on adult, female mice followed by either ...
Tópico(s): Cardiomyopathy and Myosin Studies
2004 - Wiley | Neurourology and Urodynamics