Produção Nacional
Revisado por pares
Fábio P. Sellera, Nilton Lincopán, Danny Fuentes‐Castillo, Eliana Guedes Stehling, João Pedro Rueda Furlan,
Enterobacterales co-producing Klebsiella pneumoniae carbapenemase (KPC) and New Delhi metallo-β-lactamase (NDM) enzymes are rapidly emerging worldwide.1Thomas GR Corso A ... Detecting KPC-2 and NDM-1 coexpression in Klebsiella pneumoniae complex from human and animal hosts in ... of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings.EBioMedicine. 2020; 51102599Summary Full ... Detecting KPC-2 and NDM-1 coexpression in Klebsiella pneumoniae complex from human and animal hosts in ... of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings.EBioMedicine. 2020; 51102599Summary Full ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2024 - Elsevier BV | The Lancet Microbe
Leake Gebremeskel, Tewolde Teklu, Gebremicheal Gebreslassie Kasahun, Kald Beshir Tuem,
Abstract Background The burden of Klebsiella drug resistance to antimicrobials is a major public health concern worldwide; particularly the problem is severe in developing countries including Ethiopia. ... analysis is to establish the pooled estimate of Klebsiella drug resistance; and antimicrobial-specific resistance pattern among Klebsiella clinical isoaltes in Ethiopia. Methods Articles were searched ... 3). The main outcome measures were the overall Klebsiella resistance; and drug-specific resistance patterns. A random- ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2023 - BioMed Central | BMC Infectious Diseases
Sudha Sajeev, Muneeb Hamza, Vineeth Rajan, Ardhra Vijayan, G. K. Sivaraman, Bibek R. Shome, Mark A. Holmes,
... two most important Enterobacteriaceae members, E. coli and Klebsiella sp. was performed. 94 fish samples were collected ... were E. coli; 23 (20.35%) belonged to Klebsiella genus. Among E. coli, 48.88% (n = 22) ... 66% of E. coli and 30.43% of Klebsiella sp. were categorized as multi drug resistance (MDR) ... E. coli. Out of the 23 isolates of Klebsiella, 14(60.86%) were ampicillin (AM)-resistant (11( ... K. oxytoca showed intermediate resistance to AM. All Klebsiella isolates were susceptible to AN, SCP, MEM and ... and aac(6)-Ib-cr (27%); however, in Klebsiella, these genes, respectively, had a prevalence of 87%, ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2023 - Elsevier BV | Infection Genetics and Evolution
Spencer Coleman, Katrin Unterhauser, Karim Rezaul, Nagender Ledala, Stephanie Lesmes, Melissa J. Caimano, Yanjiao Zhou, Eric W. Jackson, Dawn Gratalo, Mark D. Driscoll, Adam Matson,
Abstract Intestinal colonization with Klebsiella has been linked to necrotizing enterocolitis (NEC), but methods of analysis usually failed to discriminate Klebsiella species or strains. A novel ~ 2500-base amplicon ( ... to generate amplicon sequence variant (ASV) fingerprints for Klebsiella oxytoca and Klebsiella pneumoniae species complexes (KoSC and KpSC, respectively) and ... used to identify cytotoxin-producing isolates of KoSC. Klebsiella species colonized most preterm infants, were more prevalent ... fingerprinted strains dominated the gut microbiota, suggesting exclusionary Klebsiella competition for luminal resources. Enterococcus faecalis was co- ...
Tópico(s): Probiotics and Fermented Foods
2023 - Nature Portfolio | Scientific Reports
Jing Li, Qiannan Gao, Yiyangzi Ma, Yue Deng, Shuangyue Li, Na Shi, Haitao Niu, Xinyu Liu, Jun Cai,
... This study aimed to investigate whether opportunistic pathogen Klebsiella pneumoniae is a causal factor for hypertension pathogenesis, and explore the potential mechanisms.The enrichment of Klebsiella pneumoniae in the gut of patients with hypertension ... by meta-analysis based on 3 independent cohorts. Klebsiella pneumoniae was inoculated into germ-free mice, antibiotic pretreated and conventional mice.Klebsiella pneumoniae led to higher blood pressure, slight cardiac ... contractility of resistant arteries in recipient mice. Moreover, Klebsiella pneumoniae induced pathological damages, deficiency of tight junction ...
Tópico(s): Nutritional Studies and Diet
2022 - Lippincott Williams & Wilkins | Hypertension
Kolawole I. Ayeni, David Berry, Lukas Wisgrill, Benedikt Warth, Chibundu N. Ezekiel,
... Blautia,Catenibacterium, Collinsella Coprococcus, Clostridium, Dialister, Faecalibacterium, Haemophilus, Klebsiella Lachnobacterium, Lachnospira Lactobacillus, Prevotella, Phascolarctobacterium, Ruminococcus, SuccinivibrioSutterella, VeillonellaBifidobacteriumbHigher ... Enterobacter aerogenes, Enterobacter cloacae, Enterobacter intermedius, Escherichia coli, Klebsiella oxytoca, Staphylococcus aureus, Proteus mirabilis, Raoultella ornitholytica, Serratia ... Blautia, Butyricimonas, Camplylobacter, Catenibacterium, Clostridium, Coprococcus, Dialister, Finegoldia, Klebsiella, Lachnospira, Megasphaera, Oscillospira, Peptoniphilus, Phascolarctobacterium, Porphyromonas, Prevotella, Roseburia, ...
Tópico(s): Nutritional Studies and Diet
2022 - Elsevier BV | Trends in Microbiology
Andy Setiawan, Agung Dwi Wahyu Widodo, Pepy Dwi Endraswari,
... world, so optimization of antibiotic use is needed. Klebsiella pneumoniae is a Gram-negative bacterium that causes ... The study tested antibiotics that most effectively inhibited Klebsiella pneumoniae non-ESBL, Klebsiella pneumoniae ESBL invitro with time-kill curve analysis.This experiment used Klebsiella pneumoniae ATCC isolates, stored clinical isolates of Klebsiella pneumoniae non-ESBL, Klebsiella pneumoniae ESBL, and the control group. Isolates other ... doxycycline in this study had inhibition effects on Klebsiella pneumoniae non-ESBL and Klebsiella pneumoniae ESBL. Ciprofloxacin ...
Tópico(s): Pneumonia and Respiratory Infections
2022 - Wolters Kluwer | Annals of Medicine and Surgery
Produção Nacional
Revisado por pares
Ashish Kumar, Taihao Yang, Somnath Chakravorty, Aritri Majumdar, Brittany L. Nairn, David A. Six, Naara M. dos Santos, Sarah L. Price, Matthew B. Lawrenz, Luis A. Actis, Marilis V. Marques, Thomas A. Russo, Salete M. Newton, Phillip E. Klebba,
... Escherichia coli (Fiu, FepA, Cir, FhuA, IutA, BtuB), Klebsiella pneumoniae (IroN, FepA, FyuA), Acinetobacter baumannii (PiuA, FepA, ... Escherichia coli (Fiu, FepA, Cir, FhuA, IutA, BtuB), Klebsiella pneumoniae (IroN, FepA, FyuA), Acinetobacter baumannii (PiuA, FepA, ... Houle S. Dozois C.M. Bachman M.A. Klebsiella pneumoniae siderophores induce inflammation, bacterial dissemination, and HIF- ... enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo.Infect. Immun. ...
Tópico(s): Plant Pathogenic Bacteria Studies
2022 - Elsevier BV | Journal of Biological Chemistry
Amy Dumigan, Oisín Cappa, Brenda Morris, Joana Sá‐Pessoa, Ricardo Calderón-González, Grant Mills, Rebecca Lancaster, David Simpson, Adrien Kissenpfennig, José A. Bengoechea,
... skewing lung macrophage polarisation by the human pathogen Klebsiella pneumoniae . We identify interstitial macrophages (IMs) as the main population of lung macrophages associated with Klebsiella . Single‐cell transcriptomics and trajectory analysis of cells ... receptor signalling are features of infected alveolar macrophages. Klebsiella ‐induced macrophage polarisation is a singular M2‐type we termed M(Kp). To rewire macrophages, Klebsiella hijacks a TLR‐type I IFN‐IL10‐STAT6 axis. Absence of STAT6 limits Klebsiella intracellular survival and facilitates the clearance of the ...
Tópico(s): Immune responses and vaccinations
2022 - Springer Nature | EMBO Molecular Medicine
Megha Prasad, Sindhu K. Shetty, Bipin G. Nair, Sanjay Pal, Ajith Madhavan,
... study proposes a selective and differential medium for Klebsiella spp. Klebsiella blue agar (KBA) is completely selective against selected ... the growth of the chosen members of the Klebsiella pneumoniae species-complex with a characteristic green colouration. ... it differential. KBA was more selective than HiCrome™ Klebsiella Selective Agar Base (KSA) in replica plating experiments. ... on LB. The colonies so isolated were predominantly Klebsiella spp., on identification through colony polymerase chain reaction. ...
Tópico(s): Gut microbiota and health
2022 - Springer Science+Business Media | Applied Microbiology and Biotechnology
Leonard Ighodalo Uzairue, Ali A. Rabaan, Fumilayo Ajoke Adewumi, Obiageli Jovita Okolie, Jamiu Bello Folorunso, Muhammed A. Bakhrebah, Mohammed Garout, Wadha Alfouzan, Muhammad A. Halwani, Aref A. Alamri, Shaima A. Halawani, Fatimah Alshahrani, Abdulkarim Hasan, Abbas Al Mutair, Saad Alhumaid, Johnson Etafo, Idorenyin Utip, Ikenna Odoh, Nkolika Stella Uwaezuoke,
Background: Among gram-negative bacteria, Klebsiella pneumoniae is one of the most common causes of healthcare-related infection. Bloodstream infections (BSIs) caused by Klebsiella pneumoniae are notorious for being difficult to treat due to resistance to commonly used antimicrobials. Klebsiella pneumoniae isolates from bloodstream infections are becoming increasingly ... to carbapenems. In the fight against carbapenem-resistant Klebsiella pneumoniae, colistin [polymyxin E] is the antimicrobial of ... determine the global prevalence of colistin resistance amongst Klebsiella pneumoniae isolates from bloodstream infections. Methods: PubMed, Medline, ...
Tópico(s): Antibiotic Use and Resistance
2022 - Multidisciplinary Digital Publishing Institute | Pathogens
Asmamaw Ameshe, Tigist Engda, Mucheye Gizachew,
Klebsiella species cause pneumonia, UTI, and septicemia in human beings. Beta-lactam drugs are used extensively to treat patients infected with Klebsiella, but most of the Klebsiella species are resistant to third- and fourth-generation ... resistance, ESBL production, and associated risk factors of Klebsiella species among UTI-suspected patients in Bahir Dar ... data was maintained by following SOPs and using Klebsiella pneumoniae (ACTT700603). Logistic regression statistical analysis was done ... unable to read and/or write. The total Klebsiella species detected were 38 (9.9%). Of which, ...
Tópico(s): Antibiotic Use and Resistance
2022 - Hindawi Publishing Corporation | International Journal of Microbiology
Aline Cuénod, Daniel Wüthrich, Helena M. B. Seth-Smith, Chantal Ott, Christian Gehringer, Frédéric Foucault, Roxanne Mouchet, Ali Kassim, Gunturu Revathi, D. Vogt, Stefanie von Felten, Stefano Bassetti, Sarah Tschudin‐Sutter, Timm Hettich, Götz Schlotterbeck, Christina Homberger, Carlo Casanova, Jacob Moran‐Gilad, Orli Sagi, Belén Rodríguez‐Sánchez, Franco Müller, Martina Aerni, Valeria Gaia, Helke van Dessel, Greetje A. Kampinga, Claudia Müller, Claudia Daubenberger, Valentin Pflüger, Adrian Egli,
Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are ... common cause of hospital-acquired infections. Multiple new Klebsiella species have recently been described, yet their clinical ... profiles are largely unknown. We aimed to explore Klebsiella group- and species-specific clinical impact, antimicrobial resistance ( ... genome sequence data of a diverse selection of Klebsiella spp. isolates and identified resistance and virulence factors. Using the genomes of 3594 Klebsiella isolates, we predicted the masses of 56 ribosomal ...
Tópico(s): Genomics and Phylogenetic Studies
2021 - BioMed Central | Genome Medicine
John Alexander McHardy, Vathshalan Selvaganeshapillai, Priya Khanna, Ashley Whittington, Jane F. Turton, G. Gopal Rao,
... neck abscess caused by a strain of Hypervirulent Klebsiella pneumoniae in a middle aged man with diabetes ... case report is of notable significance as Hypervirulent Klebsiella pneumoniae neck abscesses are rarely seen in the ... year old diabetic man who contracted a Hypervirulent Klebsiella pneumoniae neck abscess which led to the development of sepsis. Klebsiella pneumoniae was cultured from blood cultures and fluid ... rmp)A and rmpA2 virulence genes. Discussion Hypervirulent Klebsiella pneumoniae is a Gram-negative, encapsulated, non-motile ...
Tópico(s): Mycobacterium research and diagnosis
2021 - BioMed Central | Annals of Clinical Microbiology and Antimicrobials
Yuang Sun, Alieysa Patel, John SantaLucia, Emily Roberts, Lili Zhao, Keith S. Kaye, Krishna Rao, Michael A. Bachman,
Klebsiella pneumoniae and the closely related species K. variicola and K. quasipneumoniae are common causes of health ... intestinal colonizing strain. To assess the association between Klebsiella colonization density and subsequent infections, a case-control ... qPCR) assay was developed and validated to quantify Klebsiella (K. pneumoniae, K. variicola, and K. quasipneumoniae combined) ... bacterial DNA copies in rectal swabs. Cases of Klebsiella infection were identified based on clinical definitions and ... measure the association between the relative abundance of Klebsiella and subsequent infections. The Klebsiella relative abundance by ...
Tópico(s): Urinary Tract Infections Management
2021 - American Society for Microbiology | mSphere
Marjorie J. Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B. Avison, Andrew Kannan, Dan Kibbey, T. M. Craft, Samia Habib, Harry A. Thorpe, Jukka Corander, Barbara Kasprzyk‐Hordern, Edward J. Feil,
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae ( Kpne ) has gained notoriety as a major ... environment, the level of risk posed by resistant Klebsiella strains in hospital wastewater remains unclear. We used whole genome sequencing (WGS) to compare Klebsiella species in contemporaneous samples of wastewater from an ... As we aimed to characterize representative samples of Klebsiella communities, we did not actively select for antibiotic ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2021 - Microbiology Society | Microbial Genomics
Susmita Kuinkel, Jyoti Acharya, Binod Dhungel, Sanjib Adhikari, Nabaraj Adhikari, Upendra Thapa Shrestha, Megha Raj Banjara, Komal Raj Rijal, Prakash Ghimire,
Klebsiella spp. are associated with several nosocomial and opportunistic infections. Increasing antimicrobial resistance of Klebsiella species is aggravated by a number of intrinsic ... ESBL), metallo-beta-lactamase (MBL) and AmpC and Klebsiella pneumoniae carbapenemase (KPC) and biofilm formation in Klebsiella isolates. A total of 2197 non-duplicate specimens ... NPHL), Kathmandu, Nepal, between February and August 2019. Klebsiella species were isolated, identified and screened for antimicrobial ... negative bacteria and 37.7% (57/151) were Klebsiella spp. Of the total Klebsiella spp., 56% (32/ ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2021 - Multidisciplinary Digital Publishing Institute | Microbiology Research
Jing Yang, Haiyan Long, Ya Hu, Yu Feng, Alan McNally, Zhiyong Zong,
Klebsiella oxytoca is actually a complex of nine species-Klebsiella grimontii, Klebsiella huaxiensis, Klebsiella michiganensis, K. oxytoca, Klebsiella pasteurii, Klebsiella spallanzanii, and three unnamed novel species. Phenotypic tests ... to AAHC, while many virulence factors seen in Klebsiella pneumoniae, such as capsular polysaccharides and fimbriae, have ...
Tópico(s): Genomics and Phylogenetic Studies
2021 - American Society for Microbiology | Clinical Microbiology Reviews
Sébastien Bridel, Stephen C. Watts, Louise M. Judd, Taylor Harshegyi, Virginie Passet, Carla Rodrigues, Kathryn E. Holt, Sylvain Brisse,
Klebsiella pathogens affect human and animal health and are widely distributed in the environment. Among these, the Klebsiella pneumoniae species complex, which includes seven phylogroups, is ... important cause of community and hospital infections. The Klebsiella oxytoca species complex also causes hospital infections and ... individual species. We developed a web-based tool, Klebsiella MALDI TypeR, a platform-independent and user-friendly ... TOF mass spectrometry data in order to identify Klebsiella isolates at the species complex and phylogroup levels. ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
2021 - Elsevier BV | Research in Microbiology
Mykhailo Savin, Gabriele Bierbaum, Ricarda Maria Schmithausen, Céline Heinemann, Judith Kreyenschmidt, Silvia Schmoger, Inna Akbaba, Annemarie Käsbohrer, Jens A. Hammerl,
Klebsiella spp. are ubiquitous bacteria capable of colonizing humans and animals, and sometimes leading to severe infections ... potential in aquiring antimicrobial/metal/biocide resistance determinants, Klebsiella spp. are recognized as an emerging threat to ... impact of livestock for the spread of pathogenic Klebsiella spp. is available. Thus, the phenotypic and genotypic ... extended-spectrum β-lactamase-producing, and colistin-resistant Klebsiella strains (n = 185) from process- and wastewater of ... environment by surviving the wastewater treatment. Selectively-isolated Klebsiella spp. from slaughterhouses including effluents and receiving waterbodies ...
Tópico(s): Bacterial biofilms and quorum sensing
2021 - Elsevier BV | The Science of The Total Environment
Dan Lee, Jae Young Oh, Samuth Sum, Hee‐Myung Park,
Background Klebsiella spp. is an important conditional pathogen in humans and animals. However, due to the indiscriminate use of ... was to investigate antimicrobial resistance in strains of Klebsiella strains and the phylogenetic relatedness of extended-spectrum cephalosporin (ESC)-resistance among Klebsiella strains isolated from clinically ill companion animals. Methods ... specimens were collected from animal hospitals. Identification of Klebsiella species, determination of minimum inhibitory concentrations, detection of ...
Tópico(s): Salmonella and Campylobacter epidemiology
2021 - Korean Society of Veterinary Science | Journal of Veterinary Science
Patricia Saxenborn, John D. Baxter, Andreas Tilevik, Magnus Fagerlind, Fredrik Dyrkell, Anna-Karin Pernestig, Helena Enroth, Diana Tilevik,
Klebsiella is a genus of Gram-negative bacteria known to be opportunistic pathogens that may cause a variety of infections in humans. Highly drug-resistant Klebsiella species, especially K. pneumoniae , have emerged rapidly and ... we have characterized the diversity and traits of Klebsiella spp. in community-onset infections by WGS of ... been misidentified. Of these, 23 were identified as Klebsiella variicola and nine as other members of the ... that significantly fewer resistance genes were detected in Klebsiella oxytoca compared to K. pneumoniae and K. variicola ( ...
Tópico(s): Genomics and Phylogenetic Studies
2021 - Frontiers Media | Frontiers in Microbiology
Natalia C. Rosas, Trevor Lithgow,
... Scholar]. Major porins have also been studied in Klebsiella pneumoniae [7.Jasim R. et al.A comparative ... between paired colistin-susceptible and extremely colistin-resistant Klebsiella pneumoniae strains.ACS Infect. Dis. 2018; 4: 1692- ... of the outer membrane modulate antimicrobial permeability in Klebsiella pneumoniae.mBio. 2020; 11e00603-20Crossref PubMed Scopus (24) ... of the outer membrane modulate antimicrobial permeability in Klebsiella pneumoniae.mBio. 2020; 11e00603-20Crossref PubMed Scopus (24) ... et al.Porin expression in clinical isolates of Klebsiella pneumoniae.Microbiology (Reading). 1999; 145: 673-679Crossref PubMed ...
Tópico(s): Bacterial biofilms and quorum sensing
2021 - Elsevier BV | Trends in Microbiology
Yuanyuan Ma, Xiuqin Wu, Shuying Li, Lie Tang, Mingyue Chen, Qianli An,
... including the family Enterobacteriaceae in 2016. The genus Klebsiella within the family Enterobacteriaceae was divided into two genera Klebsiella and Raoultella in 2001. Here, our phylogenomic analysis ... the genus Raoultella is nested within the genus Klebsiella. Klebsiella and Raoultella together are monophyletic and share average ... 86%) for genus delimitation within the family Enterobacteriaceae. Klebsiella and Raoultella share AAIs of 79.9%-85.0% with the other genera within the subfamily "Klebsiella clade", which are in the range of inter- ...
Tópico(s): Microbial Community Ecology and Physiology
2021 - Elsevier BV | Research in Microbiology
Cong Zhou, Qiang Wu, Leqi He, Hui Zhang, Maosuo Xu, Baoyu Yuan, Zhi Jin, Fang Shen,
The convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae has led to a significant public health ... more and more reports on carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) isolates.Clinical data of patients ... were retrospectively evaluated. The number of isolates of Klebsiella pneumoniae, hypermucoviscous Klebsiella pneumoniae (hmKP), carbapenem-resistant hypermucoviscous Klebsiella pneumoniae (CR-hmKP) and carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) collected during the period of ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2021 - Dove Medical Press | Infection and Drug Resistance
Yvonne N Wekesa, Fatuma Namusoke, Musa Sekikubo, Dennis Wandera Mango, Freddie Bwanga,
... mechanism of resistance to ceftriaxone and ceftazidime among Klebsiella species and Escherichia coli and examine the burden ... were 69 (58.5%), including 44 (37.3%) Klebsiella species, 11 (9.3%) E. coli, 6 (5. ... and in 43 (97.7%) of the 44 Klebsiella species and to ceftazidime in all 11 (100%) ... E. coli and 40 (91%) of the 44 Klebsiella species. Extended-spectrum beta-lactamase explained resistance to ... E. coli and 19 (48%) of the 40 Klebsiella species. Carbapenemase production explained 15 (38%) of the 40 ceftazidime-resistant Klebsiella species. Methicillin-resistant S. aureus was detected in ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2020 - SAGE Publishing | SAGE Open Medicine
Oana Falup‐Pecurariu, Eugene Leibovitz, Cristiana Vorovenci, Raluca Lixandru, Flavia Rochman, Vlad Monescu, Ron Leibovitz, Laura Bleotu, Cristian Falup‐Pecurariu,
... The five most common uropathogens were Escherichia coli, Klebsiella spp., Enterococcus spp., Proteus mirabilis and Staphylococcus aureus. ... piperacillin/tazobactam and gentamicin among E. coli and Klebsiella spp.; 29.15% E. coli and 42.9% Klebsiella spp. were ESBL-positive. 53.2% of recurrent ... initial UTI episode. E. coli (40.6%) and Klebsiella spp. (37.55) were the most frequent R- ... for a significant increase in E. coli and Klebsiella spp. resistance to piperacillin/tazobactam.ConclusionWe reported high ...
Tópico(s): Urological Disorders and Treatments
2020 - Elsevier BV | Pediatrics & Neonatology
Wei Jiang, Wenjie Yang, Xuequn Zhao, Na Wang, Haixia Ren,
... which has become a significant public health concern. Klebsiella pneumoniae is the most common pathogenic bacteria underlying ... lactamase is involved in the antibiotic resistance of Klebsiella pneumoniae to β‑lactam antibiotics. The aim of ... the molecular biological mechanisms of antibiotic resistance of Klebsiella pneumoniae and extended‑spectrum β‑lactamase (ESBL). In ... assess temporal trends in prevalence and antimicrobial susceptibility, Klebsiella pneumoniae bacteria were isolated and the ESBL expression ...
Tópico(s): Bacterial biofilms and quorum sensing
2020 - Spandidos Publishing | Experimental and Therapeutic Medicine
Yuhao Chen, Thomas C. Brook, Cho Zin Soe, Ian O’Neill, Cristina Alcon‐Giner, Onnicha Leelastwattanagul, Sarah Phillips, Shabhonam Caim, Paul Clarke, Lindsay J. Hall, Lesley Hoyles,
Klebsiella spp. are frequently enriched in the gut microbiota of preterm neonates, and overgrowth is associated with ... the genomic and phenotypic characteristics of preterm-associated Klebsiella , as previous studies have focused on the recovery ... this study was to better characterize preterm-associated Klebsiella populations using phenotypic and genotypic approaches. Faecal samples ... positive Enterobacteriaceae . Whole-genome sequences were generated for Klebsiella spp., and virulence and antimicrobial resistance genes identified. ...
Tópico(s): Antibiotic Resistance in Bacteria
2020 - Microbiology Society | Microbial Genomics
Catherine L. Tooke, Philip Hinchliffe, Robert A. Bonomo, Christopher J. Schofield, Adrian J. Mulholland, James Spencer,
... via a hydrolytically labile covalent acyl–enzyme intermediate. Klebsiella pneumoniae carbapenemase (KPC) is a widespread SBL that ... via a hydrolytically labile covalent acyl–enzyme intermediate. Klebsiella pneumoniae carbapenemase (KPC) is a widespread SBL that ... Health and Human Services, CDC, Atlanta, GA2019Google Scholar). Klebsiella pneumoniae carbapenemase-2 (KPC-2), a class A ... KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.Antimicrob. Agents Chemother. 2001; 45: 1151-1161Crossref ...
Tópico(s): Berberine and alkaloids research
2020 - Elsevier BV | Journal of Biological Chemistry