Hideyuki Miyoshi, Koji Umeshita, Masato Sakon, Shinobu Imajoh‐Ohmi, Kazumasa Fujitani, Mari Gotoh, Eiji Oiki, J. Kambayashi, Morito Monden,
BACKGROUND & AIMS: The mechanism of plasma membrane blebbing (dissociation of the lipid bilayer from the membrane cytoskeleton) in hepatocyte injury is not known. The aim of this study was to investigate the role of calpain, a calcium-dependent cytosolic protease, in bleb formation induced by oxidative stress. METHODS: Hepatocytes from Wistar rats were injured with tertbutyl hydroperoxide in the presence or absence of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) or a ...
Tópico(s): Calpain Protease Function and Regulation
1996 - Elsevier BV | Gastroenterology
Noriyuki Miyoshi, Kôji Uchida, Toshihiko Osawa, Yoshimasa Nakamura,
Abstract Naturally occurring isothiocyanates are effective chemoprotective agents against chemical carcinogenesis in experimental animals. In the present study, we clarified the molecular mechanism underlying the relationship between benzyl isothiocyanate (BITC)‐induced cell cycle arrest and apoptosis. The exposure of HL‐60 cells to BITC resulted in the inhibition of the G 2 /M progression that coincided with the apoptosis induction. We demonstrated that BITC significantly up‐regulated expression ...
Tópico(s): Synthesis and Biological Evaluation
2004 - Wiley | BioFactors
Noriyuki Miyoshi, Kôji Uchida, Toshihiko Osawa, Yoshimasa Nakamura,
Abstract In the present study, we clarified the molecular mechanism underlying the relationship between benzyl isothiocyanate (BITC)-induced cell cycle arrest and apoptosis and the involvement of mitogen-activated protein kinases (MAPKs). The exposure of Jurkat human T-cell leukemia cells to BITC resulted in the inhibition of the G2-M progression that coincided with the apoptosis induction. The experiment using the phase-specific synchronized cells demonstrated that the G2-M phase-arrested cells are ...
Tópico(s): T-cell and Retrovirus Studies
2004 - American Association for Cancer Research | Cancer Research
Hiroshi Ogawara, Susumu Horikawa, Sachiko Shimada-Miyoshi, Koji Yasuzawa,
Productivity and property of beta-lactamases of Streptomyces strains isolated from soil some 30 years ago were studied in comparison with those of the newly isolated strains. At least three-quarters of the Streptomyces strains produced beta-lactamase constitutively and extracellularly, mainly as penicillinases, as in the cases of those from the newly isolated strains. Strains such as S. albus, S. diastatochromogenes, S. fradiae, and S. lavendulae were the highest producing strains, and the amounts ...
Tópico(s): Antibiotic Resistance in Bacteria
1978 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Sunao Yamada, Fumihiro Miyoshi, Koji Kano, Teiichiro Ogawa,
Tópico(s): Electrochemical Analysis and Applications
1981 - Elsevier BV | Analytica Chimica Acta
Shin-ichi Miyoshi, Koji Kawata, Masayoshi Hosokawa, Ken‐ichi Tomochika, Sumió Shinoda,
Tópico(s): Mast cells and histamine
2003 - Elsevier BV | Life Sciences
Satoshi Urabe, Hisaya Fujiwara, Hiroshi Miyoshi, Koji Arihiro, Hiroaki Soma, Isao Yoshihama, Shoichiro Mineo, Yoshiki Kudo,
Abstract Epithelioid trophoblastic tumor (ETT) is a rare type of gestational trophoblastic disease and only 25 cases have been reported so far. It was first proposed by Mazur and Kurman in 1994 as an unusual type of trophoblastic tumor that is distinct from placental site trophoblastic tumor and choriocarcinoma and has features resembling carcinoma. A case of ETT of the lung in a 38‐year‐old Japanese woman is reported. The patient had suffered from a hydatidiform mole at the age of 27 years, and ...
Tópico(s): Prenatal Screening and Diagnostics
2007 - Wiley | Journal of Obstetrics and Gynaecology Research
Yuri Takahashi, Yasuo Miyoshi, Koji Morimoto, Tetsuya Taguchi, Yasuhiro Tamaki, Shinzaburo Noguchi,
Tópico(s): Cancer-related Molecular Pathways
2007 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Keiichi Muramatsu, Koichiro Ihara, Tomoyuki Miyoshi, Kōji Yoshida, Toshihiko Taguchi,
Background Malignant sarcomas of the femur present major challenges in their management. Radical resection of sarcoma frequently requires concomitant major femoral vessel resection and reconstruction. We describe the clinical outcomes of vascular reconstruction, the long-term patency of vascular repair, and complications involved, and also discuss possible solutions to the problems associated with this procedure. Methods In the past 15 years, 15 patients underwent wide resection of sarcoma of the ...
Tópico(s): Reconstructive Surgery and Microvascular Techniques
2011 - Elsevier BV | Annals of Vascular Surgery
Keiichi Muramatsu, Kenji Ihara, Takahiro Miyoshi, Kōji Yoshida, Takahiro Hashimoto, Toshihiko Taguchi,
Wide resection of tumours in the anterior compartment of the thigh frequently requires en bloc removal of the quadriceps femoris muscle. Such resection can result in significantly decreased muscle power of knee extension. Functional muscle transfer is a beneficial tool for the reconstruction process. Until now, however, there have been few reports on the outcome of quadriceps muscle reconstruction using free innervated muscle transfer. We reviewed 14 patients (seven women and seven men, mean age ...
Tópico(s): Management of metastatic bone disease
2011 - Elsevier BV | Journal of Plastic Reconstructive & Aesthetic Surgery
Noriyuki Miyoshi, Kôji Uchida, Toshihiko Osawa, Yoshimasa Nakamura,
Abstract In the present study, experiments using presynchronization culture cells demonstrated that benzyl ITC (BITC), previously isolated from a tropical papaya fruit extract, induced the cytotoxic effect preferentially in the proliferating human colon CCD‐18Co cells to the quiescent ones. Quiescent CCD‐18Co cells were virtually unaffected by BITC and marginal cytotoxicity was observed at 15 μM. We observed that BITC dramatically induced the p53 phosphorylation and stabilization only in the quiescent ( ...
Tópico(s): Plant Disease Resistance and Genetics
2006 - Wiley | International Journal of Cancer
Tomoko Fuke, Seiji Mizuno, Toshiro Nagai, Tomonobu Hasegawa, Reiko Horikawa, Yoko Miyoshi, Koji Muroya, Tatsuro Kondoh, Chikahiko Numakura, Seiji Sato, Kazuhiko Nakabayashi, Chiharu Tayama, Kenichiro Hata, Shinichiro Sano, Keiko Matsubara, Masayo Kagami, Kazuki Yamazawa, Tsutomu Ogata,
Recent studies have revealed relative frequency and characteristic phenotype of two major causative factors for Silver-Russell syndrome (SRS), i.e. epimutation of the H19-differentially methylated region (DMR) and uniparental maternal disomy 7 (upd(7)mat), as well as multilocus methylation abnormalities and positive correlation between methylation index and body and placental sizes in H19-DMR epimutation. Furthermore, rare genomic alterations have been found in a few of patients with idiopathic SRS. ...
Tópico(s): Prenatal Screening and Diagnostics
2013 - Public Library of Science | PLoS ONE
Shunji Kotsuki, Takemasa Miyoshi, Koji Terasaki, Guo‐Yuan Lien, Eugenia Kalnay,
Abstract This study aims to propose two new approaches to improve precipitation forecasts from numerical weather prediction (NWP) models through effective data assimilation of satellite‐derived precipitation. The assimilation of precipitation data is known to be very difficult mainly because of highly non‐Gaussian statistics of precipitation variables. Following Lien et al., this study addresses the non‐Gaussianity issue by applying the Gaussian transformation (GT) based on the empirical cumulative ...
Tópico(s): Climate variability and models
2016 - Wiley | Journal of Geophysical Research Atmospheres
Toshiaki Haraguchi, Hiroaki Miyoshi, Koji Hiraoka, Shintaro Yokoyama, Yukinao Ishibashi, Toshihiro Hashiguchi, Koutaro Matsuda, Tetsuya Hamada, Takahiro Okawa, Naoto Shiba, Koichi Ohshima,
Objective Recent studies have investigated the significance of GATA3 expression in patients with various malignant tumors. However, no previous studies have evaluated the clinicopathological importance of GATA3 expression in soft tissue sarcomas (STS) patients. Methods We evaluated GATA3 expression in 76 STS cases using immunohistochemical analysis, and statistically compared clinicopathological characteristics between GATA3-positive and GATA3-negative cases. Result GATA3-positive expression was ...
Tópico(s): Cancer Diagnosis and Treatment
2016 - Public Library of Science | PLoS ONE
Rat 1-cell embryos, recovered from naturally mated females, were cultured in a chemically defined medium (mR1ECM). When examined after 24, 56, 64 and 80 h of culture, embryos developed to the 2-cell (100%), 4-cell (93%), 4-cell to 8-cell (97%) and > or = 8-cell (95%) stages, respectively. When 0.4 M phosphate (NaH2PO4) was added to the medium after 0, 24, 56 and 64 h of culture, percentages (0-67%) of embryos that developed to the blastocyst stage after 115 h of culture were lower than that (86%) in the medium ...
Tópico(s): Pluripotent Stem Cells Research
1997 - Cambridge University Press | Zygote
Kotaro Matsuda, Hiroaki Miyoshi, Koji Hiraoka, Tetsuya Hamada, Kazutaka Nakashima, Naoto Shiba, Koichi Ohshima,
Transforming acidic coiled-coil containing protein 3 (TACC3) is expressed during the mitotic phase of nuclear division and regulates microtubules. Recently, high TACC3 expression in tumor cells of various cancers including soft tissue sarcoma has been reported. However, its role in osteosarcoma remains unknown. Because we have few prognostic markers for survival in osteosarcoma, we wanted to investigate the potential role of TACC3 in human osteosarcoma and determine if it is associated with survival.( ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2018 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Kotaro Matsuda, Hiroaki Miyoshi, Koji Hiraoka, Tetsuya Hamada, Shirô Yoshida, Yukinao Ishibashi, Toshiaki Haraguchi, Naoto Shiba, Koichi Ohshima,
Tópico(s): Cytokine Signaling Pathways and Interactions
2018 - Springer Science+Business Media | Clinical and Experimental Medicine
Narihiko Hayashi, Kimito Osaka, Kentaro Muraoka, Hisashi Hasumi, Kazuhide Makiyama, Keiichi Kondo, Noboru Nakaigawa, Masahiro Yao, Yuki Mukai, Madoka Sugiura, Shoko Takano, Eiko Ito, Hisashi Kaizu, Izumi Koike, Masaharu Hata, Masataka Taguri, Yasuhide Miyoshi, Koji Izumi, Takashi Kawahara, Hiroji Uemura,
Tópico(s): Colorectal Cancer Screening and Detection
2019 - Springer Science+Business Media | World Journal of Urology
Tadaki Miyoshi, Koji Nitta, Hiroyuki Ohkuni Hiroyuki Ohkuni, F Ikeda, Naoto Matsuo,
The effect of laser irradiation on photodarkened CdS-doped glass has been investigated as a function of the wavelength of laser light, using electron spin resonance (ESR) and time-resolved luminescence. When the wavelength of laser light is tuned to 500 nm, the intensity of the ESR signal associated with photodarkening decreases, as does the decay rate of luminescence. This indicates laser-induced reversion of photodarkening.
Tópico(s): Solid State Laser Technologies
1997 - Institute of Physics | Japanese Journal of Applied Physics
Keiichi Muramatsu, Koichiro Ihara, Tomoyuki Miyoshi, Kōji Yoshida, Ryuta Iwanaga, Takahiro Hashimoto, Toshihiko Taguchi,
Reconstruction for large bone and osteochondral defects following musculoskeletal tumor excision remains challenging. Mega-prosthesis is clearly a useful reconstructive tool. Because the survival time of tumor patients has been increasing due to better treatment options, the aim of our group is to achieve complete biological reconstruction without using any artificial materials. With this approach, durability would not be a limitation. In the present study, we reviewed the biological reconstructive ...
Tópico(s): Management of metastatic bone disease
2012 - Elsevier BV | Surgical Oncology
Shin‐ichi Miyoshi, Koji Kawata, Ken‐ichi Tomochika, Sumió Shinoda,
Vibrio vulnificus protease (VVP), a 45-kDa zinc metalloprotease, consists of two functional domains: an N-terminal 35-kDa polypeptide having endoproteinase activity, and a C-terminal 10-kDa polypeptide that mediates the binding of VVP to the erythrocyte membrane. Therefore, VVP, but not its N-terminal endoproteinase domain alone, has agglutinating activity to rabbit erythrocytes. When a single zinc atom in the catalytic center was substituted by treatment with CuCl2 or NiCl2, proteolytic and hemagglutinating ...
Tópico(s): Vibrio bacteria research studies
1999 - Wiley | Microbiology and Immunology
Norikazu Miyoshi, Koji Kamiura, Oka Hiromi, Akiko Kita, Rika Kuwata, Daitetsu Ikehara, Makoto Wada,
In the presence of metallic strontium, the Barbier-type alkylation of aldehydes with alkyl iodides proceeded smoothly at −15 °C under an argon atmosphere to afford the corresponding alkylated alcoh...
Tópico(s): Advanced Synthetic Organic Chemistry
2004 - Oxford University Press | Bulletin of the Chemical Society of Japan
Meng Wang, Masato Sakon, Hideyuki Miyoshi, Koji Umeshita, Shinichi Kishimoto, Kazunori Taniguchi, Mitsukazu Gotoh, Shinobu Imajoh-Ohmi, Morito Monden,
Abstract Prostaglandin I 2 has a protective effect on hepatic ischemia–reperfusion injury. However, the exact intracellular mechanisms of this effect have not been elucidated. Calpain μ, a Ca 2+ -dependent protease, has been found to play a role in the ischemia–reperfusion injury of various organs. The hilar area of the left lateral and median lobes of rat livers was clamped for 60 min. A prostaglandin I 2 analog (OP2507, C 35 H 41 NO 4 ) was intravenously administered at 0.1, 0.32, or 1.0 μg/kg/min from 20 ...
Tópico(s): Heat shock proteins research
1997 - Elsevier BV | Journal of Surgical Research
H. Toda, Kazufumi Nakamura, Kazuyoshi Shimizu, Kentaro Ejiri, Takayuki Iwano, Toru Miyoshi, Koji Nakagawa, Masashi Yoshida, Atsuyuki Watanabe, Nobuhiro Nishii, Yukiko Hikasa, Masao Hayashi, Hiroshi Morita, Hiroshi Morimatsu, Hiroshi Ito,
The aim of this study was to evaluate the efficacy and safety of transdermal β-blocker patches, which offer stable blood concentration and easy availability during operation, for prevention of perioperative myocardial injury (PMI) in high-risk patients.
Tópico(s): Anesthesia and Pain Management
2020 - Japanese Circulation Society | Circulation Journal
Yuma Nihashi, Mana Miyoshi, Koji Umezawa, Takeshi Shimosato, Tomohide Takaya,
Dysfunction of bone-forming cells, osteoblasts, is one of the causes of osteoporosis. Accumulating evidence has indicated that oligodeoxynucleotides (ODNs) designed from genome sequences have the potential to regulate osteogenic cell fate. Such osteogenetic ODNs (osteoDNs) targeting and activating osteoblasts can be the candidates of nucleic acid drugs for osteoporosis. In this study, the ODN library derived from the Lacticaseibacillus rhamnosus GG genome was screened to determine its osteogenetic ...
Tópico(s): RNA modifications and cancer
2022 - Multidisciplinary Digital Publishing Institute | Nanomaterials
N. Kagei, Heiji Kumazawa, Koji Miyoshi, Isao Kosugi, Akira Ishih,
A 34-year-old male living in Aichi Prefecture, Japan, complained of lower abdominal pain. Ileus was suspected based on his clinical history and symptoms, and a laparotomy was performed. Four sections of a nematode were found in a large eosinophilic granuloma in the intestinal wall, and were identified as the larva of a spiruroid nematode. This is the third reported case of a spiruroid nematode infection found in the ileum.
Tópico(s): Oral and Craniofacial Lesions
1992 - Elsevier BV | International Journal for Parasitology
Yuya Makiguchi, Yoshifumi Konno, Koji Konishi, Koji Miyoshi, Taku Sakashita, Hisaya Nii, Katsuya Nakao, Hiroshi Ueda,
Tópico(s): Fish biology, ecology, and behavior
2011 - Springer Science+Business Media | Fish Physiology and Biochemistry
Yoichi UTANOHARA, Akira Nakamura, Koji MIYOSHI, Naoto Kasahara,
Thermal fatigue cracks may be initiated at mixing tees where high and low temperature fluids flow in and mix. According to a previous study, damage by thermal fatigue depends on the frequency of the fluid temperature fluctuation near the wall surface. Structures have the time constant of structural response that depends on physical properties of the structure and the gain of the frequency response tends to become maximum at the frequency lower than the typical frequency of fluid temperature fluctuation. ...
Tópico(s): Combustion and Detonation Processes
2016 - Elsevier BV | Nuclear Engineering and Design
Koji MIYOSHI, Masayuki Kamaya, Yoichi UTANOHARA, Akira Nakamura,
Thermal fatigue cracking may initiate at a tee pipe where high and low temperature fluids flow in. The mixing flow causes temperature fluctuation near the pipe wall and may result in fatigue crack initiation. In this paper, characteristics of the wall temperature and thermal stress fluctuation at a mixing tee were investigated by tests, in which wall temperature was measured with 148 thermocouples. Then, the thermal stress fluctuation was estimated by finite element analysis (FEA) based on the measured ...
Tópico(s): Heat transfer and supercritical fluids
2016 - Elsevier BV | Nuclear Engineering and Design
Shin Takeda, Akimasa Nakao, Koji MIYOSHI, Hiroshi Takagi,
It has been approximately 7 years since the introduction of gene therapy. Since conventional procedures such as surgery, chemotherapy, and radiotherapy have had limited therapeutic value for cancer patients, the evolution of gene therapy seems a promising alternative to many researchers and clinicians. Indeed, about half of all gene therapy treatments are administered to patients with cancer. However, there are relatively few studies of using gene therapy with pancreatic cancer. We will review the ...
Tópico(s): CAR-T cell therapy research
1998 - Wiley | Seminars in Surgical Oncology