Sangah Lee, Jiyae Jung, Yujin Lee, Seon‐Kyu Kim, Jung‐Ae Kim, Bo‐Kyung Kim, Kyung Chan Park, Byoung‐Mog Kwon, Dong Cho Han,
Although EGFR-TKI treatment of NSCLC (non-small-cell lung cancer) patients often achieves profound initial responses, the efficacy is transient due to acquired resistance. Multiple receptor tyrosine kinase (RTK) pathways contribute to the resistance of NSCLC to first- and third-generation EGFR-TKIs, such as erlotinib and osimertinib. To identify potential targets for overcoming EGFR-TKI resistance, we performed a gene expression signature-based strategy using connectivity map (CMap) analysis. We generated ...
Tópico(s): FOXO transcription factor regulation
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Naeun Jo, Hyoung Sul La, Jeong‐Hoon Kim, Kwanwoo Kim, Bo Kyung Kim, Myung Joon Kim, Wuju Son, Sang Heon Lee,
Marine particulate organic matter (POM) largely derived from phytoplankton is a primary food source for upper trophic consumers. Their biochemical compositions are important for heterotrophs. Especially, essential amino acids (EAAs) in phytoplankton are well known to have impacts on the survival and egg productions of herbivorous zooplankton. To estimate the nutritional quality of POM, the biochemical compositions [biomolecular and amino acid (AA) compositions] of POM were investigated in the northwestern ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2021 - Frontiers Media | Frontiers in Microbiology
Ravi Naik, Hyun Seung Ban, Kyusic Jang, Inhyub Kim, Xuezhen Xu, Dipesh S. Harmalkar, Seong-Ah Shin, Minkyoung Kim, Bo‐Kyung Kim, Jaehyung Park, Bonsu Ku, Soo Jin Oh, Misun Won, Kyeong Lee,
Previously, we reported a hypoxia-inducible factor (HIF)-1 inhibitor LW6 containing an (aryloxyacetylamino)benzoic acid moiety inhibits malate dehydrogenase 2 (MDH2) using a chemical biology approach. Structure–activity relationship studies on a series of (aryloxyacetylamino)benzoic acids identified selective MDH1, MDH2, and dual inhibitors, which were used to study the relationship between MDH enzyme activity and HIF-1 inhibition. We hypothesized that dual inhibition of MDH1 and MDH2 might be a powerful ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2017 - American Chemical Society | Journal of Medicinal Chemistry
Hyun Seung Ban, Xuezhen Xu, Kusik Jang, Inhyub Kim, Bo‐Kyung Kim, Kyeong Lee, Misun Won,
We previously reported that hypoxia-inducible factor (HIF)-1 inhibitor LW6, an aryloxyacetylamino benzoic acid derivative, inhibits malate dehydrogenase 2 (MDH2) activity during the mitochondrial tricarboxylic acid (TCA) cycle. In this study, we present a novel MDH2 inhibitor compound 7 containing benzohydrazide moiety, which was identified through structure-based virtual screening of chemical library. Similar to LW6, compound 7 inhibited MDH2 activity in a competitive fashion, thereby reducing NADH ...
Tópico(s): Mitochondrial Function and Pathology
2016 - Public Library of Science | PLoS ONE
Mee‐Ra Rhyu, Duk‐Kyung Kim, Hyeyoung Kim, Bo‐Kyung Kim,
Vasodilatory effects of aqueous extract of red rice fermented with Monascus ruber IFO32318 were examined on the isolated rat aorta. The water phase of fermented rice with Monascus (WP/FRM, 0.1–10 mg/ml) caused a transient relaxation of the endothelium-intact rat aorta precontracted with norepinephrine (NE, 300 nM). The WP/FRM-induced relaxation was abolished by removal of endothelium or in the presence of NG-nitro-l-arginine (l-NNA, 10 μM), a nitric oxide (NO) synthase inhibitor. Neither atropine, a ...
Tópico(s): Medicinal Plants and Neuroprotection
2000 - Elsevier BV | Journal of Ethnopharmacology
Eun‐Seok Park, Jun Chul Kang, Yong Chang Jang, Jong Seok Park, Shin Yi Jang, Dae‐Eun Kim, Bo‐Kyung Kim, Hwa‐Sup Shin,
Many studies have emphasized that flavonoids, found in various fruits, vegetables, and seeds, as well as tea and red wine, have potential health-promoting and disease-preventing effects. Rhamnetin is a flavonoid that exhibits antioxidant capabilities. However, little is known about its effect on cardiac myocytes under oxidative stress and the underlying mechanisms. H9c2 cardiomyoblast cells were subjected to H2O2, to study the protective effect of rhamnetin on cell viability, apoptosis, and ROS ...
Tópico(s): Sirtuins and Resveratrol in Medicine
2014 - Elsevier BV | Journal of Ethnopharmacology
HYO-YEOL LIM, Kyung Min Kim, Bo Kyung Kim, Jin‐Kyoung Shim, Ji-Hyun Lee, Yong‐Min Huh, Se Hoon Kim, Eui Hyun Kim, Eun-Kyung Park, Kyu‐Won Shim, Jong Hee Chang, Dong-Seok Kim, Sun Ho Kim, Yong-Kil Hong, Su‐Jae Lee, Seok‐Gu Kang,
Cells resembling bone marrow mesenchymal stem cells (BM-MSCs) have been isolated from glioma specimens; however, little is known about the existence of mesenchymal stem-like cells (MSLCs) in meningioma. Here, we hypothesized that cells similar to BM-MSCs exist in meningioma specimens and sought to investigate whether these putative meningioma stroma MSLCs (MS-MSLCs) could be isolated. To this end, we cultured fresh meningioma specimens using the same protocols as used previously to isolate BM-MSC. ...
Tópico(s): Cancer Cells and Metastasis
2013 - Spandidos Publishing | International Journal of Oncology
Byung Sik Kim, Bo Kyung Kim, Hung Soo Kim,
Abstract This paper reports the results of an investigation into flood simulation by areal rainfall estimated from the combination of gauged and radar rainfalls and a rainfall–runoff model on the Anseong‐cheon basin in the southern part of Korea. The spatial and temporal characteristics and behaviour of rainfall are analysed using various approaches combining radar and rain gauges: (1) using kriging of the rain gauge alone; (2) using radar data alone; (3) using mean field bias (MFB) of both radar and ...
Tópico(s): Flood Risk Assessment and Management
2008 - Wiley | Hydrological Processes
Hong-Man Kim, Sung‐Jin Bae, Dong‐Wook Kim, Bo‐Kyung Kim, Soo‐Bok Lee, Ung-Soo Lee, Cheorl‐Ho Kim, Sung‐Kwon Moon,
Magnolol, an active component extracted from Magnolia officinalis, has been reported to inhibit the development of atherosclerotic disease. However, it is not known whether magnolol exerts similar cardioprotective effects in cells treated with TNF-α. In the present study, magnolol treatment was found to show potent inhibitory effects on cell proliferation in cultured VSMC in the presence of TNF-α. These inhibitory effects were associated with reduced extracellular signal-regulated kinase (ERK) 1/ ...
Tópico(s): Oxidative Organic Chemistry Reactions
2007 - Elsevier BV | International Immunopharmacology
Beong Ou Lim, Jun‐Ho Lee, Na Young Ko, Se Hwan Mun, Jie Wan Kim, Do Kyun Kim, Ju Dong Kim, Bo Kyung Kim, Hyung Sik Kim, Erk Her, Hoi Young Lee, Wahn Soo Choi,
The antiallergic activity of Polygoni cuspidati radix (PR) and the mechanism of action by which it functions were investigated in this study. The extract of PR exhibited potent inhibitory activity in mast cells; its IC50 values were 62 +/- 2.1 microg/ml for RBL-2H3 mast cells and 46 +/- 3.2 microg/m for bone marrow-derived mast cells by antigen stimulation, and it also suppressed the expression of tumor necrosis factor-alpha and interleukin-4 in RBL-2H3 cells. According to the in vivo animal allergy model, ...
Tópico(s): Contact Dermatitis and Allergies
2007 - SAGE Publishing | Experimental Biology and Medicine
Ah Young Oh, Yang Hyun Kim, Bo Kyung Kim, Hee‐Soo Kim, Chong Sung Kim,
Tracheomalacia results in narrowing of the tracheal lumen during increased intrathoracic pressure caused by a thin tracheal wall. Symptomatic tracheomalacia is known to cause airway obstruction during general anesthesia (1). However, there are few reports showing these respiratory difficulties. We report an unexpected tracheomalacia exhibiting CO2 retention and an increased peak inspiratory pressure after the beginning of the operation; it was confirmed with fiberoptic bronchoscopy. Case Report A ...
Tópico(s): Pectus Deformity Diagnosis and Treatment
2002 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Ah Young Oh, Yang Hyun Kim, Bo Kyung Kim, Hee‐Soo Kim, Chong Sung Kim,
Tracheomalacia results in narrowing of the tracheal lumen during increased intrathoracic pressure caused by a thin tracheal wall. Symptomatic tracheomalacia is known to cause airway obstruction during general anesthesia (1). However, there are few reports showing these respiratory difficulties. We report an unexpected tracheomalacia exhibiting CO2 retention and an increased peak inspiratory pressure after the beginning of the operation; it was confirmed with fiberoptic bronchoscopy. Case Report A ...
Tópico(s): Airway Management and Intubation Techniques
2002 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
This essay is undertaken to analyze South Korea's successful strategies in tracing promptly and dealing properly with the corona pandemic. The "K-Quarantine" model can be identified as a combined total package of state-society synergy, equipped with a series of critical factors, such as institutionalized learning effects from MERS, the government leadership inherited from Korea's development state in the past, civic engagements with voluntary and transparent channels, high level of medical and ICT ...
Tópico(s): China's Socioeconomic Reforms and Governance
2020 - Routledge | Inter-Asia Cultural Studies
Hyun‐Ju Kim, Bo Kyung Kim, Boram Ohk, Hye‐Jin Yoon, Woo Youl Kang, Seung Il Cho, Sook Jin Seong, Hae Won Lee, Young‐Ran Yoon,
Estrogen‐related receptor γ (ERRγ) is an orphan nuclear receptor that plays an important role in various metabolic processes under physiological and pathophysiological conditions. Here, we report that ERRγ functions as a negative regulator in receptor activator of nuclear factor κΒ ligand (RANKL)–induced osteoclast differentiation. We observed that ERRγ was strongly expressed in osteoclast precursors, bone marrow–derived macrophages (BMMs) while its expression was significantly reduced by RANKL during ...
Tópico(s): Estrogen and related hormone effects
2018 - Wiley | Journal of Cellular Physiology
Sang Ah Yi, Jieun Lee, Sun Kyu Park, Jeom Yong Kim, Jong Woo Park, Min Gyu Lee, Ki Hong Nam, Jee Hun Park, Hwamok Oh, Saetbyul Kim, Jihoon Han, Bo Kyung Kim, Dong‐Gyu Jo, Jeung‐Whan Han,
The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition of the S6 kinase 1 (S6K1) signaling pathway.The inhibitory effects of BST204 on S6K1 signaling were investigated by immunoblot, nuclear fractionation, immunoprecipitation analyses. The antiadipogenic ...
Tópico(s): Autophagy in Disease and Therapy
2018 - Elsevier BV | Journal of Ginseng Research
Jun‐Ho Lee, Young Mi Kim, Nam Wook Kim, Jie Wan Kim, Erk Her, Bo Kyung Kim, Jong Hyun Kim, Sung Ho Ryu, Jong Woo Park, Dong Wan Seo, Jeung Whan Han, Michael A. Beaven, Wahn Soo Choi,
Abstract Mast cells are responsible for IgE-mediated allergic reactions. Phospholipase D1 (PLD1) and PLD2 regulate mast cell activation, but the mechanisms remain unclear. Here we show that PLD2 associates with and promotes activation of Syk, a key enzyme in mast cell activation. Antigen stimulation resulted in increased association and colocalization of Syk with PLD2 on the plasma membrane as indicated by coimmunoprecipitation and confocal microscopy. This association was dependent on tyrosine phosphorylation ...
Tópico(s): Asthma and respiratory diseases
2006 - Elsevier BV | Blood
Joo‐Young Im, Da-Mi Kim, Hyunkyung Park, Mi‐Jung Kang, Da-Yoon Kim, Kwan Young Chang, Bo‐Kyung Kim, Misun Won,
We previously reported that vestigial-like 1 (VGLL1), a cofactor of transcriptional enhanced associate domain 4 (TEAD4), is transcriptionally regulated by PI3K and β-catenin signaling and is involved in gastric cancer malignancy. However, the precise mechanism underlying the regulation of VGLL1 activation remains unknown. Therefore, we aimed to investigate the molecular mechanism underlying the transforming growth factor-β (TGF-β)-mediated activation of VGLL1 and the VGLL1-TEAD4 interaction in gastric ...
Tópico(s): Mechanisms of cancer metastasis
2020 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Marcus Noland, Sherman Robinson, Wang Tao,
... 07311613-9155154Taekyoon Kim, Jong‐Kyun Mok, Changbin Woo, Bo Kyung Kim From Humanitarian Relief to Democracy Aid: US Foreign ...
Tópico(s): Korean Peninsula Historical and Political Studies
2001 - University of Chicago Press | Economic Development and Cultural Change
Hyun‐Ju Kim, Hye‐Jin Yoon, Bo Kyung Kim, Woo Youl Kang, Sook Jin Seong, Mi‐sun Lim, Shin‐Yoon Kim, Young‐Ran Yoon,
G protein-coupled receptor 120 (GPR120) plays an important role in the regulation of inflammation and lipid metabolism. In this study, we investigated the role of GPR120 in osteoclast development and found that GPR120 regulates osteoclast differentiation, survival and function. We observed that GPR120 was highly expressed in osteoclasts compared to their precursors, bone marrow-derived macrophages (BMMs). Activation of GPR120 by its ligand GW9508 suppressed receptor activator of NF- κB ligand (RANKL)- ...
Tópico(s): NF-κB Signaling Pathways
2015 - Wiley | Journal of Cellular Physiology
Hye Young Kim, Seo Eun Lee, Min Jung Kim, Jin Il Han, Bo Kyung Kim, Yong Sung Lee, Young Seek Lee, Jin‐Hyuk Kim,
The quality of cDNA microarray data is crucial for expanding its application to other research areas, such as the study of gene regulatory networks. Despite the fact that a number of algorithms have been suggested to increase the accuracy of microarray gene expression data, it is necessary to obtain reliable microarray images by improving wet-lab experiments. As the first step of a cDNA microarray experiment, spotting cDNA probes is critical to determining the quality of spot images. We developed ...
Tópico(s): Nanofabrication and Lithography Techniques
2007 - BioMed Central | BMC Bioinformatics
Yu‐Hee Kim, Minhwa Park, Kyung‐Ah Cho, Bo‐Kyung Kim, Jung-Hwa Ryu, So‐Youn Woo, Kyung‐Ha Ryu,
Osteoporosis is a disease that affects 35% women and 20% men aged more than 65 years. Reduction in bone formation and increased bone resorption are known factors that drive osteoporosis, but recent studies suggest a positive correlation between bone marrow adipose tissue (MAT) and osteoporosis. Previously, we have observed that tonsil-derived mesenchymal stem cells (T-MSCs) reduce MAT in a mouse model of bone marrow depletion. That prompted us to investigate on the senile osteoporosis to characterize ...
Tópico(s): Fibroblast Growth Factor Research
2016 - Mary Ann Liebert, Inc. | Stem Cells and Development
Jung‐Hak Kim, Sun-Ji Park, Tae-Shin Kim, Hyo‐Jin Park, Junghyung Park, Bo Kyung Kim, Gyeong-Ryul Kim, Jin‐Man Kim, Song Huang, Jung‐Il Chae, Choon‐Keun Park, Dong‐Seok Lee,
The testes of most mammals are sensitive to temperature. To survive and adapt under conditions that promote endoplasmic reticulum (ER) stress such as heat shock, cells have a self-protective mechanism against ER stress that has been termed the "Unfolded Protein Response" (UPR). However, the cellular and molecular events underlying spermatogenesis with testicular hyperthermia involved in the UPR signaling pathway under ER stress remain poorly understood. In the present study, we verified that UPR signaling ...
Tópico(s): Autophagy in Disease and Therapy
2013 - Elsevier BV | Biochemical and Biophysical Research Communications
Sang-Ho Kim, Jin-Hyung Jeong, Jung-Hwa Lim, Bo-Kyung Kim,
Insomnia symptoms are common, affecting almost 30% of the population of the population. Many use medications that may be ineffective and cause substantial harm. In complementary and alternative medicine, acupuncture is widely used to manage mental health problems. Acupuncture therapy emphasizes individualized treatment according to TCM pattern diagnosis. Although there are some systematic reviews that acupuncture has the benefit for insomnia, there is no systematic review on acupuncture using pattern ...
Tópico(s): Acupuncture Treatment Research Studies
2019 - Elsevier BV | Integrative Medicine Research
Se Hwan Mun, Jie Wan Kim, Seong Su Nah, Na Young Ko, Jun‐Ho Lee, Ju Dong Kim, Do Kyun Kim, Hyuk Soon Kim, Ji Da Choi, Soo Hyun Kim, Chang Keun Lee, Seung Hwa Park, Bo Kyung Kim, Hyung Sik Kim, Young Mi Kim, Wahn Soo Choi,
Abstract Objective Interleukin‐32 (IL‐32) is a recently discovered cytokine that appears to play a critical role in human rheumatoid arthritis (RA). It is highly expressed in synovium and fibroblast‐like synoviocytes (FLS) from RA patients, but not in patients with osteoarthritis (OA). This study was undertaken to assess IL‐32 levels in RA synovial fluid (SF) and to investigate the secretion and regulation of IL‐32 in RA FLS. Methods FLS and SF were obtained from the joints of RA patients. The secretion ...
Tópico(s): Pharmacological Effects of Natural Compounds
2009 - Wiley | Arthritis & Rheumatism
Soojin Kim, Jae Won Jeong, Hye-Seon Jung, Bo-Kyung Kim, Ye-Eun Kim, Da-Sol Lim, Sodam Kim, Yun Seon Song,
Glucagon like peptide-1 (GLP-1) stimulates glucose-dependent insulin secretion.Dipeptidyl peptidase-4 (DPP-4) inhibitors, which block inactivation of GLP-1, are currently in clinical use for type 2 diabetes mellitus.Recently, GLP-1 has also been reported to have neuroprotective effects in cases of cerebral ischemia.We therefore investigated the neuroprotective effects of GLP-1 receptor (GLP-1R) agonist, exendin-4 (ex-4), after cerebral ischemia-reperfusion injury.Transient middle cerebral artery occlusion ( ...
Tópico(s): Adenosine and Purinergic Signaling
2017 - | Experimental Neurobiology
Kyoung‐Jae Won, Joo‐Young Im, Chae‐Ok Yun, Kyung‐Sook Chung, Young Joo Kim, Jung‐Sun Lee, Young–Jin Jung, Bo‐Kyung Kim, Kyung Bin Song, Young‐Ho Kim, Ho‐Kyung Chun, Kyeong Eun Jung, Moon‐Hee Kim, Misun Won,
Human Noxin (hNoxin, C11Orf82), a homolog of mouse noxin, is highly expressed in colorectal and lung cancer tissues. hNoxin contains a DNA-binding C-domain in RPA1, which mediates DNA metabolic processes, such as DNA replication and DNA repair. Expression of hNoxin is associated with S phase in cancer cells and in normal cells. Expression of hNoxin was induced by ultraviolet (UV) irradiation. Knockdown of hNoxin caused growth inhibition of colorectal and lung cancer cells. The comet assay and western ...
Tópico(s): Cancer Cells and Metastasis
2013 - Wiley | International Journal of Cancer
Se Hwan Mun, Na Young Ko, Hyuk Soon Kim, Jie Wan Kim, Do Kyun Kim, Aram Kim, Seung Hyun Lee, Yong‐Gil Kim, Chang Keun Lee, Seoung Hoon Lee, Bo Kyung Kim, Michael A. Beaven, Young Mi Kim, Wahn Soo Choi,
Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33 as a regulator of functional osteoclasts (OCs) from human CD14+ monocytes. IL-33 stimulates formation of tartrate-resistant acid phosphatase (TRAP)+ multinuclear OCs from monocytes. This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2, but not by the receptor activator of NF-κB ligand (RANKL) decoy, osteoprotegerin, or anti-RANKL antibody. IL-33 stimulated ...
Tópico(s): RNA Research and Splicing
2010 - Springer Nature | Cellular and Molecular Life Sciences
Seung‐Jae Lee, Yon-Suk Kim, Seong-Eun Kim, Eun‐Kyung Kim, Jin-Woo Hwang, Tae-Kyu Park, Bo Kyung Kim, Sang-Ho Moon, Byong-Tae Jeon, You‐Jin Jeon, Chang‐Bum Ahn, Jae‐Young Je, Pyo‐Jam Park,
An angiotensin I-converting enzyme (ACE) inhibitory peptide was isolated and identified from hydrolysates of duck skin byproducts. Duck skin byproducts were hydrolyzed using nine proteases (Alcalase, Collagenase, Flavourzyme, Neutrase, papain, pepsin, Protamex, trypsin, and α-chymotrypsin) to produce an antihypertensive peptide. Of the various hydrolysates produced, the α-chymotrypsin hydrolysate exhibited the highest ACE inhibitory activity. The hydrolysate was purified using fast protein liquid ...
Tópico(s): Meat and Animal Product Quality
2012 - American Chemical Society | Journal of Agricultural and Food Chemistry
Yu Jeong Lim, Tae‐Wan Kim, SangHoon Lee, Dabin Lee, Jisoo Park, Bo Kyung Kim, Kwanwoo Kim, Hyo Keun Jang, P. S. Bhavya, Sang Heon Lee,
Abstract The importance of small phytoplankton in warming and stratified water conditions has been emphasized, but little information on the small phytoplankton contribution is currently available in the Southern Ocean. In this study, we analyzed temporal variations in the carbon uptake rates of large and small phytoplankton and the small phytoplankton contributions to the total primary production. The data were collected in the Amundsen Sea polynya region using three different field observations ( ...
Tópico(s): Cryospheric studies and observations
2019 - Wiley | Journal of Geophysical Research Oceans
Jun‐Ho Lee, Jie Wan Kim, Na Young Ko, Se Hwan Mun, Erk Her, Bo Kyung Kim, Jeung Whan Han, Hoi Young Lee, Michael A. Beaven, Young Mi Kim, Wahn Soo Choi,
Background Activation of mast cells through the high-affinity receptor for IgE (FcɛRI) underlies atopic allergic reactions. Curcumin can block this activation, but the mechanism and the effects of curcumin on IgE-mediated allergic reactions are unknown. Objectives We sought to determine the antiallergic activity of curcumin in vivo and its mechanism of action in mast cells. Methods The antiallergic activity of curcumin was evaluated in mast cell cultures and the passive cutaneous anaphylaxis model. The effects ...
Tópico(s): Allergic Rhinitis and Sensitization
2008 - Elsevier BV | Journal of Allergy and Clinical Immunology