David F. Friedman, Piotr Kraj, Leslie E. Silberstein,
... of PhiladelphiaSearch for more papers by this authorPIOTR KRAJ, PIOTR KRAJ Department of Pathology and Laboratory Medicine Hospital of ... of PhiladelphiaSearch for more papers by this authorPIOTR KRAJ, PIOTR KRAJ Department of Pathology and Laboratory Medicine Hospital of ...
Tópico(s): T-cell and B-cell Immunology
1995 - Wiley | Annals of the New York Academy of Sciences
Dong Fang, James R. Hallman, Namrata Sangha, Timothy E. Kute, James A. Hammarback, Wain L. White, Vijayasaradhi Setaluri,
... Google Scholar, 16Satyamoorthy K DeJesus E Linnenbach AJ Kraj B Kornreich DL Rendle S Elder DE Herlyn ... months later.16Satyamoorthy K DeJesus E Linnenbach AJ Kraj B Kornreich DL Rendle S Elder DE Herlyn ... follow-up.16Satyamoorthy K DeJesus E Linnenbach AJ Kraj B Kornreich DL Rendle S Elder DE Herlyn ... Google Scholar, 16Satyamoorthy K DeJesus E Linnenbach AJ Kraj B Kornreich DL Rendle S Elder DE Herlyn ...
Tópico(s): Melanoma and MAPK Pathways
2001 - Elsevier BV | American Journal Of Pathology
... acquired infection in children.9Krenke K. Krawiec M. Kraj G. Peradzynska J. Krauze A. Kulus M. Risk ... identified as risk factors.9Krenke K. Krawiec M. Kraj G. Peradzynska J. Krauze A. Kulus M. Risk ...
Tópico(s): Pericarditis and Cardiac Tamponade
2020 - Elsevier BV | CHEST Journal
Akihiko Shinohara, Hideho Hara, David R. Smith,
... Is., Honshu, Shikoku), Korea and Russia (Sakhalin, Primorskij kraj), X. kanba n. sp. from Japan (Hokkaido, Honshu), X. kastsheevi Ermolenko, 1979, from Russia (Primorskij Kraj), X. konishii n. sp. from Japan (Hokkaido, Honshu) ...
Tópico(s): Hymenoptera taxonomy and phylogeny
2020 - Q15088586 | Zootaxa
Tanja Prodović, Branko Ristić, Nemanja Rančić, Zoran Bukumirić, Željko Stepanović, Dragana Ignjatović Ristić,
... mobilnost pred poškodbo, tip zloma, slab kognitivni status, kraj bivanja. Cilj te študije je bil oceniti vpliv ... zlomom, slab kognitivni status, vsakodnevne aktivnosti, komorbidnost in kraj, kjer so padli. Multivariantno regresijsko modeliranje je pokazalo, ...
Tópico(s): Bone health and osteoporosis research
2016 - De Gruyter Open | Slovenian Journal of Public Health
Aleksandra Rysiewska, Simona Prevorčnik, Artur Osikowski, Sebastian Hofman, Luboš Beran, Andrzej Falniowski,
... of the Czech Republic, Regional Office Kokořínsko – Máchův kraj Protected Landscape Area Administration, Mělník, Czech RepublicSearch for ... of the Czech Republic, Regional Office Kokořínsko – Máchův kraj Protected Landscape Area Administration, Mělník, Czech RepublicSearch for ...
Tópico(s): Environmental DNA in Biodiversity Studies
2016 - Wiley | Journal of Zoological Systematics & Evolutionary Research
... as refugees in the United States. SAŽETAK Zvanični kraj komunizma u istočnoj Evropi obilježio je početak velikih ... žene koriste jedan proizvod – kafu – za izlaženje na kraj sa svojom razmještenošću, kao i za vrednovanje svoje ...
Tópico(s): Migration, Ethnicity, and Economy
2011 - Wiley | American Anthropologist
Louis Deharveng, Anne Bedòs, Wanda Maria Weiner,
... n., two new species from East Russia (Primorskij Kraj) are described. They are closely related to Leenurina ...
Tópico(s): Marine and environmental studies
2011 - Pensoft Publishers | ZooKeys
Anna Świeboda-Sadlej, Leszek Kraj, Joanna Krawczyk, Ewa Nita, Jadwiga Dwilewicz‐Trojaczek,
... Reference Manager, RefWorks, Zotero AMA Świeboda-Sadlej A, Kraj L, Krawczyk J, Nita E, Dwilewicz-Trojaczek J. ... 5114/wo.2012.30068. APA Świeboda-Sadlej, A., Kraj, L., Krawczyk, J., Nita, E., & Dwilewicz-Trojaczek, J. ( ... wo.2012.30068 Chicago Świeboda-Sadlej, Anna, Leszek Kraj, Joanna Krawczyk, Ewa Nita, and Jadwiga Dwilewicz-Trojaczek. ... 5114/wo.2012.30068. Harvard Świeboda-Sadlej, A., Kraj, L., Krawczyk, J., Nita, E., and Dwilewicz-Trojaczek, ... 5114/wo.2012.30068. Vancouver Świeboda-Sadlej A, Kraj L, Krawczyk J, Nita E, Dwilewicz-Trojaczek J. ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2012 - Termedia Publishing House | Współczesna Onkologia
... w międzynarodowych rankingach wolności prasy jest oceniany jako „kraj pozbawiony wolności”, a Polska – jako „kraj wolny”. Prezentowana metoda pozwala także na określenie realnej ...
Tópico(s): Language, Metaphor, and Cognition
2018 - | Studia Medioznawcze
Leszek Kraj, Marta Krawiec, Marek Koter, Wojciech Graboń, Grażyna Kraj, Małgorzata Chołojczyk, Marek Kulus, Anna Barańczyk‐Kuźma,
Decreased level of L-arginine may lead to airway hyperresponsiveness, inflammation, and airway remodeling. Changes in L-arginine metabolism were observed earlier in adult asthmatic patients. Studies on L-arginine metabolism in children with bronchial asthma are limited. Because biosynthesis of L-arginine is insufficient in growing children, its potential metabolic alterations may have important clinical implications. This study was designed to evaluate L-arginine metabolism in children with well- ...
Tópico(s): Chemical Synthesis and Analysis
2014 - OceanSide Publications, Inc | Allergy and Asthma Proceedings
Rolf Ekman, Jerzy Silberring, Ann Brinkmalm, Agnieszka Kraj,
... Molndal, SwedenSearch for more papers by this authorAgnieszka Kraj, Agnieszka Kraj Poland Faculty of Chemistry and Regional Laboratory, Jagiellonian ...
Tópico(s): Mass Spectrometry Techniques and Applications
2008 - | Mass Spectrometry
Josep M. Llovet, Masatoshi Kudo, Philippe Merle, Tim Meyer, Shukui Qin, Masafumi Ikeda, Ruocai Xu, Julien Edeline, Baek‐Yeol Ryoo, Zhenggang Ren, Gianluca Masi, Mariusz Kwiatkowski, Ho Yeong Lim, Jee Hyun Kim, В. В. Бредер, Hiromitsu Kumada, Ann‐Lii Cheng, Peter R. Galle, Shuichi Kaneko, Anran Wang, Kalgi Mody, Corina E. Dutcus, Leonid Dubrovsky, Abby B. Siegel, Richard S. Finn, Simone I. Strasser, Alexander Thompson, Aflah Roohullah, William Sievert, Vladimir Andelkovic, Jennifer J. Knox, Janine M. Davies, Jamil Asselah, Mayur Brahmania, Habeeb Majeed, Luis J. Villanueva-Rivera, Patricio Yanez Weber, Marcelo Garrido, Gonzalo Pizarro, Nicolás Yáñez, Ruocai Xu, Shuangyan Ou, Zhenggang Ren, Hongming Pan, Zhiqiang Meng, Kangsheng Gu, Xi Chen, Tao Zhang, Chunyi Hao, Peiguo Cao, Yabing Guo, Shukui Qin, Juxiang Xiao, Weijia Fang, Xin Wang, Yuxian Bai, Xiaohong Chen, Yan Dong, Hong Zhao, Jieer Ying, Carlos Bonilla, Olga Urrego, Ángela R. Zambrano, Mauricio Lema, Juan Carlos Restrepo, Andrés F. Cardona, Sandra Franco Millan, Madiedo Oscar, Víctor Ramos, Philippe Merle, Samuel Lesourd, Julien Edeline, Jean‐Pierre Bronowicki, Marc Bourlière, Stéphane Cattan, Mohamed Bouattour, Laurent Mineur, Hélène Regnault, Barbara Dauvois, Kornelius Schulze, Gunnar Folprecht, Andreas Geier, Oliver Waidmann, Fabian Finkelmeier, Marino Venerito, Marie‐Luise Berres, Thomas Berg, Christian M. Lange, Hartmut Schmidt, Dirk Waldschmidt, Michael Bitzer, Ray McDermott, Austin G. Duffy, Gianluca Masi, Vittorina Zagonel, Giuseppe Tonini, Fabio Piscaglia, Stefania Gori, Mimma Rizzo, Elisa Biscaldi, Luisa Foltran, Giuseppe Cabibbo, Masafumi Ikeda, Masatoshi Kudo, Hiroshi Aikata, Kazushi Numata, Hiroyuki Marusawa, Naoya Kato, Masayuki Kurosaki, Manabu Morimoto, Tatsuya Yamashita, Hironori Koga, Tsutomu Masaki, Ryosuke Tateishi, Yoshitaka Inaba, Tomohiro Arakawa, Yoshiyuki Suzuki, Norio Akua, Masahiro Kobayashi, Tetsuya Hosaka, Makoto Nakamuta, Noriko Oza, Shunsuke Kondo, Junji Furuse, Fumio Nagashima, Masayuki Kitano, Koichi Takaguchi, Baek‐Yeol Ryoo, Ho Yeong Lim, Jee Hyun Kim, Tae‐You Kim, Han Sang Kim, Carlos Hernández Hernández, Daniel Kuba, Manuel Segura Gonzalez, Jesus Cabrera Luviano, Fidel Huitzil Melendez, Francisco Ramirez Godinez, Fernando Silva-Bravo, Edward Gane, Catherine Stedman, Mariusz Kwiatkowski, Lucjan Wyrwicz, Ewa Nowakowska‐Zajdel, Leszek Kraj, Ewa Janczewska, Renata Surma-Wlodarczyk, В. В. Бредер, Marina Sekacheva, Р. В. Орлова, Alexander Vasilyev, Р. А. Зуков, Vladimir Vladimirov, Beatriz Mínguez, Ana M. Sánchez Peña, J.F. Castroagudı́n, Manuel Romero‐Gómez, José Luis Lledó, Ángel Rubín, Araceli Garcia Sanchez, Jose Calleja Panero, Ming‐Chin Yu, Ying‐Chun Shen, Yi‐Hsiang Huang, Long‐Bin Jeng, Ting‐Tsung Chang, Sheng‐Shun Yang, Shinn‐Cherng Chen, Arunee Dechaphunkul, Tawesak Tanwandee, Apinya Leerapun, Mesut Şeker, Hakan Harputluoğlu, İrfan Çiçin, Berna Öksüzoğlu, Mehmet Bilici, Sema Sezgin Göksu, Mehmet Artaç, Timuçin Çil, Şuayib Yalçın, Tim Meyer, Debashis Sarker, Ankit Rao, Daniel H. Palmer, JEFF EVANS, Richard Hubner, Richard S. Finn, Susanna V. Ulahannan, Ahmed Zakari, Lynn G. Feun, Raed Moh’d Taiseer Al-Rajabi, Max W. Sung, Aiwu Ruth He, Adel Kardosh, Lipika Goyal, Daneng Li, Lipika Goyal, Minsig Choi, Juan G. Posada, Jyothi Dodlapati, Rachna T. Shroff, Saurabh Agrawal, Srivalli Gopaluni, Mehmet Akce, Olatunji B. Alese, Ari David Baron, Richard F. Dunne, Arturo Loaiza‐Bonilla, Catherine Frenette,
Background Systemic therapies have improved the management of hepatocellular carcinoma, but there is still a need to further enhance overall survival in first-line advanced stages. This study aimed to evaluate the addition of pembrolizumab to lenvatinib versus lenvatinib plus placebo in the first-line setting for unresectable hepatocellular carcinoma. Methods In this global, randomised, double-blind, phase 3 study (LEAP-002), patients aged 18 years or older with unresectable hepatocellular carcinoma, ...
Tópico(s): Cancer Mechanisms and Therapy
2023 - Elsevier BV | The Lancet Oncology
Maciej Słodkowski, Marek Wroński, Dominika Karkocha, Leszek Kraj, Kaja Śmigielska, Aneta Jachnis,
Radical resection is the only curative treatment for pancreatic cancer. However, only up to 20% of patients are considered eligible for surgical resection at the time of diagnosis. Although upfront surgery followed by adjuvant chemotherapy has become the gold standard of treatment for resectable pancreatic cancer there are numerous ongoing trials aiming to compare the clinical outcomes of various surgical strategies (e.g., upfront surgery or neoadjuvant treatment with subsequent resection). Neoadjuvant ...
Tópico(s): Renal cell carcinoma treatment
2023 - Multidisciplinary Digital Publishing Institute | Cancers
Maksymilian Baryła, Aleksandra Semeniuk-Wojtaś, Letycja Róg, Leszek Kraj, Jacek Małyszko, Rafał Stec,
The tumor microenvironment is the space between healthy tissues and cancer cells, created by the extracellular matrix, blood vessels, infiltrating cells such as immune cells, and cancer-associated fibroblasts. These components constantly interact and influence each other, enabling cancer cells to survive and develop in the host organism. Accumulated intermediate metabolites favoring dysregulation and compensatory responses in the cell, called oncometabolites, provide a method of communication between ...
Tópico(s): ATP Synthase and ATPases Research
2022 - Multidisciplinary Digital Publishing Institute | Biology
Pawel Kraj, Ekaterina Selivanovitch, Byeongdu Lee, Trevor Douglas,
Virus-like particles (VLPs) are a class of biomaterials which serve as platforms for achieving the desired functionality through interior and exterior modifications. Through ionic strength-mediated electrostatic interactions, VLPs have been assembled into hierarchically ordered materials. This work builds on predictive models to prepare polymer-coated VLP clusters at very low ionic strength. Zeta potential measurements showed that the clusters carried a strongly positive charge, a complete charge ...
Tópico(s): Respiratory viral infections research
2021 - American Chemical Society | Biomacromolecules
Jolanta Kunikowska, Bartosz Cieślak, Beata Gierej, Waldemar Patkowski, Leszek Kraj, Marcin Kotulski, Krzysztof Zieniewicz, Leszek Królicki,
Abstract Purpose Prostate-specific membrane antigen (PSMA) is not only highly expressed on the surface prostate cancer cells but is also elevated during angiogenesis in other cancer cell types, including hepatocellular carcinoma (HCC). This study aimed to evaluate the feasibility of using PET/CT imaging with [ 68 Ga]Ga-PSMA-11 in HCC and its impact on patient management. Methods Fifteen patients (13 men and two women; aged 55.6 ± 18.2 years) with HCC were enrolled in this prospective, single-institution ...
Tópico(s): Peptidase Inhibition and Analysis
2020 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Maciej Gryziak, Krzysztof Woźniak, Leszek Kraj, Rafał Stec,
Tópico(s): Cancer Mechanisms and Therapy
2020 - Elsevier BV | Critical Reviews in Oncology/Hematology
Michal Kuczma, Edyta Szurek, Anna Cebula, Vu L. Ngo, Maciej Pietrzak, Piotr Kraj, Timothy L. Denning, Leszek Ignatowicz,
The physiological role of T cell anergy induction as a key mechanism supporting self-tolerance remains undefined, and natural antigens that induce anergy are largely unknown. In this report, we used TCR sequencing to show that the recruitment of CD4+CD44+Foxp3-CD73+FR4+ anergic (Tan) cells expands the CD4+Foxp3+ (Tregs) repertoire. Next, we report that blockade in peripherally-induced Tregs (pTregs) formation due to mutation in CNS1 region of Foxp3 or chronic exposure to a selecting self-peptide result ...
Tópico(s): Immunotherapy and Immune Responses
2020 - Elsevier BV | Mucosal Immunology
Łukasz Szymański, Rafał Skopek, Małgorzata Palusińska, Tino Schenk, Sven Stengel, Sławomir Lewicki, Leszek Kraj, Paweł Kamiński, Arthur Zelent,
The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are involved in the regulation of cell growth and differentiation. Vitamin A derivatives have held promise in cancer treatment and ATRA is used in differentiation therapy of acute promyelocytic leukemia (APL). ATRA and other retinoids have also been successfully ...
Tópico(s): Estrogen and related hormone effects
2020 - Multidisciplinary Digital Publishing Institute | Cells
Produção Nacional
Revisado por pares
Gustavo de Novaes Pires Leite, F. Weschenfelder, Alex Maurício Araújo, Álvaro Antônio Villa Ochoa, Newton da Franca Prestrelo Neto, Andrea Kraj,
Current air conditioning systems have become consistently energy-efficient, but usually, these systems represent the largest electricity consumer in residential, commercial and industrial buildings. The variability in electricity costs also imposes uncertainties in the future operational costs of air conditioning installations. This study presents an economic analysis considering technical aspects related to the integrated use of solar photovoltaic, as a complementary energy source, and air conditioning ...
Tópico(s): Energy and Environment Impacts
2019 - Elsevier BV | Energy Conversion and Management
Anna Cebula, Michal Kuczma, Edyta Szurek, Maciej Pietrzak, Natasha M. Savage, Wessam Elhefnawy, Grzegorz A. Rempała, Piotr Kraj, Leszek Ignatowicz,
Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4
Tópico(s): Immunotherapy and Immune Responses
2019 - Nature Portfolio | Nature Communications
Akihiko Shinohara, Yuichi Kameda,
... described as a new species from Russia (Primorskij Kraj), China (Heilongjiang) and Japan (Hokkaido). Collection records are ...
Tópico(s): Insect and Arachnid Ecology and Behavior
2019 - Q15088586 | Zootaxa
Eva Koišová, Eva Grmanová, Katarína Škrovánková, Júlia Kostrová,
... na úrovni NUTS 2. Zdá sa, že Bratislavský kraj je najviac konkurencieschopný región vo vyšehradských krajinách, ako ...
Tópico(s): Economic Growth and Productivity
2019 - Kaunas University of Technology | Engineering Economics
Lauren M. Browning, Maciej Pietrzak, Michal Kuczma, Colin Simms, Agnieszka Kurczewska, Justin Refugia, Dustin J. Lowery, Grzegorz A. Rempała, Dmitriy W. Gutkin, Leszek Ignatowicz, Pawel Muranski, Piotr Kraj,
BMP receptor 1α activation limits the TGF-β–mediated differentiation of CD4 + T cells that produce the cytokine IL-17.
Tópico(s): Cytokine Signaling Pathways and Interactions
2018 - American Association for the Advancement of Science | Science Signaling
Monika Ziętarska, Joanna Krawczyk-Lipiec, Leszek Kraj, Renata Zaucha, Sylwia Małgorzewicz,
Background: Cancer disease is usually associated with impaired nutritional status, which is one of the factors contributing to deterioration of the results of surgery, chemotherapy or radiotherapy. Objectives: The aim of the study was to determine whether nutritional support with high protein (ONS) in adult oncologic patients in the first step of cancer cachexia—asymptomatic precachexia, has an influence on the toxicity of systemic therapy. However, secondary endpoints were established: to determine ...
Tópico(s): Body Composition Measurement Techniques
2017 - Multidisciplinary Digital Publishing Institute | Nutrients
Piotr Kraj, Leszek Ignatowicz,
Summary Regulatory T (Treg) cells expressing Foxp3 transcription factor control homeostasis of the immune system, antigenic responses to commensal and pathogenic microbiota, and immune responses to self and tumour antigens. The Treg cells differentiate in the thymus, along with conventional CD 4 + T cells, in processes of positive and negative selection. Another class of Treg cells is generated in peripheral tissues by inducing Foxp3 expression in conventional CD 4 + T cells in response to antigenic ...
Tópico(s): Immunotherapy and Immune Responses
2017 - Wiley | Immunology
Monika Ziętarska, Joanna Krawczyk-Lipiec, Leszek Kraj, Renata Zaucha, Sylwia Małgorzewicz,
Cancer is usually associated with impaired nutritional status, which is one of the factors contributing to the deterioration of the results of surgery, chemotherapy, or radiotherapy. The aim of this study was the assessment of the nutritional status of patients with CRC qualified to chemotherapy.Seventy-five persons aged 40-86 years with colorectal cancer were examined. To evaluate the nutritional status NRS 2002, SGA, SCRINIO Working Group classification, VAS scale for appetite, and FAACT questionnaire ...
Tópico(s): Stoma care and complications
2017 - Termedia Publishing House | Współczesna Onkologia
T. Kowalski, Wojciech Kraj, Bartłomiej Bednarz,
F. excelsior is affected by dieback in the major part of its natural geographical range in Europe, which results in economic and ecological losses. The disease is caused by the ascomycetous fungus Hymenoscyphus fraxineus, a pathogen introduced to Europe most probably from East Asia. This paper presents data on fungi identified on F. excelsior trees representing two different stages of ash dieback in Poland. Fungal communities were identified in initial necrotic lesions on living stems and twigs ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2016 - Springer Science+Business Media | European Journal of Forest Research
Katarzyna Krenke, Marta Krawiec, Grażyna Kraj, Joanna Peradzyńska, Agnieszka Krauze, Marek Kulus,
The aim of this study was to evaluate the factors that could predict the development of local complications (parapneumonic effusion/pleural empyema, necrotizing pneumonia, and lung abscess) in children with community-acquired pneumonia (CAP).Demographic, clinical, and laboratory data were prospectively collected and compared in children with noncomplicated and complicated CAP.Two-hundred and three patients aged from 2 months to 17 years were enrolled. There were 141 and 62 children with noncomplicated ...
Tópico(s): Pleural and Pulmonary Diseases
2016 - Wiley | The Clinical Respiratory Journal