Shinji Sato, Kiyoshi Ito, Ryo Konno, Satoshi Okamoto, Akira Yajima,
... this author on: This Site PubMed Google Scholar Kiyoshi Ito; Kiyoshi Ito From the Department of Obstetrics and Gynecology, Tohoku ... Cite Icon Cite Search Site Citation Shinji Sato, Kiyoshi Ito, Ryo Konno, Satoshi Okamoto, Akira Yajima; Adenoma Malignum: ...
Tópico(s): Cervical Cancer and HPV Research
2000 - Karger Publishers | Acta Cytologica
Takashi Murakami, Hisako Higashitsuji, Kousuke Yoshinaga, Yukihiro Terada, Kiyoshi Ito, Hidetoshi Ikeda,
... JapanSearch for more papers by this authorKiyoshi Ito, Kiyoshi Ito Department of Obstetrics and Gynaecology, Tohoku University Graduate ... JapanSearch for more papers by this authorKiyoshi Ito, Kiyoshi Ito Department of Obstetrics and Gynaecology, Tohoku University Graduate ...
Tópico(s): Endometriosis Research and Treatment
2004 - Wiley | BJOG An International Journal of Obstetrics & Gynaecology
Kiyoshi Ito, Kazuhiro Iwashita, Kimio IWANO,
... Encoding Acid Xylanase of Aspergillus kawachii Get access Kiyoshi Ito, Kiyoshi Ito National Research Institute of Brewing, 2–6–30, ...
Tópico(s): Enzyme Production and Characterization
1992 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Kiyoshi Ito, Toru Ikemasu, Takeaki Ishikawa,
... Encoding Xylanase A of Aspergillus kawachii Get access Kiyoshi Ito, Kiyoshi Ito National Research Institute of Brewing, 2–6–30, ...
Tópico(s): Plant Disease Resistance and Genetics
1992 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Kenichi Harano, Akihiro Hirakawa, Mayu Yunokawa, Toshiaki Nakamura, Toyomi Satoh, Tadaaki Nishikawa, Daisuke Aoki, Kimihiko Ito, Kiyoshi Ito, Toru Nakanishi, Nobuyuki Susumu, Kazuhiro Takehara, Yoh Watanabe, Hidemichi Watari, Toshiaki Saito,
The benefits of cytoreductive surgery for uterine carcinosarcoma (UCS) are unknown. The objective of this study was to determine the impact of optimal surgery on advanced UCS patient survival.We performed a multi-institutional, retrospective study of women diagnosed with stage IIIIV UCS between 2007 and 2012. Data were obtained retrospectively from medical records, including demographic, clinicopathologic, treatment, and outcome information. Optimal cytoreductive surgery was defined as surgery resulting ...
Tópico(s): Endometriosis Research and Treatment
2016 - Elsevier BV | Gynecologic Oncology
Kazuro Hirahara, Naoshi Hirata, Akira Ikami, Hiroki Miyamachi, Tetsuichiro Yabuki, Harumi Aoki, Iwao Fujii, Toshio Haneda, Akira Hasegawa, Shinichi Hashimoto, N. Hirano, Shigeki Horiuchi, Yoshihisa Iio, Yukio Ishiketa, Akihiko Ito, Kiyoshi Ito, T. Kanazawa, Satoshi Kaneshima, Ikuo Karakama, Masaru Kobayashi, M. Koizumi, Toshio Kono, Masahiro Kosuga, Yuji Kurata, Satoru Kuriyama, Akio Kuroiso, Toru Matsuzawa, Takeshi Mikumo, Toshio Mitsunami, Katsumi Miura, Kazuaki Miura, Rikio Miyajima, Megumi Mizoue, Takeo Moriya, Atsushi Nakajima, Isao Nakamura, Masaru Nakamura, Toru Nakamura, K. Nishigami, Kazuo Oike, T. Okamoto, Takahiro Okura, Tooru OOIDA, Toru Ouchi, Tatsuo Saeki, Kaname Sakai, Takuo Shibutani, Masayuki Suzuki, Sadaomi Suzuki, Masayoshi Takahashi, Akio Takagi, Fumiaki Takeuchi, Toshikazu Tanada, Shoji Tomita, Tameshige Tsukuda, Yasuhiro Umeda, Hiroo Wada, Mamoru Yamada, Akihiko Yamamoto, Ken’ichiro Yamashina, Fumihito Yamazaki, Manabu Yokohama,
The detailed three-dimensional P and S wave velocity structure in the focal region of the 1984 Western Nagano Prefecture Earthquake occurring close to an active volcano, Mt. Ontake, central Japan, is derived from a tomographic inversion of travel time data obtained by the 1986 Joint Seismological Research in Western Nagano Prefecture. The data set includes 7, 693 P-wave and 6, 070 S-wave arrival times observed at 49 stations from 212 local earthquakes and 2 explosions. The velocities in the shallow ...
Tópico(s): Earthquake Detection and Analysis
1992 - | Journal of Physics of the Earth
Kazutoshi Imanishi, Yasuto Kuwahara, Tetsuya Takeda, Takashi Mizuno, Hisao Ito, Kiyoshi Ito, Hiroo Wada, Yoshikatsu Haryu,
[1] Focal mechanisms have been determined from P wave polarity data as well as body wave amplitudes for 154 microearthquakes that occurred around the Atotsugawa fault in central Japan between 2002 and 2004. While we found many microearthquakes with a pure strike-slip mechanism that is similar to the faulting style of the Atotsugawa fault, a considerable number of microearthquakes with reverse faulting components are also occurring. Most of the P axes are horizontal and oriented in the WNW-ESE direction, ...
Tópico(s): Geological and Geochemical Analysis
2011 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Kenichi Harano, Akihiro Hirakawa, Mayu Yunokawa, Toshiaki Nakamura, Toyomi Satoh, Tadaaki Nishikawa, Daisuke Aoki, Kimihiko Ito, Kiyoshi Ito, Toru Nakanishi, Nobuyuki Susumu, Kazuhiro Takehara, Yoh Watanabe, Hidemichi Watari, Toshiaki Saito,
Tópico(s): Endometriosis Research and Treatment
2015 - Springer Science+Business Media | International Journal of Clinical Oncology
Tadashi Takahashi, Ayako Mitamura, Toyoaki Ito, Kiyoshi Ito, Masami Nanzyo, Masahiko Saigusa,
Abstract The aluminum solubility of acidified soils both from furrows and under tree canopies of a tea garden was studied using equilibrium experiments in 0.01 mol L−1 CaCl2 solution systems. The soils were originally classified as allophanic Andosols. The furrow soils were more severely acidified because of the heavy application of nitrogen fertilizer, especially in the upper soil horizons (pH[H2O] of 3.6–3.8 in the A1 and 2A2 horizons). These acidified soils were characterized by the dissolution ...
Tópico(s): Arsenic contamination and mitigation
2008 - Taylor & Francis | Soil Science & Plant Nutrition
Takuya Koseki, Yasurou Ito, Shinji Furuse, Kiyoshi Ito, Kimio IWANO,
4-Vinylguaiacol (4-hydroxy-3-methoxystyrene), vanillin (4-hydroxy-3-methoxybenzaldehyde), and vanillic acid (4-hydroxy-3-methoxybenzoic acid) were isolated from distilled and stored model solutions of shochu (MSS) that originally contained only ferulic acid (4-hydroxy-3-methoxycinnamic acid) using a solid-phase extraction technique. These compounds were analyzed by high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection. The amounts of the metabolites converted from ferulic acid was ...
Tópico(s): Phytochemicals and Antioxidant Activities
1996 - Elsevier BV | Journal of Fermentation and Bioengineering
Mineo Shimizu, T. Ito, Satoshi Terashima, Toshimitsu Hayashi, Munehisa Arisawa, Naokata Morita, S. Kurokawa, Kiyoshi Ito, Yoshinobu Hashimoto,
Tópico(s): Biochemical effects in animals
1984 - Elsevier BV | Phytochemistry
Y. Nakajima, Kiyoshi Ito, T. Toshima, Takashi Egawa, Heng Zheng, Hiroshi Ōyama, Yufan Wu, Eiji Takahashi, Kiyoshi Kyono, Tadashi Yoshimoto,
The crystal structure of dipeptidyl aminopeptidase IV from Stenotrophomonas maltophilia was determined at 2.8-A resolution by the multiple isomorphous replacement method, using platinum and selenomethionine derivatives. The crystals belong to space group P4(3)2(1)2, with unit cell parameters a = b = 105.9 A and c = 161.9 A. Dipeptidyl aminopeptidase IV is a homodimer, and the subunit structure is composed of two domains, namely, N-terminal beta-propeller and C-terminal catalytic domains. At the active ...
Tópico(s): Oral and gingival health research
2008 - American Society for Microbiology | Journal of Bacteriology
Junzo Kasahara, Shinji Ito, Tomohiro Fujiwara, Yoko Hasada, K. Tsuruga, Ryoya Ikuta, Naoyuki Fujii, Koshun Yamaoka, Kiyoshi Ito, K. Nishigami,
To examine the effectiveness of our time lapse method for CCS monitoring, we carried out a field-test in Japan using an ultra-stable seismic source. We injected 80-tons air in total into 100 m depth. We obtained transfer functions between the source and 31 seismometers. All residual waveforms between before and after the injection revealed very large changes on records. A station at 200m distance from the injected-well showed 10ms travel-time delay at 1-day after the injection. The time-reversal ...
Tópico(s): Seismology and Earthquake Studies
2013 - Elsevier BV | Energy Procedia
Hitoshi Niikura, Satoshi Okamoto, Takeo Otsuki, Kosuke Yoshinaga, Hiroki Utsunomiya, Satoru Nagase, Tadao Takano, Kiyoshi Ito, Mika Watanabe, Nobuo Yaegashi,
The aim of the present study was to evaluate the incidence of lymphedema and cancer recurrence rate in patients with cervical cancer who undergo sentinel lymph node (SLN) biopsy alone in the absence of SLN metastases.The study included 35 consecutive patients with cervical cancer scheduled for radical hysterectomy at Tohoku University Hospital between May 2006 and July 2009. All patients had International Federation of Gynecology and Obstetrics stages IA1 to IIA1 disease. Patients in whom SLNs were ...
Tópico(s): Cancer Risks and Factors
2012 - BMJ | International Journal of Gynecological Cancer
Takashi Takeda, Tze Fang Wong, Tomoko Adachi, Kiyoshi Ito, Shigeki Uehara, Yasushi Kanaoka, Masaharu Kamada, Hiroaki Kitagawa, Satoshi Koseki, Hideto Gomibuchi, Juichiro Saito, Kazuhiro Shirasu, Kou Sueoka, Mitsuhiro Sugimoto, Mitsuaki Suzuki, Toshiyuki Sumi, Satoru Takeda, Keiichi Tasaka, Yasuyuki Noguchi, Shunsaku Fujii, Tsuneo Fujii, Michihisa Fujiwara, Tsugio Maeda, Koji Matsumoto, Mikio Momoeda, Mineto Morita, Kazuaki Yoshimura, Yasuo Hirai, Toshiro Kubota, Noriaki Sakuragi, Masakiyo Kawabata, Hiroyuki Yoshikawa, Hiroshi Kobayashi, Nobuo Yaegashi,
Abstract Gynecology in the office setting is developing worldwide. Clinical guidelines for office gynecology were first published by the Japan Society of Obstetrics and Gynecology and the Japan Association of Obstetricians and Gynecologists in 2011. These guidelines include a total of 72 clinical questions covering four areas (Infectious disease, Malignancies and benign tumors, Endocrinology and infertility, and Healthcare for women). These clinical questions were followed by several answers, backgrounds, ...
Tópico(s): Clinical practice guidelines implementation
2012 - Wiley | Journal of Obstetrics and Gynaecology Research
Richard A. Hiipakka, Marjorie Wang, Tim A. Bloss, Kiyoshi Ito, Shutsung Liao,
A cDNA encoding a full-length rat 5α-reductase was isolated using female rat liver mRNA and the polymerase chain reaction, and fused to the Escherichia coli trp E gene in a pATH expression vector. The trp E-5α-reductase fusion protein expressed in bacteria and a synthetic oligopeptide corresponding to the C-terminus of rat 5α-reductase were used as antigens to produce rabbit polyclonal antibodies to 5α-reductase. Antibodies to the 5α-reductase portion of the fusion protein and to the peptide were ...
Tópico(s): Hormonal and reproductive studies
1993 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology
Saku Miyamoto, Keiko Kashiwagi, Kiyoshi Ito, Satoru Watanabe, Kazuei Igarashi,
To estimate the polyamine distribution in Escherichia coli, the binding constants (K) for DNA, RNA, phospholipids, and ATP were calculated under the condition of 10 mM Tris-HCl, pH 7.5, 150 mM K+, and 10 mM Mg2+. The binding constants of spermidine for E. coli DNA, E. coli 16S rRNA, phospholipids in E. coli membrane, and ATP were 0.015, 0.066, 0.028, and 0.081 mM−1, respectively. Similarly, those of putrescine were 0.0 10, 0.0 10, 0.007, and 0.037 mM−1, respectively. The concentrations of putrescine, ...
Tópico(s): Biopolymer Synthesis and Applications
1993 - Elsevier BV | Archives of Biochemistry and Biophysics
Kazuya Murakami, Tadashi Yoshimoto, Taiji Shimoda, Ana A. Kitazono, Tsutomu Kabashima, Kiyoshi Ito, Daisuke Tsuru,
The pyroglutamyl peptidase [EC 3.4.11.8] gene from Bacillus amyloliquefaciens was cloned and expressed in Escherichia coli DHL The transformant of E. coli DH1 harboring plasmid pBPG 1 with a 2.1 kb chromosomal DNA fragment showed 80-fold higher activity than B. amyloliquefaciens. The nucleotide sequence of a 0.9 kb fragment that contains the promoter and the mature protein coding region was determined by the dideoxy chaintermination method. An open reading frame of 648 bp starting with an ATG methionine ...
Tópico(s): Cancer Research and Treatments
1993 - Oxford University Press | The Journal of Biochemistry
Cutoff depths of seismicity in the earth's crust change from place to place over a range of 5–25 km. These variations are closely related to the values of the surface heat flow. In order to examine regional variations in greater detail, available cross sections of well-determined focal depths have been collected for five areas located near active volcanoes, where the thermal structure is considered to change abruptly. The seismic-aseismic boundary is located at depths of about 5–8 km immediately ...
Tópico(s): Seismic Waves and Analysis
1993 - Elsevier BV | Tectonophysics
Hong Wu, Kiyoshi Ito, Hitoshi Shimoi,
ABSTRACT Yeast Saccharomyces cerevisiae cells generally cannot synthesize biotin, a vitamin required for many carboxylation reactions. Although sake yeasts, which are used for Japanese sake brewing, are classified as S. cerevisiae , they do not require biotin for their growth. In this study, we identified a novel open reading frame (ORF) in the genome of one strain of sake yeast that we speculated to be involved in biotin synthesis. Homologs of this gene are widely distributed in the genomes of sake ...
Tópico(s): Fungal and yeast genetics research
2005 - American Society for Microbiology | Applied and Environmental Microbiology
Satoshi Okamoto, Kiyoshi Ito, Hironobu Sasano, Takuya Moriya, Hitoshi Niikura, Yukihiro Terada, Shinji Sato, Kunihiro Okamura, Nobuo Yaegashi,
The differential diagnosis between reactive mesothelial cells and ovarian carcinoma cells is often difficult in cytologic specimens. Immunocytochemical procedures have been utilized in assisting this differential diagnosis, with limitations. Furthermore, previous studies examined only serous type but not other histological types of ovarian carcinoma cases. Therefore, we evaluated the practical value of various epithelial and mesothelial markers in differential diagnosis of these two types of cells. ...
Tópico(s): Vascular Tumors and Angiosarcomas
2005 - Tohoku University | The Tohoku Journal of Experimental Medicine
Masafumi Toyoshima, Chikako Okamura, Hitoshi Niikura, Kiyoshi Ito, Nobuo Yaegashi,
Abstract Background. Epithelioid leiomyosarcomas arising from the uterine cervix are extremely rare neoplasms, with only three cases reported in the English literature. Case. A 53-year-old Japanese woman was admitted to our university hospital due to massive vaginal bleeding from a cervical tumor. A total hysterectomy with bilateral salpingo-oophorectomy was performed. Histological findings, including immunohistochemical study using desmin, SMA, cytokeratin, S-100, HMB-45, vimentin, melan-A, and CD68, led ...
Tópico(s): Vascular Tumors and Angiosarcomas
2005 - Elsevier BV | Gynecologic Oncology
Bogdan Enescu, Kiyoshi Ito, Zbigniew R. Struzik,
This study introduces a new approach (based on the Continuous Wavelet Transform Modulus Maxima method) to describe qualitatively and quantitatively the complex temporal patterns of seismicity, their multifractal and clustering properties in particular. Firstly, we analyse the temporal characteristics of intermediate-depth seismic activity (M≥ 2.6 events) in the Vrancea region, Romania, from 1974 to 2002. The second case studied is the shallow, crustal seismicity (M≥ 1.5 events), which occurred from ...
Tópico(s): Statistical and numerical algorithms
2005 - Oxford University Press | Geophysical Journal International
Atsushi Kimoto, Jun‐Sang Cho, Kiyoshi Ito, Daigo Aoki, Tohru Miyake, Kimihisa Yamamoto,
Abstract Summary: The photo‐crosslinking of carbazole dendrimers was analyzed by UV and IR spectroscopic methods. Photoirradiation results in the formation of a film that is insoluble in toluene and benzene. Time‐of‐flight mass spectrometry studies revealed that the photoirradiation lead to an oligomerization of the dendrimer through crosslinking. The resulting insoluble dendrimer film could be applied as a hole‐transport layer in efficient polymer electroluminescence devices (PLEDs). Luminance‐voltage ...
Tópico(s): Conducting polymers and applications
2005 - Wiley | Macromolecular Rapid Communications
Michiko Sakuma, Jun‐ichi Akahira, Takashi Suzuki, Satoshi Inoue, Kiyoshi Ito, Takuya Moriya, Hironobu Sasano, Kunihiro Okamura, Nobuo Yaegashi,
Objective. The estrogen-responsive ring finger protein (Efp) gene, one of estrogen receptor (ER) target genes, is considered to be essential for estrogen-dependent cell proliferation. To understand the estrogenic action on ovarian cancer, we studied the relationships between Efp and ERs expressions and the correlations of Efp expression with clinicopathological parameters in epithelial ovarian cancer. Methods. The protein expressions for Efp, ERα and ERβ were examined by immunoblotting in 12 ovarian ...
Tópico(s): RNA Research and Splicing
2005 - Elsevier BV | Gynecologic Oncology
Kiyoshi Ito, Y. Nakajima, Emi Ichihara, Kyohei Ogawa, Naoko Katayama, Kanako Nakashima, Tadashi Yoshimoto,
The gene coding for d-3-hydroxybutyrate dehydrogenase (HBDH) was cloned from Pseudomonas fragi. The nucleotide sequence contained a 780 bp open reading frame encoding a 260 amino acid residue protein. The recombinant enzyme was efficiently expressed in Escherichia coli cells harboring pHBDH11 and was purified to homogeneity as judged by SDS-PAGE. The enzyme showed a strict stereospecificity to the D-enantiomer (3R-configuration) of 3-hydroxybutyrate as a substrate. Crystals of the ligand-free HBDH ...
Tópico(s): Metabolism and Genetic Disorders
2005 - Elsevier BV | Journal of Molecular Biology
Kiyoshi Ito, Takashi Suzuki, Jun‐ichi Akahira, Michiko Sakuma, Sumika Saitou, Satoshi Okamoto, Hitoshi Niikura, Kunihiro Okamura, Nobuo Yaegashi, Hironobu Sasano, Satoshi Inoue,
We examined expression of 14-3-3sigma, a regulator of cell proliferation, and evaluated its clinical significance in endometrioid endometrial carcinoma.One hundred three endometrioid endometrial adenocarcinoma cases were examined using immunohistochemistry with archival specimens. We correlated this finding with various clinicopathologic variables, including the status of estrogen receptor, progesterone receptor, and MIB-1 (Ki-57).14-3-3sigma Immunoreactivity was detected in 78 of 103 (75.3%) of carcinoma ...
Tópico(s): Ubiquitin and proteasome pathways
2005 - American Association for Cancer Research | Clinical Cancer Research
Takashi Suzuki, Yasuhiro Miki, Yasuhiro Nakamura, Takuya Moriya, Kiyoshi Ito, Noriaki Ohuchi, Hironobu Sasano,
It is well known that sex steroids are involved in the growth of breast cancers, and the great majority of breast carcinomas express estrogen (ER), progesterone (PR), and androgen (AR) receptors. In particular, recent studies have demonstrated that estrogens and androgens are locally produced in breast carcinoma tissues, and total blockade of in situ estrogen production potentially leads to an improvement in prognosis of breast cancer patients. Therefore, it is important to obtain a better understanding ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2005 - Bioscientifica | Endocrine Related Cancer
Hiroshi Nakagawa, Sang‐Don Kim, Junichi Mizuno, Yukoh Ohara, Kiyoshi Ito,
The authors discuss the safety and efficacy of an ultrasonic bone curette in various spinal surgeries and report its advantages in clinical application.Between April 2002 and September 2003, 76 patients with various spinal diseases (29 cervical, five thoracic, 40 lumbosacral, and two foramen magnum regions) were treated microsurgically by using a Sonopet ultrasonic bone curette with longitudinal and torsional tips and lightweight handpieces. The operations were performed successfully and the device ...
Tópico(s): Spinal Fractures and Fixation Techniques
2005 - | Journal of Neurosurgery Spine
Sumika Saito, Kiyoshi Ito, Takashi Suzuki, Hiroki Utsunomiya, Jun‐ichi Akahira, Youko Sugihashi, Hitoshi Niikura, Kunihiro Okamura, Nobuo Yaegashi, Hironobu Sasano,
DAX‐1 (dosage‐sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome gene 1) is a recently characterized member of the orphan nuclear receptor family. DAX‐1 functions as a global negative regulator of steroid hormone production. It inhibits adrenal 4 binding protein (Ad4BP)/steroidogenic factor‐1 (SF‐1) pathway‐dependent P450arom expression in cultured human endometriotic stromal cells and acts as a corepressor for estrogen receptors (ER). In this study we first examined ...
Tópico(s): Sexual Differentiation and Disorders
2005 - Wiley | Cancer Science