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Artigo Acesso aberto Revisado por pares

Min Zhang, Li Sun, Xueer Wang, Shixuan Chen, Yanan Kong, Nuyun Liu, Yinghua Chen, Qin Jia, Lu Zhang, Lin Zhang,

Bone marrow-derived mesenchymal stem cells (BMSCs) are able to differentiate into various types of skin cells and participate in skin regeneration and repair. Activin signaling can regulate wound healing and reepithelialization. The present study assessed the impact of activin B on BMSC-mediated cutaneous wound healing in rats and explored the possible mechanism involved. We found that CFSE-labeled BMSCs participated in wound healing in vivo, and compared to administration with PBS, activin B, or ...

Tópico(s): Periodontal Regeneration and Treatments

2013 - SAGE Publishing | Cell Transplantation

Artigo Acesso aberto Revisado por pares

Xueer Wang, Honghai Zhang, Zhugui Shao, Wanxin Zhuang, Chao Sui, Feng Liu, Xiaorong Chen, Jinxiu Hou, Lingli Kong, Hansen Liu, Yi Zheng, Bingyu Liu, Tian Chen, Lei Zhang, Xin‐Ming Jia, Chengjiang Gao,

Abstract Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly understood. Here we identified the E3 ligase TRIM31 as a crucial regulator of SYK activation. We found that TRIM31 interacted with SYK and catalyzed K27-linked polyubiquitination at Lys375 and Lys517 of SYK. This K27-linked polyubiquitination of SYK promoted its plasma membrane translocation ...

Tópico(s): Immunotherapy and Immune Responses

2021 - Springer Nature | Signal Transduction and Targeted Therapy

Artigo Revisado por pares

Qin Jia, Min Zhang, Yanan Kong, Shixuan Chen, Yinghua Chen, Xueer Wang, Lei Zhang, Weiya Lang, Lu Zhang, Lin Zhang,

Activin B has been reported to promote the regeneration of hair follicles during wound healing. However, its role in the development and life cycle of hair follicles has not been elucidated.<b> </b>In our study, the effect of activin B on mouse hair follicles of cultured and neonatal mouse skin was investigated. In these models, PBS or activin B (5, 10 or 50 ng/ml) was applied, and hair follicle development was monitored. Hair follicle initiation and development was examined using hematoxylin ...

Tópico(s): Dermatologic Treatments and Research

2013 - Karger Publishers | Cells Tissues Organs

Artigo Revisado por pares

Yadong Zhou, Boayin He, Xiaoyu Cao, Yu Xiao, Qi Feng, Fan Yang, Fei Xiao, Xueer Geng, Yun Du,

In many coastal cities around the world, continuing water degradation threatens the living environment of humans and aquatic organisms. To assess and control the water pollution situation, this study estimated the Biochemical Oxygen Demand (BOD) concentration of Hong Kong's marine waters using remote sensing and an improved machine learning (ML) method. The scheme was derived from four ML algorithms (RBF, SVR, RF, XGB) and calibrated using a large amount (N > 1000) of in-situ BOD

Tópico(s): Air Quality Monitoring and Forecasting

2024 - Elsevier BV | The Science of The Total Environment

Artigo Revisado por pares

Xueer Chen,

Adult literacy and literacy education have long been a global agenda. China's literacy education has been developing amid the backdrop of international commitments and goals of adult literacy. Since the founding of new China in 1949, adult literacy policy in China has been continuously evolved within the changing political, economic and social background, and has made great success in illiteracy reduction. By tracing the up-up–plateau–transformation processes of adult literacy policy in China, this ...

Tópico(s): Hong

2022 - Taylor & Francis | Studies in the Education of Adults