Katsuyasu Kouda, Yuki Fujita, Yuho Sato, Kumiko Ohara, Harunobu Nakamura, Kazuhiro Uenishi, Masayuki Iki,
... August 2010 and in August 2013 from the Kitakata Kids Health Study in Japan. We obtained cross- ...
Tópico(s): Nutrition and Health in Aging
2014 - Elsevier BV | Bone
Katsuyasu Kouda, Masayuki Iki, Yuki Fujita, Harunobu Nakamura, Kazuhiro Uenishi, Kumiko Ohara, Toshimasa Nishiyama,
... 10-12 y) in the Shiokawa area of Kitakata City, Fukushima. We obtained complete information from 220 ...
Tópico(s): Nutrition and Health in Aging
2020 - Center for Academic Publications Japan | Journal of Nutritional Science and Vitaminology
Genki Ichihara, Yoshinori Katsumata, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Jin Endo, Atsushi Anzai, Kohsuke Shirakawa, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Shinichi Goto, Seien Ko, Yuji Iwasawa, Kazuhisa Sugai, Kyohei Daigo, Shinya Goto, Kazuki Sato, Ken‐ichi Yamada, Makoto Suematsu, Masaki Ieda, Motoaki Sano,
The membrane components of cardiomyocytes are rich in polyunsaturated fatty acids, which are easily oxidized. Thus, an efficient glutathione-based lipid redox system is essential for maintaining cellular functions. However, the relationship between disruption of the redox system during ischemia-reperfusion (IR), oxidized lipid production, and consequent cell death (ferroptosis) remains unclear. We investigated the mechanisms underlying the disruption of the glutathione-mediated reduction system related ...
Tópico(s): Cancer, Lipids, and Metabolism
2023 - Lippincott Williams & Wilkins | Circulation Research
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano,
Doxorubicin (DOX) is the most widely used anthracycline anticancer agent; however, its cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms underlying DOX-induced cardiotoxicity, wherein apoptosis has been reported as the most common final step leading to cardiomyocyte death. However, in the past two years, the involvement of ferroptosis, a novel programmed cell death, has been proposed. The purpose of this review is to summarize the historical background that ...
Tópico(s): Lung Cancer Research Studies
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Kohsuke Shirakawa, Eiji Kobayashi, Genki Ichihara, Hiroki Kitakata, Yoshinori Katsumata, Kazuhisa Sugai, Yoji Hakamata, Motoaki Sano,
Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis in numerous conditions, including infectious and cardiovascular diseases, and have attracted attention as potential therapeutic targets. H2 acts as an antioxidant and has been clinically and experimentally proven to ameliorate inflammation. This study was performed to investigate whether H2 could inhibit NET formation and excessive neutrophil activation. Neutrophils isolated from the blood of healthy volunteers were stimulated ...
Tópico(s): Inflammasome and immune disorders
2022 - Elsevier BV | JACC Basic to Translational Science
Hidehiko Ikura, Jin Endo, Hiroki Kitakata, Hidenori Moriyama, Motoaki Sano, Keiichi Fukuda,
In amyloid light-chain (AL) amyloidosis, small B-cell clones (mostly plasma cell clones) present in the bone marrow proliferate and secrete unstable monoclonal free light chains (FLCs), which form amyloid fibrils that deposit in the interstitial tissue, resulting in organ injury and dysfunction. AL amyloidosis progresses much faster than other types of amyloidosis, with a slight delay in diagnosis leading to a marked exacerbation of cardiomyopathy. In some cases, the resulting heart failure is so severe ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Hiroki Kitakata, Takashi Kohno, Shun Kohsaka, Daisuke Fujisawa, Naomi Nakano, Yasuyuki Shiraishi, Yoshinori Katsumata, Yuji Nagatomo, Shinsuke Yuasa, Keiichi Fukuda,
Abstract Aims Early engagement in advance care planning (ACP) is recommended in heart failure (HF) management. We investigated the preferences of patients with HF regarding ACP and end‐of‐life (EOL) care, including their desired timing of ACP initiation. Methods and results Data were collected using a 92‐item questionnaire survey, which was directly distributed to hospitalized patients by dedicated physicians and nurses in a university hospital setting. One‐hundred eighty‐seven patients agreed to participate ( ...
Tópico(s): Family and Patient Care in Intensive Care Units
2021 - Wiley | ESC Heart Failure
Genki Ichihara, Yoshinori Katsumata, Hidenori Moriyama, Hiroki Kitakata, Akeo Hirai, Mizuki Momoi, Seien Ko, Yoshiki Shinya, Kenichiro Kinouchi, Eiji Kobayashi, Motoaki Sano,
Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich water in neuropsychiatric and endocrine metabolic disorders, their authenticity has been questioned because none examined the associated pharmacokinetics of H2. Therefore, we performed the first study to investigate the pharmacokinetics of H2 in pigs given an H2-rich glucose solution with the aim to extrapolate the findings to humans. We inserted blood collection catheters ...
Tópico(s): Dietary Effects on Health
2021 - Elsevier BV | Heliyon
Hiroki Kitakata, Jin Endo, Shun Hashimoto, Erika Mizuno, Hidenori Moriyama, Kohsuke Shirakawa, Shinichi Goto, Yoshinori Katsumata, Keiichi Fukuda, Motoaki Sano,
The pathogenesis of heart failure with preserved ejection fraction (HFpEF) in obese diabetic patients has been implicated in metainflammation. Increased expression of inducible nitric oxide synthase (iNOS) and dysfunction of the unfolded protein response (UPR), especially inositol-requiring enzyme 1α-X-box binding protein 1 (IRE1α-Xbp1s) signaling in the heart, have been associated with HFpEF. We investigated the effect of imeglimin, a potential new treatment for type 2 diabetes, on the pathogenesis ...
Tópico(s): Cardiac Fibrosis and Remodeling
2021 - Elsevier BV | Biochemical and Biophysical Research Communications
Hiroki Kitakata, Jin Endo, Hirokazu Matsushima, Shoichi Yamamoto, Hidehiko Ikura, Akeo Hirai, Seien Koh, Genki Ichihara, Takahiro Hiraide, Hidenori Moriyama, Kohsuke Shirakawa, Shinichi Goto, Yoshinori Katsumata, Atsushi Anzai, Masaharu Kataoka, Takeshi Tokuyama, Satoshi Ishido, Shigeru Yanagi, Keiichi Fukuda, Motoaki Sano,
MITOL/MARCH5 is an E3 ubiquitin ligase that plays a crucial role in the control of mitochondrial quality and function. However, the significance of MITOL in cardiomyocytes under physiological and pathological conditions remains unclear. First, to determine the significance of MITOL in unstressed hearts, we assessed the cellular changes with the reduction of MITOL expression by siRNA in neonatal rat primary ventricular cardiomyocytes (NRVMs). MITOL knockdown in NRVMs induced cell death via ferroptosis, ...
Tópico(s): RNA modifications and cancer
2021 - Elsevier BV | Journal of Molecular and Cellular Cardiology
Hiroki Kitakata, Takashi Kohno, Shun Kohsaka, Yasuyuki Shiraishi, Justin Parizo, Nozomi Niimi, Ayumi Goda, Yosuke Nishihata, Paul A. Heidenreich, Tsutomu Yoshikawa,
Background Although 30-day readmission is thought to be an important quality indicator in patients with hospitalized heart failure, its prognostic impact and comparison of patients who were readmitted beyond 30 days has not been investigated. We assessed early (0-30 days) versus midrange (31-90 days) readmission in terms of incidence and distribution, and elucidated whether the timing of readmission could have a different prognostic significance. Methods and Results We examined patients with hospitalized ...
Tópico(s): Mechanical Circulatory Support Devices
2020 - Wiley | Journal of the American Heart Association
Kohsuke Shirakawa, Jin Endo, Masaharu Kataoka, Yoshinori Katsumata, Atsushi Anzai, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Seien Ko, Shinichi Goto, Genki Ichihara, Keiichi Fukuda, Tohru Minamino, Motoaki Sano,
Background We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) and galectin‐3 hi CD206 + macrophages is the main source of osteopontin in post‐MI heart. Interleukin‐10– STAT3 (signal transducer and activator of transcription 3)–galectin‐3 axis is essential for Spp1 (encoding osteopontin) transcriptional activation in cardiac macrophages after MI. Here, ...
Tópico(s): Macrophage Migration Inhibitory Factor
2020 - Wiley | Journal of the American Heart Association
Hiroki Kitakata, Takashi Kohno, Shun Kohsaka, Daisuke Fujisawa, Naomi Nakano, Yasuyuki Shiraishi, Yoshinori Katsumata, Shinsuke Yuasa, Keiichi Fukuda,
Background Heart failure (HF) is a highly prevalent, heterogeneous, and life-threatening condition. Precise prognostic understanding is essential for effective decision making, but little is known about patients' attitudes toward prognostic communication with their physicians. Methods and Results We conducted a questionnaire survey, consisting of patients' prognostic understanding, preferences for information disclosure, and depressive symptoms, among hospitalized patients with HF (92 items in total). ...
Tópico(s): Chronic Disease Management Strategies
2020 - Elsevier BV | Journal of Cardiac Failure
Alice K. Jacobs, Murtuza J. Ali, Patricia J.M. Best, Mark C. Bieniarz, Mauricio G. Cohen, William J. French, Gregg C. Fonarow, Christopher B. Granger, Abhinav Goyal, Timothy D. Henry, Lori Hollowell, Hani Jneid, James G. Jollis, Jason N. Katz, Peter Mason, Venu Menon, Michael Redlener, Jacqueline E. Tamis‐Holland, Jessica K. Zègre‐Hemsey,
... 23:6, Online publication date: 1-Jun-2021. Kitakata H, Katsumata Y, Kohsaka S, Sekine O, Kohno ...
Tópico(s): Mechanical Circulatory Support Devices
2020 - Lippincott Williams & Wilkins | Circulation
Takahiro Hiraide, Masaharu Kataoka, Hisato Suzuki, Yuki Aimi, Tomohiro Chiba, Sarasa Isobe, Yoshinori Katsumata, Shinichi Goto, Kohsuke Kanekura, Yoshitake Yamada, Hidenori Moriyama, Hiroki Kitakata, Jin Endo, Shinsuke Yuasa, Yasumichi Arai, Nobuyoshi Hirose, Toru Satoh, Yoji Hakamata, Motoaki Sano, Shinobu Gamou, Kenjiro Kosaki, Keiichi Fukuda,
BACKGROUNDA variant of c.14429G>A (p.Arg4810Lys, rs112735431) in the ring finger protein 213 gene (RNF213; NM_001256071.2) has been recently identified as a risk allele for pulmonary arterial hypertension (PAH). PAH can be added as a new member of RNF213-associated vascular diseases, which include Moyamoya disease and peripheral pulmonary stenosis. Our aim was to identify the clinical features and outcomes of PAH patients with this variant.METHODSWhole-exome sequencing was performed in 139 idiopathic ( ...
Tópico(s): Vascular Anomalies and Treatments
2019 - Elsevier BV | The Journal of Heart and Lung Transplantation
Naohiro Yoshida, Jin Endo, Kenichiro Kinouchi, Hiroki Kitakata, Hidenori Moriyama, Masaharu Kataoka, Tsunehisa Yamamoto, Kohsuke Shirakawa, Satoshi Morimoto, Akira Nishiyama, Akihiro Hashiguchi, Itsuro Higuchi, Keiichi Fukuda, Atsuhiro Ichihara, Motoaki Sano,
Abstract To extend life expectancy and ensure healthy aging, it is crucial to prevent and minimize age‐induced skeletal muscle atrophy, also known as sarcopenia. However, the disease's molecular mechanism remains unclear. The age‐related Wnt/β‐catenin signaling pathway has been recently shown to be activated by the (pro)renin receptor ((P)RR). We report here that (P)RR expression was increased in the atrophied skeletal muscles of aged mice and humans. Therefore, we developed a gain‐of‐function model ...
Tópico(s): Genetics and Physical Performance
2019 - Wiley | Aging Cell
Silvio E. Inzucchi, Mikhail Kosiborod, David Fitchett, Christoph Wanner, Uwe Hehnke, Stefan Kaspers, Jyothis T. George, Bernard Zinman,
... 180, (109036), Online publication date: 1-Oct-2021. Kitakata H, Endo J, Hashimoto S, Mizuno E, Moriyama ...
Tópico(s): Diabetes Management and Research
2018 - Lippincott Williams & Wilkins | Circulation
Kohsuke Shirakawa, Jin Endo, Masaharu Kataoka, Yoshinori Katsumata, Naohiro Yoshida, Tsunehisa Yamamoto, Sarasa Isobe, Hidenori Moriyama, Shinichi Goto, Hiroki Kitakata, Takahiro Hiraide, Keiichi Fukuda, Motoaki Sano,
Both osteopontin (OPN) and galectin-3 have been implicated in phagocytic clearance of dead cells and reparative fibrosis during wound healing. CD206+ macrophages are involved in tissue repair through phagocytosis and fibrosis after myocardial infarction (MI). However, the relationship among OPN, galectin-3, and macrophage polarization in the context of MI remains unclear.The time course of Spp1 (encoding OPN) expression in the heart after MI showed a strong activation of Spp1 on day 3 after MI. To ...
Tópico(s): Macrophage Migration Inhibitory Factor
2018 - Lippincott Williams & Wilkins | Circulation
Hisato Suzuki, Masaharu Kataoka, Takahiro Hiraide, Yuki Aimi, Yoshitake Yamada, Yoshinori Katsumata, Tomohiro Chiba, Kohsuke Kanekura, Sarasa Isobe, Yasunori Sato, Toru Satoh, Shinobu Gamou, Keiichi Fukuda, Kenjiro Kosaki,
... Goto S, Kanekura K, Yamada Y, Moriyama H, Kitakata H, Endo J, Yuasa S, Arai Y, Hirose ...
Tópico(s): Vascular Anomalies and Treatments
2018 - Wolters Kluwer | Circulation Genomic and Precision Medicine
Aina Gotoh, Misaki Nara, Yuta Sugiyama, Mikiyasu Sakanaka, Hiroyuki Yachi, Aya Kitakata, Akira Nakagawa, Hiromichi Minami, Shujiro Okuda, Toshihiko Katoh, Takane Katayama, Shin Kurihara,
Recently, a "human gut microbial gene catalogue," which ranks the dominance of microbe genus/species in human fecal samples, was published. Most of the bacteria ranked in the catalog are currently publicly available; however, the growth media recommended by the distributors vary among species, hampering physiological comparisons among the bacteria. To address this problem, we evaluated Gifu anaerobic medium (GAM) as a standard medium. Forty-four publicly available species of the top 56 species listed ...
Tópico(s): Probiotics and Fermented Foods
2017 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Yuta Sugiyama, Misaki Nara, Mikiyasu Sakanaka, Aina Gotoh, Aya Kitakata, Shujiro Okuda, Shin Kurihara,
Recent studies have reported that polyamines in the colonic lumen might affect animal health and these polyamines are thought to be produced by gut bacteria. In the present study, we measured the concentrations of three polyamines (putrescine, spermidine, and spermine) in cells and culture supernatants of 32 dominant human gut bacterial species in their growing and stationary phases. Combining polyamine concentration analysis in culture supernatant and cells with available genomic information showed ...
Tópico(s): Amino Acid Enzymes and Metabolism
2017 - Elsevier BV | The International Journal of Biochemistry & Cell Biology
Mikiyasu Sakanaka, Yuta Sugiyama, Aya Kitakata, Takane Katayama, Shin Kurihara,
Tópico(s): Probiotics and Fermented Foods
2016 - Springer Science+Business Media | Amino Acids
Takuya Okada, Toru Matsuzawa, Norihito Umino, Keisuke Yoshida, Akira Hasegawa, Hiroaki Takahashi, Takuji Yamada, Masahiro Kosuga, Tetsuya Takeda, Aitaro Kato, Toshihiro Igarashi, Kenjiro Obara, S. Sakai, Atsushi Saiga, Takashi Iidaka, T. Iwasaki, Naoshi Hirata, Noriko Tsumura, Yasuhiro Yamanaka, Toshiko Terakawa, Haruhisa Nakamichi, Takashi Okuda, Shinichiro Horikawa, Hiroshi Katao, Tsutomu Miura, A. Kubo, T. Matsushima, Kazuhiko Goto, Hiroki Miyamachi,
... Senya fault, and the Yamagata–Fukushima border (Aizu‐Kitakata area, west of Azuma volcano), we can observe ...
Tópico(s): High-pressure geophysics and materials
2014 - Hindawi Publishing Corporation | Geofluids
Vikram Brahmanandam, Sloane McGraw, Omer Mirza, Ankit A. Desai, Afshin Farzaneh‐Far,
... top Next FiguresReferencesRelatedDetailsCited By Ikura H, Endo J, Kitakata H, Moriyama H, Sano M and Fukuda K ( ...
Tópico(s): Eosinophilic Disorders and Syndromes
2014 - Lippincott Williams & Wilkins | Circulation
... 1347-1355), Online publication date: 1-Sep-2020. Kitakata H, Kohno T, Kohsaka S, Shiraishi Y, Parizo ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
2012 - Lippincott Williams & Wilkins | Circulation Heart Failure
Susan Redline, JoAnne M. Foody,
... Jul-2021. Horie H, Kohno T, Kohsaka S, Kitakata H, Shiraishi Y, Katsumata Y, Hayashida K, Yuasa ...
Tópico(s): Obstructive Sleep Apnea Research
2011 - Lippincott Williams & Wilkins | Circulation
Hidekazu Kitakata, Kazuo Yasumoto, Yoshiko Sudo, Hiroshi Minato, Yutaka Takahashi,
Tópico(s): Chromatin Remodeling and Cancer
2007 - Springer Science+Business Media | Breast Cancer
Kazuki ENOMOTO, Shintaro Kitakata, Toshiyuki Yasuhara, Naoto Ohtake, Tôru Kuzumaki, Yoshitaka Mitsuda,
A method for quantifying the nanomechanics of nanomaterials was developed using a nanoprobe manipulator fitted into a transmission electron microscope. Apparent Young’s moduli of various carbon nanotubes (CNTs) were measured using this method. The apparent Young’s modulus of an arc-grown CNT is as large as approximately 3.3TPa, which is close to the theoretical Young’s modulus (5.5TPa) of the single-walled CNT simulated using molecular dynamics. The relationship between the apparent Young’s modulus ...
Tópico(s): Force Microscopy Techniques and Applications
2006 - American Institute of Physics | Applied Physics Letters
Tôru Kuzumaki, Shintaro Kitakata, Kazuki ENOMOTO, T. Yasuhara, Naoto Ohtake, Yoshitaka Mitsuda,
Tópico(s): Graphene research and applications
2004 - Elsevier BV | Carbon
H. Minoura, Takeshi Negoro, M. Kitakata, Y. Ueno,
The electrodeposition of CdSe crystals has been examined under potentiostatic condition on graphite electrodes in LiClKCl melts containing CdCl2 and Na2SeO3. Deposits with various morphologies, needle-like, hollow-like, dendritic and columnar crystals, have been obtained by controlling the deposition potential. These as-grown deposits have fairly good photoelectrochemical characteristics and photoelectrochemical cells with a maximum conversion efficiency of 6.1% under white light illumination of ...
Tópico(s): Advanced Photocatalysis Techniques
1985 - Elsevier BV | Solar Energy Materials