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Artigo Revisado por pares

Yukitoshi Satoh, Rira Hoshi, Masafumi TSUZUKU, Yuichi Ishikawa, Kentaro Inamura, Takeshi Horai,

... Cancer Institute Hospital, Japanese Foundation for Cancer Research, Kotoku, Tokyo, Japan. Search for other works by this ... Cancer Institute Hospital, Japanese Foundation for Cancer Research, Kotoku, Tokyo, Japan. Search for other works by this ... Cancer Institute Hospital, Japanese Foundation for Cancer Research, Kotoku, Tokyo, Japan. Search for other works by this ... Cancer Institute Hospital, Japanese Foundation for Cancer Research, Kotoku, Tokyo, Japan. Search for other works by this ... Cancer Institute Hospital, Japanese Foundation for Cancer Research, Kotoku, Tokyo, Japan. Search for other works by this ...

Tópico(s): Gastrointestinal Tumor Research and Treatment

2006 - Karger Publishers | Acta Cytologica

Artigo Revisado por pares

Barbara Lynne Ward,

Akim-Kotoku: an “oman” of the Gold Coast Get access Akim-Kotoku: an “oman” of the Gold Coast. M. J. ...

Tópico(s): African history and culture studies

1949 - Oxford University Press | African Affairs

Artigo

Acknowledgments Introduction KOTOKU SHUSUI AND ANTI-IMPERIALIST THOUGHT In the Shadow of Revolution What Is Imperialism? What Causes Imperialism? JAPAN'S ... Case IMPERIALISM: MONSTER OF THE TWENTIETH CENTURY BY KOTOKU SHUSUI Preface Three preliminary observations Chapter 1. Introduction ...

Tópico(s): Japanese History and Culture

2015 - Association of College and Research Libraries | Choice Reviews Online

Artigo Revisado por pares

Steven P. Leytus, Keith R. Loeb, F S Hagen, Kotoku Kurachi, Earl W. Davie,

... P. Leytus, Keith R. Loeb, Frederick S. Hagen, Kotoku Kurachi, and Earl W. DavieCite this: Biochemistry 1988, ...

Tópico(s): Liver physiology and pathology

1988 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Steven P. Leytus, Donald C. Foster, Kotoku Kurachi, Earl W. Davie,

... and protein CSteven P. Leytus, Donald C. Foster, Kotoku Kurachi, and Earl W. DavieCite this: Biochemistry 1986, ...

Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema

1986 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Steven P. Leytus, Kotoku Kurachi, Kjell S. Sakaríassen, Earl W. Davie,

... cDNA coding for human complement C1rSteven P. Leytus, Kotoku Kurachi, Kjell S. Sakariassen, and Earl W. DavieCite ...

Tópico(s): Monoclonal and Polyclonal Antibodies Research

1986 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Kiyotoshi Sekiguchi, Anthony M. Klos, Kotoku Kurachi, Shinji Yoshitake, Sen-itiroh Hakomori,

... subunits of plasma fibronectinKiyotoshi Sekiguchi, Anthony M. Klos, Kotoku Kurachi, Shinji Yoshitake, and Sen Itiroh HakomoriCite this: ...

Tópico(s): RNA Interference and Gene Delivery

1986 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Shinji Yoshitake, Barbara G. Schach, Donald C. Foster, Earl W. Davie, Kotoku Kurachi,

... Schach, Donald C. Foster, Earl W. Davie, and Kotoku KurachiCite this: Biochemistry 1985, 24, 14, 3736–3750Publication ...

Tópico(s): Blood Coagulation and Thrombosis Mechanisms

1985 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Kyu‐Jin Cho, Takumi Tanaka, Robert R. Cook, Walter Kisiel, Kazuo Fujikawa, Kotoku Kurachi, James C. Powers,

... Tanaka, Robert R. Cook, Walter Kisiel, Kazuo Fujikawa, Kotoku Kurachi, and James C. PowersCite this: Biochemistry 1984, ...

Tópico(s): Click Chemistry and Applications

1984 - American Chemical Society | Biochemistry

Artigo Revisado por pares

George L. Long, T. S. Chandra, Savio L.C. Woo, Earl W. Davie, Kotoku Kurachi,

... Savio L. C. Woo, Earl W. Davie, and Kotoku KurachiCite this: Biochemistry 1984, 23, 21, 4828–4837Publication ...

Tópico(s): Silk-based biomaterials and applications

1984 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Iwao Ohkubo, Kotoku Kurachi, Toshihide Takasawa, Hiroyuki Shiokawa, Makoto Sasaki,

... its identity with low molecular weight kininogenIwao Ohkubo, Kotoku Kurachi, Toshihide Takasawa, Hiroyuki Shiokawa, and Makoto SasakiCite ...

Tópico(s): Click Chemistry and Applications

1984 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Mario J. Castillo, Kotoku Kurachi, Norikazu Nishino, Iwao Ohkubo, James C. Powers,

... bovine factor IX and factor XMario J. Castillo, Kotoku Kurachi, Norikazu Nishino, Iwao Ohkubo, and James C. ...

Tópico(s): Hemophilia Treatment and Research

1983 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Brian J. McRae, Kotoku Kurachi, Ronald L. Heimark, Kazuo Fujikawa, Earl W. Davie, James C. Powers,

... thioesters: development of new sensitive substratesBrian J. McRae, Kotoku Kurachi, Ronald L. Heimark, Kazuo Fujikawa, Earl W. ...

Tópico(s): Protease and Inhibitor Mechanisms

1981 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Kazuo Fujikawa, Ronald L. Heimark, Kotoku Kurachi, Earl W. Davie,

... factor) by plasma kallikreinKazuo Fujikawa, Ronald L. Heimark, Kotoku Kurachi, and Earl W. DavieCite this: Biochemistry 1980, ...

Tópico(s): Blood Coagulation and Thrombosis Mechanisms

1980 - American Chemical Society | Biochemistry

Artigo Revisado por pares

Kotoku Kurachi, Earl W. Davie,

... thromboplastin antecedent) by factor XIIa (activated Hageman factor)Kotoku Kurachi and Earl W. DavieCite this: Biochemistry 1977, ...

Tópico(s): Hemophilia Treatment and Research

1977 - American Chemical Society | Biochemistry

Artigo Acesso aberto Revisado por pares

F. G. Notehelfer,

Kōtoku Shūsui is generally known as a socialist and anarchist who participated in the plot against the ... of nationalism? And yet, contrary to surface appearance, Kōtoku was and remained a nationalist. But his image ...

Tópico(s): Japanese History and Culture

1971 - Cambridge University Press | The Journal of Asian Studies

Artigo Acesso aberto Revisado por pares

Patrick W. Serruys, Shigetaka Kageyama, Giulio Pompilio, Daniele Andreini, Gianluca Pontone, Saima Mushtaq, Mark La Meir, Johan De Mey, Kaoru Tanaka, Torsten Doenst, Ulf Teichgräber, Ulrich Schneider, John D. Puskas, Jagat Narula, Himanshu Gupta, Vikram Agarwal, Jonathon Leipsic, Shinichiro Masuda, Nozomi Kotoku, Tsung-Ying Tsai, Scot Garg, Marie‐Angèle Morel, Yoshinobu Onuma,

Abstract Background and Aims In patients with three-vessel disease and/or left main disease, selecting revascularization strategy based on coronary computed tomography angiography (CCTA) has a high level of virtual agreement with treatment decisions based on invasive coronary angiography (ICA). Methods In this study, coronary artery bypass grafting (CABG) procedures were planned based on CCTA without knowledge of ICA. The CABG strategy was recommended by a central core laboratory assessing the anatomy ...

Tópico(s): Cardiac Imaging and Diagnostics

2024 - Oxford University Press | European Heart Journal

Artigo Acesso aberto Revisado por pares

Takashi Muramatsu, Shinichiro Masuda, Nozomi Kotoku, Ken Kozuma, Hideyuki Kawashima, Yuki Ishibashi, Gaku Nakazawa, Kuniaki Takahashi, Takayuki Okamura, Yosuke Miyazaki, Hiroki Tateishi, Masato Nakamura, Norihiro Kogame, Taku Asano, Shimpei Nakatani, Yoshihiro Morino, Yuki Katagiri, Kai Ninomiya, Shigetaka Kageyama, Hiroshi Takahashi, Scot Garg, Shengxian Tu, Kengo Tanabe, Yukio Ozaki, Patrick W. Serruys, Yoshinobu Onuma,

P2Y12 inhibitor monotherapy without aspirin immediately after percutaneous coronary intervention (PCI) has not been tested in East Asian patients, so in this study we aimed to assess the safety and feasibility of reduced dose (3.75 mg/day) prasugrel monotherapy in Japanese patients presenting with chronic coronary syndrome (CCS).

Tópico(s): Acute Myocardial Infarction Research

2023 - Japanese Circulation Society | Circulation Journal

Artigo Acesso aberto Revisado por pares

Kai Ninomiya, Patrick W. Serruys, Nozomi Kotoku, Jinying Zhou, Shigetaka Kageyama, Shinichiro Masuda, Pruthvi C. Revaiah, Bo Wang, Xingqiang He, Tsung-Ying Tsai, Momoko Kageyama, Emelyne Sevestre, Faisal Sharif, Scot Garg, Takashi Akasaka, Javier Escaned, Manesh R. Patel, Yoshinobu Onuma,

Software to compute angiography-derived fractional flow reserve (angio-FFR) have been validated against pressure wire-derived fractional flow reserve (PW-FFR) with an area under the receiver-operating characteristic curve (AUC) of 0.93 to 0.97.The aim of this study was to investigate diagnostic accuracies of 5 angio-FFR software/methods by an independent core lab in a prospective cohort of 390 vessels with carefully documented sites of PW-FFR and pressure wire-derived instantaneous wave-free ratio. ...

Tópico(s): Acute Myocardial Infarction Research

2023 - Elsevier BV | КАРДИОЛОГИЯ УЗБЕКИСТАНА

Artigo Acesso aberto Revisado por pares

Kai Ninomiya, Patrick W. Serruys, Antonio Colombo, Bernhard Reimers, Sandeep Basavarajaiah, Faisal Sharif, Luca Testa, Carlo Di Mario, Roberto Nerla, Daixin Ding, Jiayue Huang, Nozomi Kotoku, Shigetaka Kageyama, Momoko Kageyama, Emelyne Sevestre, Simone Fezzi, Jouke Dijkstra, Neil O’Leary, Marie Angèle Morel, Scot Garg, Bernardo Cortese, Yoshinobu Onuma,

There are no data comparing sirolimus-coated balloons (SCBs [MagicTouch, Concept Medical]) to paclitaxel-coated balloons (PCBs [SeQuent Please Neo, B. Braun]) for the treatment of de novo small vessel disease (SVD).

Tópico(s): Cerebrovascular and Carotid Artery Diseases

2023 - Elsevier BV | КАРДИОЛОГИЯ УЗБЕКИСТАНА

Artigo Acesso aberto Revisado por pares

Patrick W. Serruys, Nozomi Kotoku, Bjarne Linde Nørgaard, Scot Garg, Koen Nieman, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Jagat Narula, Divaka Perera, Charles A. Taylor, Jonathon Leipsic, Edward Nicol, Nicolò Piazza, Carl Schultz, Kakuya Kitagawa, Bernard De Bruyne, Carlos Collet, Kaoru Tanaka, Saima Mushtaq, Marta Belmonte, Darius Dudek, Adriana Złahoda-Huzior, Shengxian Tu, William Wijns, Faisal Sharif, Matthew J. Budoff, Johan De Mey, Daniele Andreini, Yoshinobu Onuma,

Coronary computed tomographic angiography (CCTA) is becoming the first-line investigation for establishing the presence of coronary artery disease and, with fractional flow reserve (FFRCT), its haemodynamic significance. In patients without significant epicardial obstruction, its role is either to rule out atherosclerosis or to detect subclinical plaque that should be monitored for plaque progression/regression following prevention therapy and provide risk classification. Ischaemic non-obstructive ...

Tópico(s): Cardiovascular Disease and Adiposity

2023 - European Association of Percutaneous Cardiovascular Interventions | EuroIntervention

Artigo Acesso aberto Revisado por pares

Hiroe Seto, Asuka Oyama, Shuji Kitora, H. Toki, Ryohei Yamamoto, J. Kotoku, Akihiro Haga, Maki Shinzawa, Miyae Yamakawa, Sakiko Fukui, Toshiki Moriyama,

Abstract We sought to verify the reliability of machine learning (ML) in developing diabetes prediction models by utilizing big data. To this end, we compared the reliability of gradient boosting decision tree (GBDT) and logistic regression (LR) models using data obtained from the Kokuho-database of the Osaka prefecture, Japan. To develop the models, we focused on 16 predictors from health checkup data from April 2013 to December 2014. A total of 277,651 eligible participants were studied. The prediction ...

Tópico(s): Chronic Disease Management Strategies

2022 - Nature Portfolio | Scientific Reports

Artigo

Koshiro Kanaoka, Kenji Onoue, Satoshi Terasaki, Tomoya Nakano, Michikazu Nakai, Yoko Sumita, Kinta Hatakeyama, Fumio Terasaki, Rika Kawakami, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Yoshihiko Saito, Satoshi Yuda, Masaya Tanno, Toru Takahashi, Hisashi Yokoshiki, Masahiro Toba, Toshihisa Anzai, Toshiyuki Nagai, Takuma Sato, Takashi Takenaka, Seiji Yamazaki, Yuki Katagiri, Toshiharu Takeuchi, Kazuya Sugitatsu, Shigeo Kakinoki, Tomoaki Matsumoto, Kazushi Urasawa, Michinao Tan, Ichizo Tsujino, Mitsunori Kamigaki, Hirofumi Tomita, Kenji Hanada, Motoi Kushibiki, Akihiro Nakamura, Yoshihiro Morino, Takahito Nasu, Satoshi Yasuda, Hideaki Suzuki, Kaoru Iwabuchi, Kanako Tsuji, Shigeto Namiuchi, Tatsuya Komaru, Masahiro Yagi, Shoko Uematsu, Toshiaki Takahashi, Satoru Takeda, Toru Nakanishi, Masafumi Watanabe, Masahiro Wanezaki, Motoyuki Matsui, Shigeo Sugawara, Yasuchika Takeishi, Masayoshi Oikawa, Nobuo Komatsu, Satoshi Suzuki, Hiroaki Okamoto, Noriyuki Takeyasu, Daiki Akiyama, Yutaka Eki, Tsunekazu Kakuta, Tomoyo Sugiyama, Tomomi Koizumi, Koji Ueno, Kazuomi Kario, Mizuri Taki, Yuri Matsumoto, Takanori Yasu, Osamu Nishioka, Shigeto Naito, Makoto Murata, Shoichi Tange, Katsumi Kaneko, Makoto Muto, Hiroshi Inagaki, Shuichi Hasegawa, Eizo Tachibana, Wataru Atsumi, Masahiro Suzuki, Toshihiro Muramatsu, Yoshihiro Yamada, Isao Taguchi, Yoshiaki Fukuda, Akihiro Matsui, Junji Kanda, Koji Hozawa, Akihiko Matsumura, Wataru Shimizu, Takeshi Yamamoto, Issei Komuro, Masaru Hatano, Takanori Ikeda, Shunsuke Kiuchi, Taishiro Chikamori, Yasuyoshi Takei, Kyoko Soejima, Toshinori Minamishima, Hiroyuki Tanaka, Shigeo Shimizu, Masashi Kasao, Tadayuki Kadohira, Tohru Minamino, Kazunori Shimada, Hiroshi Iwata, Yukihiko Momiyama, Takashi Ashikaga, Toshihiro Nozato, Yasumasa Fujiwara, Kenji Inoue, Tetsuo Sasano, Junji Matsuda, Yasuhiro Ishii, Yuichi Ono, Kengo Tanabe, Yu Horiuchi, Toshiro Shinke, Yusuke Kodama, Masao Moroi, Y Yazaki, Taisuke Mizumura, Hiroshi Ohta, Yoshihiro J. Akashi, Nozomi Kotoku, Yuji Ikari, Mitsunori Maruyama, Yasuhiro Sato, Koichi Tamura, Masaaki Konishi, Hiroshi Suzuki, Mio Ebato, Kazuki Fukui, Kazuhiko Yumoto, Takamasa Iwasawa, Takeshi Kashimura, Kazuyoshi Takahashi, Yoshinobu Okada, Bunji Kaku, Kazuo Usuda, Michiro Maruyama, Tomoki Kameyama, Toshinori Higashikata, Akihiko Hodatsu, Kazuo Osato, Yoji Nagata, Koji Maeno, Kazuo Satake, Takao Sawanobori, Noboru Watanabe, Koichiro Kuwahara, Hirohiko Motoki, Hiroshi Kitabayashi, Kyuhachi Otagiri, Tsunesuke Kono, Daisuke Yamagishi, Yoshikazu Yazaki, Toshiyuki Noda, Itsuro Morishima, Naoki Watanabe, Shinichiro Tanaka, Tomoya Onodera, Ryuzo Nawada, Akinori Watanabe, Masaki Matsunaga, Satoru Suwa, Hiroshi Sakamoto, Hiroki Sakamoto, Takeshi Aoyama, Norio Kanamori, Masahiro Muto, Yuichiro Maekawa, Hayato Ohtani, Yukio Ozaki, Kenshin Naruse, Kenji Takemoto, Haruo Kamiya, Takeshi Suzuki, Yasushi Tomita, Susumu Suzuki, Ryosuke Kametani, Hidekazu Aoyama, Hiroyuki Osanai, Ken Harada, Kenji Kada, Tomoaki Saeki, Koichi Kobayashi, Yasuhiro Ogawa, Akihiro Terasawa, Masanori Shinoda, Mitsutoshi Oguri, Kiyokazu Shimizu, Akinori Sawamura, Atsushi Sugiura, Kosuke Hattori, Shinji Mokuno, Kazuhisa Kondo, Kaoru Dohi, Keishi Moriwaki, Atsunobu Kasai, Tetsuya Nakakuki, Kazuaki Kaitani, Toshikazu Jinnai, Takashi Yamamoto, Hiroyuki Kurata, Atsuyuki Wada, Masaharu Akao, Yasuhiro Hamatani, Kazuya Ishibashi, Yoshiki Akakabe, Yasuhide Asaumi, Hideo Matama, Yasushi Sakata, Hidetaka Kioka, Hiroshi Takaishi, Yoshitaka Iwanaga, Toru Takase, Mitsuo Matsuda, Fumi Sato, Shinji Hasegawa, Kenichi Ishigami, Minoru Ichikawa, Takashi Takagi, Moriaki Inoko, Masaaki Hoshiga, Shuichi Fujita, Takeda Yoshihiro, Takahiko Kawarabayashi, Hideyuki Takaoka, Kenji Nakajima, Tadashi Yuguchi, Tatsuya Kawasaki, Yukinori Shinoda, Yukihito Sato, Masaharu Ishihara, Yuki Matsumoto, Hiroya Kawai, Tomofumi Takaya, Kouki Matsuo, Toshiaki Mano, Ken‐ichi Hirata, Eriko Hisamatsu, Nobutaka Inoue, Koichi Tamita, N Mukohara, Hisashi Shimoyama, Toru Miyajima, Toshihiro Tamura, Yodo Tamaki, Megumi Suzuki, Ryoji Yokota, Manabu Horii, Kazuo Yamanaka, Hiroyuki Kawata, Yukihiro Hashimoto, Yasuki Nakada, Hitoshi Nakagawa, Tomoya Ueda, Taku Nishida, Ayako Seno, Makoto Watanabe, Takashi Akasaka, Takashi Tanimoto, Mamoru Toyofuku, Kazuhiro Yamamoto, Yoshiharu Kinugasa, Masayuki Hirai, Hiroshi Nasu, Kinya Shirota, Tsuyoshi ODA, Takefumi Oka, Kazushige Kadota, Masanobu Ohya, Hiroshi Ito, Kazufumi Nakamura, Soichiro Ogura, Soichiro Fuke, Shiro Uemura, Hiromi Matsubara, Atsuyuki Watanabe, Nobuyuki Morishima, Kihara Yasuki, Takayuki Hidaka, Hironori Ueda, Yujiro Ono, Yuji Muraoka, Miyo Hatanari, Yoshinori Miyamoto, Keigo Dote, Masaya Kato, Masafumi Yano, Mamoru Mochizuki, Yasuhiro Ikeda, Hiroyuki Fujinaga, Shinobu Hosokawa, Masataka Sata, Koji Yamaguchi, Naoko Aki,

Fulminant myocarditis presentation (FMP) is a rare and severe presentation of myocarditis. The natural history of FMP and its clinical features associated with poor outcomes are incompletely understood because there is a lack of generalizable evidence.This multicenter retrospective cohort study included patients hospitalized with histologically proven myocarditis who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 and March ...

Lippincott Williams & Wilkins

Artigo Revisado por pares

Tatsuya Nishii, Takuma Kobayashi, Hironori Tanaka, Akiyuki Kotoku, Yasutoshi Ohta, Yoshiaki Morita, Kensuke Umehara, Junko Ota, Hiroki Horinouchi, Takayuki Ishida, Tetsuya Fukuda,

Background To improve myocardial delayed enhancement (MDE) CT, a deep learning (DL)-based post hoc denoising method supervised with averaged MDE CT data was developed. Purpose To assess the image quality of denoised MDE CT images and evaluate their diagnostic performance by using late gadolinium enhancement (LGE) MRI as a reference. Materials and methods MDE CT data obtained by averaging three acquisitions with a single breath hold 5 minutes after the contrast material injection in patients from July ...

Tópico(s): Advanced MRI Techniques and Applications

2022 - Radiological Society of North America | Radiology

Revisão Acesso aberto Revisado por pares

Kotoku Kawaguchi, Shinji Asano,

Ezrin is one of the members of the ezrin/radixin/moesin (ERM) family of proteins. It was originally discovered as an actin-binding protein in the microvilli structure about forty years ago. Since then, it has been revealed as a key protein with functions in a variety of fields including cell migration, survival, and signal transduction, as well as functioning as a structural component. Ezrin acts as a cross-linker of membrane proteins or phospholipids in the plasma membrane and the actin cytoskeleton. ...

Tópico(s): Cell Adhesion Molecules Research

2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences

Artigo Revisado por pares

Yukina Hirata, Kenya Kusunose, Takumasa Tsuji, Kohei Fujimori, J. Kotoku, Masataka Sata,

Background To accurately diagnose and control heart failure (HF), it is important to carry out a simple assessment of elevated pulmonary arterial wedge pressure (PAWP). The aim of this study was to develop and validate an objective method for detecting elevated PAWP by applying deep learning (DL) to a chest x-ray (CXR). Methods We enrolled 1013 consecutive patients with a right-heart catheter between October 2009 and February 2020. We developed a convolutional neural network to identify patients with ...

Tópico(s): Pulmonary Hypertension Research and Treatments

2021 - Elsevier BV | Canadian Journal of Cardiology

Artigo Acesso aberto Revisado por pares

Takuya Hirose, J. Kotoku, Fujio Toki, Emi K. Nishimura, Daisuke Nanba,

Abstract Stem cell-based products have clinical and industrial applications. Thus, there is a need to develop quality control methods to standardize stem cell manufacturing. Here, we report a deep learning-based automated cell tracking (DeepACT) technology for noninvasive quality control and identification of cultured human stem cells. The combination of deep learning-based cascading cell detection and Kalman filter algorithm-based tracking successfully tracked the individual cells within the densely ...

Tópico(s): Cell Image Analysis Techniques

2021 - Oxford University Press | Stem Cells

Artigo Revisado por pares

Muthuraj Prakash, Yukihiro Itoh, Yoshie Fujiwara, Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb E. Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, Takayoshi Suzuki,

Fat mass obesity-associated protein (FTO) is a DNA/RNA demethylase involved in the epigenetic regulation of various genes and is considered a therapeutic target for obesity, cancer, and neurological disorders. Here, we aimed to design novel FTO-selective inhibitors by merging fragments of previously reported FTO inhibitors. Among the synthesized analogues, compound 11b, which merges key fragments of Hz (3) and MA (4), inhibited FTO selectively over alkylation repair homologue 5 (ALKBH5), another DNA/ ...

Tópico(s): Cancer-related gene regulation

2021 - American Chemical Society | Journal of Medicinal Chemistry

Artigo Revisado por pares

Masakazu Hirota, Atsushi Mizota, Tatsuya Mimura, Takao Hayashi, J. Kotoku, Tomohiro Sawa, Kenji Inoue,

Tópico(s): Retinal Diseases and Treatments

2020 - Springer Science+Business Media | International Ophthalmology

Artigo Acesso aberto Revisado por pares

Yuji Sumii, Naoyuki Kotoku, Chisu Han, Kentaro Kamiya, Andi Setiawan, Catherine Vilchèze, William R. Jacobs, Masayoshi Arai,

3-(Phenethylamino)demethyl(oxy)aaptamine (1) was re-discovered from the marine sponge of Aaptos sp. as an anti-dormant mycobacterial substance through the bioassay-guided separation. Compound 1 showed potent anti-microbial activity against Mycobacterium bovis BCG with a minimum inhibitory concentration of 0.75 µg/mL under both aerobic conditions and hypoxic conditions inducing dormant state. Compound 1 was also effective against pathogenic M. tuberculosis strains including clinical multidrug-resistant ...

Tópico(s): Mycobacterium research and diagnosis

2020 - Elsevier BV | Tetrahedron Letters