Yukari Okubo, Tomotaka Mabuchi, Keiji Iwatsuki, Hany Elmaraghy, Hitoe Torisu‐Itakura, Yoji Morisaki, Ko Nakajo,
Abstract Background Erythrodermic and generalized pustular psoriasis are rare, difficult to treat forms of psoriasis. In previous reports, we documented 24‐ and 52‐week findings of an open‐label, phase 3 trial ( UNCOVER ‐J) of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis; most patients responded to treatment and maintained response through 52 weeks. Objective To assess the long‐term (>3 years) efficacy and safety of ixekizumab in Japanese patients with erythrodermic ...
Tópico(s): Asthma and respiratory diseases
2018 - Wiley | Journal of the European Academy of Dermatology and Venereology
Taki Nishimura, Norito Tamura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Hayashi Yamamoto, Noboru Mizushima,
... Itakura & Mizushima, 2010; Kageyama et al, 2011; Kishi-Itakura et al, 2014). Figure 1. Flotation of ATG proteins derived from ATG14 KO and ATG3 KO cell homogenates A. OptiPrep membrane ... respectively (Fig 1B; Mizushima et al, 2011; Kishi-Itakura et al, 2014). Thus, early autophagosome precursors and elongating isolation membranes accumulate in ATG14 KO and ATG3 KO cells, respectively. As for the ... EV2C). Furthermore, FIP200 formed punctate structures in ATG9A KO MEFs (Fig EV1G), as did ULK1 (Itakura et al, 2012; Orsi et al, 2012). These ...
Tópico(s): Calcium signaling and nucleotide metabolism
2017 - Springer Nature | The EMBO Journal
Yoshinori Umezawa, Hitoe Torisu‐Itakura, Yoji Morisaki, Hany Elmaraghy, Ko Nakajo, Naotsugu Akashi, Hidehisa Saeki,
Abstract Background Long‐term management of moderate‐to‐severe psoriasis is usually discussed in terms of continuous administration; however, there are many situations in clinical practice where treatment may be withdrawn with subsequent retreatment. Objective To assess the clinical course after ixekizumab treatment withdrawal and retreatment, as well as the effectiveness of ixekizumab retreatment, in Japanese patients with plaque psoriasis. Methods This single‐arm, open‐label study ( UNCOVER ‐J; NCT01624233) ...
Tópico(s): Pharmaceutical studies and practices
2018 - Wiley | Journal of the European Academy of Dermatology and Venereology
Daniel Schmitt, Süleyman Bozkurt, Pascale Henning‐Domres, Heike Huesmann, Stefan Eimer, Laura Bîndilă, Christian Behrends, Emily Boyle, Florian Wilfling, Georg Tascher, Christian Münch, Christian Behl, Andreas Kern,
... confirming previous studies (Pankiv et al, 2007; Kishi-Itakura et al, 2014) (Appendix Fig S3). Upon starvation-mediated autophagy induction, we purified ATG8-positive structures and detected reduced quantities of fluorophore-labeled events in both KO lines compared with appropriate wild-type (WT) cells ( ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2022 - Springer Nature | EMBO Reports
María E. Rubio, Ko Matsui, Yugo Fukazawa, Naomi Kamasawa, Harumi Harada, Makoto Itakura, Elek Molnár, Manabu Abe, Kenji Sakimura, Ryuichi Shigemoto,
The neurotransmitter receptor subtype, number, density, and distribution relative to the location of transmitter release sites are key determinants of signal transmission. AMPA-type ionotropic glutamate receptors (AMPARs) containing GluA3 and GluA4 subunits are prominently expressed in subsets of neurons capable of firing action potentials at high frequencies, such as auditory relay neurons. The auditory nerve (AN) forms glutamatergic synapses on two types of relay neurons, bushy cells (BCs) and fusiform ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2017 - Springer Science+Business Media | Brain Structure and Function
Yuexi Gu, Yakubu Princely Abudu, Suresh Kumar, Bhawana Bissa, Seong Won Choi, Jingyue Jia, Michael Lazarou, Eeva‐Liisa Eskelinen, Terje Johansen, Vojo Deretić,
... has been implicated in mammalian autophagosome–lysosome fusion (Itakura et al, 2012). However, additional SNAREs have now been shown to contribute to this process (Matsui et al, 2018), but relative contributions remain to be fully defined. We generated CRISPR/Cas9-mediated STX17 knockout (KO) in different cell lines (HeLa and Huh7; Fig ...
Tópico(s): Adenosine and Purinergic Signaling
2019 - Springer Nature | The EMBO Journal
Michael C. Frank, Katie Alcock, Natalia Arias‐Trejo, Gisa Aschersleben, Dare A. Baldwin, Stéphanie Barbu, Elika Bergelson, Christina Bergmann, Alexis K. Black, Ryan Blything, Maximilian P. Böhland, Petra Bolitho, Arielle Borovsky, Shannon M. Brady, Bettina Braun, Anna Brown, Krista Byers‐Heinlein, Linda Campbell, Cara H. Cashon, Mihye Choi, Joan Christodoulou, Laura K. Cirelli, Stefania Conte, Sara Cordes, Christopher Martin Mikkelsen Cox, Alejandrina Cristià, Rhodri Cusack, Catherine Davies, Maartje de Klerk, Claire Delle Luche, Laura de Ruiter, Dhanya Dinakar, Kate C. Dixon, Virginie Durier, Samantha Durrant, Christopher T. Fennell, Brock Ferguson, Alissa L. Ferry, Paula Fikkert, Teresa Flanagan, Caroline Floccia, Megan Foley, Tom Fritzsche, Rebecca Louise Ann Frost, Anja Gampe, Judit Gervain, Nayeli Gonzalez‐Gomez, Anna Gupta, Laura E. Hahn, J. Kiley Hamlin, Erin E. Hannon, Naomi Havron, Jessica Hay, Mikołaj Hernik, Barbara Höhle, Derek M. Houston, Lauren H. Howard, Mitsuhiko Ishikawa, Shoji Itakura, Iain Jackson, Krisztina V. Jakobsen, Marianna Jartó, Scott P. Johnson, Caroline Junge, Didar Karadağ, Natalia Kartushina, Danielle Kellier, Tamar Keren‐Portnoy, Kelsey Klassen, Melissa Kline, Eon-Suk Ko, Jonathan F. Kominsky, Jessica Elizabeth Kosie, Haley E. Kragness, Andrea A. R. Krieger, Florian Krieger, Jill Lany, Roberto J. Lazo, Michelle Lee, Chloé Leservoisier, Clara C. Levelt, Casey Lew‐Williams, Matthias Lippold, Ulf Liszkowski, Liquan Liu, Steven G. Luke, Rebecca A. Lundwall, Viola Macchi Cassia, Nivedita Mani, Caterina Marino, Alia Martin, Meghan Mastroberardino, Victoria Mateu, Julien Mayor, Katharina Menn, Christine Michel, Yusuke Moriguchi, Benjamin Morris, Karli Nave, Thierry Nazzi, Claire Noble, Miriam A. Novack, Nonah M. Olesen, Adriel John Orena, Mitsuhiko Ota, Robin Panneton, Sara Parvanezadeh Esfahani, Markus Paulus, Carolina Pletti, Linda Polka, Christine Potter, Hugh Rabagliati, Sasvath Ramachandran, Jennifer L. Rennels, Greg D. Reynolds, Kelly C. Roth, Charlotte Rothwell, Doroteja Rubez, Yana Ryjova, Jenny R. Saffran, Ayumi Sato, Sophie Savelkouls, Adena Schachner, Graham Schafer, Melanie S. Schreiner, Amanda Seidl, Mohinish Shukla, Elizabeth A. Simpson, Leher Singh, Barbora Skarabela, Gaye Soley, Megha Sundara, Anna Theakston, Abbie Thompson, Laurel J. Trainor, Sandra E. Trehub, Anna S. Trøan, Angeline Tsui, Katherine E. Twomey, Katie Von Holzen, Yuanyuan Wang, Sandra Waxman, Janet F. Werker, Stephanie Wermelinger, Alix Woolard, Daniel Yurovsky, Katharina Zahner, Martin Zettersten, Mélanie Söderström,
Psychological scientists have become increasingly concerned with issues related to methodology and replicability, and infancy researchers in particular face specific challenges related to replicability: For example, high-powered studies are difficult to conduct, testing conditions vary across labs, and different labs have access to different infant populations. Addressing these concerns, we report on a large-scale, multisite study aimed at (a) assessing the overall replicability of a single theoretically ...
Tópico(s): Early Childhood Education and Development
2020 - SAGE Publishing | Advances in Methods and Practices in Psychological Science
Keisuke Okita, Naoki Nagata, Shinya Yamanaka,
... 287-304), Online publication date: 1-May-2015. Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M and Muotri A (2015) Controlling Immune Rejection Is a Fail-Safe System against Potential Tumorigenicity after Human iPSC-Derived Neural Stem Cell Transplantation, PLOS ONE, 10.1371/journal.pone.0116413, 10:2, (e0116413) Chung H, Ko I, Atala A and Yoo J (2015) Cell- ...
Tópico(s): Renal and related cancers
2011 - Lippincott Williams & Wilkins | Circulation Research
Ipsita Subudhi, James Shorter,
... the proteasome, UBQLNs bind ubiquitin and proteasomes directly (Itakura et al., 2016Itakura E. Zavodszky E. Shao S. Wohlever M.L. Keenan R.J. Hegde R.S. Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation.Mol. Cell. 2016; 63: 21-33Abstract Full Text Full Text PDF PubMed Scopus (144) Google Scholar, Ko et al., 2004Ko H.S. Uehara T. Tsuruma ...
Tópico(s): RNA Research and Splicing
2018 - Elsevier BV | Molecular Cell
Kobayashi Toru, Linh Thi Thuy Pham, Mutsumi Kobayashi, Ko Yamanaka, Atsuo Itakura, Hidefumi Waki,
Tópico(s): Neonatal and fetal brain pathology
2025 - Wiley | Physiological Reports
Véronique Bolduc, Gareth Marlow, Kym M. Boycott, Khalil Saleki, Hiroshi Inoue, J. Kroon, Mitsuo Itakura, Yves Robitaille, Lucie Parent, Frank Baas, Kuniko Mizuta, Nobuyuki Kamata, Isabelle Richard, Wim H.J.P. Linssen, I. Mahjneh, Marjolein Visser, Rumaisa Bashir, Bernard Brais,
... Inoue H. Sakamoto Y. Mizuta K. Kamata N. Itakura M. Molecular cloning and characterization of the murine ... Miyatake K. Miyawaki K. Noji S. Kamata N. Itakura M. Molecular characterization of GDD1/TMEM16E, the gene ...
Tópico(s): Muscle Physiology and Disorders
2010 - Elsevier BV | The American Journal of Human Genetics
Ashari Rashmi Kannangara, Daniel M. Poole, Colten M. McEwan, Joshua C. Youngs, Vajira Weeresekara, Alexandra Thornock, Misael T Lazaro, Eranga R. Balasooriya, Laura M. Oh, Erik J. Soderblom, Jonathan J. Lee, Daniel L. Simmons, Joshua L. Andersen,
... PAS is considered an apical step in autophagy (Itakura et al, 2012; Kishi-Itakura et al, 2014; Karanasios et al, 2016). While ... easily fit within current autophagy paradigms. Although ATG9A KO MEFs still display LC3B puncta (suggesting that autophagosomes ... fully rescue defective LC3 processing in an ATG9A KO line (Fig EV1C). These data suggest that the ... n = 1(bottom left). Hela ATG9A WT, ATG9A KO, or ATG9A KO cells reconstituted with ATG9A WT and ATG9A ΔC ... p62/SQSTM1 degradation and LC3B lipidation in ATG9A KO cells and showed the same cellular localization patterns ...
Tópico(s): RNA modifications and cancer
2021 - Springer Nature | EMBO Reports
Kaito Mimura, Jun-Ichi Sakamaki, Hideaki Morishita, Masahito Kawazu, Hiroyuki Mano, Noboru Mizushima,
... PubMed Scopus (144) Google Scholar, 12Itakura E. Kishi-Itakura C. Mizushima N. The hairpin-type tail-anchored ... Google Scholar, 13Jiang P. Nishimura T. Sakamaki Y. Itakura E. Hatta T. Natsume T. Mizushima N. The ... effect of PFAS knockout, we established a PFAS-KO HEK293T cell clone and then introduced the GFP- ... without hypoxanthine supplementation) for 2 days, the PFAS-KO clone showed a clear decline in the GFP: ... that the activation of autophagy observed in PFAS-KO cells involves the impairment of the de novo ...
Tópico(s): Mosquito-borne diseases and control
2021 - Elsevier BV | Journal of Biological Chemistry
Juan G. Mella, Ramin Schirin-Sokhan, Attilio Rigotti, Fernando Pimentel, Luís Villarroel, Hermann E. Wasmuth, Tilman Sauerbruch, Flavio Nervi, Frank Lammert, Juan Francisco Miquel,
... Scholar, 32.Hasegawa K. Terada S. Kubota K. Itakura H. Imamura H. Ohnishi S. Aoki T. Ijichi ... Scholar, 32.Hasegawa K. Terada S. Kubota K. Itakura H. Imamura H. Ohnishi S. Aoki T. Ijichi ...
Tópico(s): Phytase and its Applications
2007 - Elsevier BV | Journal of Lipid Research
Takeyori Saheki, Mikio Iijima, Meng Xian Li, Keiko Kobayashi, Masahisa Horiuchi, Miharu Ushikai, Fumihiko Okumura, Xiao jian Meng, Ituro Inoue, Atsushi Tajima, Mitsuaki Moriyama, Kazuhiro Eto, Takashi Kadowaki, David S. Sinasac, Lap‐Chee Tsui, Mihoko Tsuji, Akira Okano, Tsuyoshi Kobayashi,
... 10Saheki T. Nakano K. Kobayashi K. Imamura Y. Itakura Y. Sase M. Hagihara S. Matuo S. J. ... function. To test this hypothesis, we crossed mGPD-KO mice with Ctrn-KO mice. The resultant Ctrn/mGPD double knock-out ( ... also differentially expressed in either of the Ctrn-KO or mGPD-KO mice. These results support our contention that compensatory ... Slc25a13 gene that encodes citrin (Ctrn-/- or Ctrn-KO) and for the mGPD gene that encodes mGPD (mGPD-/- or mGPD-KO) were generated as described previously (42Sinasac D.S. ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2007 - Elsevier BV | Journal of Biological Chemistry
Lisheng Dai, Chon‐Hwa Tsai‐Morris, Hisashi Satô, Joaquín Villar, Jung‐Hoon Kang, Jiabao Zhang, Maria Dufau,
... Wang E.L. Rahman M.M. Inoue H. Itakura M. Kudo E. Sano T. Mod. Pathol. 2009; ... PubMed Scopus (87) Google Scholar). In the GRTH KO mice, the HMGA2 protein is completely absent, but ... Google Scholar). let-7 increases in the GRTH KO could effectively silence the HMGA2 mRNA and prevent ... contribute to the phenotype observed in the GRTH KO mice. Thus, let-7 regulation of germ cell ... the present differential microarray panel (GRTH WT versus KO). In the case of miR-469-mediated down- ... are excluded from this organelle in the GRTH KO (8Sato H. Tsai-Morris C.H. Dufau M. ...
Tópico(s): RNA Research and Splicing
2011 - Elsevier BV | Journal of Biological Chemistry
Pengyan Xia, Shuo Wang, Ying Du, Zhen‐Ao Zhao, Lei Shi, Lei Sun, Guanling Huang, Buqing Ye, Chong Li, Zhonghua Dai, Ning Hou, Xuan Cheng, Qing‐Yuan Sun, Lei Li, Xiao Yang, Zusen Fan,
... and incorporated into autophagosomes (Mathew et al, 2009; Itakura and Mizushima, 2011). Expectedly, WASH colocalized with p62 ... and shown in the right panel. (B) WASH KO MEFs were treated with or without EBSS at ... to restore the accelerated autophagy process in WASH KO MEFs (Supplementary Figure S5A). However, the deletion of ... to rescue the enhanced EGFR degradation in WASH KO MEFs, while the WASH (ΔVCA) mutant had no ...
Tópico(s): Advanced Glycation End Products research
2013 - Springer Nature | The EMBO Journal
Kimie Niimi, Chieko Nishioka, Tomomi Miyamoto, Eiki Takahashi, Ichiro Miyoshi, C. Itakura, Tadashi Yamashita,
... and drug administration in juvenile GM3-knockout (GM3-KO) mice. GM3-KO male and female mice showed hyperactivity in the ... was significantly less spontaneous alternation behavior in GM3-KO male mice than in wild-type mice. In ... time spent on the open arms by GM3-KO male mice was significantly higher than that of ... contrast, there was no significant difference between GM3-KO and wild-type female mice in these tests. Thus, juvenile GM3-KO mice show gender-specific phenotypes resembling attention-deficit ... ameliorate hyperactivity in either male or female GM3-KO mice. Although these data demonstrate the involvement of ...
Tópico(s): Ion Transport and Channel Regulation
2011 - Elsevier BV | Biochemical and Biophysical Research Communications
Maya Yamazaki, Masahiro Fukaya, Kouichi Hashimoto, Miwako Yamasaki, Mika Tsujita, Makoto Itakura, Manabu Abe, Rie Natsume, Masami Takahashi, Masanobu Kano, Kenji Sakimura, Masahiko Watanabe,
... mild reduction in GluA4 in γ‐2‐knockout (KO) cerebellum, whereas GluA1 and GluA4 were moderately reduced in γ‐7‐KO cerebellum. GluA2, GluA3 and GluA4 were further reduced in γ‐2/γ‐7 double‐KO (DKO) cerebellum. The large losses of GluA2 and GluA3 in γ‐2‐KO mice and further reductions in DKO mice were ... hand, the reduction in GluA4 in γ‐7‐KO granular layer reflected its loss at mossy fiber– ... that of GluA1 and GluA4 in γ‐7‐KO molecular layer was caused, at least partly, by ...
Tópico(s): RNA regulation and disease
2010 - Wiley | European Journal of Neuroscience
Sakuma Takahashi, Teizo Yoshimura, Takahiro Ohkura, Masayoshi Fujisawa, Soichiro Fushimi, Toshihiro Ito, Junya Itakura, Sakiko Hiraoka, Hiroyuki Okada, Kazuhide Yamamoto, Akihiro Matsukawa,
... mucosal homeostasis and inflammation by using Spred2 knockout (KO) mice. We first detected increased epithelial cell proliferation ... 1 expression in the colon of naïve Spred2 KO mice compared to wild-type mice. Interestingly, Spred2 KO mice were resistant to dextran sulfate sodium (DSS)- ... were milder in the colonic mucosa of Spred2 KO mice on day 3 and almost undetectable by ... for the reduced sensitivity to DSS. Finally, Spred2 KO mice developed significantly fewer tumors in response to ...
Tópico(s): Pancreatitis Pathology and Treatment
2016 - Nature Portfolio | Scientific Reports
Yuichi Hara, Izumi Yanatori, Masanori Ikeda, Emi Kiyokage, Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida, Fumio Kishi, Nobuyuki Kato, Michio Imamura, Kazuaki Chayama, Keisuke Hino,
... autophagosome at a later stage.20Itakura E. Kishi-Itakura C. Koyama-Honda I. Mizushima N. Structures containing ...
Tópico(s): Adenosine and Purinergic Signaling
2014 - Elsevier BV | American Journal Of Pathology
Daniel J. Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo‐Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander Agrotis, Patricia V. Aguilar, S. Tariq Ahmad, Zubair M. Ahmed, Ulises Ahumada-Castro, Sonja Aits, Shu Aizawa, Yunus Akkoç, Tonia Akoumianaki, Hafize Aysin Akpinar, Ahmed M. Al‐Abd, Lina Al-Akra, Abeer Gharaibeh, Moulay A. Alaoui‐Jamali, Simon Alberti, Elísabet Alcocer‐Gómez, Cristiano Alessandri, Muhammad Ali, Md. Abdul Alim Al‐Bari, Saeb Aliwaini, Javad Alizadeh, Eugènia Almacellas, Alexandru Almasan, Alicia Alonso, G. Alonso, Nihal Altan‐Bonnet, Dario C. Altieri, Élida Álvarez, Sara Alves, Cristine Alvès da Costa, Mazen M. Alzaharna, Marialaura Amadio, Consuelo Amantini, Cristina Amaral, Susanna Ambrosio, Amal O. Amer, Veena Ammanathan, Zhenyi An, Stig Uggerhøj Andersen, Shaida A. Andrabi, Magaiver Andrade-Silva, Allen M. Andres, Sabrina Angelini, David K. Ann, Uche C. Anozie, Mohammad Y. Ansari, Pedro Antas, Adam Antebi, Zuriñe Antón, Tahira Anwar, Lionel Apétoh, Nadezda Apostolova, Toshiyuki Araki, Yasuhiro Araki, Kohei Arasaki, Wagner L. Araújo, Jun Araya, Catherine Arden, María‐Ángeles Arévalo, Sandro Argüelles, Esperanza Arias, Jyothi Arikkath, Hirokazu Arimoto, Aileen Ariosa, Darius Armstrong‐James, Laetitia Pelloquin, Ángeles Aroca, Daniela S. Arroyo, Ivica Arsov, Rubén Artero, Dalia Maria Lucia Asaro, Michael Aschner, Milad Ashrafizadeh, Osnat Ashur‐Fabian, Atanas G. Atanasov, Alicia K. Au, Patrick Auberger, Holger W. Auner, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Yenniffer Ávalos, Sanja Aveic, Célia A. Aveleira, Tamar Avin‐Wittenberg, Yücel Aydın, Scott Ayton, Srinivas Ayyadevara, Maria Azzopardi, Misuzu Baba, Jonathan Backer, Steven K. Backues, Dong-Hun Bae, Ok‐Nam Bae, Soo Han Bae, Eric H. Baehrecke, Ahruem Baek, Seung‐Hoon Baek, Sung Hee Baek, Giacinto Bagetta, Agnieszka Bagniewska‐Zadworna, Hua Bai, Jie Bai, Xiyuan Bai, Yidong Bai, Nandadulal Bairagi, Shounak Baksi, Teresa Balbi, Cosima T. Baldari, Walter Balduini, Andrea Ballabio, María Ballester, Salma Balazadeh, Rena Balzan, Rina Bandopadhyay, Sreeparna Banerjee, Sulagna Banerjee, Ágnes Bánréti, Yan Bao, Maurı́cio S. Baptista, Alessandra Baracca, Cristiana Barbati, Ariadna Bargiela, Daniela Barilà, Peter G. Barlow, Sami J. Barmada, Esther Barreiro, George E. Barreto, Jiří Bártek, Bonnie Bartel, Alberto Bartolomé, Gaurav Barve, Suresh H. Basagoudanavar, Diane C. Bassham, Robert C. Bast, Alakananda Basu, Henri Batoko, Isabella Batten, E.E. Baulieu, Bradley L. Baumgarner, Jagadeesh Bayry, Rupert Beale, Isabelle Beau, Florian Beaumatin, Luiz Roberto Grassmann Bechara, George R. Beck, Michael F. Beers, Jakob Begun, Christian Behrends, Georg M. N. Behrens, Roberto Bei, Eloy Bejarano, Shai Bel, Christian Behl, Amine Belaïd, Naïma Belgareh‐Touzé, Cristina Bellarosa, Francesca Belleudi, Melissa Belló-Pérez, Raquel Bello-Morales, Jackeline Soares de Oliveira Beltran, Sebastián Beltran, Doris M. Benbrook, Mykolas Bendorius, Bruno A. Benítez, Irene Benito‐Cuesta, Julien Bensalem, Martin W. Berchtold, Sabina Berezowska, Daniele Bergamaschi, Matteo Bergami, Andreas Bergmann, Laura Berliocchi, Clarisse Berlioz‐Torrent, Amélie Bernard, Lionel Berthoux, Cagri G. Besirli, Sébastien Besteiro, Virginie M.S. Betin, Rudi Beyaert, Jelena S. Bezbradica, Kiran Bhaskar, Ingrid Bhatia‐Kiššová, Resham Bhattacharya, Sujoy Bhattacharya, Shalmoli Bhattacharyya, Md. Shenuarin Bhuiyan, Sujit K. Bhutia, Lanrong Bi, Xiaolin Bi, Trevor J. Biden, Krikor Bijian, Viktor Billes, Nadine Binart, Cláudia Bincoletto, Åsa Birna Birgisdottir, Geir Bjørkøy, Gonzalo Blanco, Ana Blas‐García, Janusz Błasiak, Robert Blomgran, Klas Blomgren, Janice S. Blum, Emilio Boada-Romero, Mirta Boban, Kathleen Boesze‐Battaglia, Philippe Boeuf, Barry Boland, Pascale Bomont, Paolo Bonaldo, Srinivasa Reddy Bonam, Laura Bonfili, Juan S. Bonifacino, Brian A. Boone, Martin D. Bootman, Matteo Bordi, Christoph Borner, Beat Bornhäuser, Gautam Borthakur, Jürgen Bosch, Santanu Bose, Luís M. Botana, Juan Botas, Chantal M. Boulanger, Michael E. Boulton, Mathieu Bourdenx, Benjamin Bourgeois, Nollaig M. Bourke, Guilhem Bousquet, Patricia Boya, Peter V. Bozhkov, Luiz H. M. Bozi, Tolga O. Bozkurt, Doug E. Brackney, Christian Brandts, Ralf J. Braun, Gerhard H. Braus, Roberto Bravo, José Manuel Bravo‐San Pedro, Patrick Brest, Marie-Agnès Bringer, Alfredo Briones‐Herrera, V. Courtney Broaddus, Peter Brodersen, Jeffrey L. Brodsky, Steven L. Brody, Paola G. Bronson, Jeff M. Bronstein, Carolyn N. Brown, Rhoderick E. Brown, Patrı́cia C. Brum, John H. Brumell, Nicola Brunetti‐Pierri, Daniele Bruno, Robert J. Bryson‐Richardson, Cecilia Bucci, Carmen Buchrieser, Marta Bueno, Laura Elisa Buitrago‐Molina, Simone Buraschi, Shilpa Buch, J. Ross Buchan, Erin M. Buckingham, Hikmet Budak, Mauricio Budini, Geert Bultynck, Florin Burada, Joseph R. Burgoyne, María I. Burón, Victor Bustos, Sabrina Büttner, Elena Butturini, Aaron Byrd, Isabel Cabas, Sandra Cabrera,
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, ...
Taylor & Francis
Hiroshi Wakabayashi, Toshihiro Ito, Soichiro Fushimi, Yuki Nakashima, Jyunya Itakura, Qiuying Liu, Min Win, Sun Cuiming, Chen Cao, Miwa Sato, Megumi Mino, Tetsuya Ogino, Hirofumi Makino, Akihiko Yoshimura, Akihiro Matsukawa,
... ERK pathway in APAP-hepatotoxicity. Spred-2 knockout (KO) mice demonstrated exacerbated liver injury, an event that ... activate these cells were increased in Spred-2 KO-liver. Kupffer cells isolated from Spred-2 KO mice after APAP challenge expressed higher levels of ... or IFNγ, naïve Kupffer cells from Spred-2 KO mice expressed higher levels of CXCL9/CXCL10. NK ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - Elsevier BV | Clinical Immunology
Deborah A. Shackelford, Jim Kaufman, Alan J. Korman, Jack L. Strominger,
... Moriuchi, J., Wakisaka, A., Kimura, S., Aizawa, M. & Itakura, K. (1979) Evidence for two B-cell alloantigen ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1982 - Wiley | Immunological Reviews
Ricardo V. Lloyd, Lori A. Erickson, Long Jin, Elzbieta Kulig, Xiang Qian, John C. Cheville, Bernd W. Scheithauer,
... Kimura T Yamada S Moritani M Saro T Itakura M Infrequent mutations of p27kip1 gene and trisomy ... Google Scholar, 45Kiyokawa H Kinerman RD Manova-Todorova KO Soares VC Hoffman ES Ono M Khanam D ...
Tópico(s): Hedgehog Signaling Pathway Studies
1999 - Elsevier BV | American Journal Of Pathology
Herbert L. Bonkovsky, Barbara F. Banner, Alan L. Rothman,
... 29: 138–141. 32 Senba M, Nakamura T, Itakura H. Statistical analysis of relationship between iron accumulation ... Capriles I, Maertens G, DeLeys R, Murray K, Kos T, Schellekens H, et al. Sequence evolution of ...
Tópico(s): Viral gastroenteritis research and epidemiology
1997 - Lippincott Williams & Wilkins | Hepatology
William A. Boisvert, David M. Rose, Kristen Johnson, María E. Fuentes, Sérgio A. Lira, Linda K. Curtiss, Robert Terkeltaub,
... Matsumoto A Azuma S Noda T Toyoda Y Itakura H Yazaki Y Horiuchi S Takahashi K Kruijt ... of pPNT-XN, generating the final vector pPNTKC/ko. Orientation of the BamHI insertion was confirmed by ...
Tópico(s): Cell Adhesion Molecules Research
2006 - Elsevier BV | American Journal Of Pathology
Polymnia Galiatsatos, Lidia Kasprzak, George Chong, J R Jass, William D. Foulkes,
... 1995: 39 (2): 116–118. 19 Kamiike W, Itakura T, Tanaka H et al. Hepatic segmentectomy on ... SP, Janas M, Karikoski R, Tarkkila T, Simola KO. X-linked laterality sequence in a family with ...
Tópico(s): Genomics and Rare Diseases
2006 - Wiley | Clinical Genetics
Joel Thompson, Patricia G. Wilson, Katie Brandewie, Deepa Taneja, Liliana Schaefer, Bonnie Mitchell, Lisa R. Tannock,
... Yoshioka K. Aya N. Murakami K. Matumoto A. Itakura H. Kodama T. Suzuki H. Maki S. lipoproteins ... H.S. Lee J.S. Koh H.I. Ko K.W. Intraglomerular lipid deposition in routine biopsies. ...
Tópico(s): Chronic Kidney Disease and Diabetes
2011 - Elsevier BV | American Journal Of Pathology
H. Li, S. Wei, Kenneth K.Y. Cheng, Natalia V. Gounko, Russell Ericksen, Aimin Xu, Wanjin Hong, Weiping Han,
... Sadakata T, Shinoda Y, Sekine Y, Saruta C, Itakura M, Takahashi M, Furuichi T (2010) Interaction of ...
Tópico(s): Glycosylation and Glycoproteins Research
2014 - Springer Nature | EMBO Reports