Kiyoshi Tamura, Bayin Hua, Susumu Adachi, Isil Guney, Junya Kawauchi, M. Morioka, Mimi Tamamori‐Adachi, Yujiro Tanaka, Yusaku Nakabeppu, Makoto Sunamori, John M. Sedivy, Shigetaka Kitajima,
... c-myc in serum-induced cell proliferation Kiyoshi Tamura Kiyoshi Tamura Department of Biochemical Genetics, Medical Research Institute ... Search for more papers by this author Kiyoshi Tamura Kiyoshi Tamura Department of Biochemical Genetics, Medical Research Institute and ...
Tópico(s): Heat shock proteins research
2005 - Springer Nature | The EMBO Journal
Kozo Ogawa, Fumio Tanaka, Jun‐ichi Tamura, Kiyoshi Kadowaki, Keizo Okamura,
... coupled with conformational analysisKozo Ogawa, Fumio Tanaka, Junichi Tamura, Kiyoshi Kadowaki, and Keizo OkamuraCite this: Macromolecules 1987, 20, ...
Tópico(s): Chemical Synthesis and Analysis
1987 - American Chemical Society | Macromolecules
Jun‐ichi Tamura, Kiyoshi Kubota, Hirokazu Murakami, Morio Sawamura, T Matsushima, Tomohiko Tamura, Takayuki Saitoh, Hitoshi Kurabayshi, Takuji Naruse,
SUMMARY It has been suggested that vitamin B12 (vit.B12) plays an important role in immune system regulation, but the details are still obscure. In order to examine the action of vit.B12 on cells of the human immune system, lymphocyte subpopulations and NK cell activity were evaluated in 11 patients with vit.B12 deficiency anaemia and in 13 control subjects. Decreases in the number of lymphocytes and CD8+ cells and in the proportion of CD4+ cells, an abnormally high CD4/CD8 ratio, and suppressed ...
1999 - Oxford University Press | Clinical & Experimental Immunology
Keitaro Yamagami, Ryota Kurogi, Ai Kurogi, Kunihiro Nishimura, Daisuke Onozuka, Nice Ren, Akiko Kada, Ataru Nishimura, Koichi Arimura, Keisuke Ido, Masahiro Mizoguchi, Tetsuya Sakamoto, Takamasa Kayama, Michiyasu Suzuki, Hajime Arai, Akihito Hagihara, Koji Iihara, Masayoshi Takigami, Kenji Kamiyama, Kiyohiro Houkin, Shougo Nishi, Tetsuyuki Yoshimoto, Sadao Kaneko, Koji Oka, Hiroshi Ooyama, Kyousuke Kamada, Kenichi Makino, Naoki Tokumitsu, Kazuhiro Sako, Naoki Tokumitsu, Susumu Suzuki, Nozomi Suzuki, Naoto Izumi, K. Nitta, Masahumi Ootaki, Masanori Isobe, Mikio NISHIYA, Takaaki Yamazaki, Syouji Mabuchi, Kuniaki Ogasawara, Naohiko Kubo, Yukihiko Shimizu, Keiichi Saito, Tatumi Yamanome, Atsuo Yoshino, Mitsuyuki Fujitsuka, Masaaki Takami, Hirotoshi Ohtaka, Teruyuki Hirano, Y Shiokawa, Takaharu Okada, Ichirô Suzuki, Michihiro Kohno, Jou Haraoka, Yoshinori Arai, Noriyoshi Kawamura, Akira Isoshima, Masaharu Yasue, Mitsuhiko Hokari Takayoshi Kobayashi, Kensuke Kawai, Taketoshi Maehara, Hajime Arai, Makoto Noguchi, Haruhiko Hoshino, Hirofumi Hiyama, Kensaku Yoshida, Osamu Utsugi, Yasuaki Takeda, Kouichi Tamaki, Hirohide Karasudani, Takao Urabe, Shiro Kobayashi, Michio Nakamura, Yorio Koguchi, Junichi Ono, Sumio Suda, Hiromu Hadeishi, Toshio Fukutake, Kenji Wakui, Hirokazu Tanno, Naoki Ishige, Takashi Ohasi, Hideki Sakai, Yasuaki Nishimura, Takayuki Watanabe, Takashi Matsumoto, Naoki Koketsu, Yuichi Hirose, Manabu Doyu, Toshinori Hasegawa, Naoto Kuwayama, Shin-ichi Terao, Nobuhiko Mizutani, Noriyuki Suzaki, Satoshi Okuda, Keizo Yasui, Yukio Seki, Yasuhiro Hasegawa, Akira Ikeda, Youtarou Takeuchi, Sigeki Ohara, Yoshio Araki, Toshihiko Wakabayashi, Hisashi Tanaka, Junpei Yoshimoto, Makoto Sugiura, Koichiro Ogura, Nozomu Kobayashi, Tomonori Yamada, Amami Kato, Toshiho Ohtsuki, Akatsuki Wakayama, Jun Takahashi, Hiroharu Kataoka, Toshiki Yoshimine, Yoshikazu Nakajima, Hidehuku Gi, Ryunosuke Uranishi, Yusaku Nakamura, Kazunori Yamanaka, Kazumi Ohmori, Hiroyuki Matsumoto, Yoshitugu Oiwa, Yosihiko Uemura, Hiroaki Fujiwara, Yoshiyasu Iwai, Masashi Morikawa, Kazuyuki Tane, Kazuo Hashikawa, Toshiyuki Fujinaka, Shunichi Yoneda, Kohsuke Yamashita, Masahiko Kitano, Shinsuke Tominaga, Kazuhito Nakamura, Katsuhiko Kono, Kenji Ohata, Hirokatsu Taniguchi, Takanori Hazama, Toshihiko Kuroiwa, Yoji Tamura, Kazusige Maeno, Motohiro Arai, Masaaki Iwase, Kenji Hashimoto, K. Yamada, Takashi Turuno, Tsutomu Ichinose, Shinichiro Kurokawa, Takeshi Matsuyama, Toshiaki Fujita, Takamichi Yuguchi, Yoshihumi Teramoto, Hiroto Kakita, Takayuki Matsuo, Tsuyoshi Izumo, Nobutoshi Ryu, Wataru Haraguchi Naoki Kitagawa, Makio Kaminogo, Seisaburo Sakamoto, Yosiharu Tokunaga, Eiichirou Urasaki, Jun‐ichi Kuratsu, Akira Takada, Tadashi Terasaki, Isao Fuwa Hisami Oosima, Shigeo Yamashiro, Makoto Yoshikawa Hiromasa Tsuiki, Kazunori Koga, Hiroshi Egami, Tadao Kawamura, Kunihiko Mitsuo, Takamitu Hikawa Masaki Morisige, Yuu Takeda, Yutaka Yamaguchi, Shiro Miyata Shunro Uchinokura, Tomokazu Goya, Hideo Takeshima, Kazutaka Yatsushiro, Hajime Ohta, Tatsui Nagadou, Kazuho Hirahara, Souichi Obara, Hiroshi Seto, Koiti Moroki, Kazunori Arita, Shogo Ishiuchi, Toshimitsu Uchihara, Susumu Mekaru, Tomoaki Nagamine, Naoki Tomiyama Jin Momoji, Kouzi Idomari Atusi Kimoto, Tsutomu Kadekaru, Hirosi Syamoto, Osamu Sasaki, Makoto Minagawa, Hideaki Takahashi, Kiyoshi Onda Hiroyuki Arai, Shigekazu Takeuchi, Hiroshi Abe, Osamu Fukuda, Mitsuo Kouno, Tetsuro Tamura, Yukio Horie Michiya Kubo, Hiroaki Hondo, Hisashi Takada, Toru Masuoka, Naoki Shirasaki, Hisashi Nitta, Makoto Kimura Yasuo Katsuki, Yutaka Hayashi Hisato Minamide, S Munemoto, Kiyonobu Ikeda, Mitsutoshi Nakada Yutaka Hayashi, Syuji Sato, Taketo Hatano, Osamu Yamamura, Masanori Kabuto, Takahiro Hayashi, Hiroyuki Kinouchi, Hidehito Koizumi, Syougo Imae, Manabu Fujita, Masakazu Suga, Shinji Iwata Kanehisa Kohno, Kiichiro Zenke, Mutsuo Fujisawa, Hikaru Mizobuchi, Satoru Hayashi, Masanori Morimoto, Tetsuya Ueba, Hiroyuki Nishimura, Naoki Ikawa, Yuzo Matsumoto, Seiji Kannuki, M Kagawa, Naoki Hayashi, Takashi Tamiya Atsushi Shindo, Kimihiro Yoshino, Tetsuya Masaoka, Ichiro NAKAHARA, Akira Nakamizo Satoshi Suzuki, Yuji Okamoto, Haruki Takahashi, Koji Iihara, Katsuyuki Hirakawa, Shinji Nagata, Akio Ookura, Hidenori Yoshida Yoshiro Kaneko, Hiroshi Nakane, Isao Inoue, Tsutomu Hitotsumatsu, Terukazu Kuramoto, Yoshihisa Matumoto Hiromichi Ooishi, Tooru Inoue Masani Nonaka, Motohiro Morioka, Hiroshi SAKATA, Hiroshi Takashima, Shin-ichiro Ishihara, Kenji Suzuyama, Masayuki Miyazono, Masafumi Morimoto Itaro Hattori, Satoshi Ozaki, Nobuo Hirota, Yasunori Takemoto Yasuhiko Mochimatsu, Makoto Takagi, Isao Yamamoto Kenji Nakayama, Yoshinori Tanaka, Katsumi Sakata, Nobutaka Kawahara, Motohiro Nomura, Hitoshi Ozawa, Kotaro Tsumura, Makoto Inaba Michiyuki Maruyama, Tatsuro Mori, Takahisa Mori, Masato Sugitani, Yuichiro Tanaka, Masaru Yamada, Mitsunori Matsumae, Keiichirou Onitsuka, Kosuke Miyahara Tatsuya Takahashi, Sumio Endou, Hidekazu Takahashi, Hiroyuki Kaidu, Akira Tsunoda Chikashi Maruki, Takamitsu Fujimaki, Hidetoshi Ooigawa, Masahiko Tanaka Masatsugu Uchida, Hiroshi Katoh, Akio Hyodo, Ken Asakura, Shigeyoshi Nakajima, Takao Kanzawa, Hideyuki Kurihara, Sigehiro Ohmori,
The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging societies. We assessed the influence of age on outcomes of patients with TBI and sought to identify prognostic factors for in-hospital mortality of TBI among elderly patients.Using a nationwide database, we analyzed data from 5651 patients with TBI. Univariate analysis was conducted to compare patient demographics, neurologic status on admission, radiologic ...
Elsevier BV
Ryota Kurogi, Kunihiro Nishimura, Michikazu Nakai, Akiko Kada, Satoru Kamitani, Jyoji Nakagawara, Ḱazunori Toyoda, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Shinya Matsuda, Shinichi Yoshimura, Kazuo Okuchi, Akifumi Suzuki, Fumiaki Nakamura, Daisuke Onozuka, Keisuke Ido, Ai Kurogi, Nobutaka Mukae, Ataru Nishimura, Koichi Arimura, Takanari Kitazono, Akihito Hagihara, Koji Iihara, Masayoshi Takigami, Kenji Kamiyama, Kiyohiro Houkin, Shougo Nishi, Tetsuyuki Yoshimoto, Sadao Kaneko, Koji Oka, Yusuke Nakagaki, Hiroshi Ooyama, Kyousuke Kamada, Kenichi Makino, Naoki Tokumitsu, Kazuhiro Sako, Naoki Tokumitsu, Susumu Suzuki, Nozomi Suzuki, Teruo Kimura, Naoto Izumi, K. Nitta, Masahumi Ootaki, Masanori Isobe, Mikio NISHIYA, Takaaki Yamazaki, Syouji Mabuchi, Kuniaki Ogasawara, Naohiko Kubo, Yukihiko Shimizu, Keiichi Saito, Tatumi Yamanome, Akinori Yabuta, Akira Suzuki, Atsuo Yoshino, Junichi Harashina, Mitsuyuki Fujitsuka, Hiroyuki Masaoka, Masaaki Takami, Hirotoshi Ohtaka, Teruyuki Hirano, Y Shiokawa, Takaharu Okada, Ichirô Suzuki, Michihiro Kohno, Jou Haraoka, Yoshinori Arai, Noriyoshi Kawamura, Akira Isoshima, Masaharu Yasue, Mitsuhiko Hokari, Takayoshi Kobayashi, Kensuke Kawai, Taketoshi Maehara, Hajime Arai, Takakazu Kawamata, Yoshikazu Okada, Makoto Noguchi, Haruhiko Hoshino, Hirofumi Hiyama, Kensaku Yoshida, Mitsuyuki Fujitsuka, Osamu Utsugi, Yasuaki Takeda, Kouichi Tamaki, Hirohide Karasudani, Takao Urabe, Shiro Kobayashi, Michio Nakamura, Yorio Koguchi, Junichi Ono, Sumio Suda, Hiromu Hadeishi, Toshio Fukutake, Kenji Wakui, Hirokazu Tanno, Naoki Ishige, Takashi Ohasi, Naoaki Sato, Hideki Sakai, Yasuaki Nishimura, Takayuki Watanabe, Takashi Matsumoto, Naoki Koketsu, Yuichi Hirose, Manabu Doyu, Toshinori Hasegawa, Naoto Kuwayama, Shin-ichi Terao, Nobuhiko Mizutani, Noriyuki Suzaki, Satoshi Okuda, Keizo Yasui, Yukio Seki, Yasuhiro Hasegawa, Akira Ikeda, Youtarou Takeuchi, Sigeki Ohara, Yoshio Araki, Toshihiko Wakabayashi, Hisashi Tanaka, Junpei Yoshimoto, Makoto Sugiura, Koichiro Ogura, Nozomu Kobayashi, Toshio Yokoe, Kenichi Murao, Tomonori Yamada, Amami Kato, Toshiho Ohtsuki, Akatsuki Wakayama, Jun Takahashi, Hiroharu Kataoka, Toshiki Yoshimine, Yoshikazu Nakajima, Hidehuku Gi, Ryunosuke Uranishi, Yusaku Nakamura, Kazunori Yamanaka, Kazumi Ohmori, Hiroyuki Matsumoto, Yoshitugu Oiwa, Yosihiko Uemura, Hiroaki Fujiwara, Yoshiyasu Iwai, Masashi Morikawa, Kazuyuki Tane, Kazuo Hashikawa, Toshiyuki Fujinaka, Shunichi Yoneda, Kohsuke Yamashita, Masahiko Kitano, Shinsuke Tominaga, Kazuhito Nakamura, Katsuhiko Kono, Kenji Ohata, Hirokatsu Taniguchi, Takanori Hazama, Toshihiko Kuroiwa, Yoji Tamura, Kazusige Maeno, Motohiro Arai, Masaaki Iwase, Kenji Hashimoto, K. Yamada, Takashi Turuno, Tsutomu Ichinose, Shinichiro Kurokawa, Takeshi Matsuyama, Toshiaki Fujita, Takamichi Yuguchi, Yoshihumi Teramoto, Hiroto Kakita, Takayuki Matsuo, Tsuyoshi Izumo, Nobutoshi Ryu, Wataru Haraguchi, Naoki Kitagawa, Makio Kaminogo, Seisaburo Sakamoto, Yosiharu Tokunaga, Eiichirou Urasaki, Jun‐ichi Kuratsu, Akira Takada, Tadashi Terasaki, Toru Nishi, Isao Fuwa, Hisami Ooshima, Shigeo Yamashiro, Makoto Yoshikawa, Hiromasa Tsuiki, Kazunori Koga, Hiroshi Egami, Hirofumi Nagatomi, Tadao Kawamura, Makoto Goda, Y. Takeda, Kunihiko Mitsuo, Takamitu Hikawa, Masaki Morisige, Yuu Takeda, Yutaka Yamaguchi, Shiro Miyata, Shunro Uchinokura, Tomokazu Goya, Hideo Takeshima, Kazutaka Yatsushiro, Hajime Ohta, Tatsui Nagadou, Kazuho Hirahara, Souichi Obara, Hiroshi Seto, S. Tanaka, Koichi Moroki, Kazunori Arita, Shogo Ishiuchi, Toshimitsu Uchihara, Susumu Mekaru, Tomoaki Nagamine, Naoki Tomiyama, Jin Momoji, Satoshi Yamamoto, Koji Idomari, Atushi Kimoto, Tsutomu Kadekaru, Hirosi Syamoto, Osamu Sasaki, Makoto Minagawa, Yukihiko Fujii, Hideaki Takahashi, Kiyoshi Onda, Hiroyuki Arai, Shigekazu Takeuchi, Hiroshi Abe, Osamu Fukuda, Mitsuo Kouno, Tetsuro Tamura, Yukio Horie, Michiya Kubo, Hiroaki Hondo, Tadao Miyamori, Hisashi Takada, Toru Masuoka, Naoki Shirasaki, Hisashi Nitta, Makoto Kimura, Yasuo Katsuki, Yutaka Hayashi, Hisato Minamide, S Munemoto, Shunsuke Shiraga, Kiyonobu Ikeda, Mitsutoshi Nakada, Yutaka Hayashi, Syuji Sato, Taketo Hatano, Osamu Yamamura, Masanori Kabuto, Takahiro Sakuma, Jyunya Hayashi, Hiroyuki Kinouchi, Hidehito Koizumi, Mikito Uchida, Syougo Imae, Hiroshi Ozawa, Osamu Nishizaki, Manabu Fujita, Masakazu Suga, Shinji Iwata, Kanehisa Kohno, Takeharu Kunieda, Kiichiro Zenke, Mutsuo Fujisawa, Hiromichi Sadashima, Hikaru Mizobuchi, Satoru Hayashi, Masanori Morimoto, Takeshi Kohno, Tetsuya Ueba, Hiroyuki Nishimura, Naoki Ikawa, Yuzo Matsumoto, Seiji Kannuki, M Kagawa, Naoki Hayashi, Takashi Tamiya, Atsushi Shindo, Kimihiro Yoshino, Tetsuya Masaoka, Ichiro NAKAHARA, Akira Nakamizo, Yuji Okamoto,
Objectives This cross-sectional survey explored the characteristics and outcomes of direct oral anticoagulant (DOAC)–associated nontraumatic intracerebral hemorrhages (ICHs) by analyzing a large nationwide Japanese discharge database. Methods We analyzed data from 2,245 patients who experienced ICHs while taking anticoagulants (DOAC: 227; warfarin: 2,018) and were urgently hospitalized at 621 institutions in Japan between April 2010 and March 2015. We compared the DOAC- and warfarin-treated patients based on ...
Lippincott Williams & Wilkins
Yoichi Tamura, Kiyoshi Kakuta, Hideo Ogura,
Tópico(s): Dental Implant Techniques and Outcomes
2012 - Springer Science+Business Media | Odontology
Takayuki Tamura, Kiyoshi Hayashida, Shutaro Ueda, Masaaki Nagai,
The results from Suzaku observations of the galaxy cluster Abell2256 are presented. This cluster is a prototypical and well-studied merging system, exhibiting substructures both in the X-ray surface brightness and in the radial velocity distribution of member galaxies. There are main and sub components separating by 3'.5 in the sky and by about 2000 km s$^{-1}$ in radial velocity peaks of member galaxies. In order to measure Doppler shifts of iron K-shell lines from the two gas components by the ...
Tópico(s): Astrophysical Phenomena and Observations
2011 - Oxford University Press | Publications of the Astronomical Society of Japan
Keisuke TOMOCHIKA, Akiko Shimizu‐Ibuka, Tomoko Tamura, Kiyoshi Mura, Naoki Abe, Jun‐ichi Onose, Soichi Arai,
Peanut skin contains large amounts of polyphenols having antiallergic effects. We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2011 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Motoshi Tamura, Kiyoshi Tsuge, A. Igashira-Kamiyama, Takumi Konno,
Treatment of [Os(bpy)2Cl2] (bpy = 2,2′-bipyridine) with 2-aminoethanethiolate was accompanied by air oxidation to give [Os(2-aminoethanesulfinato-N,S)(bpy)2]+ ([1]+), which was further oxidized by air to be converted into [Os(2-iminoethanesulfinato-N,S)(bpy)2]+ ([2]+) under photoirradiation. Complex [2]+ was reverted back to [1]+ by treatment with BH4−.
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2011 - Royal Society of Chemistry | Chemical Communications
Masaki Mori, K Sugimachi, Takashi Ohiwa, Tomonori Okamura, Shunsuke Tamura, Kiyoshi Inokuchi,
Abstract The clinicopathological characteristics of early gastric carcinoma (EGC) in 23 Japanese under 30 years of age were reviewed and the findings compared with data on 53 patients over age 70. In the young patients, there was a female preponderance, a macroscopic solitary lesion and the cancer was of the poorly differentiated type without intestinal metaplasia in the surrounding mucosa. In the old patients, there was a male preponderance; about half the number of patients had macro-scopically ...
Tópico(s): Metastasis and carcinoma case studies
1985 - Oxford University Press | British journal of surgery
Masaki Yamamoto, Nobuhisa Akamatsu, Taku Aoki, Yoshihiro Sakamoto, Sumihito Tamura, Kiyoshi Hasegawa, Norihiro Kokudo,
Background There are several techniques for reconstructing the portal vein-superior mesenteric vein during pancreatoduodenectomy. The aim of the present study was to present our results with portal vein-superior mesenteric vein reconstruction using cryopreserved homologous veins during pancreatoduodenectomy for patients with pancreatic head cancer. Methods Patients who underwent pancreatoduodenectomy for pancreatic head cancer were reviewed retrospectively. In patients with portal vein-superior ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2016 - Elsevier BV | Surgery
Takumi Kayukawa, Mika Murata, Isao Kobayashi, Daisuke Muramatsu, Chieko Okada, Keiro Uchino, Hideki Sezutsu, Makoto Kiuchi, Toshiki Tamura, Kiyoshi Hiruma, Yukio Ishikawa, Tetsuro Shinoda,
Juvenile hormone (JH) has an ability to repress the precocious metamorphosis of insects during their larval development. Krüppel homolog 1 (Kr-h1) is an early JH-inducible gene that mediates this action of JH; however, the fine hormonal regulation of Kr-h1 and the molecular mechanism underlying its antimetamorphic effect are little understood. In this study, we attempted to elucidate the hormonal regulation and developmental role of Kr-h1. We found that the expression of Kr-h1 in the epidermis of ...
Tópico(s): Silkworms and Sericulture Research
2014 - Elsevier BV | Developmental Biology
Hideki Matsumura, Tadashi Kondo, Koichi Ogawa, Takafumi Tamura, Kiyoshi Fukunaga, Soichiro Murata, Nobuhiro Ohkohchi,
Although Kupffer cells (KCs) play an important role in the liver's immune response, their role in colon cancer metastasis to the liver is unclear. We here analyzed the relationship between KCs and tumor cells (TCs) in colon cancer metastasis to the liver. Fischer 344 (F344) rats were divided into control group (KC+ group) and KC elimination group (KC‑ group), in which KC elimination was induced by Cl2MDP liposome injection. RCN‑H4 colon cancer cells were injected into the rats of both groups, and the ...
Tópico(s): Immune cells in cancer
2014 - Spandidos Publishing | International Journal of Oncology
Takayuki Tamura, Kiyoshi Taniguchi, Yumiko Suzuki, Toshiyuki Okubo, Ryoji Takata, Tomonori Konno,
Fishy aftertaste is sometimes perceived in wine with fish and seafood pairing. However, what component of wine clashes with seafood or what compound contributes to the unpleasant fishy aftertaste in the mouth remains an open problem. First, intensities of unpleasant fishy aftertaste of wine and dried scallop pairings were rated by sensory analysis. Second, components of the wines were analyzed. Strong positive correlations were found between the intensity of fishy aftertaste and the concentration ...
Tópico(s): Wine Industry and Tourism
2009 - American Chemical Society | Journal of Agricultural and Food Chemistry
Andrea J. Wolf, Ludovic Desvignes, Beth Linas, Niaz Banaiee, Toshiki Tamura, Kiyoshi Takatsu, J. Ernst,
The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed compared with that of other infections or immunization, and allows the bacterial population in the lungs to expand markedly during the preimmune phase of infection. We used adoptive transfer of M. tuberculosis Ag85B-specific CD4+ T cells to determine that the delayed adaptive response is caused by a delay in initial activation of CD4+ T cells, which occurs earliest in the local lung-draining mediastinal lymph node. ...
Tópico(s): Tuberculosis Research and Epidemiology
2007 - Rockefeller University Press | The Journal of Experimental Medicine
Andrea J. Wolf, Beth Linas, Giraldina Trevejo-Nuñez, Eleanor Kincaid, Toshiki Tamura, Kiyoshi Takatsu, J. Ernst,
Abstract Mycobacterium tuberculosis (Mtb) is thought to reside in macrophages, although infected dendritic cells (DCs) have been observed. Thus, although cellular associations have been made, global characterization of the cells harboring Mtb is lacking. We have performed temporal and quantitative characterization of the cells harboring Mtb following aerosol infection of mice by using GFP-expressing bacteria and flow cytometry. We discovered that Mtb infects phagocytic cells of diverse phenotypes, ...
Tópico(s): Immunotherapy and Immune Responses
2007 - American Association of Immunologists | The Journal of Immunology
Wen Rui Xu, Toshiki Tamura, Kiyoshi Takatsu,
Allergic inflammation is induced by type 2 T helper cell (Th2) and Th2 cytokines such as interleukin (IL)-4, IL-5 and IL-13. These cytokines induce the production of allergen-specific immunoglobulin (Ig)E by B cells, and the ensuing degranulation of mast cells via IgE cross-linking leads to most clinical manifestations of allergic diseases. We examined the ability of immunomodulatory unmethylated CpG oligodeoxynucleotides (ODN), which are potent inducers of Th1 cytokines, to prevent allergic symptoms ...
Tópico(s): Mast cells and histamine
2007 - Elsevier BV | International Immunopharmacology
Haruyuki Ariga, Yoko Shimohakamada, Makiyo Nakada, Takeshi Tokunaga, Takeshi Kikuchi, Ai Kariyone, Toshiki Tamura, Kiyoshi Takatsu,
Summary Using T‐cell receptor (TCR) transgenic mice, we demonstrate that TCR stimulation of naive CD4 + T cells induces transient T‐bet expression, interleukin (IL)‐12 receptor β2 up‐regulation, and GATA‐3 down‐regulation, which leads to T helper (Th)1 differentiation even when the cells are stimulated with peptide‐loaded I‐A b ‐transfected Chinese hamster ovary cells in the absence of interferon‐γ (IFN‐γ) and IL‐12. Sustained IFN‐γ and IL‐12 stimulation augments naive T‐cell differentiation into Th1 cells. ...
Tópico(s): CAR-T cell therapy research
2007 - Wiley | Immunology
Shinichiro Koide, Masahiro Okazaki, Masahito Tamura, Kiyoshi Ozumi, Hiroyuki Takatsu, Fumihiko Kamezaki, Akihide Tanimoto, Hiromi Tasaki, Yasuyuki Sasaguri, Yasuhide Nakashima, Y. Otsuji,
An inflammatory response followed by vascular injury plays an important role in neointima formation and development of atherosclerotic lesions, which are in part mediated by proinflammatory cytokines. Using a cuff injury model, we examined the effects of adenovirus-mediated overexpression of phosphatase and tensin homology deleted on chromosome 10 (PTEN) on neointima formation and the proinflammatory response. A cuff was placed around the femoral artery, and adenovirus expressing human PTEN type ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2007 - American Physical Society | AJP Heart and Circulatory Physiology
Takuya Hashimoto, Yasuhiko Sugawara, Sumihito Tamura, Kiyoshi Hasegawa, Yoji Kishi, Norihiro Kokudo, Masatoshi Makuuchi,
Standard liver volume (SLV) is an important concept in adult living liver donor transplantation. The purpose of this study was to re-evaluate and modify the authors' previous formula for predicting total liver volume (TLV).The TLV of 301 Japanese living donors was measured by computed tomography. This TLV was then compared with the liver volume calculated using established formulas. The correlation between TLV and several factors including body surface area (BSA) were analyzed and a new equation (SLVn) ...
Tópico(s): Organ Donation and Transplantation
2006 - Wiley | Journal of Gastroenterology and Hepatology
Shinji Miura, Eriko Tomitsuka, Yasutomi Kamei, Tomomi Yamazaki, Yuko Kai, Mayumi Tamura, Kiyoshi Kita, Ichizo Nishino, Osamu Ezaki,
Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a key nuclear receptor co-activator for mitochondrial biogenesis. Here we report that overexpression of PGC-1α in skeletal muscles increased mitochondrial number and caused atrophy of skeletal muscle, especially type 2B fiber-rich muscles (gastrocnemius, quadriceps, and plantaris). Muscle atrophy became evident at 25 weeks of age, and a portion of the muscle was replaced by adipocytes. Mice showed increased energy expenditure ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2006 - Elsevier BV | American Journal Of Pathology
Takeshi Kikuchi, Shuichiro Uehara, Haruyuki Ariga, Takeshi Tokunaga, Ai Kariyone, Toshiki Tamura, Kiyoshi Takatsu,
Summary The effector CD8 + T cells recognize major histocompatibility complex (MHC) class I binding altered self‐peptides expressed in tumour cells. Although the requirement for CD4 + T helper type 1 (Th1) cells in regulating CD8 + T cells has been documented, their target epitopes and functional impact in antitumour responses remain unclear. We examined whether a potent immunogenic peptide of Mycobacterium tuberculosis eliciting Th1 immunity contributes to the generation of CD8 + T cells and to protective ...
Tópico(s): T-cell and B-cell Immunology
2005 - Wiley | Immunology
Atsutaka TAMURA, Kiyoshi Omori, Kazuo MIKI, Jong B. Lee, King H. Yang, Albert I. King,
Typical automotive related abdominal injuries occur due to contact with the rim of the steering wheel, seatbelt and armrest, however, the rate is less than in other body regions. When solid abdominal organs, such as the liver, kidneys and spleen are involved, the injury severity tends to be higher. Although sled and pendulum impact tests have been conducted using cadavers and animals, the mechanical properties and the tissue level injury tolerance of abdominal solid organs are not well characterized. ...
Tópico(s): Agriculture and Farm Safety
2002 - | SAE technical papers on CD-ROM/SAE technical paper series
Gen Tamura, Kiyoshi Sato, Sunao Akiyama, Takashi Tsuchiya, Yasushi Endoh, Osamu Usuba, Wataru Kimura, Satoshi Nishizuka, Teiichi Motoyama,
As the great majority of gastric cancers develop histologically differentiated, and a significant proportion of differentiated-type carcinomas progress to become undifferentiated, both histological types are likely to share several common genetic abnormalities, such as p53 mutations at advanced stages. However, a subset of gastric cancers develop as undifferentiated carcinomas, including signet-ring cell carcinoma and poorly differentiated adenocarcinoma, and the molecular pathogenesis of this tumor ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2001 - Elsevier BV | Laboratory Investigation
Takashi Tsuchiya, Gen Tamura, Kiyoshi Sato, Yasushi Endoh, Ken Sakata, Zhe Jin, Teiichi Motoyama, Osamu Usuba, Wataru Kimura, Satoshi Nishizuka, Keith T. Wilson, Stephen P. James, Jing Yin, A. Steven Fleisher, Tongtong Zou, Steven G. Silverberg, Dehe Kong, Stephen J. Meltzer,
Tópico(s): Genetic factors in colorectal cancer
2000 - Springer Nature | Oncogene
Kazuhiro Tamura, Kiyoshi Yamaguchi, Hiroshi Kogo,
Tópico(s): Menopause: Health Impacts and Treatments
2000 - Elsevier BV | Life Sciences
Akihiro Yasoda, Yoshihiro Ogawa, Michio Suda, Naohisa Tamura, Kiyoshi Mori, Yoko Sakuma, Hideki Chusho, Kohei Shiota, Kiyoshi Tanaka, Kazuwa Nakao,
The natriuretic peptide family consists of three structurally related endogenous ligands: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The biological actions of natriuretic peptides are thought to be mediated through the activation of two guanylyl cyclase (GC)-coupled receptor subtypes (GC-A and GC-B). In this study, we examined the effects of ANP and CNP, which are endogenous ligands for GC-A and GC-B, respectively, on bone growth using an ...
Tópico(s): Heterotopic Ossification and Related Conditions
1998 - Elsevier BV | Journal of Biological Chemistry
Koji Takechi, Hideyuki Tamura, Kiyoshi Yamaoka, Hiromu Sakurat,
In pharmacokinetic studies, a variety of analytical method including radioisotopic detection and HPLC (high performance liquid chromatography) has been used. In the present investigation, we developed in vivo BCM (Blood Circulation Monitoring)-ESR method, which is a new technique with a conventional X-band ESR spectrometer for observing stable free radicals in the circulating blood of living rats under anaesthesia. Both 5–(PROXYL derivatives) and 6–(TEMPO derivatives) membered nitroxide spin probes ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
1997 - Taylor & Francis | Free Radical Research
Tomoaki Ishigami, Satoshi Umemura, Kouichi Tamura, Kiyoshi Hibi, Nobuo Nyui, Minoru Kihara, Machiko Yabana, Y. Watanabe, Yoichi Sumida, Toshihiro Nagahara, Hisao Ochiai, Masao Ishii,
The angiotensinogen (AGT) gene M235T variant is associated with essential hypertension and elevated plasma AGT concentrations, although the underlying mechanisms are unknown. Recent studies have suggested that AGCE 1 (human AGT gene core promoter element 1) located in the 5' upstream core promoter region (position -25 to -1) of the human AGT gene has an important part in the expression of AGT mRNA by binding with transcription factor AGCF 1 (human AGT gene core promoter element binding factor 1), and ...
Tópico(s): Genetic Associations and Epidemiology
1997 - Lippincott Williams & Wilkins | Hypertension
Masato Kotani, Issei Tanaka, Yoshihiro Ogawa, Takeshi Usui, Naohisa Tamura, Kiyoshi Mori, Shuh Narumiya, Teruya Yoshimi, Kazuwa Nakao,
Prostaglandin EP3 receptor subtype is a seven-membrane-spanning protein with multiple C-terminal tails generated by alternative mRNA splicing. We report here the structural organization of the human EP3 gene (PTGER3). The human EP3 gene spanned more than 80 kb and was composed of 10 exons separated by nine introns. Exon 1 and the 5' 180-bp portion of exon 2 (exon 2a) encoded the seven transmembrane domains and 10 amino acid residues of the cytoplasmic tail, which are common to all EP3 isoforms. The ...
Tópico(s): Neuropeptides and Animal Physiology
1997 - Elsevier BV | Genomics