Ji-Na Lim, Jin-Ju Oh, Tao Wang, Jae‐Sung Lee, Sang Hoon Kim, Yoon-Jin Kim, Hong-Gu Lee,
Trans vaccenic acid (TVA; trans-11 18:1) is a positional and geometric isomer of oleic acid and it is the predominant trans isomer found in ruminant fats. TVA can be converted into cis-9, trans-11 conjugated linoleic acid (c9, t11-CLA), a CLA isomer that has many beneficial effects, by stearoyl CoA desaturase 1 (SCD1) in the mammary gland. The health benefits associated with CLA are well documented, but it is unclear whether trans fatty acids (TFAs) from ruminant products have healthy effects. Therefore, ...
Tópico(s): Cancer, Lipids, and Metabolism
2014 - Multidisciplinary Digital Publishing Institute | Nutrients
Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, J. A. Smith, Kaori Ono, Jinah Kim, Kristin Eckel‐Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung‐Hee Yoo, Zheng Chen,
Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor response to standard therapies and therefore unfavorable clinical outcomes. Better understanding of TNBC and new therapeutic strategies are urgently needed. ROR nuclear receptors are multifunctional transcription factors with important roles in circadian pathways and other processes including immunity and tumorigenesis. Nobiletin (NOB) is a natural compound known to display anticancer effects, and our previous studies ...
Tópico(s): Flavonoids in Medical Research
2022 - Springer Nature | Cell Death and Disease
Suyeon Shin, Byeongyeon Kim, Yoon-Jin Kim, Sungyoung Choi,
Developing simple, portable, rapid, and easy-to-use diagnostic technologies is essential for point-of-care (POC) blood molecular testing. Integrated microfluidic devices that include the functionalities of blood separation, microfluidic pumping, and molecular detection are desirable for POC testing; however, current technologies still rely on off-chip sample processing or require bulky equipment. We report a fully-integrated microfluidic diagnostic device, i.e., an integrated pneumatic microfluidic ...
Tópico(s): Microfluidic and Bio-sensing Technologies
2019 - Elsevier BV | Biosensors and Bioelectronics
Hye Young Kim, Young Hee Kim, Bo‐Hye Nam, Hee Jeong Kong, Hyung Hoi Kim, Yoon Jin Kim, Won Gun An, JaeHun Cheong,
HIF-1alpha is a transcription factor that acts as a master regulator of gene expression induced by hypoxia. Recent studies have demonstrated that the potent inflammatory factor, lipopolysaccharide (LPS), can also activate HIF-1alpha in myeloid cells. However, the molecular mechanisms at the transcriptional level of HIF-1alpha induction by LPS remained undefined. Here, we investigated the regulatory mechanism of HIF-1alpha expression by LPS in hepatocytes and identified that LPS-induced HIF-1alpha ...
Tópico(s): Adipose Tissue and Metabolism
2007 - Elsevier BV | Experimental Cell Research
Byeongyeon Kim, Dongwon You, Yoon-Jin Kim, Insung Oh, Sungyoung Choi,
Simple and institutionalized testing of circulating biomarkers is essential for rapid cancer diagnosis and prognosis. However, blood sample preparation typically requires time-consuming separation steps and bulky, costly equipment. Although microfluidic separators have been developed for rapid and simple blood separation, their fluidic accessories such as syringe pumps still need to be miniaturized at a lower price before translating the separators into clinical practice. Here, we present a motorized ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2018 - Elsevier BV | Sensors and Actuators B Chemical
Byeongyeon Kim, Min-Gyu Jeon, Yoon-Jin Kim, Sungyoung Choi,
Translating spectrometers into a field-portable, open-source analytical device offers great potential for clinical and environmental applications. However, current spectrometers lack one or more of the following features that might be necessary for the next-generation spectrometer: open-source engineering, multi-spectral analysis, rapid mixing, and portable, wireless operation. We herein report a handheld spectrometer made from commercially available parts, including a spectrometer sensor and a ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2019 - Elsevier BV | Sensors and Actuators B Chemical
Do Lee Yun, Hyun‐Jin Kim, Yoon Jin Kim,
Tópico(s): Plant Water Relations and Carbon Dynamics
2018 - Springer Science+Business Media | Horticulture Environment and Biotechnology
Tae‐Wook Kang, Hyung‐Sik Kim, Byung‐Chul Lee, Tae–Hoon Shin, Soon Won Choi, Yoon‐Jin Kim, Hwa‐Yong Lee, Yeon-Kwon Jung, Kwang–Won Seo, Kyung‐Sun Kang,
Mica, an aluminosilicate mineral, has been proven to possess anti-tumor and immunostimulatory effects. However, its efficacy and mechanisms in treating various types of tumor are less verified and the mechanistic link between anti-tumor and immunostimulatory effects has not been elucidated. We sought to investigate the therapeutic effect of STB-HO (mica nanoparticles) against one of the most prevalent cancers, the breast cancer. STB-HO was orally administered into MCF-7 xenograft model or directly ...
Tópico(s): Immunotherapy and Immune Responses
2015 - Nature Portfolio | Scientific Reports
Tae–Hoon Shin, Hyung-Sik Kim, Tae‐Wook Kang, Byung Chul Lee, Hwa-Yong Lee, Yoon-Jin Kim, Ji-Hee Shin, Yoojin Seo, Soon Won Choi, Seunghee Lee, Kichul Shin, Kwang-Won Seo, Kyung‐Sun Kang,
Rheumatoid arthritis (RA) is a long-lasting intractable autoimmune disorder, which has become a substantial public health problem. Despite widespread use of biologic drugs, there have been uncertainties in efficacy and long-term safety. Mesenchymal stem cells (MSCs) have been suggested as a promising alternative for the treatment of RA because of their immunomodulatory properties. However, the precise mechanisms of MSCs on RA-related immune cells are not fully elucidated. The aim of this study was ...
Tópico(s): Extracellular vesicles in disease
2016 - Springer Nature | Cell Death and Disease
Jung Soon Kim, Ihn Sook Jeong, Yoon Jin Kim, Sun Kyung Hwang, Byung Chul Choi,
This study was to develop a screening model for identifying a high risk group of dementia and to develop and evaluate the web-based prevention program.It was conducted in 5 phases. 1) Data were collected from dementia patients and non-dementia patients in a community. 2) A screening model of the high risk population was constructed. 3) The validity test was performed and the model was confirmed. 4) Four weeks-prevention program was developed. 5) The program was administered, and evaluated the effects. ...
Tópico(s): Education and Learning Interventions
2003 - | Daehan ganho haghoeji
Yoon‐Jin Kim, Sae Mi Yoo, Hwan Hee Park, Hye Jin Lim, Yu-Lee Kim, Seunghee Lee, Kwang–Won Seo, Kyung‐Sun Kang,
Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro ...
Tópico(s): Advancements in Transdermal Drug Delivery
2017 - Elsevier BV | Biochemical and Biophysical Research Communications
Yu Xiang, Youqiong Ye, Yanyan Lou, Yang Yang, Chunyan Cai, Zhao Zhang, Tingting Mills, Ning-Yuan Chen, Yoon-Jin Kim, Fatma Muge Ozguc, Lixia Diao, Harry Karmouty‐Quintana, Xia Yang, Rodney E. Kellems, Zheng Chen, Michael R. Blackburn, Seung Hee Yoo, Ann‐Bin Shyu, Gordon B. Mills, Leng Han,
Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several human diseases. However, the functional consequences of APA in human cancer are not fully understood. Particularly, there is no large-scale analysis in cancer cell lines.We characterized the global APA profiles of 6398 patient samples across 17 cancer types from The Cancer Genome Atlas and 739 cancer cell lines from the Cancer Cell Line Encyclopedia. ...
Tópico(s): RNA modifications and cancer
2017 - Oxford University Press | JNCI Journal of the National Cancer Institute
Greeshma Agasthya, Ellen M. D’Orsi, Yoon-Jin Kim, Priyanka Handa, Christopher P. Ho, Carl J. D’Orsi, Ioannis Sechopoulos,
The objective of this study was to investigate the impact of decreasing breast compression during digital mammography and breast tomosynthesis (DBT) on perceived pain and image quality.In this two-part study, two groups of women with prior mammograms were recruited. In part 1, subjects were positioned for craniocaudal (CC) and mediolateral oblique (MLO) views, and four levels of compression force were applied to evaluate changes in breast thickness, perceived pain, and relative tissue coverage. No ...
Tópico(s): Breast Lesions and Carcinomas
2017 - American Roentgen Ray Society | American Journal of Roentgenology
Kumud Malika Tripathi, Tuan Sang Tran, Yoon Jin Kim, Tae Young Kim,
Onion-like carbon nanoparticles (CNOs) were synthesized via traditional pyrolysis of flaxseed oil. Oxidative treatment of as-synthesized carbon soot introduced numerous carboxyl (−COOH) functionalities, rendering them hydrophilic and stable in aqueous phase. The water-soluble onion-like carbon nanoparticles (wsCNOs) were 4–8 nm in size and exhibited stable green photoluminescence (PL) emission. CNOs were explored as efficient photocatalysts for the degradation of methylene blue (MB) as model organic pollutant ...
Tópico(s): Graphene and Nanomaterials Applications
2017 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Yoon‐Jin Kim, Dong Hee Seo, Seung Hee Lee, Sunghoon Lee, Geun-Ho An, Hee-Jin Ahn, Daekee Kwon, Kwang–Won Seo, Kyung‐Sun Kang,
Developing treatments that inhibit skin aging is an important research project. Rejuvenation, which focuses on prevention of skin aging, is one of the major issues. Recent studies suggested that mesenchymal stem cells (MSCs) secrete many cytokines, which are important in wound healing. In this study, we investigated the effect of human umbilical cord blood-derived mesenchymal stem cells conditioned media (USC-CM) in cutaneous wound healing and collagen synthesis. We found that USC-CM has many useful ...
Tópico(s): Periodontal Regeneration and Treatments
2018 - Elsevier BV | Biochemistry and Biophysics Reports
Yoon-Jin Kim, Tae Sun Min, Kang-Seok Seo, Sang Hoon Kim,
Tópico(s): Circular RNAs in diseases
2014 - Springer Nature | Molecular Biology Reports
Yoon-Jin Kim, Chung-Hyeon Ryu, Sung-Hyeon Park, Hak‐Sung Kim,
The effect of poly (N-vinylpyrrolidone) (PVP) molecular weight (MW) on the flash light sintering of copper nanopaste was investigated. The copper nanopaste was coated on polyimide substrates using doctor blade method. PVP was used as reducing agent to functionalize the copper nanoparticles during flash light sintering process. To find the optimum sintering conditions of copper nanoparticles, the various MWs of PVP (10 000, 40 000 and 55 000) were used and the flash light irradiation energy was varied ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2014 - Elsevier BV | Thin Solid Films
Yoon-Jin Kim, Hyun‐Ji Kim, Ki Yong Chung, Inho Choi, Sang Hoon Kim,
Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of insulin and is required for adipogenesis. Regulatory subunit 1 of PI3K (PIK3R1) is a critical component of the PI3K signaling pathway. Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis. Although the PPARγ agonist rosiglitazone induces the expression of PIK3R1, the transcriptional regulation of PIK3R1 in adipocytes remains unknown. In this study, we investigated whether ...
Tópico(s): Metabolism, Diabetes, and Cancer
2014 - Springer Nature | Molecular Biology Reports
Yujin Park, Yoon Jin Kim, Ki Sun Kim,
Tópico(s): Greenhouse Technology and Climate Control
2013 - Springer Science+Business Media | Horticulture Environment and Biotechnology
Yoon Jin Kim, Hee Jae Lee, Ki Sun Kim,
The effects of night interruption (NI) on growth and soluble carbohydrate contents were investigated in Cymbidium 'Red Fire'. Plants were vegetatively propagated and grown under different light conditions for 2 years. NI was employed twice during experimental period, 16 weeks for each year: 9/15 h ambient light/dark (control), 9 h ambient light plus NI (22:00–02:00 h) with low light intensity at 3–7 μmol m−2 s−1 (LNI) and 9 h ambient light plus NI with high light intensity at 120 μmol m−2 s−1 (HNI). The ...
Tópico(s): Plant Physiology and Cultivation Studies
2013 - Elsevier BV | Scientia Horticulturae
Kenta Kuramoto, Yoon-Jin Kim, Jung Hwa Hong, Congcong He,
Autophagy dysregulation is implicated in metabolic diseases, including type 2 diabetes. However, the mechanism by which the autophagy machinery regulates metabolism is largely unknown. Autophagy is generally considered a degradation process via lysosomes. Here, we unveil a metabolically important non-cell-autonomous, non-degradative mechanism regulated by the essential autophagy protein Becn1 in adipose tissue. Upon high-fat diet challenge, autophagy-hyperactive Becn1F121A mice show systemically ...
Tópico(s): Extracellular vesicles in disease
2021 - Cell Press | Cell Reports
Yoon Jin Kim, Taek Sun Shin, Hyung Do Choi, Jong Hwa Kwon, Yeon‐Choon Chung, Ho Gyu Yoon,
The electrical conductivity of oxidized multiwalled carbon nanotubes (MWNT)/epoxy composites is investigated with respect to the chemical treatment of the MWNT. The oxidation is carried out by refluxing the as-received MWNT in concentrated HNO3 and H2O2/NH4OH solutions, respectively, under several different treatment conditions. The oxidized MWNT are negatively charged and functionalized with carboxylic groups by both solutions. The MWNT oxidized under severe conditions are well purified, but their ...
Tópico(s): Smart Materials for Construction
2004 - Elsevier BV | Carbon
Soo Young Cho, Jae Hee Woo, Yoon Jin Kim, Eun Hee Chun, Jong In Han, Dong Yeon Kim, Hee Jung Baik, Rack Kyung Chung,
Securing the airway in patients undergoing surgical intervention to control a deep neck infection (DNI) is challenging for anesthesiologists due to the distorted airway anatomy, limited mouth opening, tissue edema, and immobility. It is critical to assess the risk of a potential difficult airway and prepare the most appropriate airway management method. We reviewed our anesthetic experiences managing patients with DNIs, focusing on the need for video-laryngoscope or awake fiberoptic intubation beyond ...
Tópico(s): Airway Management and Intubation Techniques
2016 - Wolters Kluwer | Medicine
Yoon‐Jin Kim, Hee Seung Lee, Dawoon Jung, Jeong Mi Kim, Si Young Song,
Abstract Pancreatic cancer remains one of the most common and lethal cancers. Most patients (80%) present with inoperable advanced pancreatic cancer at initial diagnosis, and their early diagnosis is a significant unmet challenge. Recent studies indicate that cancer, including pancreatic cancer, is initiated and propagated by cancer stem cells (CSCs). CSCs are responsible not only for the pathogenesis of cancer but also for the heterogeneity, malignant degree, anticancer therapy resistance, and recurrence ...
Tópico(s): RNA Interference and Gene Delivery
2016 - Wiley | Journal of Molecular Recognition
Phạm Thị Mai Hương, Sung Hoon Jung, Yoon Jin Kim, Tae Young Kim,
In this study, carbon-based aerogels derived from waste paper (CWP) were explored as an efficent adsorbent to remove organic pollutants including phenol (Ph) and 2-chlorophenol (2CP) from wastewater. CWP exhibited a highly porous structure and large specific surface area of 892 m2 g−1, which facilitated the adsorption of Ph and 2CP in wastewater. The adsorption behavior of Ph and 2CP on CWP could be well described by the pseudo-second-order kinetics and Langmuir isotherm models. Based on the Langmuir ...
Tópico(s): Aerogels and thermal insulation
2020 - Elsevier BV | Chemosphere
Yoon-Jin Kim, Hee-Jin Ahn, Seunghee Lee, Mi‐Hye Lee, Kyung‐Sun Kang,
Atopic dermatitis (AD) is an inflammatory skin disease in which type 2 allergic inflammation plays a critical role. In this study, the anti-inflammatory effect of conditioned media from human umbilical cord blood-derived mesenchymal stem cells (USC-CM) was investigated in order to apply it as an effective treatment with a low risk of side effects that can overcome the limitations of AD treatment which is currently in use. We found that USC-CM has various growth factors and cytokines associated with ...
Tópico(s): IL-33, ST2, and ILC Pathways
2020 - Elsevier BV | Biomedicine & Pharmacotherapy
Yoon-Jin Kim, Jeong Hwa Lee, Soll Jin, Jung Hoon Kim, Sang Hoon Kim,
Tópico(s): Circular RNAs in diseases
2018 - Elsevier BV | Cancer Letters
Youqiong Ye, Yu Xiang, Fatma Muge Ozguc, Yoon-Jin Kim, Chunjie Liu, Peter K. Park, Qingsong Hu, Lixia Diao, Yanyan Lou, Chunru Lin, An‐Yuan Guo, Bingying Zhou, Li Wang, Zheng Chen, Joseph S. Takahashi, Gordon B. Mills, Seung Hee Yoo, Leng Han,
Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of clock genes and their clinical relevance in cancer is lacking. We systematically characterized the alterations of clock genes across 32 cancer types by analyzing data from The Cancer Genome Atlas, Cancer Therapeutics Response Portal, and The Genomics of Drug Sensitivity in Cancer databases. Expression alterations of ...
Tópico(s): Gene Regulatory Network Analysis
2018 - Elsevier BV | Cell Systems
Yoon Jin Kim, Marcelle C. Dawson, Tania Cassidy,
Despite burgeoning literature on the agency of sports coaches and the nature of coaching fields, scant attention has been paid to the process through which coaches' identities are socially constructed. Informed by Goffman's concept, total institution, and Scott's reinventive institution, this article explores how coaches' athletic experiences within totalising sports environments influence the formation of their identity as coaches. Drawing on South Korea's elite sports context where almost all ...
Tópico(s): Sport Psychology and Performance
2018 - Taylor & Francis | Sport Education and Society
Yeonsil Yu, Sae Mi Yoo, Hwan Hee Park, Song Yi Baek, Yoon‐Jin Kim, Seunghee Lee, Yu Lee Kim, Kwang–Won Seo, Kyung‐Sun Kang,
Preconditioning with inflammatory cytokines has improved mesenchymal stem cells characteristics, including differentiation and immunomodulating functions. In this study, we developed a preconditioning combination strategy using interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ) to enhance the immuneregulatory ability of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs). Our results showed that hUCB-MSCs preconditioned with IL-1β and IFN-γ (primed hUCB-MSCs) created a statistically ...
Tópico(s): MicroRNA in disease regulation
2019 - Wiley | Journal of Tissue Engineering and Regenerative Medicine