Hanako Takagishi, Daisaku NISHINA, Toshiro Yoshihara, Kota Kawase, Wei Lu, Hua Jin, Takahiro Tanaka,
The purpose of this study is to clarify how Chinese tourists evaluate tourism landscape images of Hiroshima, and to obtain the basic data for increase of Chinese tourists who comes to Japan in the future. We defined Chinese students and Chinese ordinary employees as the potential visitors to Japan, and carried out the psychological experiment to ask them to evaluate 40 tourism landscapeimages.Theevaluationtendenciesbytwosubjectsgroupswerecomparedbyfactoranalysisandsimultaneousanalysis of several ...
Tópico(s): Urban and spatial planning
2016 - | Journal of Environmental Engineering (Transactions of AIJ)
Kota Yoshihara, Yo Kamei, Mizuno Atsuki, Haruka Ohgaki, Takuma Hori, Ichiro Ueno,
We investigate experimentally and numerically the effect of wettability on viscous-liquid impregnation into a single layer of woven fibers confined between the parallel plates. In our experiments, special attention is paid to the flow-front behaviors and the characteristic flow fields induced by the pressure difference attempted to the mold. We change the wettability between the fiber and viscous fluid by coating the bundles with fluorine-based coating agent. Correlation between the flow-front behaviors ...
Tópico(s): Surface Modification and Superhydrophobicity
2020 - Elsevier BV | Composites Part A Applied Science and Manufacturing
Jun‐ichi Kashiwakura, Mari Yoshihara, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Iori Inagaki, Yuichi Kitai, Ryuta Muromoto, Tadashi Matsuda,
Propolis is a resinous mixture produced by honey bees that contains cinnamic acid derivatives and flavonoids. Although propolis has been reported to inhibit mast cell functions and mast cell-dependent allergic responses, the effect of propolis on basophil biology remains unknown. This study aimed to investigate the inhibitory effect of propolis on FcεRI-mediated basophil activation.To determine the inhibitory effect of propolis on basophil activation in vitro, cytokine production and FcεRI signal ...
Tópico(s): Allergic Rhinitis and Sensitization
2020 - Elsevier BV | Allergology International
Hiromi Shioya, Hiromi Tadaki, Fusae Yamazaki, Manabu Miyamoto, Shigemi Yoshihara, Mayumi Enseki, Hideyuki Tabata, Kota Hirai, Hiroyuki Furuya, Masahiko Katô, Shuichi Ito, Hiroyuki Mochizuki,
Breath sound parameters have been suggested as biomarkers of the airway narrowing in children. Using a commercially available breath sound analyzer, the characteristics of the airway condition were investigated in infants with the risk factors for asthma development.A total of 443 infants (mean age, 9.9 months; range, 3-24 months) were included in the present study. The breath sound parameters of the frequency limiting 99% of the power spectrum (F99), the roll-off from 600 to 1200 Hz (Slope) and spectrum ...
Tópico(s): Phonocardiography and Auscultation Techniques
2018 - Elsevier BV | Allergology International
Akihiro Yoshihara, Kota Nishihama, Chisa Inoue, Yuko Okano, Kazuhito Eguchi, Soichiro Tanaka, Kanako Maki, Valeria Fridman D’Alessandro, Atsuro Takeshita, Taro Yasuma, Mei Uemura, Toshinari Suzuki, Esteban C. Gabazza, Yutaka Yano,
Ectopic adrenocorticotropic hormone (ACTH)-secreting neuroendocrine tumors are rare diseases. Patients with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor prognosis. Infections and coagulopathies have been reported as the cause of death. However, detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been reported.A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric discomfort. Laboratory ...
Tópico(s): Lung Cancer Research Studies
2022 - Baishideng Publishing Group | World Journal of Clinical Cases
Kenji Ishida, H. Wakimoto, K. Yoshihara, Masashi Konno, S. Shimizu, Y. Kitaura, Kota Tomita, Toshihiro Suzuki, Naotaka Uchitomi,
An ultrahigh-speed 8-b multiplexer (MUX) and demultiplexer (DMUX) chip set has been developed for the synchronous optical network (SONET) next-generation optical-fiber communication systems, which will require data bit rates of about 10 Gb/s. These ICs were designed using three novel concepts: a tree-type architecture giving reliable operation, a dynamic divider with a wide operating range, and a 50- Omega on-chip transmission line with high-speed pulse propagation. They were fabricated using a 0.5- ...
Tópico(s): Advanced Photonic Communication Systems
1991 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
Shinya Sato, Toru Hiruma, Mitsuyuki Koizumi, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Hiroko Tadokoro, Sadako Motomatsu, Takashi Yamanaka, Kota Washimi, Yoichiro Okubo, Emi Yoshioka, Rika Kasajima, Toshinari Yamashita, Takeshi Kishida, Tomoyuki Yokose, Yohei Miyagi,
Bone metastasis occurs frequently in cancer patients. Conventional therapies have limited therapeutic outcomes, and thus, exploring the mechanisms of cancer progression in bone metastasis is important to develop new effective therapies. In the bone microenvironment, adipocytes are the major stromal cells that interact with cancer cells during bone metastasis. However, the comprehensive functions of bone marrow adipocytes in cancer progression are not yet fully understood. To address this, we investigated ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2023 - Wiley | Cancer Science
Tadahito Yasuda, Mayu Koiwa, Atsuko Yonemura, Keisuke Miyake, Ryusho Kariya, Sho Kubota, Takako Yokomizo‐Nakano, Noriko Yasuda‐Yoshihara, Tomoyuki Uchihara, Rumi Itoyama, Luke Bu, Lingfeng Fu, Kota Arima, Daisuke Izumi, Shiro Iwagami, Kojiro Eto, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hiroto Ohguchi, Seiji Okada, Keisuke Matsusaki, Goro Sashida, Akiko Takahashi, Patrick Tan, Hideo Baba, Takatsugu Ishimoto,
In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress conditions; this senescence-associated secretory phenotype (SASP) leads to cancer progression and chemoresistance. However, the role of senescent CAFs in metastatic lesions and the molecular mechanism of inflammation-related SASP induction are not well understood. We show that pro-inflammatory cytokine-driven EZH2 downregulation maintains the SASP by ...
Tópico(s): Epigenetics and DNA Methylation
2021 - Cell Press | Cell Reports
Hirokazu Arakawa, Yuichi Adachi, Motohiro Ebisawa, Takao Fujisawa, Hirokazu Arakawa, Yuichi Adachi, Motohiro Ebisaw, Takao Fujisawa, Akira Akasawa, Toshishige Inoue, Yukihiro Ohya, Makoto Kameda, Kazuyuki Kurihara, Naoki Shimojo, Yutaka Suehiro, Hiroyuki Mochizuki, Shigemi Yoshihara, Takashi Iwanaga, Haruo Kuroki, Masato Takase, I. Masuko, Kota Hirai, Koichi Yoshida, Yuzaburo Inoue, Mizuho Nagao, Yumiko Miyaji, Misa Iio, Yasunori Ito, Takumi Takizawa, Masaki Futamura, Junichiro Tezuka, Hironobu Fukuda, Yukinori Yoshida, Hajime Nishimoto, Tatsuki Fukuie, Sakura Sato, Y. Yamada, Ikuo Okafuji, Kiwako Yamamoto‐Hanada, Mari Sasaki, Yuya Tanaka, Yoichi Nakajima, Atsushi Isozaki, Eisuke Inage, Hisako Yagi, M. Shimizu, Kenichi Akashi, Norio Kawamoto, Tetsuharu Manabe, Hiroki Murai, Yuri Takaoka, Taro Miura, Yukiko Hiraguchi, Takeshi Sugiyama, Mayumi Sugimoto, Shuichi Suzuki, Osamu Natsume, Hiroshi Kitazawa, Akiko Yamaide, Takuya Wada, Sankei Nishima,
The Japanese Guideline for Childhood Asthma (JGCA) 2020 is a translation of the Japanese Pediatric Guideline for the Treatment and Management of Asthma (JPGL) 2017 into English, which was published by the Japanese Society of Pediatric Allergy and Clinical Immunology. It makes recommendations for best practices in the management of childhood asthma, including management of acute exacerbations and non-pharmacological and pharmacological management. These guidelines will be of interest to non-specialist ...
Tópico(s): Pediatric health and respiratory diseases
2020 - Elsevier BV | Allergology International
Toshiro Yoshihara, Daisaku NISHINA, Takahiro Tanaka, Kota Kawase, Hanako Takagishi,
In this study, similarities and differences in psychological evaluations of sightseeing scenes in Hiroshima by Korean, Chinese and Japanese subjects were examined to identify new and attractive features for foreigners. Forty scenes were chosen as the stimuli for the psychological experiments; these were sourced from sightseeing homepages in Hiroshima Prefecture. In the evaluation for ′Hope to visit′, scenes that largely contained artificial elements received lower evaluations. In contrast, scenes ...
2017 - Taylor & Francis | Journal of Asian Architecture and Building Engineering
Yoshitaka Arase, Koshi Matsumoto, Kazuya Anzai, Kota Tsuruya, Satoru Sugiyama, Shihou Yoshihara, Shunji Hirose, Haruki Uojima, Hisashi Hidaka, Takahide Nakazawa, Ryuzo Deguchi, Seiichiro Kojima, Shinji Takashimizu, Koichi Shiraishi, Takayuki Shirai, Tatehiro Kagawa,
We aimed to elucidate the characteristics and prognosis of autoimmune hepatitis (AIH) patients with immunoglobulin (Ig) G4-positive plasma cell infiltration.We enrolled 84 AIH patients. The number of IgG- and IgG4-positive plasma cells was immunohistochemically counted per high-power field in the portal area. Patients with 3 or more IgG4-positive plasma cells on average and a ratio of IgG4 to IgG-positive plasma cells ≥5% were defined as IgG4-associated AIH (IgG4-AIH), and their clinicopathological ...
Tópico(s): Pancreatitis Pathology and Treatment
2020 - Karger Publishers | Digestive Diseases
Rumi Itoyama, Noriko Yasuda‐Yoshihara, Fumimasa Kitamura, Tadahito Yasuda, Luke Bu, Atsuko Yonemura, Tomoyuki Uchihara, Kota Arima, Xichen Hu, Jun Zhang, Yuya Okamoto, Takahiko Akiyama, Kohei Yamashita, Yosuke Nakao, Toshihiko Yusa, Yuki Kitano, Takaaki Higashi, Tatsunori Miyata, Katsunori Imai, Hiromitsu Hayashi, Yo‐ichi Yamashita, Takumi Mikawa, Hiroshi Kondoh, Hideo Baba, Takatsugu Ishimoto,
Cancer cells craftily adapt their energy metabolism to their microenvironment. Nutrient deprivation due to hypovascularity and fibrosis is a major characteristic of pancreatic ductal adenocarcinoma (PDAC); thus, PDAC cells must produce energy intrinsically. However, the enhancement of energy production via activating Kras mutations is insufficient to explain the metabolic rewiring of PDAC cells. Here, we investigated the molecular mechanism underlying the metabolic shift in PDAC cells under serine ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2021 - Elsevier BV | Cancer Letters
Kosuke Tanaka, Hidenori Ohkubo, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Noboru Misawa, Akiko Fuyuki, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Takeo Kurihashi, Masataka Taguri, Atsushi Nakajima, Kok‐Ann Gwee, Takaomi Kessoku,
Kosuke Tanaka, Hidenori Ohkubo, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Noboru Misawa, Akiko Fuyuki, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Takeo Kurihashi, Masataka Taguri, Atsushi Nakajima, Kok-Ann Gwee, and ...
Tópico(s): Enhanced Recovery After Surgery
2023 - The Korean Society of Neurogastroenterology and Motility | Journal of Neurogastroenterology and Motility
Fumihiko Urabe, Katsuki Muramoto, Takafumi Yanagisawa, Wataru Fukuokaya, Keiichiro Mori, Kojiro Tashiro, Kota Katsumi, Hidetsugu Takahashi, Kentaro Yoshihara, Keiichiro Miyajima, Yu Imai, Kosuke Iwatani, Sotaro Kayano, Taro Igarashi, Masaya Murakami, Shunsuke Tsuzuki, Tatsuya Shimomura, Hiroki Yamada, Jun Miki, Takahiro Kimura,
Background A multicenter database was utilized to examine the current treatment landscape and clinical outcomes among patients with metastatic hormone‐sensitive prostate cancer (mHSPC) following approval of upfront androgen receptor signaling inhibitors (ARSIs). Methods We retrospectively analyzed patients with mHSPC who commenced treatment between February 2018 and June 2023. The Kaplan–Meier method was used to assess oncological outcomes, including time to castration‐resistant prostate cancer (CRPC), ...
Tópico(s): Cancer, Lipids, and Metabolism
2024 - Wiley | International Journal of Urology
Shoutaro Tsuji, Kota Washimi, Taihei Kageyama, Makiko Yamashita, Mitsuyo Yoshihara, Rieko Matsuura, Tomoyuki Yokose, Yoichi Kameda, Hiroyuki Hayashi, Takao Morohoshi, Yukio Tsuura, Toshikazu Yusa, Takashi Sato, Akira Togayachi, Hisashi Narimatsu, Toshinori Nagasaki, Kotaro Nakamoto, Yasuhiro Moriwaki, Hidemi Misawa, Kenzo Hiroshima, Yohei Miyagi, Kohzoh Imai,
Abstract The absence of highly specific markers for malignant mesothelioma (MM) has served an obstacle for its diagnosis and development of molecular-targeting therapy against MM. Here, we show that a novel mucin-like membrane protein, sialylated protein HEG homolog 1 (HEG1), is a highly specific marker for MM. A monoclonal antibody against sialylated HEG1, SKM9-2, can detect even sarcomatoid and desmoplastic MM. The specificity and sensitivity of SKM9-2 to MM reached 99% and 92%, respectively; this ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2017 - Nature Portfolio | Scientific Reports
Luke Bu, Atsuko Yonemura, Noriko Yasuda‐Yoshihara, Tomoyuki Uchihara, Galym Ismagulov, Sanae Takasugi, Tadahito Yasuda, Yuya Okamoto, Fumimasa Kitamura, Takahiko Akiyama, Kota Arima, Rumi Itoyama, Jun Zhang, Lingfeng Fu, Xichen Hu, Wei Feng, Yuichiro Arima, Toshiro Moroishi, Koichi Nishiyama, Guojun Sheng, Toshifumi Mukunoki, Jun Otani, Hideo Baba, Takatsugu Ishimoto,
The arachidonic acid cascade is a major inflammatory pathway that produces prostaglandin E2 (PGE2). Although inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is reported to lead to PGE2 accumulation, the role of 15-PGDH expression in the tumor microenvironment remains unclear. We utilized Panc02 murine pancreatic cancer cells for orthotopic transplantation into wild-type and 15-pgdh+/- mice and found that 15-pgdh depletion in the tumor microenvironment leads to enhanced tumorigenesis ...
Tópico(s): Cancer Research and Treatments
2022 - Wiley | Cancer Science
Anna Ozaki, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuma Takeda, Yuki Kasai, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Takayuki Kato, Akihiro Suzuki, Yasushi Honda, Yuji Ogawa, Akiko Fuyuki, Kento Imajo, Takuma Higurashi, Masato Yoneda, Masataka Taguri, Hiroto Ishiki, Noritoshi Kobayashi, Satoru Saito, Yasushi Ichikawa, Atsushi Nakajima,
Opioid-induced constipation (OIC) may occur in patients receiving opioid treatment, decreasing their quality of life (QOL). We compared the effectiveness of magnesium oxide (MgO) with that of naldemedine (NAL) in preventing OIC. This proof-of-concept, randomized controlled trial (registration number UMIN000031891) involved 120 patients with cancer scheduled to receive opioid therapy. The patients were randomly assigned and stratified by age and sex to receive MgO (500 mg, thrice daily) or NAL (0.2 mg, ...
Tópico(s): Pathogenesis and Treatment of Hiccups
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Kota Washimi, Tomoyuki Yokose, Makiko Yamashita, Taihei Kageyama, Katsuo Suzuki, Mitsuyo Yoshihara, Yohei Miyagi, Hiroyuki Hayashi, Shoutaro Tsuji,
Malignant pleural mesothelioma (MPM) is a fatal tumor. It is often hard to discriminate MPM from metastatic tumors of other types because currently, there are no reliable immunopathological markers for MPM. MPM is differentially diagnosed by some immunohistochemical tests on pathology specimens. In the present study, we investigated the expression of intelectin-1, a new mesothelioma marker, in normal tissues in the whole body and in many cancers, including MPM, by immunohistochemical analysis. We ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2012 - Public Library of Science | PLoS ONE
Masahiro Kanai, Shea J. Andrews, Mattia Cordioli, Christine Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Akiko Iwasaki, Juha Karjalainen, Juha Mehtonen, Matti Pirinen, Karolina Chwiałkowska, Amy Trankiem, Mary K. Balaconis, Kumar Veerapen, Brooke N. Wolford, Hajar Fauzan Ahmad, Shea J. Andrews, Kathrin Aprile von Hohenstaufen Puoti, Cindy G. Boer, Palwendé Romuald Boua, Guillaume Butler‐Laporte, Carmen L. Cadilla, Karolina Chwiałkowska, Francesca Colombo, Venceslas Douillard, Nicole Dueker, Atanu Kumar Dutta, Yasser M. El‐Sherbiny, Madonna M. Eltoukhy, Sahar Esmaeeli, Annika Faucon, Marie-Julie Favé, Israel Fernández Cadenas, Margherita Francescatto, Laurent C. Francioli, Lude Franke, Macarena Fuentes‐Guajardo, Rocío Gallego Durán, David Gómez-Cabrero, Emi N. Harry, Philip R. Jansen, József Szentpéteri, Elżbieta Kaja, Masahiro Kanai, Chloe Kirk, Athanasios Kousathanas, José Eduardo Krieger, Sanjay Patel, Audrey Lemaçon, Sophie Limou, Píetro Lió, Eirini Marouli, M. Marttila, Carolina Medina‐Gómez, Yael Michaeli, Isabelle Migeotte, Soumyajit Mondal, Andrés Moreno‐Estrada, Leire Moya, Tomoko Nakanishi, Jamal Nasir, Dorote Pasko, Nathaniel M. Pearson, Alexandre C. Pereira, James R. Priest, Vid Prijatelj, Ivana Nedeljković, Alexander Teumer, Réka Várnai, Manuel Romero‐Gómez, Christina Roos, Jeffrey Rosenfeld, Ruolin Li, Eva C. Schulte, Claudia Schurmann, Bahareh Sedaghati-khayat, Doaa Shaheen, Ilangumaran Shivanathan, Csilla Sipeky, Zhou Sirui, Pasquale Striano, Yosuke Tanigawa, Alicia Utrilla Remesal, Nirmal Vadgama, Costanza L. Vallerga, Sander W. van der Laan, Ricardo A. Verdugo, Qingbo Wang, Wei Zhou, Ummu Afeera Zainulabid, Ruth N. Zárate, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Catherine H. Weldon, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Alexander S. Hatoum, Amit Agrawal, Ryan Bogdan, Sarah M. C. Colbert, Wesley K. Thompson, Chun Fan, Emma C. Johnson, Lyudmila Niazyan, Mher Davidyants, Arsen Arakelyan, Diana Avetyan, Makhabbat Bekbossynova, Ainur Tauekelova, Mukhtar Tuleutayev, Aliya Sailybayeva, Yerlan Ramankulov, Elena Zholdybayeva, Jarkyn Dzharmukhanov, Kuat Kassymbek, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Zauresh Smagulova, Timur Muratov, Sadyk Khamitov, Alex S. F. Kwong, Nicholas J. Timpson, Mari Niemi, Souad Rahmouni, Julien Guntz, Y Beguin, Mattia Cordioli, Sara Pigazzini, Lindokuhle Nkambule, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Stéphanie Gofflot, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Nicky Tiembe, David Morrison, Jonathan Afilalo, Vincent Mooser, J. Brent Richards, Simon Rousseau, Madéleine Durand, Guillaume Butler‐Laporte, Vincenzo Forgetta, Lætitia Laurent, Zaman Afrasiabi, Meriem Bouab, Chris Tselios, Xiaoqing Xue, Marc Afilalo, Maureen Oliveira, Janick St-Cyr, Ariane Boisclair, Jiannis Ragoussis, Daniel Auld, Daniel E. Kaufmann, G. Mark Lathrop, Guillaume Bourque, Simon Décary, Emilia Liana Falcone, Alexandre Montpetit, Alain Piché, Christel Renoux, Natàlia Blay, Sze Man Tse, Ma’n H. Zawati, Lea K. Davis, Nancy J. Cox, Jennifer E. Below, Julia Sealock, Annika Faucon, Megan M. Shuey, Hannah G. Polikowsky, Lauren E. Petty, Douglas M. Shaw, Hung‐Hsin Chen, Wanying Zhu, Axel Schmidt, Kerstin U. Ludwig, Carlo Maj, Selina Rolker, Daniella Balla, Pari Behzad, Markus M. Nöthen, Julia Fazaal, Verena Keitel, Verena Keitel, Björn‐Erik Ole Jensen, Torsten Feldt, Nikolaus Marx, Michael Dreher, Isabell Pink, Markus Cornberg, Thomas Illig, Clara Lehmann, Philipp Schommers, Jan Rybniker, Max Augustin, Lisa Knopp, Ingo Kurth, Thomas Eggermann, Sonja Volland, Marc Moritz Berger, Thorsten Brenner, Anke Hinney, Oliver Witzke, Margarethe Konik, Robert Bals, Christian Herr, Nicole Ludwig, Jörn Walter, Eicke Latz, Susanne V. Schmidt, Jennifer D. Brooks, Shelley B. Bull, Lloyd T. Elliott, France Gagnon, Celia M.T. Greenwood, Rayjean J. Hung, Jerry Lawless, Andrew D. Paterson, Lei Sun, Michael J. Rauh, Laurent Briollais, Anne‐Claude Gingras, Yvonne Bombard, Trevor J. Pugh, Jared T. Simpson, Lee Goneau, Anat R. Halevy, David M. Maslove, Bjug Borgundvaag, Luke Devine, Erin Bearss, David Richardson, Saranya Arnoldo, Steven Friedman, Ahmed Taher, Seth Stern, Marc Dagher, Jovanka Vasilevska‐Ristovska, Catherine M. Biggs, Beata Mickiewicz, Lisa J. Strug, Stephen W. Scherer, Naveed Aziz, Steven J.M. Jones, Bartha Maria Knoppers, Mark Lathrop, Stuart E. Turvey, Rae S. M. Yeung, Upton Allen, Angela M. Cheung, Margaret S. Herridge, Miranda Hunt, Jordan Lerner‐Ellis, Jennifer Taher, Rulan S. Parekh, Linda T. Hiraki, Juthaporn Cowan, Francine M. Ducharme, Mario Ostrowski, François Bernier, Jim Kellner, Elika Garg, Samantha Yoo, Caitlyn Vlasschaert, Erika Frangione, Monica Chung, Abdul Noor, Elena Greenfeld, Karen Colwill, Marc Clausen, Gary Chao, FengYun Yue, Marvin J. Fritzler, Joseph Whitney, Bhooma Thiruvahindrapuram, Jean‐Michel Garant, Rohan Abraham, Adrienne D. Davis, Aaron Campigotto,
Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1,2 .Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7).We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 ...
Nature Portfolio
Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Shea J. Andrews, Masahiro Kanai, Kumar Veerapen, Israel Fernández‐Cadenas, Eva C. Schulte, Pasquale Striano, M. Marttila, Camelia C. Minică, Eirini Marouli, Mohd Anisul Karim, Frank R. Wendt, Jeanne E. Savage, Laura Sloofman, Guillaume Butler‐Laporte, Han‐Na Kim, Stavroula Kanoni, Yukinori Okada, Jinyoung Byun, Younghun Han, Mohammed Jashim Uddin, George Davey Smith, Cristen J. Willer, Joseph D. Buxbaum, Juha Mehtonen, Hilary K. Finucane, Mattia Cordioli, Alicia R. Martin, Wei Zhou, Bogdan Paşaniuc, Hanna Julienne, Hugues Aschard, Huwenbo Shi, Loïc Yengo, Renato Polimanti, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Karolina Chwiałkowska, Margherita Francescatto, Amy Trankiem, Mary K. Balaconis, Lea K. Davis, Sulggi A. Lee, James R. Priest, Alessandra Renieri, Vijay G. Sankaran, David A. van Heel, Patrick Deelen, J. Brent Richards, Tomoko Nakanishi, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie, Francesca Mari, Anna Bernasconi, J. Kenneth Baillie, Arif Canakoglu, Brooke N. Wolford, Annika Faucon, Atanu Kumar Dutta, Claudia Schurmann, Emi N. Harry, Ewan Birney, Huy Nguyen, Jamal Nasir, Mari Kaunisto, Matthew Solomonson, Nicole Dueker, Nirmal Vadgama, Sophie Limou, Souad Rahmouni, Hamdi Mbarek, Dima Darwish, Md Mesbah Uddin, Raquel Albertos, Jordi Pérez‐Tur, Ruolin Li, Lasse Folkersen, Ida Moltke, Nils Koelling, Alexander Teumer, Athanasios Kousathanas, Alicia Utrilla, Ricardo A. Verdugo, Ruth Zárate, Carolina Medina‐Gómez, David Gómez-Cabrero, Elena Carnero‐Montoro, Carmen L. Cadilla, Andrés Moreno‐Estrada, Adriana Garmendia, Leire Moya, Bahareh Sedaghati-khayat, Palwendé Romuald Boua, Marie-Julie Favé, Laurent C. Francioli, Audrey Lemaçon, Isabelle Migeotte, Sanjay Patel, Réka Várnai, József Szentpéteri, Csilla Sipeky, Francesca Colombo, Kathrin von Hohenstaufen, Píetro Lió, Costanza L. Vallerga, Qingbo Wang, Yosuke Tanigawa, Hogune Im, Chulho Han, Han Song, Jiwoo Lim, Y.‐A. Lee, Sugyeong Kim, Sangyoon Im, Biljana Atanasovska, Hajar Fauzan Ahmad, Cindy G. Boer, Philip R. Jansen, Lude Franke, Elżbieta Kaja, Dorota Pasko, Ingrid Kennis-Szilagyi, Sergey A. Kornilov, Vid Prijatelj, Ivana Nedeljković, Ilangkumaran Sivanadhan, Sarala Perumal, Sahar Esmaeeli, Nathaniel M. Pearson, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Jorge Esparza-Gordillo, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Catherine H. Weldon, Minoli A. Perera, Kevin J. O’Leary, Matthew Tuck, Travis J. O’Brien, David Meltzer, Peter H. O’Donnell, Edith A. Nutescu, Guang Yang, Cristina Alarcón, Stefanie Herrmann, Sophia Mazurek, Jeff Banagan, Zacharia Hamidi, April Barbour, Noora Raffat, Diana Moreno, Paula N. Friedman, Bart Ferwerda, Diederik van de Beek, Matthijs C. Brouwer, Alexander P. J. Vlaar, W. Joost Wiersinga, Daniëlle Posthuma, Elleke Tissink, A. H. Koos Zwinderman, Emil Uffelmann, Michiel A. van Agtmael, Anne Geke Algera, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije K. Bomers, Peter I. Bonta, Lieuwe D. J. Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Dave A. Dongelmans, Paul Elbers, Lucas M. Fleuren, Suzanne E. Geerlings, Bart F. Geerts, Teunis B. H. Geijtenbeek, Armand R. J. Girbes, Abraham Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura A. Hagens, Jörg Hamann, Vanessa Harris, Robert Hemke, Sabine Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Niels van Mourik, Jeannine F. Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom D. Y. Reijnders, Michiel Schinkel, Marcus J. Schultz, Alex R. Schuurman, Kim Sigaloff, Marry R. Smit, Cornelis Stijnis, Willemke Stilma, Charlotte E. Teunissen, Patrick Thoral, Anissa M. Tsonas, Marc van der Valk, Denise P. Veelo, Heder de Vries, Michèle van Vugt, Dorien Wouters, René Minnaar, Adrie Kromhout, Kees W. J. van Uffelen, Ruud A. Wolterman, Genevieve Roberts, Daniel J. Park, Catherine A. Ball, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, Souad Rahmouni, Julien Guntz, Y Beguin, Sara Pigazzini, Lindokuhle Nkambule, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Laurent Jadot, Samira Azarzar, Patricia Dellot, Stéphanie Gofflot, Sabine Claassen, Axelle Bertrand, Gilles Parzibut, Mathilde Clarinval, Catherine Moermans, Olivier Malaise, Kamilia El Kandoussi, Raphaël Thonon, Pascale Huynen, Alyssia Mesdagh, Sofia Ferreira Melo, Nicolas Jacques, Emmanuel Di Valentin, François Giroule,
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed ...
Nature Portfolio
Takeshi Yoroidaka, Hiroyuki Takamatsu, Mitsuhiro Itagaki, Satoshi Yoshihara, Kota Sato, Naoki Takezako, Shuji Ozaki, Kazuhito Suzuki, Kentaro Kohno, Morio Matsumoto, Yasushi Terasaki, Takeshi Yamashita, Shin‐ichi Fuchida, Ryota Urushihara, Yuji Hiragori, Kenshi Suzuki, Hirokazu Murakami, Shinji Nakao, Brian G.M. Durie, Kazuyuki Shimizu,
Abstract Background: Novel agents capable of inducing deeper responses dramatically improve the prognosis of patients with multiple myeloma (MM). Innovative technologies such as multiparameter flow cytometry (MFC) and next-generation sequencing (NGS) are utilized to assess minimal residual disease (MRD) for further stratification of patients who achieve a complete response (CR). EuroFlow-next-generation flow (EuroFlow-NGF) is one of the gold standard MFC methods. Recently, both NGF and NGS have been used ...
Tópico(s): Protein Degradation and Inhibitors
2021 - Elsevier BV | Blood
Hirokazu Kagawa, Fumihiko Urabe, Yuria Kiuchi, Kota Katsumi, R. Yamaguchi, Yushi Suhara, Kentaro Yoshihara, Yuma Goto, Ibuki Sadakane, Yuji Yata, Shun Saito, Shiro Kurawaki, Shino Ajisaka, Keiichiro Miyajima, Kazuhiro Takahashi, Kosuke Iwatani, Yu Imai, Keigo Sakanaka, Minoru Nakazono, Takashi Kurauchi, Sotaro Kayano, Hajime Onuma, Koichi Aikawa, Takafumi Yanagisawa, Kojiro Tashiro, Shunsuke Tsuzuki, Akira Furuta, Jun Miki, Takahiro Kimura,
Tópico(s): Cancer Immunotherapy and Biomarkers
2023 - Springer Science+Business Media | International Journal of Clinical Oncology
Kota Kawase, Daisaku NISHINA, Wei Lu, Hua Jin, Takahiro Tanaka, Toshiro Yoshihara,
The purpose of this study is to clarify the evaluation of tourism landscape in Hiroshima by subjects of Chinese tourists, and to obtain the fundamental data of tourism planning in future for increasing of Chinese tourists to Japan. We carried out the psychological experiment about 40 tourism landscape images by subjects of Chinese foreign students, Japanese students of Hiroshima University and Chinese students of Dalian University of Technology and Dalian Nationalities University. Evaluation tendency ...
Tópico(s): Rural development and sustainability
2015 - | Journal of Environmental Engineering (Transactions of AIJ)
Mitsuyuki Koizumi, Shinya Sato, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Hideyuki Terao, Yoichiro Okubo, Kota Washimi, Emi Yoshioka, Tomoyuki Yokose, Takeshi Kishida, Naohiko Koshikawa, Yohei Miyagi,
Bladder cancer is the most common urinary tract cancer. Patients diagnosed with advanced T-stage/muscle-invasive bladder cancer through transurethral resection of bladder tumors (TURBT) are treated with total radical cystectomy; however, there is a high chance of recurrence. Nevertheless, markers for predicting this recurrence are not currently available. Here, we evaluated the chronological change of ephrin type-A receptor 2 (EPHA2) expression, a molecule known for its role in cell adhesion, to predict ...
Tópico(s): Prostate Cancer Treatment and Research
2022 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Katsufumi Hashimoto, Kota NAKASE, Rei Yoshihara, Yoshiki Honda, Katsuya Kono,
Tópico(s): BIM and Construction Integration
2025 - Springer Nature | Lecture notes in civil engineering
Chinami Kaiga, Manabu Miyamoto, Takashi Matsushita, Yu Kuramochi, Hiromi Tadaki, Mayumi Enseki, Kota Hirai, Shigemi Yoshihara, Hiroyuki Furuya, Fumio Niimura, Masahiko Kato, Hiroyuki Mochizuki,
It is speculated that the coronavirus disease 2019 (COVID-19) pandemic-associated reduction in the prevalence of respiratory tract infections has influenced the incidence of asthma in young children.
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2024 - Elsevier BV | Journal of Allergy and Clinical Immunology Global
Satoko Sasatsu, Yosuke Ono, Dai Miyashita, T Yoshihara, Kota Tanaka, So Owada, Koji Makino, Akira Nakagomi, Maki Ogi, Eriko Ogasawara, Hikaru Tagaya, Hiroko Fukasawa, Yasuhiko Okuda, Osamu Yoshino,
Tópico(s): Homicide, Infanticide, and Child Abuse
2025 - Frontiers Media | Frontiers in Medicine
Takeshi Yoroidaka, Hiroyuki Takamatsu, Ryota Urushihara, Mitsuhiro Itagaki, Satoshi Yoshihara, Kota Sato, Naoki Takezako, Shuji Ozaki, Kazuhito Suzuki, Kentaro Kohno, Tsuyoshi Muta, Morio Matsumoto, Yasushi Terasaki, Takeshi Yamashita, Shin‐ichi Fuchida, Jun Sakamoto, Tadao Ishida, Kenshi Suzuki, Hirokazu Murakami, Brian G.M. Durie, Kazuyuki Shimizu,
Tópico(s): Cancer Treatment and Pharmacology
2025 - Ferrata Storti Foundation | Haematologica
Rei Yoshihara, Kota NAKASE, Katsufumi Hashimoto, Takafumi Sugiyama, Yoshiki Honda,
The mechanical performance of a printed object in 3D concrete printing is influenced by the interfacial bonding strength between the deposited filaments. Hence, the physical properties of the layer interface and the influential factors have been studied. This study aims to clarify the mechanism of aggregate distribution heterogeneity as well as the influence of printing material extrusion speed on the heterogeneity inside the filament. A laboratory-scale material extruder is developed and used in ...
Tópico(s): BIM and Construction Integration
2024 - Multidisciplinary Digital Publishing Institute | Buildings
Rei Yoshihara, Kota NAKASE, Katsufumi Hashimoto, Takafumi Sugiyama, Yoshiki Honda,
Tópico(s): BIM and Construction Integration
2024 - Society of Materials Science | Journal of the Society of Materials Science Japan