Krisztián Tóth, Kristóf László, E Lukács, László Lénárd,
The brain–gut peptide acylated-ghrelin (A-Ghr) is a potent growth hormone (GH) secretagogue substance. A-Ghr is also known to influence on memory and learning processes. Its effect is mediated partly via GH secretagogue receptor (GHS-R) type 1a. The amygdaloid body (AMY) plays important role in memory and learning processes. Projections of ghrelinergic neurons were identified in the AMY, and previously we verified that A-Ghr infused into basolateral nucleus of the AMY (ABL) caused liquid food intake ...
Tópico(s): Adipose Tissue and Metabolism
2009 - Elsevier BV | Behavioural Brain Research
Krisztián Tóth, Kristóf László, László Lénárd,
According to recently published papers acylated-ghrelin (A-Ghr) modifies memory and learning. The basolateral nucleus of amygdala (ABL) participates in the regulation of memory and learning mechanisms. Previously we verified A-Ghr responsive neurons in the ABL by electrophysiological methods. In male Wistar rats effects of bilateral intraamygdaloid microinfusion of 50 ng, 100 ng A-Ghr, 15 ng Ghr receptor antagonist d-Lys3-GHRP-6 (ANT) or ANT+50 ng A-Ghr [dissolved in 0.15M sterile saline], or vehicle ...
Tópico(s): Biochemical effects in animals
2009 - Elsevier BV | Brain Research Bulletin
Kristóf László, Krisztián Tóth, Erika Kertes, László Péczely, László Lénárd,
In the central nervous system neurotensin (NT) acts as a neurotransmitter and neuromodulator. It was shown that NT has positive reinforcing effects after its direct microinjection into the ventral tegmental area. The central nucleus of amygdala (CeA), part of the limbic system, plays an important role in learning, memory, regulation of feeding, anxiety and emotional behavior. By means of immunohistochemical and radioimmune methods it was shown that the amygdaloid body is relatively rich in NT immunoreactive ...
Tópico(s): Neuroendocrine regulation and behavior
2009 - Elsevier BV | Behavioural Brain Research
Kristóf László, Krisztián Tóth, Erika Kertes, László Péczely, Tamás Ollmann, László Lénárd,
Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. ...
Tópico(s): Neuroendocrine regulation and behavior
2010 - Elsevier BV | Behavioural Brain Research
É Lányi, Katalin Csernus, Éva Erhardt, Krisztián Tóth, Barbara Urbán, László Lénárd, Dénes Molnár,
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2007 - Springer Science+Business Media | Journal of Endocrinological Investigation
Kristóf László, Krisztián Tóth, Erika Kertes, László Péczely, Tamás Ollmann, Anna Madarassy-Szücs, László Lénárd,
Tridecapeptide neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reinforcement. The central nucleus of amygdala (CeA), which is relatively rich in NT and neurotensin-1 receptors (NTS1), participates in the regulation of memory and learning mechanisms. The aim of this study was to examine the possible effect of NT and NTS1 antagonist (ANT) on passive avoidance learning after their microinjection into the CeA of male wistar rats. NT significantly increased ...
Tópico(s): Receptor Mechanisms and Signaling
2011 - Elsevier BV | Behavioural Brain Research
Éva Fekete, E. E. Bagi, Krisztián Tóth, László Lénárd,
Bombesin-like peptides including gastrin releasing peptide and neuromedin C are known to inhibit feeding. Bombesin receptors have been found in moderate to high densities in the amygdaloid body, which is essentially involved in the regulation of feeding and body weight. In the present experiments neuromedin C (15, 30, and 60 ng), a carboxyterminal decapeptid fragment of gastrin releasing peptide, was bilaterally microinjected into the central part of the amygdala in ad libitum fed male CFY rats. ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2006 - Elsevier BV | Brain Research Bulletin
Anita Kovács, Kristóf László, Rita Gálosi, Krisztián Tóth, Tamás Ollmann, László Péczely, László Lénárd,
Several members of the RFamide peptide family are known to have role in the regulation of feeding. For example, neuropeptide FF and prolactin-releasing peptide cause anorexigenic, while 26RFa and QRFP result in orexigenic effects in rodents. I.c.v. microinjection of neuropeptide RFRP-1 significantly reduced food and water intake in chicks. However, feeding related effects of RFRP-1 have not been studied in mammals yet. The central part of amygdala (CeA) is essentially involved in the regulation of ...
Tópico(s): Regulation of Appetite and Obesity
2012 - Elsevier BV | Brain Research Bulletin
Attila Bajkó, Anita Maknics, Krisztián Tóth, Péter Vékás,
a magyar nyugdíjrendszer fenntarthatóságáról Sok más fejlett országhoz hasonlóan Magyarországnak is szembe
Tópico(s): Hungarian Social, Economic and Educational Studies
2015 - Economic Review Foundation | Közgazdasági Szemle
Lauren M. Slosky, Yushi Bai, Krisztián Tóth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, Vladimir M. Pogorelov, Dennis Abraham, Namratha Atluri, Satyamaheshwar Peddibhotla, Michael P. Hedrick, Paul Hershberger, Patrick Maloney, Hong Yuan, Zibo Li, William C. Wetsel, Anthony B. Pinkerton, Lawrence S Barak, Marc G. Caron,
Small molecule neurotensin receptor 1 (NTSR1) agonists have been pursued for more than 40 years as potential therapeutics for psychiatric disorders, including drug addiction. Clinical development of NTSR1 agonists has, however, been precluded by their severe side effects. NTSR1, a G protein-coupled receptor (GPCR), signals through the canonical activation of G proteins and engages β-arrestins to mediate distinct cellular signaling events. Here, we characterize the allosteric NTSR1 modulator SBI-553. ...
Tópico(s): Pharmacological Effects and Assays
2020 - Cell Press | Cell
Krisztián Tóth, Kristóf László, E. E. Bagi, E Lukács, László Lénárd,
Ghrelin (Ghr) has two main forms in the blood: the acylated (A-Ghr) and non-acylated (NA-Ghr) Ghr. A-Ghr was discovered as a potent growth hormone (GH) secretion increasing substance acting on GH secretagouge receptor (GHS-R) type 1a. A-Ghr facilitates food intake after its i.p., i.c.v. or direct hypothalamic application. Immunohistological assays identified projections of ghrelinergic neurons to the basolateral nucleus (ABL) of the amygdala (AMY). A-Ghr injected into the hypothalamus caused c-Fos overexpression ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2008 - Elsevier BV | Brain Research Bulletin
Amanda C. Martyn, Krisztián Tóth, Robert Schmalzigaug, Nathan G. Hedrick, Ramona M. Rodriguiz, Ryohei Yasuda, William C. Wetsel, Richard T. Premont,
The signaling scaffold protein GIT1 is expressed widely throughout the brain, but its function in vivo remains elusive. Mice lacking GIT1 have been proposed as a model for attention deficit-hyperactivity disorder, due to alterations in basal locomotor activity as well as paradoxical locomotor suppression by the psychostimulant amphetamine. Since we had previously shown that GIT1-knockout mice have normal locomotor activity, here we examined GIT1-deficient mice for ADHD-like behavior in more detail, ...
Tópico(s): Cellular transport and secretion
2018 - Public Library of Science | PLoS ONE
Krisztián Tóth, Georg Höfner, Klaus T. Wanner,
Our study presents the synthesis and structure-activity relationship (SAR) of novel N-substituted nipecotic acid derivatives closely related to DDPM-1457 [(S)-2a], a chemically stable analog of (S)-SNAP-5114 (1), in the pursuit of finding new and potent mGAT4 selective inhibitors. Iminium ion chemistry served as key step for the preparation of the desired, new N-substituted nipecotic acid derivatives containing a variety of different heterocycles attached to the nipecotic acid moiety via a trans-alkene ...
Tópico(s): DNA and Nucleic Acid Chemistry
2018 - Elsevier BV | Bioorganic & Medicinal Chemistry
Krisztián Tóth, Lauren M. Slosky, Thomas F. Pack, Nikhil M. Urs, Peter G. Boone, Lan Mao, Dennis Abraham, Marc G. Caron, Lawrence S Barak,
The "brain-gut" peptide ghrelin, which mediates food-seeking behaviors, is recognized as a very strong endogenous modulator of dopamine (DA) signaling. Ghrelin binds the G protein-coupled receptor GHSR1a, and administration of ghrelin increases the rewarding properties of psychostimulants while ghrelin receptor antagonists decrease them. In addition, the GHSR1a signals through βarrestin-2 to regulate actin/stress fiber rearrangement, suggesting βarrestin-2 participation in the regulation of actin- ...
Tópico(s): Receptor Mechanisms and Signaling
2017 - Wiley | Synapse
Krisztián Tóth, Georg Höfner, Klaus T. Wanner,
In this study, we present the synthesis and structure–activity relationships (SAR) of novel N-substituted nipecotic acid derivatives closely related to (S)-SNAP-5114 (2) in the pursuit of finding new and potent mGAT4 selective inhibitors. By the use of iminium ion chemistry, a series of new N-substituted nipecotic acid derivatives containing a variety of heterocycles, and an alkyne spacer were synthesized. Biological evaluation of the prepared compounds showed, how the inhibitory potency and subtype ...
Tópico(s): Molecular Sensors and Ion Detection
2018 - Elsevier BV | Bioorganic & Medicinal Chemistry
Lauren M. Slosky, Andrea Pires, Yushi Bai, Nicholas Clark, Elizabeth R. Hauser, Joshua Gross, Fiona Porkka, Yang Zhou, Xiaoxiao Chen, Vladimir M. Pogorelov, Krisztián Tóth, William C. Wetsel, Lawrence S Barak, Marc G. Caron,
Genetically tractable animal models provide needed strategies to resolve the biological basis of drug addiction. Intravenous self-administration (IVSA) is the gold standard for modeling psychostimulant and opioid addiction in animals, but technical limitations have precluded the widespread use of IVSA in mice. Here, we describe IVSA paradigms for mice that capture the multi-stage nature of the disorder and permit predictive modeling. In these paradigms, C57BL/6J mice with long-standing indwelling ...
Tópico(s): Receptor Mechanisms and Signaling
2022 - Nature Portfolio | Scientific Reports
Ágnes Györgyey, László Janovák, András Ádám, Judit Kopniczky, Krisztián László Tóth, Ágota Deák, Ivan Panayotov, Frédéric Cuisinier, Imre Dékány, Kinga Turzó,
Antibacterial surfaces have been in the focus of research for years, driven by an unmet clinical need to manage an increasing incidence of implant-associated infections. The use of silver has become a topic of interest because of its proven broad-spectrum antibacterial activity and track record as a coating agent of soft tissue implants and catheters. However, for the time being, the translation of these technological achievements for the improvement of the antibacterial property of hard tissue ...
Tópico(s): Dental Research and COVID-19
2016 - SAGE Publishing | Journal of Biomaterials Applications
Miklós Weszl, Krisztián László Tóth, Imre Kientzl, Péter Nagy, Dávid Pammer, Liza Pelyhe, Nihal Engin Vrana, Dieter Scharnweber, Cornelia Wolf‐Brandstetter, Árpád Joób F., Eszter Bognár,
The objective of this study was to investigate the reproducibility, mechanical integrity, surface characteristics and corrosion behavior of nanotubular (NT) titanium oxide arrays in comparison with a novel nano-pitted (NP) anodic film.Surface treatment processes were developed to grow homogenous NT and NP anodic films on the surface of grade 2 titanium discs and dental implants. The effect of process parameters on the surface characteristics and reproducibility of the anodic films was investigated ...
Tópico(s): Titanium Alloys Microstructure and Properties
2017 - Elsevier BV | Materials Science and Engineering C
Krisztián Tóth, Karim Nagi, Lauren M. Slosky, Lauren K. Rochelle, Caroline Ray, Suneet Kaur, Sudha K. Shenoy, Marc G. Caron, Larry S. Barak,
G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement depend on multiple receptor determinants. Using ghrelin receptor GHR1a, we demonstrate by bioluminescence resonance energy transfer and fluorescence microscopy a critical role for its second intracellular loop 2 (ICL2) domain in stabilizing β-arrestin/GHSR1a core interactions and ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - American Chemical Society | ACS Pharmacology & Translational Science
Raquel Hernando, Beatriz Gamarra, Ashley McCall, Olivia Cheronet, Daniel Fernandes, Kendra Sirak, Ryan Schmidt, Marina Lozano, Tamás Szeniczey, Tamás Hajdu, Annamária Bárány, András Kalli, Eszter K. Tutkovics, Kitti Köhler, Krisztián Kiss, Judit Koós, Piroska Csengeri, Ágnes Király, Antónia Horváth, Melinda L. Hajdu, Krisztián Tóth, R Patay, Robin N. M. Feeney, Ron Pinhasi,
Abstract Dietary reconstruction is used to make inferences about the subsistence strategies of ancient human populations, but it may also serve as a proxy to characterise their diverse cultural and technological manifestations. Dental microwear and stable isotope analyses have been shown to be successful techniques for paleodietary reconstruction of ancient populations but, despite yielding complementary dietary information, these techniques have rarely been combined within the same study. Here ...
Tópico(s): Pacific and Southeast Asian Studies
2021 - Nature Portfolio | Scientific Reports
Joshua Gross, D. W. Kim, Yang Zhou, Daniel J. Jansen, Lauren M. Slosky, Nicholas Clark, Caroline Ray, Xin Hu, Noel Southall, Anyang Wang, Xin Xu, Elena Barnaeva, William C. Wetsel, Marc Ferrer, Juan Marugán, Marc G. Caron, Lawrence S Barak, Krisztián Tóth,
SignificanceThe modulation of growth hormone secretagogue receptor-1a (GHSR1a) signaling is a promising strategy for treating brain conditions of metabolism, aging, and addiction. GHSR1a activation results in pleiotropic physiological outcomes through distinct and pharmacologically separable G protein- and β-arrestin (βarr)-dependent signaling pathways. Thus, pathway-selective modulation can enable improved pharmacotherapeutics that can promote therapeutic efficacy while mitigating side effects. Here, ...
Tópico(s): Adipose Tissue and Metabolism
2022 - National Academy of Sciences | Proceedings of the National Academy of Sciences
J. Csotye, Krisztián Sisák, Loránt Bardócz, Kálmán Tóth,
Csotye, Janos MD; Sisak, Krisztian MD; Bardocz, Lorant MD; Toth, Kalman MD, PhD Author Information
Tópico(s): Bone and Joint Diseases
2010 - Lippincott Williams & Wilkins | Journal of Trauma and Acute Care Surgery
Mihály Minda, György Tóth, István Horváth, Ivan Barnet, Krisztián Hámori, Eszter Tóth,
Tópico(s): Nuclear and radioactivity studies
2008 - Springer Nature | Environmental Geology
Niina Halonen, Krisztián Kordás, Géza Tóth, Tero Mustonen, Jani Mäklin, Jouko Vähäkangas, Pulickel M. Ajayan, Róbert Vajtai,
The emerging interest toward applications of robust highly aligned carbon nanotube forests requires synthesis of such films in a controlled manner. In this paper, the growth mechanism and influence of growth parameters on the structural properties of multiwalled carbon nanotube films grown by catalytic chemical vapor deposition on SiO2 surfaces are investigated. The experimental studies are complemented with computational finite element simulations of temperature and flow fields in the reactor to ...
Tópico(s): Nanopore and Nanochannel Transport Studies
2008 - American Chemical Society | The Journal of Physical Chemistry C
Gábor Janositz, Krisztián Sisák, K. Tóth,
Tópico(s): Bone and Joint Diseases
2010 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Miklós Mézes, Krisztián Balogh, Katalin Tóth,
Ingredients used in animal feeds and their contamination with undesirable substances, such as mycotoxins, are fundamentally important both in terms of the quality of animal products and the potential human health impacts associated with the animal-based food production chain. Feed ingredients contaminated with mycotoxins may have a wide range of toxicological effects on animals. Therefore, mycotoxin contamination of feed ingredients constituting complete feed products represents an important potential ...
Tópico(s): Selenium in Biological Systems
2010 - Akadémiai Kiadó | Acta Veterinaria Hungarica
Krisztián Kordás, Géza Tóth, Pasi Moilanen, M. Kumpumäki, Jouko Vähäkangas, A. Uusimäki, Róbert Vajtai, Pulickel M. Ajayan,
Efficient cooling of silicon chips using microfin structures made of aligned multiwalled carbon nanotube arrays is achieved. The tiny cooling elements mounted on the back side of the chips enable power dissipation from the heated chips on the level of modern electronics demands. The nanotube fins are mechanically superior compared to other materials being ten times lighter, flexible, and stiff at the same time. These properties accompanied with the relative simplicity of the fabrication makes the ...
Tópico(s): Thermal properties of materials
2007 - American Institute of Physics | Applied Physics Letters
Kerttu Aitola, Janne Halme, Niina Halonen, Antti Kaskela, Minna Toivola, Albert G. Nasibulin, Krisztián Kordás, Géza Tóth, Esko I. Kauppinen, Peter D. Lund,
Three characteristically different carbon nanomaterials were compared and analyzed as platinum-free counter electrodes for dye solar cells: 1) single-walled carbon nanotube (SWCNT) random network films on glass, 2) aligned multi-walled carbon nanotube (MWCNT) forest films on Inconel steel and quartz, and 3) pressed carbon nanoparticle composite films on indium tin oxide-polyethylene terephtalate plastic. Results from electrochemical impedance spectroscopy and electron microscopy were discussed in ...
Tópico(s): Quantum Dots Synthesis And Properties
2011 - Elsevier BV | Thin Solid Films
Krisztián Hámori, Eszter Tóth, Lénard Pál, George Köteles, András Losonci, Mihály Minda,
The RAD Laboratory measured annual means of radon activity concentrations in 15 277 first-floor rooms of dwellings and in 325 rooms on upper floors in Hungary (1994–2004). The original purpose of the survey was to find radon-prone area in Hungary. The maximum measured value was 5800 Bq m−3, while the minimum was 10 Bq m−3. Due to geological diversity and different structures of buildings, the data set of first-floor rooms did not follow the lognormal distribution. Therefore, strata were chosen so ...
Tópico(s): Radioactive contamination and transfer
2006 - Elsevier BV | Journal of Environmental Radioactivity
Krisztián Kordás, Géza Tóth, J. Levoska, Mika Huuhtanen, Riitta L. Keiski, Matti Härkönen, Thomas F. George, Jouko Vähäkangas,
Palladium nanoparticles are deposited in the pores of freestanding, mesoporous anodic aluminium oxide (AAO) templates via a chemical route at room temperature. In the precursor, Pd2+ ions are complexed with ammonia and reduced to Pd0 by adding an excess amount of formaldehyde. To enhance the infiltration of pores with the precursor, 2-propanol is added to the solution. After a few hours of plating at room temperature, crystalline Pd0 nanoparticles with an average size of ~4 nm form on the pore walls ...
Tópico(s): Corrosion Behavior and Inhibition
2006 - IOP Publishing | Nanotechnology