Shu Xia, Manish Kohli, Meijun Du, Rachel L. Dittmar, Adam F. Lee, Debashis Nandy, Tiezheng Yuan, Yongchen Guo, Yuan Wang, Michael Tschannen, Elizabeth A. Worthey, Howard J. Jacob, William A. See, Deepak Kilari, Xuexia Wang, Raymond Hovey, Chiang‐Ching Huang, Liang Wang,
... 5 , Howard Jacob 5 , William See 6 , Deepak Kilari 6 , Xuexia Wang 7 , Raymond L. Hovey 8 , ...
Tópico(s): Genetic factors in colorectal cancer
2015 - Impact Journals LLC | Oncotarget
David T. Hoang, Kenneth A. Iczkowski, Deepak Kilari, William A. See, Marja T. Nevalainen,
... T. Hoang 1 , Kenneth A. Iczkowski 2 , Deepak Kilari 3 , William See 4 , Marja T. Nevalainen 2, ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2016 - Impact Journals LLC | Oncotarget
Savita Mehendale, Anitha S. Kilari, Kamini Dangat, Vaishali Taralekar, Sahebarao P. Mahadik, Sadhana Joshi,
Mehendale, S.; Kilari, A.; Dangat, K.; Taralekar, V.; Mahadik, S.; Joshi, S. Author Information
Tópico(s): Birth, Development, and Health
2009 - Lippincott Williams & Wilkins | Obstetric Anesthesia Digest
Timothy C. Flynn, Elizabeth A. Guancial, Maria Kilari, Deepak Kilari,
Androgen receptor (AR) signaling pathway inhibition has been the mainstay of treatment for men with systemic prostate cancer (PC) since Charles Huggins' seminal publication in 1941.1 Even in men with metastatic castrate-resistant prostate cancer (mCRPC), disease progression is androgen-driven, as demonstrated by the overall survival advantage noted with abiraterone acetate (AA) and enzalutamide (enza), agents that interfere with either androgen biosynthesis or AR signaling, respectively, and the observation ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2016 - Elsevier BV | Clinical Genitourinary Cancer
Anitha S. Kilari, Savita Mehendale, Kamini Dangat, Hemlata R. Yadav, Asmita V. Kulakarni, Madhavi Dhobale, Vaishali Taralekar, Sadhana Joshi,
To establish the levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in both plasma and erythrocytes of maternal and cord blood as well as in breast milk of mothers delivering babies at term.A total of 148 mothers delivering babies at term were recruited from Bharati Medical Hospital, Pune, India.Levels of DHA and AA in both plasma and erythrocyte were higher in cord blood compared to levels in maternal blood (P<0.001). Maternal plasma and erythrocyte DHA levels had a positive association ...
Tópico(s): Neonatal Respiratory Health Research
2009 - De Gruyter | Journal of Perinatal Medicine
S. K. Mastan, G. Chaitanya, T Latha, A. Srikanth, G Sumalatha, Eswar Kumar Kilari,
The present study was designed to scientifically ev aluate the cardioprotective potential of methanolic extract of Syzygium cumini (Family: Myrtaceae) seeds, a medicinal herb, on isoproterenol-induced Myocardial Infarction (MI) in rats. Five groups of albino rats, each comprising six animals, were selected for this stud y. Group I served as a control, Group II rats were given isoproterenol (20 mg/100 g, subc utaneously), and Group III rats were given methanolic extract of Syzygium cumini seeds (SME) ...
Tópico(s): Natural Products and Biological Research
2009 - | Der pharmacia lettre
Savita Mehendale, Anitha S. Kilari Bams, Chaya S. Deshmukh, Bharati Dhorepatil, Vandana N. Nimbargi, Sadhana Joshi,
Prostaglandins are exclusively synthesized in vivo from cell membrane essential fatty acids and together are known to regulate many aspects of reproductive processes. The objective of the study was to examine whether disturbances in fatty acid profile as a result of increased oxidative stress could be one of the causes of female infertility. Forty-five infertile and 30 control women were enrolled via the Department of Obstetrics and Gynecology of Bharati Medical College Hospital, Pune, India. Essential ...
Tópico(s): Reproductive Physiology in Livestock
2009 - Taylor & Francis | Human Fertility
S. K. Mastan, Eswar Kumar Kilari,
Type 2 diabetes may occur as a result of HIV infection and/or its treatment. Gliclazide is a widely used drug for the treatment of type 2 diabetes. Efavirenz and nevirapine are widely used non-nucleoside reverse transcriptase inhibitors for the treatment of HIV infection. The role of Efavirenz and nevirapine on the pharmacodynamic activity of gliclazide is not currently known. The objective of this study was to examine the effect of oral administration of efavirenz and nevirapine on blood glucose ...
Tópico(s): HIV Research and Treatment
2009 - BioMed Central | Diabetology & Metabolic Syndrome
Kamini Dangat, Savita Mehendale, Hemlata R. Yadav, Anitha S. Kilari, Asmita Kulkarni, Vaishali Taralekar, Sadhana Joshi,
<i>Background:</i> Maternal fatty acid nutrition during pregnancy and lactation determines the transfer of long-chain polyunsaturated fatty acids via the placenta and through human milk. Neural maturation of breast-fed infants is known to be linked to breast-milk long-chain polyunsaturated fatty acid concentrations. In spite of this, the fatty acid composition of breast milk in pre-eclamptic mothers is poorly understood. <i>Objectives:</i> To compare the fatty acid composition ...
Tópico(s): Breastfeeding Practices and Influences
2009 - Karger Publishers | Neonatology
Shaik Mastan, Eswar Kumar Kilari,
The objective of this study was to investigate the effect of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination. Blood samples were analysed for blood glucose by GOD/POD method, serum gliclazide levels by HPLC method and insulin by Radio Immuno Assay method. In combination, atazanavir significantly enhanced the pharmacodynamic activity and altered the pharmacokinetic parameters ...
Tópico(s): HIV Research and Treatment
2009 - Elsevier BV | International Journal of Diabetes Mellitus
... Sep-2021. Zhao C, Zuckerman S, Cai C, Kilari S, Singh A, Simeon M, von Recum H, ...
Tópico(s): Inflammatory mediators and NSAID effects
2002 - Lippincott Williams & Wilkins | Circulation
Bernard Escudier, Jean‐Pierre Droz, Frédéric Rolland, Marie-Josée Terrier-Lacombe, Gwénaëlle Gravis, Philippe Beuzeboc, B. Chauvet, Christine Chevreau, J.C. Eymard, Thierry Lesimple, Yacine Merrouche, Stéphane Oudard, Frank Priou, C. Guillemare, Sophie Gourgou, Stéphane Culine,
... G, Schmidt L, Tolat P, Riese M and Kilari D (2020) Salvage ipilimumab associated with a significant ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2002 - Lippincott Williams & Wilkins | The Journal of Urology
Sadhana R. Joshi, Savita Mehendale, Kamini Dangat, Anitha S. Kilari, Hemlata R. Yadav, Vaishali Taralekar,
<i>Background/Aims:</i> Our earlier study has shown that increased maternal oxidative stress and reduced antioxidants like vitamin E and C play an important role in fetal growth in preeclampsia. However, the role of antioxidants and their effects on gestation and birth outcome in normotensive pregnancies are not conclusive. The present study examined plasma malondialdehyde as a marker of oxidative stress and antioxidant concentrations (vitamins E and C) in maternal as well as in cord ...
Tópico(s): Pregnancy and Medication Impact
2008 - Karger Publishers | Annals of Nutrition and Metabolism
Sreenivasulu Kilari, Raghu Pullakhandam, Punjal Ravinder, K. Madhavan Nair,
The kinetics, depletion/repletion of zinc, and effects of dietary ligands/food matrices on 65Zn uptake was studied in Caco-2 cells. The uptake of zinc showed a saturable and nonsaturable component, depending upon the media zinc concentrations. Intracellular depletion increased zinc uptake, whereas zinc loading did not. Phytic acid and histidine inhibited zinc uptake, while tannic acid, tartaric acid, arginine, and methionine increased zinc uptake. Tannic acid at a 1:50 molar ratio promoted zinc ...
Tópico(s): Phytase and its Applications
2008 - American Chemical Society | Journal of Agricultural and Food Chemistry
Sreenivasulu Kilari, Raghu Pullakhandam, K. Madhavan Nair,
The effect of red wine (RW), red grape juice (RGJ), green tea (GT), and representative polyphenols on Caco-2 cell (65)Zn uptake was explored. RW, RGJ, and GT enhanced the uptake of zinc from rice matrix. Fractionation of RW revealed that enhancing activity of zinc uptake was exclusively resided in the polyphenol fraction. Among the polyphenols tested, only tannic acid and quercitin stimulated the uptake of zinc while others did not influence the uptake. In tune with these results, only tannic acid and ...
Tópico(s): Plant Micronutrient Interactions and Effects
2010 - Wiley | Journal of Food Science
Asmita Kulkarni, Savita Mehendale, Hemlata R. Yadav, Anitha S. Kilari, Vaishali Taralekar, Sadhana Joshi,
Tópico(s): Gestational Diabetes Research and Management
2010 - Springer Nature | Hypertension Research
Absar Ahmed Qureshi, Eswar Kumar Kilari,
This paper reviews the morphology, traditional uses, chemical constituents, and pharmacological activities (including analgesic, antibacterial, antifungal, antioxidant, antiplatelet, antitussive, antiviral, gastroprotective, insecticidal and spermicidal) of Trachyspermum ammi
Tópico(s): Natural Antidiabetic Agents Studies
2010 - Dr. R.S. Yadav | PLANT ARCHIVES
Tongdan Jin, Haitao Liao, Madhu Kilari,
A latent failure mode is a type of failure that may not occur until the system has operated in the field for a certain period of time. Predicting latent failures is often difficult, but it has a great importance for reliability management in terms of system maintenance and warranty services. This paper proposes a stochastic model to predict the reliability growth for field or in-service electronic systems considering latent failures. The proposed model can be applied to electronics industries where ...
Tópico(s): Safety Systems Engineering in Autonomy
2010 - Elsevier BV | Microelectronics Reliability
Anitha S. Kilari, Savita Mehendale, Hemlata Pisal, Tushar Panchanadikar, Anvita Kale, Sadhana Joshi,
The present study compares nerve growth factor (NGF) levels between preeclamptic (PE) (n=86) and normotensive (NT) women (n=105) and their associations with blood pressure and infant size. Maternal plasma NGF levels were reduced (p<0.05) in the PE group as compared to the NT group. Furthermore, NGF levels were reduced in PE mothers delivering low birth weight babies (LBW) as compared to NT mothers delivering LBW babies. Maternal NGF levels were negatively (p=0.029) associated with blood pressure in preeclamptic ...
Tópico(s): Reproductive System and Pregnancy
2010 - Wiley | International Journal of Developmental Neuroscience
Anitha S. Kilari, Savita Mehendale, Kamini Dangat, Hemalata R. Yadav, Arti Gupta, Vaishali Taralekar, Sadhana Joshi,
to examine the levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in both plasma and erythrocytes of maternal and cord blood as well as in breast milk of mothers of preterm babies.a total of 63 mothers of preterm babies were recruited from the Bharati Medical Hospital, Pune, India.plasma and erythrocyte DHA and AA levels were higher (P<0.001) in cord blood than in maternal blood. Maternal plasma DHA and AA were positively (P<0.01) associated with their respective maternal erythrocyte levels. ...
Tópico(s): Infant Nutrition and Health
2010 - De Gruyter | Journal of Perinatal Medicine
Sreenivasulu Kilari, Raghu Pullakhandam, K. Madhavan Nair,
Studies in humans and animals have suggested negative interactions of iron and zinc during their intestinal absorption. Further, zinc seems to prevent iron-induced oxidative damage in rats, which was hypothesized to be through the modulation of the intracellular iron signaling pathway. The aim of this study was, therefore, to understand the effects of zinc on oxidant-induced iron signaling and cell death in human enterocyte-like Caco-2 cells. We demonstrate that zinc decreases glucose/glucose oxidase ( ...
Tópico(s): Heavy Metal Exposure and Toxicity
2010 - Elsevier BV | Free Radical Biology and Medicine
Asmita Kulkarni, Savita Mehendale, Hemlata Pisal, Anitha S. Kilari, Kamini Dangat, Satyajeet Salunkhe, Vaishali Taralekar, Sadhana Joshi,
Background & aims The present study examines the associations of folic acid, vitamin B12 and omega-3 fatty acids and increased homocysteine which are implicated in the pathology of pre-eclampsia. Methods 49 Pre-eclamptic and 57 normotensive women were recruited at Bharati hospital, Pune, India. Plasma folate, vitamin B12, homocysteine and erythrocyte omega-3 and omega-6 fatty acids were analyzed. Results Homocysteine concentrations were higher in pre-eclamptic than in normotensive women (14.28±7.31 ...
Tópico(s): Fatty Acid Research and Health
2010 - Elsevier BV | Clinical Nutrition
Absar Ahmed Qureshi, Eswar Kumar Kilari, Shaista Omer,
From ancient days to recent civilization, human beings depend on nature for running their life smoothly from day to day. Plants remain a vital source of drugs and now a day’s much emphasis have been given to nutraceuticals. Feronia limonia belonging to family Rutaceae is well known in Indian traditional systems for its traditional uses. Various parts of the plant have astringent, constipating, tonic for liver and lung, diuretic, carminative, and cardiotonic traditional uses. Various important phytoconstituents ...
Tópico(s): Phytochemicals and Medicinal Plants
2010 - Moksha Publishing House | International Journal of Research in Ayurveda and Pharmacy
Savita Mehendale, Anitha S. Kilari, Kamini Dangat, Vaishali Taralekar, Sahebarao P. Mahadik, Sadhana Joshi,
Abstract Objective To investigate whether free radical‐mediated membrane lipid peroxidation may be implicated in the pathogenesis of pre‐eclampsia. Methods A prospective study using a sample of 55 healthy pregnant women and 60 pre‐eclamptic women recruited at Bharati Medical Hospital, Pune, India. Maternal and cord samples were examined for (red blood cells and plasma) fatty acid profiles, antioxidants, and oxidative stress levels. Mean values were compared between case and control groups using the ...
Tópico(s): Birth, Development, and Health
2007 - Elsevier BV | International Journal of Gynecology & Obstetrics
Sreemantula Satyanarayana, Eswar Kumar Kilari, J. Rajasekhar, Leon Thomas, Sharada Rajanna, B. Rajanna,
Background: Since drugs from oriental medicine are used along with allopathic drug therapy in highly populated countries, such as India and China, and since optimal blood-sugar control is needed in diabetes, a herbal drug that influences blood glucose was studied for its effect on gliclazide response in normal and diabetic rats and normal rabbits. Objective: To evaluate the safety of the herb–drug combination with respect to blood glucose in animal models. Methods: Blood-glucose levels were estimated ...
Tópico(s): Diet, Metabolism, and Disease
2007 - Future Medicine | Therapy
Deepak Kilari, Supriya G. Mohile,
Cancer is primarily a disease of the elderly. According to the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) data, between the years 2003 and 2008 the median age at diagnosis for cancer of all sites was 66 years of age, with 54% of all cancers and 69.5% of all cancer deaths occurring in patients aged 65 years or older. With a steady increase in the average life expectancy and with the recent transition of the Baby Boomers into the over-65 age group, there has been a ...
Tópico(s): Genetic factors in colorectal cancer
2011 - Elsevier BV | Clinics in Geriatric Medicine
Srinath Satyanarayana, J. Rajad Sekhar, Eswar Kumar Kilari, L. Bacchus Shannika, B. Rajanna, Sharada Rajanna,
Tópico(s): Adipose Tissue and Metabolism
2006 - Springer Science+Business Media | Molecular and Cellular Biochemistry
Srinath Satyanarayana, Eswar Kumar Kilari,
Tópico(s): Veterinary Pharmacology and Anesthesia
2006 - Springer Science+Business Media | Molecular and Cellular Biochemistry
Cloud Computing provides an efficient and flexible way for services to meet escalating business needs. Cloudshared infrastructure and associated services make it cost effective alternative to traditional approaches. However, they may also introduce security breaches and privacy issues. As more cloud based applications keep evolving, the associated security threats are also growing. Many research works on cloud security exist in partial forms of either specifically on cloud issues or virtualization- ...
Tópico(s): IoT and Edge/Fog Computing
2012 - International Research Publication House | International Journal of Engineering Research and
Routhu Kasiviswanath, Alluri Ramesh, Eswar Kumar Kilari,
The hypoglycemic and antihyperglycemic effect of alcoholic extract of root of Gmelina asiatica LINN. (G. asiatica) was investigated in normal and in alloxan induced diabetic rats. The blood glucose levels were measured at 0 h and 1, 2, 4, 6, 8 and 16 h after the treatment. The alcoholic extract of G. asiatica showed significant (p<0.05) dose dependent percentage blood glucose reduction in normal (25.8% at 100 mg/kg, 28.9% at 250 mg/kg and 32.4% at 500 mg/kg body weight) and in diabetic rats (26.6% at ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2005 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin