Robert Seifert, Katharina Kessel, Katrin Schlack, Matthias Weckesser, David Kersting, Konstantin Seitzer, Manuel Weber, Martin Bögemann, Kambiz Rahbar,
Background: [ 177 Lu]-PSMA-617 (Lu-PSMA) therapy is a promising therapeutic option for end-stage prostate cancer patients.Early treatment response at the first restaging after two therapy cycles might correlate with high treatment efficacy and long overall survival (OS).Therefore, the aim of this study was to evaluate whether early reduction in tumor volume is a positive prognosticator for OS.To this end, PSMA PET prior to therapy (baseline) and at first restaging after two therapy cycles (interim; i. ...
Tópico(s): Ubiquitin and proteasome pathways
2021 - Ivyspring International Publisher | Theranostics
Maurice Balke, Anna Neumann, Christian Kersting, Konstantin Agelopoulos, Carsten Gebert, Georg Gosheger, Horst Buerger, Martin Hagedorn,
The chick chorio-allantoic membrane (CAM) assay is a commonly used method for studying angiogenic or anti-angiogenic activities in vivo. The ease of access allows direct monitoring of tumour growth by biomicroscopy and the possibility to screen many samples in an inexpensive way. The CAM model provides a powerful tool to study effects of molecules, which interfere with physiological angiogenesis, or experimental tumours derived from cancer cell lines. We therefore screened eight osteosarcoma cell ...
Tópico(s): Reproductive biology and impacts on aquatic species
2010 - BioMed Central | BMC Research Notes
Christian Kersting, Konstantin Agelopoulos, H Schmidt, Eberhard Korsching, Christian August, Georg Gosheger, Uta Dirksen, Heribert Juergens, Wilfried Winkelmann, Burkhard Brandt, Stefan Bielack, Horst Buerger, Carsten Gebert,
Abstract Expression of EGFR in high grade osteosarcomas has been observed to be correlated with an improved prognosis. Yet, the underlying mechanism remained unclear since amplifications of EGFR have rarely been described. Recently, the length of a polymorphic CA repeat located at a 5′‐regulatory sequence in the intron 1 of the EGFR gene (SSR I) has been shown to be associated with its basal transcriptional activity. We therefore determined the allelic length of CA SSR‐I in 219 cases of high grade ...
Tópico(s): CAR-T cell therapy research
2008 - Wiley | Genes Chromosomes and Cancer
Christian Kersting, Carsten Gebert, Konstantin Agelopoulos, H Schmidt, P. J. van Diest, Heribert Juergens, Winfried Winkelmann, Matthias Kevric, Georg Gosheger, Burkhard Brandt, Stefan Bielack, Horst Buerger,
Abstract Purpose: The expression of the epidermal growth factor receptor (EGFR) in osteosarcomas has repeatedly been described. With the introduction of anti-EGFR–targeted therapies in clinical practice, these findings regain increased attention. Experience with anti-EGFR–targeted therapies in other cancers has made clear that besides the expression status of EGFR, a detailed knowledge about gene mutations is of major predictive power. We therefore aimed to explore the EGFR expression and gene mutation ...
Tópico(s): Cancer Genomics and Diagnostics
2007 - American Association for Cancer Research | Clinical Cancer Research
Konstantin Agelopoulos, Christian Kersting, Eberhard Korsching, H Schmidt, Arno Kuijper, Christian August, P Wülfing, Joke Tio, Werner Boecker, P. J. van Diest, Burkhard Brandt, Horst Buerger,
Background : Recently, we were able to show that amplifications of the epidermal growth factor receptor ( egfr ) gene and the overexpression of EGFR were associated with the initiation and progression of phyllodes tumours. Methods : In order to gain further insights into regulation mechanisms associated with egfr amplifications and EGFR expression in phyllodes tumours, we performed global gene expression analysis (Affymetrix A133.2) on a series of 10 phyllodes tumours, of these three with and seven without ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2007 - Springer Science+Business Media | Analytical Cellular Pathology
Vasile Lozan, P.Y. Solntsev, Guido Leibeling, Konstantin V. Domasevitch, Berthold Kersting,
Abstract The ability of the ligands 4,4′‐bipyrazolyl (H 2 bpz ), 1,4‐bis(4′‐pyrazolyl)benzene (H 2 bpzb ), and 4,4′‐bipyridazine ( bpdz ) to link two dioctahedral LNi 2 units has been examined. Thefollowing complexes were prepared: [L 1 Ni II 2 (H bpz )][BPh 4 ] ( 6 [BPh 4 ]), [L 1 Ni II 2 ( bpdz )][ClO 4 ] 2 ( 7 [ClO 4 ] 2 ), [(L 1 Ni II 2 ) 2 ( bpzb )][BPh 4 ] 2 ( 8 [BPh 4 ] 2 ), and [(L 2 Ni II 2 ) 2 ( bpz )][BPh 4 ] 2 ( 9 [BPh 4 ] 2 ), where (L 1 ) 2– and (L 2 ) 2– represent macrocyclic hexaaza‐dithiophenolate ligands. All complexes have been characterised by UV/Vis spectroscopy, ...
Tópico(s): Inorganic Chemistry and Materials
2007 - Wiley | European Journal of Inorganic Chemistry