Beom Jin Kim, Hyuk Lee, Yong Chan Lee, Seong Woo Jeon, Gwang Ha Kim, Hyun‐Soo Kim, Jae Kyu Sung, Dong Ho Lee, Heung Up Kim, Moo In Park, Il Ju Choi, Soon Man Yoon, Sang Wook Kim, Gwang Ho Baik, Ju Yup Lee, Jin Il Kim, Sang Gyun Kim, Jayoun Kim, Joongyup Lee, Jae Gyu Kim, Jae J. Kim,
... Kim, Sang Gyun Kim, Jayoun Kim, Joongyup Lee, Jae Gyu Kim, and Jae J. Kim, Korean College of Helicobacter ...
Tópico(s): Galectins and Cancer Biology
2019 - Korean Association for the Study of the Liver | Gut and Liver
Gwang Ha Kim, Myung‐Gyu Choi, Jin Il Kim, Soo Teik Lee, Hoon Jai Chun, Kook Lae Lee, Suk Chei Choi, Jae Young Jang, Yong Chan Lee, Jae Gyu Kim, Ki Bae Kim, Ki–Nam Shim, Chong Il Sohn, Sung Kook Kim, Sang Gyun Kim, Jin Seok Jang, Nayoung Kim, Hwoon‐Yong Jung, Hyojin Park, Kyu Chan Huh, Kwang Jae Lee, Su Jin Hong, Song Ee Baek, J. Han, Oh Young Lee,
... Chei Choi, Jae-Young Jang, Yong Chan Lee, Jae Gyu Kim, Ki Bae Kim, Ki-Nam Shim, Chong Il ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2023 - Korean Association for the Study of the Liver | Gut and Liver
Hyuk Yoon, Dong Ho Lee, Yong-Hyun Lee, Ju-Cheol Jeong, Soo Teik Lee, Myung‐Gyu Choi, Seong Woo Jeon, Ki–Nam Shim, Gwang Ho Baik, Jae Gyu Kim, Jeong Seop Moon, In‐Kyung Sung, Sang Kil Lee, Poong‐Lyul Rhee, Hwoon‐Yong Jung, Bong Eun Lee, Hyun Soo Kim, Sang Gyun Kim, Kee Myung Lee, Jae Kyu Seong, Jin Seok Jang, Jong-Jae Park,
... Woo Jeon, Ki-Nam Shim, Gwang Ho Baik, Jae Gyu Kim, Jeong Seop Moon, In-Kyung Sung, Sang Kil ...
Tópico(s): Pharmacological Effects of Natural Compounds
2018 - Korean Association for the Study of the Liver | Gut and Liver
Radheshyam R. Pawar, Lalhmunsiama, Munui Kim, Jae-Gyu Kim, Seong-Min Hong, Sandesh Y. Sawant, Seung-Mok Lee,
The present communication addresses the removal of toxic lead, cadmium, and arsenic using iron oxide modified clay-activated carbon composite beads from aqueous solutions. The SEM-EDX analysis was conducted to study the heterogeneity of the surface and the elemental composition of the composite beads. The specific surface area of the composite beads was found to be 433 m2/g. Furthermore, the XRD pattern indicates the intercalation of iron particles between the layers of bentonite clay. The FT-IR ...
Tópico(s): Heavy metals in environment
2018 - Elsevier BV | Applied Clay Science
Song Ee Park, Jin Hwa Choi, Jae Yong Park, Beom Jin Kim, Jae Gyu Kim, Jong‐Won Kim, Joong‐Min Park, Kyong‐Choun Chi, In Gyu Hwang,
Abstract Cancer causes muscle mass loss, which is associated with a poor prognosis. Chemotherapy may also reduce muscle mass. We investigated skeletal muscle mass change during palliative chemotherapy for advanced gastric cancer (AGC) and its association with treatment outcomes. We retrospectively reviewed 111 consecutive AGC patients who underwent first-line palliative chemotherapy. Skeletal muscle area was measured before and after chemotherapy at the third lumbar vertebra level using computed ...
Tópico(s): Oral health in cancer treatment
2020 - Nature Portfolio | Scientific Reports
Jae Yong Park, Tae-Seop Shin, Ji Hyun Kim, Hong Jip Yoon, Beom Jin Kim, Jae Gyu Kim,
Antimicrobial resistance is one of the major factors determining the efficacy of Helicobacter pylori eradication therapy. This study aimed to estimate the recent prevalence of multidrug resistance of H. pylori and its impact on eradication in Korea. A total of 174 patients were prospectively enrolled at Chung-Ang University Hospital from 2017 to 2019. H. pylori strains were isolated from the gastric body and antrum. The minimum inhibitory concentrations of antibiotics were determined by the serial ...
Tópico(s): Gastric Cancer Management and Outcomes
2020 - Multidisciplinary Digital Publishing Institute | Antibiotics
Kwang‐Il Kim, Hye‐Kyung Jung, Chang Oh Kim, Soo‐Kyung Kim, Hyun-Ho Cho, Dae Yul Kim, Yong‐Chan Ha, Sung‐Hee Hwang, Chang Won Won, Jae‐Young Lim, Hyun Jung Kim, Jae Gyu Kim,
Falls and fall-related injuries are common in older populations and have negative effects on quality of life and independence. Falling is also associated with increased morbidity, mortality, nursing home admission, and medical costs. Korea has experienced an extreme demographic shift with its population aging at the fastest pace among developed countries, so it is important to assess fall risks and develop interventions for high-risk populations. Guidelines for the prevention of falls were first ...
Tópico(s): Health and Wellbeing Research
2017 - Korean Association of Internal Medicine | The Korean Journal of Internal Medicine
Joong‐Min Park, Beom Jin Kim, Jae Gyu Kim, Kyong-Choun Chi,
Purpose: Laparoscopic fundoplication is considered the standard surgical treatment for gastroesophageal reflux disease (GERD) in Western countries.However, some patients experience poor surgical outcomes with this procedure.The study aimed to identify the predictive factors of the surgical outcomes of laparoscopic Nissen fundoplication for the treatment of Korean GERD patients.Methods: Sixty-one patients with GERD were treated using laparoscopic Nissen fundoplication between November 2012 and February ...
Tópico(s): Eosinophilic Esophagitis
2017 - | Annals of Surgical Treatment and Research
Sang Wook Lee, Hyun Jung Kim, Jae Gyu Kim,
The efficacy of seven-day clarithromycin-based standard triple therapy (STT) for Helicobacter pylori has decreased in Korea over the past decade. The aim of this meta-analysis was to clarify the efficacy of first-line and second-line therapies in Korea. This systematic review will provide an overview of H. pylori eradication and present new therapeutic strategies used in Korea. An extensive search of the literature concerning STT, sequential therapy (SET), concomitant therapy (CT), bismuth-containing ...
Tópico(s): Gastric Cancer Management and Outcomes
2015 - Korean Academy of Medical Sciences | Journal of Korean Medical Science
Hee‐Jun Kim, Jae-Gyu Kim, Mi‐Young Moon, Seol-Hye Park, Jae‐Bong Park,
Tópico(s): NF-κB Signaling Pathways
2013 - Elsevier BV | Journal of Biological Chemistry
Mi‐Young Moon, Hee‐Jun Kim, Jae‐Gyu Kim, Jae‐Yong Lee, Jaebong Kim, Sungchan Kim, Ihn‐Geun Choi, Pyeung‐Hyeun Kim, Jae‐Bong Park,
Abstract Transforming growth factor (TGF)‐β1 regulates diverse cellular functions. Particularly, TGF‐β1 induces monocyte migration to sites of injury or inflammation in early period, whereas TGF‐β1 inhibits cell migration in late phase. In this study, we attempted to understand how TGF‐β1 suppresses cell migration in late phase. We found that TGF‐β1 of short exposure induces the production of chemokines, such as macrophage inflammatory protein (MIP)‐1α, by Raw 264.7 cells. However, knock‐down of small ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2013 - Wiley | Journal of Cellular Physiology
A worldwide increase in amoxicillin resistance in Helicobacter pylori is having an adverse effect on eradication therapy. In this study, we investigated the mechanism of the amoxicillin resistance of H. pylori in terms of amino acid substitutions in penicillin-binding protein 1 (PBP1).In total, 150 H. pylori strains were isolated from 144 patients with chronic gastritis, peptic ulcers, or stomach cancer. The minimum inhibitory concentrations (MICs) of the strains were determined with a serial 2-fold ...
Tópico(s): Gastric Cancer Management and Outcomes
2013 - Korean Association for the Study of the Liver | Gut and Liver
Kyu-Hyun Yoon, Sung Woon Park, Sang Wook Lee, Beom Jin Kim, Jae Gyu Kim,
We evaluated the antibiotic resistance rates and eradication rates of clarithromycin based triple therapy from 2005 to 2010 retrospectively. In addition, we investigated the mechanism of clarithromycin resistance in Helicobacter pylori strains isolated from Korean patients. Two hundred and twelve strains of H. pylori were isolated from 204 patients. H. pylori ATCC 43504 was used as the standard strain. The eradication rates of H. pylori from 2005 to 2010 were 89.3%, 82.6%, 86.3%, 87.7%, 81.8%, and ...
Tópico(s): Gastric Cancer Management and Outcomes
2014 - Korean Academy of Medical Sciences | Journal of Korean Medical Science
Jun-Sub Kim, Jae Gyu Kim, Mi-Young Moon, Chan-Young Jeon, Ha-Young Won, Hee‐Jun Kim, Yee-Jin Jeon, Ji-Yeon Seo, Jong‐Il Kim, Jaebong Kim, Jae‐Yong Lee, Pyeung-Hyeun Kim, Jae-Bong Park,
Abstract Brief treatment with transforming growth factor (TGF)–β1 stimulated the migration of macrophages, whereas long-term exposure decreased their migration. Cell migration stimulated by TGF-β1 was markedly inhibited by 10 μg/mL Tat-C3 exoenzyme. TGF-β1 increased mRNA and protein levels of macrophage inflammatory protein (MIP)–1α in the initial period, and these effects also were inhibited by 10 μg/mL Tat-C3 and a dominant-negative (DN)–RhoA (N19RhoA). Cycloheximide, actinomycin D, and antibodies ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2006 - Elsevier BV | Blood
Jun-Sub Kim, Jae Gyu Kim, Chan-Young Jeon, Ha-Young Won, Mi-Young Moon, Ji-Yeon Seo, Jong‐Il Kim, Jaebong Kim, Jae Yong Lee, Soo-Young Choi, Jinseu Park, Jung Han Yoon Park, Kwon‐Soo Ha, Pyeung-Hyeun Kim, Jae-Bong Park,
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis of serum- (SOZ) and IgG-opsonized zymosan particles (IOZ). In this study, we attempted to reveal the signal pathway components in the superoxide formation regulated by Rho GTPase. Tat-C3 blocked superoxide production, suggesting that RhoA is essentially involved in superoxide formation during phagocytosis of ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2005 - Springer Nature | Experimental & Molecular Medicine
Jeong Wook Kim, Jae Gyu Kim, Seok Lae Chae, Young‐Eun Joo, Sill Moo Park,
Background : The aims of our study were to determine the correlation of the strain variation and degree of homogeneity of infecting Helicobacter pylori (H. pylori) with their disease outcomes, and the relevance of duodenal H. pylori expression of cagA and/or vacA gene to the development of duodenal ulcer in Korean patients. Methods : One hundred and twenty bacterial colonies isolated from different anatomical sites of the stomach and duodenum were used. The study population was consisted of 40 Korean ...
Tópico(s): Eosinophilic Esophagitis
2004 - Korean Association of Internal Medicine | The Korean Journal of Internal Medicine
Chan‐Young Jeon, Mi‐Young Moon, Jong–Hyun Kim, Hee‐Jun Kim, Jae‐Gyu Kim, Yi Li, Jae‐Kwang Jin, Pyeung‐Hyeun Kim, Hyoung‐Chun Kim, Kathryn E. Meier, Yong‐Sun Kim, Jae‐Bong Park,
J. Neurochem. (2012) 120 , 684–698. Abstract cAMP induces neurite outgrowth in the rat pheochromocytoma cell line 12 (PC12). In particular, di‐butyric cAMP (db‐cAMP) induces a greater number of primary processes with shorter length than the number induced by nerve growth factor (NGF). db‐cAMP up‐ and down‐regulates GTP‐RhoA levels in PC12 cells in a time‐dependent manner. Tat‐C3 toxin stimulates neurite outgrowth, whereas lysophosphatidic acid (LPA) and constitutively active (CA)‐RhoA reduce neurite outgrowth, ...
Tópico(s): Ion channel regulation and function
2011 - Wiley | Journal of Neurochemistry
Jin Il Kim, Sang Gyun Kim, Nayoung Kim, Jae Gyu Kim, Sung Jae Shin, Sang Woo Kim, Hyun‐Soo Kim, Jae Kyu Sung, Chang Heon Yang, Ki–Nam Shim, Seun Ja Park, Joon Yong Park, Gwang Ho Baik, Sang Woo Lee, Jong Jae Park, Soo Jin Hong, Gin Hyug Lee, Geom Seog Seo, Sang In Lee, Hyun Chae Jung,
Changes in the pattern of gastrointestinal diseases in a population tend to be influenced by changes in diet and lifestyle. Shifts in gastrointestinal disease from 1995 to 2005 in Korea were evaluated, retrospectively.Seventeen nationwide medical centers participated in this study. The cross-sectional review of endoscopic findings in 28 893 patients included 8441 patients from 1995, 10 350 patients from 2000, and 10 102 patients from 2005.The prevalence of reflux esophagitis increased from 1.8% ...
Tópico(s): Gastric Cancer Management and Outcomes
2009 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology
Sang Gyun Kim, Jae Gyu Kim, Sung Kwan Shin, Hyun‐Soo Kim, Sang Young Seol,
Peptic ulcer is one of the most prevalent diseases in gastrointestinal field. Recently, evolution was made for pathophysiology of peptic ulcer from "no acid, no ulcer" to Helicobacter pylori and non-steroidal anti-inflammatory drugs. The prevalence of peptic ulcer disease is estimated about 10% in Korea, and has declined due to Helicobacter pylori eradication therapy. Peptic ulcer has the cycle of exacerbation and improvement in the clinical course, and has not occasionally any clinical symptom. ...
Tópico(s): Mycobacterium research and diagnosis
2009 - Jin Publishing & Printing Co. | Korean Journal of Gastroenterology
Eun Young Ze, Beom Jin Kim, Hyun Kang, Jae Gyu Kim,
To investigate the association between abdominal fat distribution represented by the visceral fat area (VFA) to subcutaneous fat area (SFA) ratio, and erosive esophagitis (EE).Seven hundred and twenty-eight participants aged >40 years underwent physical examination, blood tests, esophagogastroduodenoscopy, and abdominal computer tomography at Chung-Ang University Hospital from 2007 to 2012.Of 728 subjects, 65 (8.9%) had EE. The EE patients had higher body mass index, metabolic syndrome prevalence, triglyceride ...
Tópico(s): Bariatric Surgery and Outcomes
2017 - Springer Science+Business Media | Digestive Diseases and Sciences
Joo Hyun Lim, Sang Gyun Kim, Ji Hyun Song, Jae Jin Hwang, Dong Ho Lee, Jae Pil Han, Su Jin Hong, Ji Hyun Kim, Seong Woo Jeon, Gwang Ha Kim, Ki–Nam Shim, Woon Geon Shin, Tae Ho Kim, Sun Moon Kim, Il-Kwon Chung, Hyun‐Soo Kim, Heung Up Kim, Joongyub Lee, Jae Gyu Kim,
The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease.Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regimens ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - Korean Association for the Study of the Liver | Gut and Liver
Mi‐Young Moon, Hee‐Jun Kim, Yi Li, Jae-Gyu Kim, Yee-Jin Jeon, Ha-Young Won, Jun‐Sub Kim, Hyeok-Yil Kwon, Ihn-Geun Choi, Eusun Ro, Eun-hye Joe, Myeon Choe, Hyung‐Joo Kwon, Hyoung‐Chun Kim, Yong‐Sun Kim, Jae‐Bong Park,
Tópico(s): Advanced Glycation End Products research
2013 - Elsevier BV | Cellular Signalling
Jae‐Yong Park, Hochan Seo, Chil-Sung Kang, Tae-Seop Shin, Jong Won Kim, Joong‐Min Park, Jae Gyu Kim, Yoon‐Keun Kim,
Abstract Although there is a growing interest in the role of gastric microbiome on the development of gastric cancer, the exact mechanism is largely unknown. We aimed to investigate the changes of gastric microbiome during gastric carcinogenesis, and to predict the functional potentials of the microbiome involved in the cancer development. The gastric microbiome was analyzed using gastric juice samples from 88 prospectively enrolled patients, who were classified into gastritis, gastric adenoma, ...
Tópico(s): Gastric Cancer Management and Outcomes
2022 - Nature Portfolio | Scientific Reports
Hyun Kang, Beom Jin Kim, Geun-Joo Choi, Jae Gyu Kim,
Abstract Background: Vonoprazan, a novel potassium-competitive acid blocking agent, has been used in the management of endoscopic submucosal dissection (ESD)-induced artificial ulcers. This study aimed to perform a systematic review and meta-analysis for the comparison of the effects of vonoprazan and proton pump inhibitors (PPIs) in treating ESD-induced artificial ulcers and preventing delayed bleeding in randomized controlled trial and cohort studies. Methods: We searched OVID-MEDLINE, EMBASE, Cochrane ...
Tópico(s): Gastroesophageal reflux and treatments
2019 - Wolters Kluwer | Medicine
Eun Young Ze, Beom Jin Kim, Dong Hwan Jun, Jae Gyu Kim, Hyun Kang, Dong Young Lee,
BACKGROUND: Nonalcoholic fatty liver disease, the hepatic manifestation of metabolic syndrome, is associated with increased risk of colorectal adenoma, a precursor of colorectal cancer. Because nonalcoholic fatty liver disease and colorectal adenoma share many common risk factors of metabolic syndrome, the association between these 2 pathological findings has been investigated in multiple studies, but the results have been conflicting. OBJECTIVE: The present study aimed to assess the relationship ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2017 - Lippincott Williams & Wilkins | Diseases of the Colon & Rectum
Suh Yoon Yang, Bong Ki, Gihyeon Kim, Hyun Woong Lee, Jae Gyu Kim, Sae Kyung Chang, Hyung Joon Kim,
Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown an association between dermatomyositis and malignant tumors such as ovarian cancer, lung cancer, and colorectal cancer. However, a chronic hepatitis B virus (HBV) infection associated with dermatomyositis and hepatocellular carcinoma (HCC) has been very rarely reported. Here, we ...
Tópico(s): Muscle and Compartmental Disorders
2014 - Korean Association of Internal Medicine | The Korean Journal of Internal Medicine
Beom Jin Kim, Won Seok Cheon, Hyoung‐Chul Oh, Jeong Wook Kim, Jung Duck Park, Jae Gyu Kim,
Prevalence of erosive esophagitis (EE) has been increasing in Korea.The purpose of this study was to estimate prevalence of EE among low socioeconomic population in Korea and to investigate risk factors for EE.We reviewed the medical records of 7,278 subjects who were examined by upper endoscopy in the Korean National Cancer Screening Program at Chung-Ang University Yong-san Hospital from March 2003 to March 2008.The study population included subjects ≥ 40 yr of age who were Medicaid recipients and ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2011 - Korean Academy of Medical Sciences | Journal of Korean Medical Science
Ki‐Bong Oh, Woongchon Mar, Sanghee Kim, Ji-Yun Kim, Tae‐Hoon Lee, Jae-Gyu Kim, Dae-Hyun Shin, Chung Ja Sim, Jongheon Shin,
Bis(indole) alkaloids, of the topsentin class (1—4) and hamacanthin class (5—9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited more potent antibacterial activity than those of the topsentin class. Deoxytopsentin (1) and hamacanthin A (5) also exhibited significant antibacterial activity against methicillin-resistant ...
Tópico(s): Microbial Natural Products and Biosynthesis
2006 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Ki‐Bong Oh, Woongchon Mar, Sanghee Kim, Ji-Yun Kim, Mi‐Na Oh, Jae-Gyu Kim, Dae-Hyun Shin, Chung Ja Sim, Jongheon Shin,
A new bis(indole) alkaloid (9) of the hamacanthin class along with the previously reported compounds of the related structural classes, topsentin class (1–4) and hamacanthin class (5–8), was isolated from the marine sponge Spongosorites sp. and their inhibitory activities toward sortase A (SrtA) that play key roles in cell-wall protein anchoring and virulence in Staphylococcus aureus were evaluated. Our studies have identified a series of SrtA inhibitors, providing the basis for further development ...
Tópico(s): Glycosylation and Glycoproteins Research
2005 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Hyun-Il Choi, Jun‐Pyo Choi, Ji Won Seo, Beom Jin Kim, Mina Rho, Jin Han, Jae Gyu Kim,
Evidence indicates that Helicobacter pylori is the causative agent of chronic gastritis and perhaps gastric malignancy. Extracellular vesicles (EVs) play an important role in the evolutional process of malignancy due to their genetic material cargo. We aimed to evaluate the clinical significance and biological mechanism of H. pylori EVs on the pathogenesis of gastric malignancy. We performed 16S rDNA-based metagenomic analysis of gastric juices either from endoscopic or surgical patients. From each ...
Tópico(s): Eosinophilic Esophagitis
2017 - Springer Nature | Experimental & Molecular Medicine